SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NAR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 232
ASP A 234
LEU A 249
HIS A 288
SER A 300
PHE A 304
 FE2  A1350 ( 3.5A)
FE2  A1350 (-2.6A)
AKG  A1351 ( 4.0A)
FE2  A1350 ( 3.5A)
AKG  A1351 (-2.5A)
NAR  A1352 ( 3.5A)
 0.47A 1uobA-2brtA:
22.1		 1uobA-2brtA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.94A 1v55P-2brtA:
undetectable
1v55W-2brtA:
undetectable		 1v55P-2brtA:
19.40
1v55W-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 1.00A 2dysC-2brtA:
undetectable
2dysJ-2brtA:
undetectable		 2dysC-2brtA:
19.40
2dysJ-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.97A 2eijP-2brtA:
undetectable
2eijW-2brtA:
undetectable		 2eijP-2brtA:
19.40
2eijW-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 8 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.98A 2eilP-2brtA:
undetectable
2eilW-2brtA:
undetectable		 2eilP-2brtA:
19.40
2eilW-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.96A 2zxwC-2brtA:
undetectable
2zxwJ-2brtA:
undetectable		 2zxwC-2brtA:
19.40
2zxwJ-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.93A 2zxwP-2brtA:
undetectable
2zxwW-2brtA:
undetectable		 2zxwP-2brtA:
19.40
2zxwW-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.84A 3ag1C-2brtA:
undetectable
3ag1J-2brtA:
undetectable		 3ag1C-2brtA:
19.40
3ag1J-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 8 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.97A 3asoC-2brtA:
undetectable
3asoJ-2brtA:
undetectable		 3asoC-2brtA:
19.40
3asoJ-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		5 / 12 GLN A 211
ASP A 234
VAL A 235
LEU A 249
ALA A 302
 None
FE2  A1350 (-2.6A)
NAR  A1352 (-3.8A)
AKG  A1351 ( 4.0A)
AKG  A1351 ( 3.9A)
 1.17A 3d91B-2brtA:
undetectable		 3d91B-2brtA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXX_A_CHDA302_0
(CARBONIC ANHYDRASE 2)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		5 / 9 ILE A 338
HIS A 288
HIS A 232
PHE A 334
THR A 239
 None
FE2  A1350 ( 3.5A)
FE2  A1350 ( 3.5A)
NAR  A1352 (-4.6A)
None
 1.47A 4pxxA-2brtA:
undetectable		 4pxxA-2brtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2brt LEUCOANTHOCYANIDIN
DIOXYGENASE
(Arabidopsis
thaliana) 		4 / 5 ARG A 177
LEU A 210
PHE A 304
PHE A 184
 None
None
NAR  A1352 ( 3.5A)
None
 1.34A 6nmpP-2brtA:
undetectable
6nmpW-2brtA:
undetectable		 6nmpP-2brtA:
19.40
6nmpW-2brtA:
13.23