SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NAX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1bdm MALATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 223
ALA A 269
SER A 286
SER A 187
HIS A 186
 None
None
None
None
NAX  A 334 (-3.1A)
 1.34A 1nbhA-1bdmA:
6.8		 1nbhA-1bdmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1bdm MALATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 223
ALA A 269
SER A 286
SER A 187
HIS A 186
 None
None
None
None
NAX  A 334 (-3.1A)
 1.34A 1nbhD-1bdmA:
6.2		 1nbhD-1bdmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1bdm MALATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 ALA A 139
ILE A 107
GLY A 105
PRO A 131
ALA A 132
 None
NAX  A 334 ( 4.0A)
None
None
NAX  A 334 ( 4.0A)
 1.20A 1sguA-1bdmA:
0.0		 1sguA-1bdmA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1bdm MALATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 GLY A  16
GLY A  13
SER A 240
ALA A 245
ARG A 237
 None
NAX  A 334 (-3.4A)
NAX  A 334 ( 4.0A)
NAX  A 334 (-3.5A)
None
 0.80A 1x7pA-1bdmA:
2.6
1x7pB-1bdmA:
undetectable		 1x7pA-1bdmA:
24.30
1x7pB-1bdmA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 1bdm MALATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A 139
ILE A 107
GLY A 105
PRO A 131
VAL A 127
 None
NAX  A 334 ( 4.0A)
None
None
None
 1.08A 2b7zB-1bdmA:
undetectable		 2b7zB-1bdmA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1bdm MALATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 GLY A  10
GLY A  13
GLU A  41
ILE A  42
ILE A 107
 NAX  A 334 (-3.3A)
NAX  A 334 (-3.4A)
NAX  A 334 (-2.9A)
NAX  A 334 (-4.2A)
NAX  A 334 ( 4.0A)
 0.66A 3grvA-1bdmA:
5.6		 3grvA-1bdmA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1bdm MALATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ALA A  12
GLY A  16
LEU A  56
LEU A  39
LEU A  19
 NAX  A 334 ( 4.4A)
None
None
None
None
 1.14A 3wdmC-1bdmA:
3.6		 3wdmC-1bdmA:
22.71