SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NA7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		4 / 6 GLY A 172
ILE A 173
PRO A 159
ILE A 283
 None
None
None
NA7  A 501 (-3.5A)
 0.81A 1n49D-3dgzA:
undetectable		 1n49D-3dgzA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 204
TRP A 227
MET A 261
LEU A 267
 NA7  A1284 (-4.8A)
None
None
None
 1.41A 2oz7A-2wzmA:
undetectable		 2oz7A-2wzmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3dgz THIOREDOXIN
REDUCTASE 2
(Mus
musculus) 		3 / 3 LYS A 307
ARG A 285
VAL A 286
 NA7  A 501 ( 4.8A)
FAD  A 500 ( 3.7A)
None
 1.10A 2r2vC-3dgzA:
undetectable
2r2vD-3dgzA:
undetectable		 2r2vC-3dgzA:
4.80
2r2vD-3dgzA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 277
SER A 280
ASN A 285
GLY A 397
ASP A 396
 NA7  A1555 (-3.2A)
None
None
K  A1554 (-4.3A)
None
 1.26A 3sfuC-2uyyA:
undetectable		 3sfuC-2uyyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A  30
THR A  54
ASN A  60
 NA7  A1284 ( 3.8A)
None
None
 0.69A 5odiG-2wzmA:
undetectable		 5odiG-2wzmA:
17.69