SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NB1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		7 / 11 ASP A 242
CYH A 278
TYR A 282
THR A 310
VAL A 314
ASN A 339
TYR A 345
 NB1  A1590 (-3.7A)
NB1  A1590 (-3.4A)
NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
None
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.8A)
 0.71A 2w4xA-2j4gA:
59.3		 2w4xA-2j4gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		10 / 11 CYH A 278
TYR A 282
THR A 310
VAL A 314
TRP A 337
ASN A 339
VAL A 342
ASP A 344
TYR A 345
ASN A 372
 NB1  A1590 (-3.4A)
NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
None
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 ( 4.8A)
NB1  A1590 (-3.4A)
 0.45A 2w4xA-2j4gA:
59.3		 2w4xA-2j4gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		7 / 12 ASP A 242
TYR A 282
THR A 310
VAL A 314
ASN A 339
VAL A 342
ASP A 344
 NB1  A1590 (-3.7A)
NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
None
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
 0.75A 2x0yA-2j4gA:
41.7		 2x0yA-2j4gA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		7 / 12 LYS A 166
VAL A 314
TRP A 337
ASN A 339
VAL A 342
ASP A 344
ASN A 372
 NB1  A1590 (-3.0A)
None
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 (-3.4A)
 0.84A 2x0yA-2j4gA:
41.7		 2x0yA-2j4gA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		8 / 12 TYR A 282
THR A 310
VAL A 314
TRP A 337
ASN A 339
VAL A 342
ASP A 344
ASN A 372
 NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
None
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 (-3.4A)
 0.49A 2x0yA-2j4gA:
41.7		 2x0yA-2j4gA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		9 / 12 ASP A 242
TYR A 282
THR A 310
TRP A 337
ASN A 339
VAL A 342
ASP A 344
TYR A 345
ASN A 372
 NB1  A1590 (-3.7A)
NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 ( 4.8A)
NB1  A1590 (-3.4A)
 0.67A 2x0yB-2j4gA:
41.9		 2x0yB-2j4gA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		7 / 12 LYS A 166
THR A 310
TRP A 337
ASN A 339
VAL A 342
ASP A 344
ASN A 372
 NB1  A1590 (-3.0A)
NB1  A1590 (-3.9A)
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 (-3.4A)
 0.72A 2x0yB-2j4gA:
41.9		 2x0yB-2j4gA:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 167
HIS A 171
HIS A 207
ASP A 242
 None
None
None
NB1  A1590 (-3.7A)
 0.86A 3c0zC-2j4gA:
undetectable		 3c0zC-2j4gA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 168
TYR A 163
GLY A 135
ALA A 238
 None
None
NB1  A1590 (-4.8A)
None
 0.83A 4m48A-2j4gA:
2.2		 4m48A-2j4gA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 244
VAL A 342
PHE A 136
CYH A 278
 None
NB1  A1590 ( 4.9A)
None
NB1  A1590 (-3.4A)
 0.94A 5hieC-2j4gA:
undetectable		 5hieC-2j4gA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 431
TYR A 435
VAL A 346
VAL A 342
 None
None
None
NB1  A1590 ( 4.9A)
 1.22A 6f32B-2j4gA:
undetectable		 6f32B-2j4gA:
20.25