SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'N22'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
LEU X  28
THR X  46
ARG X  57
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
None
 0.91A 1ao8A-3i8aX:
21.6		 1ao8A-3i8aX:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 LEU X   5
ALA X   7
ASP X  27
LEU X  28
THR X  46
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.4A)
 0.58A 1ao8A-3i8aX:
21.6		 1ao8A-3i8aX:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 LEU X   5
ALA X   7
ASP X  27
THR X  46
SER X  49
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
N22  X 219 (-4.4A)
 0.73A 1ao8A-3i8aX:
21.6		 1ao8A-3i8aX:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 LEU X   5
ALA X   7
ASP X  27
LEU X  28
THR X  46
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.4A)
 0.96A 1bzfA-3i8aX:
20.8		 1bzfA-3i8aX:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
LYS X  32
THR X  46
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
NDP  X 207 (-3.2A)
None
None
N22  X 219 (-4.4A)
 0.71A 1cd2A-3i8aX:
19.5		 1cd2A-3i8aX:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.51A 1d1gA-3i8aX:
19.0		 1d1gA-3i8aX:
35.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.50A 1d1gB-3i8aX:
19.1		 1d1gB-3i8aX:
35.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
SER X  49
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
 0.76A 1ddrA-3i8aX:
24.0		 1ddrA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
THR X  46
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.87A 1ddrA-3i8aX:
24.0		 1ddrA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.58A 1ddrB-3i8aX:
24.3		 1ddrB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.87A 1ddrB-3i8aX:
24.3		 1ddrB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.63A 1ddsA-3i8aX:
24.1		 1ddsA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.67A 1ddsA-3i8aX:
24.1		 1ddsA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.73A 1ddsB-3i8aX:
24.7		 1ddsB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.83A 1ddsB-3i8aX:
24.7		 1ddsB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
 0.51A 1df7A-3i8aX:
23.3		 1df7A-3i8aX:
31.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.74A 1dhfA-3i8aX:
20.3		 1dhfA-3i8aX:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.76A 1dhfB-3i8aX:
20.3		 1dhfB-3i8aX:
29.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  28
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.91A 1dhiA-3i8aX:
24.0		 1dhiA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 11 ALA X   7
LEU X  28
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.69A 1dhiB-3i8aX:
24.7		 1dhiB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  28
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.70A 1dhjA-3i8aX:
24.1		 1dhjA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.92A 1dhjA-3i8aX:
24.1		 1dhjA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
PRO X  55
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
None
N22  X 219 (-4.4A)
 0.68A 1dhjB-3i8aX:
24.6		 1dhjB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
PRO X  55
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
None
None
N22  X 219 (-4.4A)
 0.72A 1dhjB-3i8aX:
24.6		 1dhjB-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.95A 1dlsA-3i8aX:
20.7		 1dlsA-3i8aX:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
 0.68A 1draA-3i8aX:
24.1		 1draA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.93A 1draA-3i8aX:
24.1		 1draA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.62A 1draB-3i8aX:
24.7		 1draB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.68A 1draB-3i8aX:
24.7		 1draB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.66A 1drbA-3i8aX:
24.1		 1drbA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.93A 1drbA-3i8aX:
24.1		 1drbA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.62A 1drbB-3i8aX:
24.6		 1drbB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.67A 1drbB-3i8aX:
24.6		 1drbB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
 0.56A 1dreA-3i8aX:
25.6		 1dreA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
 0.71A 1dreA-3i8aX:
25.6		 1dreA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.85A 1dreA-3i8aX:
25.6		 1dreA-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
SER X  49
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
 1.11A 1drfA-3i8aX:
20.4		 1drfA-3i8aX:
29.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.70A 1dyiA-3i8aX:
24.2		 1dyiA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
THR X  46
LEU X  40
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 1.39A 1dyiA-3i8aX:
24.2		 1dyiA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.69A 1dyiA-3i8aX:
24.2		 1dyiA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 1dyiB-3i8aX:
