SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'N5Y'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 11 ARG A 128
SER A 124
LEU A  45
PHE A 118
LEU A 175
 None
None
N5Y  A1294 (-3.7A)
None
None
 1.29A 2v0mA-4asyA:
undetectable		 2v0mA-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 110
ILE A  51
ASN A 111
LEU A 106
THR A  42
 None
None
None
None
N5Y  A1294 (-4.5A)
 1.15A 3eeyE-4asyA:
undetectable		 3eeyE-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 110
ILE A  51
ASN A 111
LEU A 106
THR A  42
 None
None
None
None
N5Y  A1294 (-4.5A)
 1.16A 3eeyF-4asyA:
undetectable		 3eeyF-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		6 / 12 PHE A 177
SER A 124
LEU A  45
PHE A 118
ALA A 136
GLY A 174
 None
None
N5Y  A1294 (-3.7A)
None
None
None
 1.26A 3nxuA-4asyA:
undetectable		 3nxuA-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 292
TYR A 283
GLU A 255
LEU A 242
 None
None
N5Y  A1294 (-3.5A)
None
 1.16A 5umwB-4asyA:
undetectable
5umwE-4asyA:
undetectable		 5umwB-4asyA:
13.31
5umwE-4asyA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 242
VAL A 292
TYR A 283
GLU A 255
 None
None
None
N5Y  A1294 (-3.5A)
 0.92A 5umwA-4asyA:
undetectable
5umwF-4asyA:
undetectable		 5umwA-4asyA:
13.31
5umwF-4asyA:
13.31