SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NBR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 7 GLN A 308
TRP A 420
TRP A 423
ASN A 345
 NBR  A1458 ( 3.3A)
NBR  A1458 (-3.4A)
NBR  A1458 ( 3.5A)
NBR  A1458 ( 4.9A)
 1.14A 1jqdA-5ftgA:
undetectable		 1jqdA-5ftgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 8 GLN A 308
TYR A 256
TRP A 420
THR A 252
 NBR  A1458 ( 3.3A)
None
NBR  A1458 (-3.4A)
None
 1.40A 2vxaF-5ftgA:
undetectable
2vxaG-5ftgA:
undetectable
2vxaI-5ftgA:
undetectable		 2vxaF-5ftgA:
12.96
2vxaG-5ftgA:
12.96
2vxaI-5ftgA:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 ASP A 306
GLU A 349
TYR A 354
TRP A 423
PHE A 435
TYR A 440
 EDO  A1466 ( 3.0A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.7A)
NBR  A1458 (-4.0A)
 0.42A 3mesA-5ftgA:
35.6		 3mesA-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 420
TRP A 423
TYR A 440
 NBR  A1458 ( 3.3A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 (-3.4A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.0A)
 0.76A 3mesA-5ftgA:
35.6		 3mesA-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 423
PHE A 435
TYR A 440
 NBR  A1458 ( 3.3A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.7A)
NBR  A1458 (-4.0A)
 0.59A 3mesA-5ftgA:
35.6		 3mesA-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 ASP A 306
GLU A 349
TYR A 354
TRP A 423
PHE A 435
TYR A 440
 EDO  A1466 ( 3.0A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.7A)
NBR  A1458 (-4.0A)
 0.44A 3mesB-5ftgA:
35.6		 3mesB-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 420
TRP A 423
TYR A 440
 NBR  A1458 ( 3.3A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 (-3.4A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.0A)
 0.75A 3mesB-5ftgA:
35.6		 3mesB-5ftgA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		6 / 10 GLN A 308
GLU A 349
TYR A 354
TRP A 423
PHE A 435
TYR A 440
 NBR  A1458 ( 3.3A)
NBR  A1458 (-4.0A)
NBR  A1458 (-3.5A)
NBR  A1458 ( 3.5A)
NBR  A1458 (-4.7A)
NBR  A1458 (-4.0A)
 0.60A 3mesB-5ftgA:
35.6		 3mesB-5ftgA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
 0.87A 4uroA-5ftgA:
undetectable		 4uroA-5ftgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
 0.99A 4uroB-5ftgA:
undetectable		 4uroB-5ftgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		5 / 12 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
 0.91A 4uroC-5ftgA:
undetectable		 4uroC-5ftgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
NBR  A1458 ( 3.3A)
None
None
 1.16A 4w5qA-5ftgA:
undetectable		 4w5qA-5ftgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
NBR  A1458 ( 3.3A)
None
None
 1.10A 4w5tA-5ftgA:
undetectable		 4w5tA-5ftgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5ftg CHOLINE KINASE ALPHA
(Homo
sapiens) 		4 / 6 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
NBR  A1458 ( 3.3A)
None
None
 1.17A 6cbdA-5ftgA:
undetectable		 6cbdA-5ftgA:
18.63