24.6		 1dyiB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 1dyiB-3i8aX:
24.6		 1dyiB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
THR X  46
LEU X  40
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 1.01A 1dyiB-3i8aX:
24.6		 1dyiB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 ALA X   7
LEU X  20
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.36A 1dyrA-3i8aX:
19.6		 1dyrA-3i8aX:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ALA X   7
ASP X  27
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.77A 1j3jA-3i8aX:
20.3		 1j3jA-3i8aX:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 9 ALA X   7
ASP X  27
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.68A 1j3jB-3i8aX:
20.2		 1j3jB-3i8aX:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.68A 1jolA-3i8aX:
24.3		 1jolA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 1jolA-3i8aX:
24.3		 1jolA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
PRO X  55
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 1jolB-3i8aX:
24.7		 1jolB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
PRO X  55
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.72A 1jolB-3i8aX:
24.7		 1jolB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 11 ALA X   7
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.50A 1jomA-3i8aX:
23.8		 1jomA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 11 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.62A 1jomA-3i8aX:
23.8		 1jomA-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		4 / 6 PHE X 117
GLU X 114
GLY X 115
THR X 111
 None
None
None
N22  X 219 (-4.4A)
 1.13A 1kqbC-3i8aX:
undetectable
1kqbD-3i8aX:
undetectable		 1kqbC-3i8aX:
22.32
1kqbD-3i8aX:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.62A 1qzfA-3i8aX:
12.8		 1qzfA-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.63A 1qzfA-3i8aX:
12.8		 1qzfA-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.62A 1qzfB-3i8aX:
20.8		 1qzfB-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.64A 1qzfB-3i8aX:
20.8		 1qzfB-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.62A 1qzfC-3i8aX:
13.4		 1qzfC-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.64A 1qzfC-3i8aX:
13.4		 1qzfC-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.63A 1qzfD-3i8aX:
12.8		 1qzfD-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 1qzfD-3i8aX:
12.8		 1qzfD-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.62A 1qzfE-3i8aX:
12.8		 1qzfE-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 1qzfE-3i8aX:
12.8		 1qzfE-3i8aX:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.71A 1ra2A-3i8aX:
24.9		 1ra2A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.69A 1ra3A-3i8aX:
24.9		 1ra3A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.69A 1ra8A-3i8aX:
24.8		 1ra8A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 ASP X  27
LYS X  32
ARG X  57
 N22  X 219 (-2.8A)
None
None
 0.69A 1ra8A-3i8aX:
24.8		 1ra8A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.53A 1rb2A-3i8aX:
24.8		 1rb2A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.69A 1rb2A-3i8aX:
24.8		 1rb2A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
None
None
N22  X 219 (-4.4A)
 0.71A 1rb2B-3i8aX:
24.6		 1rb2B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  32
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
N22  X 219 (-4.4A)
 0.75A 1rb2B-3i8aX:
24.6		 1rb2B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 10 ALA X   7
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.47A 1rb3A-3i8aX:
24.9		 1rb3A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 10 ALA X   7
ASP X  27
LYS X  32
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.57A 1rb3A-3i8aX:
24.9		 1rb3A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.43A 1rb3B-3i8aX:
24.8		 1rb3B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 1.11A 1rb3B-3i8aX:
24.8		 1rb3B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 1.28A 1rb3B-3i8aX:
24.8		 1rb3B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.38A 1rd7A-3i8aX:
24.2		 1rd7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.61A 1rd7A-3i8aX:
24.2		 1rd7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.72A 1rd7B-3i8aX:
24.0		 1rd7B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.66A 1re7A-3i8aX:
24.2		 1re7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.50A 1re7B-3i8aX:
24.1		 1re7B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
PRO X  55
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.51A 1re7B-3i8aX:
24.1		 1re7B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
PRO X  55
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.52A 1re7B-3i8aX:
24.1		 1re7B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.71A 1rg7A-3i8aX:
23.4		 1rg7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LYS X  32
