SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NAJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 ALA A 176
GLY A 170
ILE A 201
VAL A 284
 None
None
None
NAJ  A1361 (-4.1A)
 0.80A 1d4sB-1h2bA:
undetectable		 1d4sB-1h2bA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 LEU A 315
THR A 172
TRP A  65
HIS A  59
 None
NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
 0.96A 2y69C-1h2bA:
0.0
2y69N-1h2bA:
0.0
2y69P-1h2bA:
undetectable		 2y69C-1h2bA:
19.62
2y69N-1h2bA:
21.42
2y69P-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 9 VAL A 203
GLY A 197
GLY A 196
LEU A 205
ALA A 173
 None
NAJ  A1361 (-3.5A)
NAJ  A1361 (-3.2A)
None
None
 0.90A 2z0yB-1h2bA:
undetectable		 2z0yB-1h2bA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 HIS A  79
ASP A 168
THR A 172
LEU A 131
MET A 121
 ZN  A1362 ( 3.2A)
ZN  A1362 (-2.7A)
NAJ  A1361 (-3.4A)
OCA  A1360 (-4.8A)
None
 1.47A 3ce6D-1h2bA:
4.7		 3ce6D-1h2bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 GLU A  80
PHE A 128
ARG A 354
ASP A  57
 None
OCA  A1360 (-4.5A)
NAJ  A1361 (-3.1A)
None
 1.10A 3mjrD-1h2bA:
undetectable		 3mjrD-1h2bA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 9 LYS A 220
LYS A 223
VAL A 195
GLY A 196
LEU A 217
 None
NAJ  A1361 (-4.1A)
None
NAJ  A1361 (-3.2A)
None
 1.42A 4b3oA-1h2bA:
undetectable		 4b3oA-1h2bA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 GLY A 197
GLY A 170
GLU A  80
VAL A 309
 NAJ  A1361 (-3.5A)
None
None
NAJ  A1361 (-3.7A)
 0.90A 4fgzA-1h2bA:
6.1		 4fgzA-1h2bA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 THR A 172
ALA A 169
ASP A 168
ILE A 192
GLY A 194
 NAJ  A1361 (-3.4A)
None
ZN  A1362 (-2.7A)
None
NAJ  A1361 (-3.6A)
 1.01A 4xi3B-1h2bA:
undetectable		 4xi3B-1h2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.09A 5b1bA-1h2bA:
0.0
5b1bC-1h2bA:
0.0
5b1bP-1h2bA:
0.0		 5b1bA-1h2bA:
21.42
5b1bC-1h2bA:
19.62
5b1bP-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 ALA A 266
THR A 267
TYR A 270
VAL A 219
 NAJ  A1361 ( 4.1A)
NAJ  A1361 (-4.6A)
None
NAJ  A1361 (-4.4A)
 0.83A 5ecnA-1h2bA:
0.5		 5ecnA-1h2bA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 LEU A 198
THR A 172
VAL A 309
SER A 307
THR A 271
 NAJ  A1361 (-3.7A)
NAJ  A1361 (-3.4A)
NAJ  A1361 (-3.7A)
None
None
 1.17A 5v1tA-1h2bA:
undetectable		 5v1tA-1h2bA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.02A 5w97A-1h2bA:
0.0
5w97C-1h2bA:
0.0
5w97c-1h2bA:
0.0		 5w97A-1h2bA:
21.42
5w97C-1h2bA:
19.62
5w97c-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 LEU A 315
THR A 172
TRP A  65
HIS A  59
 None
NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
 1.02A 5w97C-1h2bA:
undetectable
5w97a-1h2bA:
0.0
5w97c-1h2bA:
undetectable		 5w97C-1h2bA:
19.62
5w97a-1h2bA:
21.42
5w97c-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 LEU A 315
THR A 172
TRP A  65
HIS A  59
 None
NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
 1.08A 5wauC-1h2bA:
0.0
5waua-1h2bA:
undetectable
5wauc-1h2bA:
0.0		 5wauC-1h2bA:
19.62
5waua-1h2bA:
21.42
5wauc-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.07A 5x1bA-1h2bA:
0.0
5x1bC-1h2bA:
0.0
5x1bP-1h2bA:
undetectable		 5x1bA-1h2bA:
21.42
5x1bC-1h2bA:
19.62
5x1bP-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.07A 5x1fA-1h2bA:
undetectable
5x1fC-1h2bA:
0.0
5x1fP-1h2bA:
0.0		 5x1fA-1h2bA:
21.42
5x1fC-1h2bA:
19.62
5x1fP-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 5 VAL A 309
LEU A 198
VAL A 329
LEU A 205
 NAJ  A1361 (-3.7A)
NAJ  A1361 (-3.7A)
None
None
 0.84A 6bqgA-1h2bA:
undetectable		 6bqgA-1h2bA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 HIS A  79
ASP A 168
THR A 172
LEU A 131
MET A 121
 ZN  A1362 ( 3.2A)
ZN  A1362 (-2.7A)
NAJ  A1361 (-3.4A)
OCA  A1360 (-4.8A)
None
 1.48A 6f3nB-1h2bA:
6.4		 6f3nB-1h2bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.06A 6nmfA-1h2bA:
0.0
6nmfC-1h2bA:
0.0
6nmfP-1h2bA:
undetectable		 6nmfA-1h2bA:
21.42
6nmfC-1h2bA:
19.62
6nmfP-1h2bA:
19.62