SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'N7I'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JNN_H_ESTH350_1 (MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN GAMMA-1 CHAIN MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN KAPPA CHAIN)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	5 / 10	LYS A 137 ASP A 136 TYR A 326 LEU A 139 TYR A 145	None None None N7I A 402 (-2.9A) None	1.28A	1jnnH-5cvvA: 0.0 1jnnL-5cvvA: 0.0	1jnnH-5cvvA: 19.45 1jnnL-5cvvA: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I5U_A_SAMA401_0 (O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	6 / 12	TRP A 166 MET A 183 GLY A 212 LEU A 235 ASP A 273 TRP A 274	SAH A 401 ( 3.6A) SAH A 401 ( 3.9A) SAH A 401 ( 4.2A) SAH A 401 (-4.3A) N7I A 402 ( 2.7A) None	0.94A	3i5uA-5cvvA: 28.6	3i5uA-5cvvA: 27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I5U_A_SAMA401_0 (O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	8 / 12	TRP A 166 PHE A 179 MET A 183 GLY A 212 GLY A 213 LEU A 235 ASP A 273 TRP A 274	SAH A 401 ( 3.6A) None SAH A 401 ( 3.9A) SAH A 401 ( 4.2A) SAH A 401 ( 3.7A) SAH A 401 (-4.3A) N7I A 402 ( 2.7A) None	0.45A	3i5uA-5cvvA: 28.6	3i5uA-5cvvA: 27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I5U_B_SAMB401_0 (O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	7 / 12	TRP A 166 MET A 183 GLY A 212 GLY A 213 LEU A 235 ASP A 273 TRP A 274	SAH A 401 ( 3.6A) SAH A 401 ( 3.9A) SAH A 401 ( 4.2A) SAH A 401 ( 3.7A) SAH A 401 (-4.3A) N7I A 402 ( 2.7A) None	0.46A	3i5uB-5cvvA: 26.5	3i5uB-5cvvA: 27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I5U_B_SAMB401_0 (O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	6 / 12	TRP A 166 MET A 183 GLY A 212 LEU A 235 ASP A 273 TRP A 274	SAH A 401 ( 3.6A) SAH A 401 ( 3.9A) SAH A 401 ( 4.2A) SAH A 401 (-4.3A) N7I A 402 ( 2.7A) None	0.94A	3i5uB-5cvvA: 26.5	3i5uB-5cvvA: 27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	5 / 12	GLY A 211 GLY A 213 VAL A 238 ASP A 273 TRP A 274	SAH A 401 (-3.8A) SAH A 401 ( 3.7A) None N7I A 402 ( 2.7A) None	0.39A	4a6eA-5cvvA: 35.2	4a6eA-5cvvA: 25.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PGH_B_SAMB401_0 (CAFFEIC ACID O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	11 / 12	SER A 187 ASP A 209 GLY A 211 ASP A 234 LEU A 235 ASP A 254 MET A 255 LYS A 268 ILE A 270 ASP A 273 TRP A 274	SAH A 401 (-2.5A) SAH A 401 ( 4.6A) SAH A 401 (-3.8A) SAH A 401 (-2.8A) SAH A 401 (-4.3A) SAH A 401 (-3.5A) SAH A 401 (-3.6A) SAH A 401 (-3.0A) SAH A 401 ( 4.9A) N7I A 402 ( 2.7A) None	0.73A	4pghB-5cvvA: 40.1	4pghB-5cvvA: 54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PGH_C_SAMC401_0 (CAFFEIC