SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'N32'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 10 ALA A 246
THR A 343
HIS A 313
HIS A 349
THR A 347
 None
None
N32  A 501 (-4.0A)
N32  A 501 (-3.9A)
None
 1.22A 1r55A-4f32A:
undetectable		 1r55A-4f32A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLU A 358
HIS A 313
ALA A 414
GLY A 352
GLY A 355
 None
N32  A 501 (-4.0A)
None
CSU  A 172 ( 4.7A)
None
 1.10A 1x1aA-4f32A:
undetectable		 1x1aA-4f32A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A 282
HIS A 278
ALA A 327
ALA A 292
HIS A 313
 N32  A 501 (-4.3A)
N32  A 501 (-4.2A)
None
None
N32  A 501 (-4.0A)
 1.03A 2gluA-4f32A:
undetectable		 2gluA-4f32A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 ALA A 216
PHE A 239
ILE A 117
LEU A 351
GLY A 210
 N32  A 501 ( 4.2A)
N32  A 501 ( 4.3A)
None
CSU  A 172 ( 3.9A)
None
 0.95A 3rukB-4f32A:
undetectable		 3rukB-4f32A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 8 PRO A 231
SER A 342
VAL A 319
GLY A 320
 None
None
N32  A 501 (-3.7A)
N32  A 501 (-3.3A)
 0.98A 4klrB-4f32A:
undetectable		 4klrB-4f32A:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		10 / 12 GLY A 116
ALA A 171
GLU A 200
PHE A 211
HIS A 313
THR A 315
HIS A 349
LEU A 351
GLY A 408
PHE A 409
 None
CSU  A 172 ( 2.7A)
None
None
N32  A 501 (-4.0A)
N32  A 501 (-3.4A)
N32  A 501 (-3.9A)
CSU  A 172 ( 3.9A)
CSU  A 172 (-3.2A)
CSU  A 172 ( 4.0A)
 0.33A 4ls7A-4f32A:
65.7		 4ls7A-4f32A:
48.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		8 / 12 ALA A 171
PHE A 211
HIS A 313
THR A 315
HIS A 349
LEU A 351
GLY A 408
PHE A 409
 CSU  A 172 ( 2.7A)
None
N32  A 501 (-4.0A)
N32  A 501 (-3.4A)
N32  A 501 (-3.9A)
CSU  A 172 ( 3.9A)
CSU  A 172 (-3.2A)
CSU  A 172 ( 4.0A)
 0.28A 4ls7A-4f32A:
65.7
4ls7B-4f32A:
65.4		 4ls7A-4f32A:
48.10
4ls7B-4f32A:
48.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		6 / 12 ILE A 117
ALA A 171
HIS A 313
HIS A 349
GLY A 408
PHE A 409
 None
CSU  A 172 ( 2.7A)
N32  A 501 (-4.0A)
N32  A 501 (-3.9A)
CSU  A 172 (-3.2A)
CSU  A 172 ( 4.0A)
 0.64A 4ls7A-4f32A:
65.7
4ls7B-4f32A:
65.4		 4ls7A-4f32A:
48.10
4ls7B-4f32A:
48.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 5 THR A 273
GLY A 288
GLU A 324
HIS A 313
 None
None
None
N32  A 501 (-4.0A)
 1.21A 5c0oH-4f32A:
undetectable		 5c0oH-4f32A:
23.08