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
 1.31A 1rg7A-3i8aX:
23.4		 1rg7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
THR X  46
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.75A 1rg7A-3i8aX:
23.4		 1rg7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ASP X  27
LEU X  28
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
None
 0.76A 1rh3A-3i8aX:
25.7		 1rh3A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.86A 1rh3A-3i8aX:
25.7		 1rh3A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 PHE X  92
SER X  49
ILE X  50
LEU X  54
ARG X  57
 N22  X 219 ( 3.7A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
 1.19A 1rh3A-3i8aX:
25.7		 1rh3A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.65A 1rx2A-3i8aX:
26.0		 1rx2A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.88A 1rx2A-3i8aX:
26.0		 1rx2A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.70A 1rx3A-3i8aX:
26.0		 1rx3A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.78A 1rx7A-3i8aX:
23.6		 1rx7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
LYS X  32
ILE X  50
PRO X  55
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.97A 1rx8A-3i8aX:
25.4		 1rx8A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
PRO X  55
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.91A 1rx8A-3i8aX:
25.4		 1rx8A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.75A 1tdrA-3i8aX:
24.2		 1tdrA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 10 ALA X   7
ASP X  27
LEU X  28
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 1tdrB-3i8aX:
24.6		 1tdrB-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
SER X  49
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-3.3A)
None
None
None
 0.98A 1u72A-3i8aX:
20.5		 1u72A-3i8aX:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.63A 2bl9A-3i8aX:
19.9		 2bl9A-3i8aX:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 ALA X   7
ASP X  27
SER X  49
ILE X  50
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 (-4.4A)
 0.87A 2blaA-3i8aX:
19.5		 2blaA-3i8aX:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 ALA X   7
ASP X  27
SER X  49
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
None
N22  X 219 (-4.4A)
 0.73A 2blaA-3i8aX:
19.5		 2blaA-3i8aX:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
THR X  46
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
NDP  X 207 (-3.2A)
None
None
None
N22  X 219 (-4.4A)
 0.71A 2cd2A-3i8aX:
19.6		 2cd2A-3i8aX:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ILE X  50
LEU X  54
PRO X  55
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.6A)
None
None
None
None
N22  X 219 (-4.4A)
 0.72A 2d0kA-3i8aX:
23.8		 2d0kA-3i8aX:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
ILE X  50
PRO X  55
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.72A 2d0kA-3i8aX:
23.8		 2d0kA-3i8aX:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.71A 2d0kB-3i8aX:
23.8		 2d0kB-3i8aX:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
 0.60A 2drcA-3i8aX:
24.3		 2drcA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.89A 2drcA-3i8aX:
24.3		 2drcA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.56A 2drcB-3i8aX:
24.7		 2drcB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 2drcB-3i8aX:
24.7		 2drcB-3i8aX:
36.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.70A 2oipA-3i8aX:
21.5		 2oipA-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.65A 2oipA-3i8aX:
21.5		 2oipA-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  29
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
N22  X 219 (-4.4A)
 0.95A 2oipB-3i8aX:
19.8		 2oipB-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
THR X  46
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
None
None
N22  X 219 (-4.4A)
 0.64A 2oipB-3i8aX:
19.8		 2oipB-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
LYS X  29
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
None
None
N22  X 219 (-4.4A)
 0.95A 2oipB-3i8aX:
19.8		 2oipB-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
None
None
N22  X 219 (-4.4A)
 0.61A 2oipB-3i8aX:
19.8		 2oipB-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  20
LYS X  32
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
N22  X 219 (-4.4A)
 1.17A 2oipB-3i8aX:
19.8		 2oipB-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
None
None
N22  X 219 (-4.4A)
 0.62A 2oipC-3i8aX:
21.1		 2oipC-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
THR X  46
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
None
None
N22  X 219 (-4.4A)
 0.71A 2oipC-3i8aX:
21.1		 2oipC-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.75A 2oipD-3i8aX:
21.8		 2oipD-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.67A 2oipD-3i8aX:
21.8		 2oipD-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  29
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