ACID O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	6 / 11	GLY A 212 ASP A 234 LEU A 235 VAL A 238 LYS A 268 TRP A 269	SAH A 401 ( 4.2A) SAH A 401 (-2.8A) SAH A 401 (-4.3A) None SAH A 401 (-3.0A) N7I A 402 (-4.3A)	1.37A	4pghC-5cvvA: 39.4	4pghC-5cvvA: 54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PGH_C_SAMC401_0 (CAFFEIC ACID O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	11 / 11	SER A 187 GLY A 211 ASP A 234 LEU A 235 VAL A 238 ASP A 254 MET A 255 LYS A 268 TRP A 269 ILE A 270 TRP A 274	SAH A 401 (-2.5A) SAH A 401 (-3.8A) SAH A 401 (-2.8A) SAH A 401 (-4.3A) None SAH A 401 (-3.5A) SAH A 401 (-3.6A) SAH A 401 (-3.0A) N7I A 402 (-4.3A) SAH A 401 ( 4.9A) None	0.98A	4pghC-5cvvA: 39.4	4pghC-5cvvA: 54.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W7P_A_SAMA501_0 (OXAC)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	5 / 12	GLY A 212 LEU A 235 VAL A 238 ASP A 273 TRP A 274	SAH A 401 ( 4.2A) SAH A 401 (-4.3A) None N7I A 402 ( 2.7A) None	0.39A	5w7pA-5cvvA: 28.3	5w7pA-5cvvA: 25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CLX_A_SAMA401_0 (O-METHYLTRANSFERASE)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	5 / 12	TRP A 166 GLY A 211 GLY A 213 ASP A 273 TRP A 274	SAH A 401 ( 3.6A) SAH A 401 (-3.8A) SAH A 401 ( 3.7A) N7I A 402 ( 2.7A) None	0.76A	6clxA-5cvvA: 24.0	6clxA-5cvvA: 28.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6I5Z_D_SAMD401_0 (O-METHYLTRANSFERASE 1)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	10 / 11	GLY A 211 GLY A 213 ASP A 234 LEU A 235 VAL A 238 ASP A 254 MET A 255 LYS A 268 TRP A 269 ASP A 273	SAH A 401 (-3.8A) SAH A 401 ( 3.7A) SAH A 401 (-2.8A) SAH A 401 (-4.3A) None SAH A 401 (-3.5A) SAH A 401 (-3.6A) SAH A 401 (-3.0A) N7I A 402 (-4.3A) N7I A 402 ( 2.7A)	0.77A	6i5zD-5cvvA: 36.8	6i5zD-5cvvA: 40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6I5Z_D_SAMD401_0 (O-METHYLTRANSFERASE 1)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	7 / 11	GLY A 212 ASP A 234 LEU A 235 ASP A 254 MET A 255 TRP A 269 ASP A 273	SAH A 401 ( 4.2A) SAH A 401 (-2.8A) SAH A 401 (-4.3A) SAH A 401 (-3.5A) SAH A 401 (-3.6A) N7I A 402 (-4.3A) N7I A 402 ( 2.7A)	1.20A	6i5zD-5cvvA: 36.8	6i5zD-5cvvA: 40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6I5Z_D_SAMD401_0 (O-METHYLTRANSFERASE 1)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	6 / 11	GLY A 212 ASP A 234 LEU A 235 VAL A 238 LYS A 268 TRP A 269	SAH A 401 ( 4.2A) SAH A 401 (-2.8A) SAH A 401 (-4.3A) None SAH A 401 (-3.0A) N7I A 402 (-4.3A)	1.48A	6i5zD-5cvvA: 36.8	6i5zD-5cvvA: 40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6I5Z_D_SAMD401_0 (O-METHYLTRANSFERASE 1)	5cvv	(ISO)EUGENOL O-METHYLTRANSFERASE (Clarkia breweri)	7 / 11	SER A 187 GLY A 213 LEU A 235 VAL A 238 MET A 255 LYS A 268 ASP A 273	SAH A 401 (-2.5A) SAH A 401 ( 3.7A) SAH A 401 (-4.3A) None SAH A 401 (-3.6A) SAH A 401 (-3.0A) N7I A 402 ( 2.7A)	0.91A	6i5zD-5cvvA: 36.8	6i5zD-5cvvA: 40.76

