SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NCC'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5O_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	1qwj	CYTIDINE MONOPHOSPHO-N-ACETYL NEURAMINIC ACID SYNTHETASE (Mus musculus)	4 / 7	ILE A 70 PRO A 145 ILE A 246 ASP A 245	None None None NCC A2002 ( 4.9A)	0.88A	4w5oA-1qwjA: 0.0	4w5oA-1qwjA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4E_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	1qwj	CYTIDINE MONOPHOSPHO-N-ACETYL NEURAMINIC ACID SYNTHETASE (Mus musculus)	4 / 7	ILE A 70 PRO A 145 ILE A 246 ASP A 245	None None None NCC A2002 ( 4.9A)	0.86A	4z4eA-1qwjA: 0.0	4z4eA-1qwjA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4G_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	1qwj	CYTIDINE MONOPHOSPHO-N-ACETYL NEURAMINIC ACID SYNTHETASE (Mus musculus)	4 / 7	ILE A 70 PRO A 145 ILE A 246 ASP A 245	None None None NCC A2002 ( 4.9A)	0.89A	4z4gA-1qwjA: 0.0	4z4gA-1qwjA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AD9_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4zht	BIFUNCTIONAL UDP-N-ACETYLGLUCOSAM INE 2-EPIMERASE/N-ACETYL MANNOSAMINE KINASE (Homo sapiens)	4 / 7	VAL A 249 PHE A 276 HIS A 273 GLU A 271	None None None NCC A 502 (-2.7A)	1.35A	5ad9A-4zhtA: undetectable 5ad9B-4zhtA: undetectable	5ad9A-4zhtA: 21.68 5ad9B-4zhtA: 21.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4W5O_A_IPHA904_0","PROTEIN ARGONAUTE-2","1qwj","CYTIDINE MONOPHOSPHO-N-ACETYLNEURAMINIC ACID SYNTHETASE","Mus musculus",4,"ILE A  70;PRO A 145;ILE A 246;ASP A 245","None;None;None;NCC A2002 ( 4.9A)","0.88A","4w5oA-1qwjA:0.0",null],["4Z4E_A_IPHA904_0","PROTEIN ARGONAUTE-2","1qwj","CYTIDINE MONOPHOSPHO-N-ACETYLNEURAMINIC ACID SYNTHETASE","Mus musculus",4,"ILE A  70;PRO A 145;ILE A 246;ASP A 245","None;None;None;NCC A2002 ( 4.9A)","0.86A","4z4eA-1qwjA:0.0","4w5oA-1qwjA:14.60"],["4Z4G_A_IPHA902_0","PROTEIN ARGONAUTE-2","1qwj","CYTIDINE MONOPHOSPHO-N-ACETYLNEURAMINIC ACID SYNTHETASE","Mus musculus",4,"ILE A  70;PRO A 145;ILE A 246;ASP A 245","None;None;None;NCC A2002 ( 4.9A)","0.89A","4z4gA-1qwjA:0.0","4z4eA-1qwjA:14.60"],["5AD9_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4zht","BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE\/N-ACETYLMANNOSAMINE KINASE","Homo sapiens",4,"VAL A 249;PHE A 276;HIS A 273;GLU A 271","None;None;None;NCC A 502 (-2.7A)","1.35A","5ad9A-4zhtA:undetectable;5ad9B-4zhtA:undetectable","4z4gA-1qwjA:14.60"]]