SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'N2S'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4G0V_A_MIXA1301_1 (DNA TOPOISOMERASE 2-BETA)	5gwj	DNA TOPOISOMERASE 2-BETA (Homo sapiens)	4 / 7	ARG A 503 GLY A 504 ILE A 506 ASN A 520	N2S A1301 ( 3.9A) N2W A1302 ( 4.4A) None None	1.00A	4g0vA-5gwjA: 53.7	4g0vA-5gwjA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4G0V_D_MIXD101_1 (DNA TOPOISOMERASE 2-BETA)	5gwj	DNA TOPOISOMERASE 2-BETA (Homo sapiens)	4 / 6	ARG A 503 GLY A 504 ASN A 520 GLN A 778	N2S A1301 ( 3.9A) N2W A1302 ( 4.4A) None N2W A1302 ( 2.7A)	1.05A	4g0vB-5gwjA: 52.9	4g0vB-5gwjA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2E_F_TR6F101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	5gwj	DNA TOPOISOMERASE 2-BETA (Homo sapiens)	4 / 5	GLY A 478 ARG A 503 GLY A 504 GLU A 522	N2W A1302 ( 3.0A) N2S A1301 ( 3.9A) N2W A1302 ( 4.4A) None	0.95A	4z2eB-5gwjA: 30.2 4z2eC-5gwjA: 20.0	4z2eB-5gwjA: 21.10 4z2eC-5gwjA: 16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_N_EVPN2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5gwj	DNA TOPOISOMERASE 2-BETA (Homo sapiens)	4 / 6	GLY A 478 ASP A 479 ARG A 503 GLY A 504	N2W A1302 ( 3.0A) N2W A1302 ( 3.4A) N2S A1301 ( 3.9A) N2W A1302 ( 4.4A)	0.67A	5cdnR-5gwjA: 30.8 5cdnS-5gwjA: 20.4	5cdnR-5gwjA: 21.66 5cdnS-5gwjA: 12.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4G0V_A_MIXA1301_1","DNA TOPOISOMERASE 2-BETA","5gwj","DNA TOPOISOMERASE 2-BETA","Homo sapiens",4,"ARG A 503;GLY A 504;ILE A 506;ASN A 520","N2S A1301 ( 3.9A);N2W A1302 ( 4.4A);None;None","1.00A","4g0vA-5gwjA:53.7",null],["4G0V_D_MIXD101_1","DNA TOPOISOMERASE 2-BETA","5gwj","DNA TOPOISOMERASE 2-BETA","Homo sapiens",4,"ARG A 503;GLY A 504;ASN A 520;GLN A 778","N2S A1301 ( 3.9A);N2W A1302 ( 4.4A);None;N2W A1302 ( 2.7A)","1.05A","4g0vB-5gwjA:52.9","4g0vA-5gwjA:100.00"],["4Z2E_F_TR6F101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B;SYMMETRIZED E-SITE DNA","5gwj","DNA TOPOISOMERASE 2-BETA","Homo sapiens",4,"GLY A 478;ARG A 503;GLY A 504;GLU A 522","N2W A1302 ( 3.0A);N2S A1301 ( 3.9A);N2W A1302 ( 4.4A);None","0.95A","4z2eB-5gwjA:30.2;4z2eC-5gwjA:20.0","4g0vB-5gwjA:100.00"],["5CDN_N_EVPN2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B","5gwj","DNA TOPOISOMERASE 2-BETA","Homo sapiens",4,"GLY A 478;ASP A 479;ARG A 503;GLY A 504","N2W A1302 ( 3.0A);N2W A1302 ( 3.4A);N2S A1301 ( 3.9A);N2W A1302 ( 4.4A)","0.67A","5cdnR-5gwjA:30.8;5cdnS-5gwjA:20.4","4z2eB-5gwjA:21.10;4z2eC-5gwjA:16.46"]]