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JNN_H_ESTH350_1","MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN GAMMA-1 CHAIN;MONOCLONAL ANTI-ESTRADIOL 17E12E5 IMMUNOGLOBULIN KAPPA CHAIN","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",5,"LYS A 137;ASP A 136;TYR A 326;LEU A 139;TYR A 145","None;None;None;N7I A 402 (-2.9A);None","1.28A","1jnnH-5cvvA:0.0;1jnnL-5cvvA:0.0",null],["3I5U_A_SAMA401_0","O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",6,"TRP A 166;MET A 183;GLY A 212;LEU A 235;ASP A 273;TRP A 274","SAH A 401 ( 3.6A);SAH A 401 ( 3.9A);SAH A 401 ( 4.2A);SAH A 401 (-4.3A);N7I A 402 ( 2.7A);None","0.94A","3i5uA-5cvvA:28.6","1jnnH-5cvvA:19.45;1jnnL-5cvvA:21.53"],["3I5U_A_SAMA401_0","O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",8,"TRP A 166;PHE A 179;MET A 183;GLY A 212;GLY A 213;LEU A 235;ASP A 273;TRP A 274","SAH A 401 ( 3.6A);None;SAH A 401 ( 3.9A);SAH A 401 ( 4.2A);SAH A 401 ( 3.7A);SAH A 401 (-4.3A);N7I A 402 ( 2.7A);None","0.45A","3i5uA-5cvvA:28.6","3i5uA-5cvvA:27.94"],["3I5U_B_SAMB401_0","O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",7,"TRP A 166;MET A 183;GLY A 212;GLY A 213;LEU A 235;ASP A 273;TRP A 274","SAH A 401 ( 3.6A);SAH A 401 ( 3.9A);SAH A 401 ( 4.2A);SAH A 401 ( 3.7A);SAH A 401 (-4.3A);N7I A 402 ( 2.7A);None","0.46A","3i5uB-5cvvA:26.5","3i5uA-5cvvA:27.94"],["3I5U_B_SAMB401_0","O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",6,"TRP A 166;MET A 183;GLY A 212;LEU A 235;ASP A 273;TRP A 274","SAH A 401 ( 3.6A);SAH A 401 ( 3.9A);SAH A 401 ( 4.2A);SAH A 401 (-4.3A);N7I A 402 ( 2.7A);None","0.94A","3i5uB-5cvvA:26.5","3i5uB-5cvvA:27.94"],["4A6E_A_SAMA1349_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",5,"GLY A 211;GLY A 213;VAL A 238;ASP A 273;TRP A 274","SAH A 401 (-3.8A);SAH A 401 ( 3.7A);None;N7I A 402 ( 2.7A);None","0.39A","4a6eA-5cvvA:35.2","3i5uB-5cvvA:27.94"],["4PGH_B_SAMB401_0","CAFFEIC ACID O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",11,"SER A 187;ASP A 209;GLY A 211;ASP A 234;LEU A 235;ASP A 254;MET A 255;LYS A 268;ILE A 270;ASP A 273;TRP A 274","SAH A 401 (-2.5A);SAH A 401 ( 4.6A);SAH A 401 (-3.8A);SAH A 401 (-2.8A);SAH A 401 (-4.3A);SAH A 401 (-3.5A);SAH A 401 (-3.6A);SAH A 401 (-3.0A);SAH A 401 ( 4.9A);N7I A 402 ( 2.7A);None","0.73A","4pghB-5cvvA:40.1","4a6eA-5cvvA:25.94"],["4PGH_C_SAMC401_0","CAFFEIC ACID