SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NBG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		4 / 5 LEU A 139
SER A 808
LEU A 683
GLY A 485
 NBG  A   1 ( 4.2A)
None
None
None
 1.05A 1a4lB-3cemA:
undetectable		 1a4lB-3cemA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5oyd CELLULASE, PUTATIVE,
CEL5D
(Cellvibrio
japonicus) 		5 / 12 ILE A 130
HIS A 323
VAL A 164
ALA A 163
LEU A 153
 None
NBG  A 501 ( 3.7A)
None
None
None
 1.09A 1vptA-5oydA:
undetectable		 1vptA-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5oyd CELLULASE, PUTATIVE,
CEL5D
(Cellvibrio
japonicus) 		5 / 12 ILE A 166
HIS A 323
VAL A 164
ALA A 163
LEU A 153
 None
NBG  A 501 ( 3.7A)
None
None
None
 0.93A 1vptA-5oydA:
undetectable		 1vptA-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 5oyd CELLULASE, PUTATIVE,
CEL5D
(Cellvibrio
japonicus) 		4 / 7 ASN A 206
ASN A 129
HIS A 323
VAL A 387
 None
None
NBG  A 501 ( 3.7A)
None
 1.15A 1wu8A-5oydA:
undetectable
1wu8C-5oydA:
undetectable		 1wu8A-5oydA:
14.34
1wu8C-5oydA:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		6 / 10 ASN A 133
LEU A 136
ASP A 339
HIS A 341
HIS A 571
ALA A 610
 None
NBG  A   1 (-4.1A)
None
None
None
None
 0.99A 2ecpA-3cemA:
54.7		 2ecpA-3cemA:
44.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		6 / 10 ASN A 133
LEU A 136
ASP A 339
HIS A 341
HIS A 571
ALA A 610
 None
NBG  A   1 (-4.1A)
None
None
None
None
 0.96A 2ecpB-3cemA:
53.4		 2ecpB-3cemA:
44.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		3 / 3 ASN A 133
LEU A 136
HIS A 341
 None
NBG  A   1 (-4.1A)
None
 0.87A 2q6fB-3cemA:
undetectable		 2q6fB-3cemA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		4 / 6 VAL A 455
ASP A 339
TYR A  84
ASN A 484
 NBG  A   1 ( 4.5A)
None
None
NBG  A   1 (-3.3A)
 1.47A 2zs9A-3cemA:
undetectable		 2zs9A-3cemA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		5 / 8 GLY A 675
THR A 676
GLU A 672
GLY A 694
ALA A 695
 PLP  A 832 ( 3.3A)
PLP  A 832 (-3.8A)
NBG  A   1 (-3.5A)
None
None
 1.14A 3aruA-3cemA:
undetectable		 3aruA-3cemA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EBK_B_TOYB302_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		5 / 9 GLU A 572
TYR A 613
ALA A 616
GLU A 382
ASP A 283
 None
None
None
None
NBG  A   1 ( 4.5A)
 1.46A 4ebkA-3cemA:
0.4
4ebkB-3cemA:
0.4		 4ebkA-3cemA:
15.98
4ebkB-3cemA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		5 / 8 ASN A 481
PHE A 479
VAL A 452
HIS A 459
ALA A 673
 None
None
None
None
NBG  A   1 (-3.7A)
 1.41A 4eyzA-3cemA:
undetectable		 4eyzA-3cemA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		5 / 8 ASN A 481
PHE A 479
VAL A 452
HIS A 459
ALA A 673
 None
None
None
None
NBG  A   1 (-3.7A)
 1.40A 4eyzB-3cemA:
undetectable		 4eyzB-3cemA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		3 / 3 LYS A 608
ASP A 283
ILE A 623
 None
NBG  A   1 ( 4.5A)
None
 0.75A 5kc4E-3cemA:
undetectable		 5kc4E-3cemA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		7 / 10 GLY A 135
HIS A 377
VAL A 455
ASN A 484
LYS A 574
GLU A 672
GLY A 675
 PLP  A 832 (-3.9A)
NBG  A   1 (-3.8A)
NBG  A   1 ( 4.5A)
NBG  A   1 (-3.3A)
PLP  A 832 (-2.8A)
NBG  A   1 (-3.5A)
PLP  A 832 ( 3.3A)
 0.70A 5vncC-3cemA:
17.5		 5vncC-3cemA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		6 / 12 GLY A 134
GLY A 135
ASP A 339
VAL A 455
ASN A 484
GLY A 675
 PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
None
NBG  A   1 ( 4.5A)
NBG  A   1 (-3.3A)
PLP  A 832 ( 3.3A)
 0.74A 6gneA-3cemA:
23.4		 6gneA-3cemA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		6 / 12 GLU A  88
GLY A 134
GLY A 135
VAL A 455
ASN A 484
GLY A 675
 None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 ( 4.5A)
NBG  A   1 (-3.3A)
PLP  A 832 ( 3.3A)
 0.70A 6gneB-3cemA:
23.2		 6gneB-3cemA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		6 / 12 GLU A  88
GLY A 135
ASP A 339
VAL A 455
ASN A 484
GLY A 675
 None
PLP  A 832 (-3.9A)
None
NBG  A   1 ( 4.5A)
NBG  A   1 (-3.3A)
PLP  A 832 ( 3.3A)
 0.80A 6gneB-3cemA:
23.2		 6gneB-3cemA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		5 / 12 ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
 None
None
NBG  A   1 (-3.3A)
NBG  A   1 (-3.5A)
PLP  A 832 ( 3.3A)
 0.77A 6gnfA-3cemA:
22.9		 6gnfA-3cemA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		5 / 12 ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
 None
None
NBG  A   1 (-3.3A)
NBG  A   1 (-3.5A)
PLP  A 832 ( 3.3A)
 0.76A 6gnfC-3cemA:
23.2		 6gnfC-3cemA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		5 / 12 GLY A 134
LEU A 136
ASP A 339
HIS A 341
ASN A 484
 PLP  A 832 (-3.6A)
NBG  A   1 (-4.1A)
None
None
NBG  A   1 (-3.3A)
 0.89A 6gngA-3cemA:
22.2		 6gngA-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		6 / 12 GLU A  88
GLY A 135
HIS A 377
VAL A 455
GLU A 672
GLY A 675
 None
PLP  A 832 (-3.9A)
NBG  A   1 (-3.8A)
NBG  A   1 ( 4.5A)
NBG  A   1 (-3.5A)
PLP  A 832 ( 3.3A)
 0.64A 6gngA-3cemA:
22.2		 6gngA-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		6 / 12 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ARG A 569
 None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 (-4.1A)
None
None
 1.47A 6gngB-3cemA:
22.2		 6gngB-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		6 / 12 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ASN A 284
 None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 (-4.1A)
None
NBG  A   1 (-3.5A)
 1.30A 6gngB-3cemA:
22.2		 6gngB-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens) 		4 / 5 GLY A 137
LEU A 136
SER A  86
TYR A  84
 None
NBG  A   1 (-4.1A)
None
None
 0.96A 6ji6A-3cemA:
undetectable		 6ji6A-3cemA:
14.22