SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'N2W'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 7 ARG A 503
GLY A 504
ILE A 506
ASN A 520
 N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
None
 1.00A 4g0vA-5gwjA:
53.7		 4g0vA-5gwjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 6 ARG A 503
GLY A 504
ASN A 520
GLN A 778
 N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
N2W  A1302 ( 2.7A)
 1.05A 4g0vB-5gwjA:
52.9		 4g0vB-5gwjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 7 GLY A 478
ASP A 479
GLY A 504
GLU A 522
 N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2W  A1302 ( 4.4A)
None
 0.78A 4koeA-5gwjA:
8.6
4koeB-5gwjA:
31.1
4koeD-5gwjA:
19.9		 4koeA-5gwjA:
21.86
4koeB-5gwjA:
21.86
4koeD-5gwjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 5 GLY A 478
ARG A 503
GLY A 504
GLU A 522
 N2W  A1302 ( 3.0A)
N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
 0.95A 4z2eB-5gwjA:
30.2
4z2eC-5gwjA:
20.0		 4z2eB-5gwjA:
21.10
4z2eC-5gwjA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 7 GLY A 478
ASP A 479
GLY A 504
GLU A 522
 N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2W  A1302 ( 4.4A)
None
 0.82A 4z53A-5gwjA:
31.1
4z53B-5gwjA:
31.3		 4z53A-5gwjA:
28.42
4z53B-5gwjA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 6 GLY A 478
ASP A 479
ARG A 503
GLY A 504
 N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
 0.67A 5cdnR-5gwjA:
30.8
5cdnS-5gwjA:
20.4		 5cdnR-5gwjA:
21.66
5cdnS-5gwjA:
12.96