O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",6,"GLY A 212;ASP A 234;LEU A 235;VAL A 238;LYS A 268;TRP A 269","SAH A 401 ( 4.2A);SAH A 401 (-2.8A);SAH A 401 (-4.3A);None;SAH A 401 (-3.0A);N7I A 402 (-4.3A)","1.37A","4pghC-5cvvA:39.4","4pghB-5cvvA:54.25"],["4PGH_C_SAMC401_0","CAFFEIC ACID O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",11,"SER A 187;GLY A 211;ASP A 234;LEU A 235;VAL A 238;ASP A 254;MET A 255;LYS A 268;TRP A 269;ILE A 270;TRP A 274","SAH A 401 (-2.5A);SAH A 401 (-3.8A);SAH A 401 (-2.8A);SAH A 401 (-4.3A);None;SAH A 401 (-3.5A);SAH A 401 (-3.6A);SAH A 401 (-3.0A);N7I A 402 (-4.3A);SAH A 401 ( 4.9A);None","0.98A","4pghC-5cvvA:39.4","4pghC-5cvvA:54.25"],["5W7P_A_SAMA501_0","OXAC","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",5,"GLY A 212;LEU A 235;VAL A 238;ASP A 273;TRP A 274","SAH A 401 ( 4.2A);SAH A 401 (-4.3A);None;N7I A 402 ( 2.7A);None","0.39A","5w7pA-5cvvA:28.3","4pghC-5cvvA:54.25"],["6CLX_A_SAMA401_0","O-METHYLTRANSFERASE","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",5,"TRP A 166;GLY A 211;GLY A 213;ASP A 273;TRP A 274","SAH A 401 ( 3.6A);SAH A 401 (-3.8A);SAH A 401 ( 3.7A);N7I A 402 ( 2.7A);None","0.76A","6clxA-5cvvA:24.0","5w7pA-5cvvA:25.51"],["6I5Z_D_SAMD401_0","O-METHYLTRANSFERASE 1","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",10,"GLY A 211;GLY A 213;ASP A 234;LEU A 235;VAL A 238;ASP A 254;MET A 255;LYS A 268;TRP A 269;ASP A 273","SAH A 401 (-3.8A);SAH A 401 ( 3.7A);SAH A 401 (-2.8A);SAH A 401 (-4.3A);None;SAH A 401 (-3.5A);SAH A 401 (-3.6A);SAH A 401 (-3.0A);N7I A 402 (-4.3A);N7I A 402 ( 2.7A)","0.77A","6i5zD-5cvvA:36.8","6clxA-5cvvA:28.50"],["6I5Z_D_SAMD401_0","O-METHYLTRANSFERASE 1","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",7,"GLY A 212;ASP A 234;LEU A 235;ASP A 254;MET A 255;TRP A 269;ASP A 273","SAH A 401 ( 4.2A);SAH A 401 (-2.8A);SAH A 401 (-4.3A);SAH A 401 (-3.5A);SAH A 401 (-3.6A);N7I A 402 (-4.3A);N7I A 402 ( 2.7A)","1.20A","6i5zD-5cvvA:36.8","6i5zD-5cvvA:40.76"],["6I5Z_D_SAMD401_0","O-METHYLTRANSFERASE 1","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",6,"GLY A 212;ASP A 234;LEU A 235;VAL A 238;LYS A 268;TRP A 269","SAH A 401 ( 4.2A);SAH A 401 (-2.8A);SAH A 401 (-4.3A);None;SAH A 401 (-3.0A);N7I A 402 (-4.3A)","1.48A","6i5zD-5cvvA:36.8","6i5zD-5cvvA:40.76"],["6I5Z_D_SAMD401_0","O-METHYLTRANSFERASE 1","5cvv","(ISO)EUGENOL O-METHYLTRANSFERASE","Clarkia breweri",7,"SER A 187;GLY A 213;LEU A 235;VAL A 238;MET A 255;LYS A 268;ASP A 273","SAH A 401 (-2.5A);SAH A 401 ( 3.7A);SAH A 401 (-4.3A);None;SAH A 401 (-3.6A);SAH A 401 (-3.0A);N7I A 402 ( 2.7A)","0.91A","6i5zD-5cvvA:36.8","6i5zD-5cvvA:40.76"]]