SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NCN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM
(Thermoplasma
acidophilum) 		4 / 4 SER A 296
ILE A 295
VAL A 163
THR A 179
 None
None
None
NCN  A 401 (-3.1A)
 1.05A 1u70A-1ytkA:
undetectable		 1u70A-1ytkA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 12 LEU A 167
ALA A 135
SER A 248
MET A 169
LEU A 220
 None
None
NCN  A 301 (-2.9A)
NCN  A 301 ( 4.6A)
None
 1.35A 1ya3B-4i9aA:
undetectable		 1ya3B-4i9aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM
(Thermoplasma
acidophilum) 		6 / 6 PHE A 138
ARG A 141
SER A 164
GLY A 178
THR A 179
ARG A 235
 NCN  A 401 (-3.4A)
NCN  A 401 (-3.5A)
NCN  A 401 (-3.6A)
NCN  A 401 (-3.1A)
NCN  A 401 (-3.1A)
NCN  A 401 (-3.1A)
 0.63A 2f7fA-1ytkA:
33.9		 2f7fA-1ytkA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 7 SER A 248
ASP A 222
SER A 268
VAL A 266
 NCN  A 301 (-2.9A)
NCN  A 301 (-3.3A)
NCN  A 301 (-3.4A)
None
 1.06A 2hdnE-4i9aA:
undetectable
2hdnF-4i9aA:
2.2
2hdnH-4i9aA:
undetectable		 2hdnE-4i9aA:
7.94
2hdnF-4i9aA:
22.42
2hdnH-4i9aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 7 SER A 268
VAL A 266
SER A 248
ASP A 222
 NCN  A 301 (-3.4A)
None
NCN  A 301 (-2.9A)
NCN  A 301 (-3.3A)
 1.05A 2hdnF-4i9aA:
2.4
2hdnG-4i9aA:
undetectable
2hdnH-4i9aA:
undetectable		 2hdnF-4i9aA:
22.42
2hdnG-4i9aA:
7.94
2hdnH-4i9aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 SER A 248
ASP A 222
SER A 268
VAL A 266
 NCN  A 301 (-2.9A)
NCN  A 301 (-3.3A)
NCN  A 301 (-3.4A)
None
 1.04A 2hdnI-4i9aA:
undetectable
2hdnJ-4i9aA:
2.4
2hdnL-4i9aA:
2.1		 2hdnI-4i9aA:
7.94
2hdnJ-4i9aA:
22.42
2hdnL-4i9aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 SER A 268
VAL A 266
SER A 248
ASP A 222
 NCN  A 301 (-3.4A)
None
NCN  A 301 (-2.9A)
NCN  A 301 (-3.3A)
 1.09A 2hdnJ-4i9aA:
2.3
2hdnK-4i9aA:
undetectable
2hdnL-4i9aA:
2.3		 2hdnJ-4i9aA:
22.42
2hdnK-4i9aA:
7.94
2hdnL-4i9aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 7 LEU A 220
GLU A 201
ASP A 172
SER A 248
 None
NCN  A 301 (-3.6A)
None
NCN  A 301 (-2.9A)
 1.41A 3dzgA-4i9aA:
undetectable		 3dzgA-4i9aA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 7 LEU A 220
GLU A 201
ASP A 172
SER A 248
THR A 137
 None
NCN  A 301 (-3.6A)
None
NCN  A 301 (-2.9A)
NCN  A 301 ( 4.4A)
 1.50A 3dzgB-4i9aA:
2.2		 3dzgB-4i9aA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 LEU A 220
GLU A 199
SER A 248
THR A 137
 None
None
NCN  A 301 (-2.9A)
NCN  A 301 ( 4.4A)
 1.41A 3ropA-4i9aA:
2.1		 3ropA-4i9aA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		3 / 3 LYS A 171
ARG A 145
LEU A 164
 NCN  A 301 (-3.3A)
None
None
 1.34A 3v4tE-4i9aA:
undetectable		 3v4tE-4i9aA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 7 SER A 268
HIS A 160
GLY A 136
LEU A 220
 NCN  A 301 (-3.4A)
NCN  A 301 (-3.5A)
None
None
 1.08A 6btxA-4i9aA:
undetectable		 6btxA-4i9aA:
21.14