None
None
 1.13A 2oipE-3i8aX:
20.6		 2oipE-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.71A 2oipE-3i8aX:
20.6		 2oipE-3i8aX:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.73A 2oipE-3i8aX:
20.6		 2oipE-3i8aX:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		10 / 12 ALA X   7
LEU X  28
VAL X  31
LYS X  32
ILE X  50
LEU X  54
PRO X  55
ARG X  57
PHE X  92
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 ( 3.7A)
None
 0.67A 2qk8A-3i8aX:
25.2		 2qk8A-3i8aX:
46.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 ALA X   7
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.53A 2w3aA-3i8aX:
20.2		 2w3aA-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ALA X   7
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.78A 2w3aB-3i8aX:
20.1		 2w3aB-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.78A 2w3bA-3i8aX:
20.3		 2w3bA-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.83A 2w3bB-3i8aX:
20.3		 2w3bB-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.81A 2w3mA-3i8aX:
20.0		 2w3mA-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  20
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
N22  X 219 (-4.4A)
 0.81A 2w3mA-3i8aX:
20.0		 2w3mA-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.81A 2w3mB-3i8aX:
20.0		 2w3mB-3i8aX:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
SER X  49
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
None
N22  X 219 (-4.4A)
 0.74A 2w3vA-3i8aX:
22.6		 2w3vA-3i8aX:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 10 LEU X   5
ALA X   7
LEU X  20
ASP X  27
LEU X  28
VAL X  31
ILE X  50
PHE X  92
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.47A 2w9gA-3i8aX:
30.7		 2w9gA-3i8aX:
98.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 10 LEU X   5
ALA X   7
LEU X  20
ASP X  27
VAL X  31
SER X  49
ILE X  50
PHE X  92
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.56A 2w9gA-3i8aX:
30.7		 2w9gA-3i8aX:
98.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 10 LEU X   5
ALA X   7
LEU X  20
ASP X  27
LEU X  28
VAL X  31
ILE X  50
PHE X  92
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.57A 2w9hA-3i8aX:
30.2		 2w9hA-3i8aX:
98.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 10 LEU X   5
ALA X   7
LEU X  20
ASP X  27
VAL X  31
SER X  49
ILE X  50
PHE X  92
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.69A 2w9hA-3i8aX:
30.2		 2w9hA-3i8aX:
98.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 11 ALA X   7
LEU X  20
ASP X  27
LEU X  28
SER X  49
ILE X  50
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.63A 2w9sA-3i8aX:
30.1		 2w9sA-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 11 ALA X   7
LEU X  20
ASP X  27
LEU X  28
SER X  49
ILE X  50
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.61A 2w9sB-3i8aX:
30.1		 2w9sB-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 10 ALA X   7
LEU X  20
ASP X  27
SER X  49
ILE X  50
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.60A 2w9sC-3i8aX:
30.0		 2w9sC-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 10 ALA X   7
LEU X  20
ASP X  27
LEU X  28
SER X  49
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.74A 2w9sD-3i8aX:
29.7		 2w9sD-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 8 ALA X   7
ASP X  27
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.13A 2w9sE-3i8aX:
29.8		 2w9sE-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 8 LEU X  20
ASP X  27
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.52A 2w9sE-3i8aX:
29.8		 2w9sE-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 10 ALA X   7
LEU X  20
ASP X  27
LEU X  28
SER X  49
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.74A 2w9sF-3i8aX:
29.6		 2w9sF-3i8aX:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.62A 2zzaA-3i8aX:
26.0		 2zzaA-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.67A 2zzaA-3i8aX:
26.0		 2zzaA-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 11 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.66A 2zzaB-3i8aX:
26.0		 2zzaB-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 11 ALA X   7
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.88A 2zzaB-3i8aX:
26.0		 2zzaB-3i8aX:
40.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
THR X  46
SER X  49
LEU X  54
PRO X  55
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
None
None
None
None
 0.93A 3cl9A-3i8aX:
19.0		 3cl9A-3i8aX:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 ALA X   7
ASP X  27
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 3clbA-3i8aX:
19.3		 3clbA-3i8aX:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
 0.44A 3clbB-3i8aX:
18.1		 3clbB-3i8aX:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.65A 3clbC-3i8aX:
19.2		 3clbC-3i8aX:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.37A 3clbD-3i8aX:
19.1		 3clbD-3i8aX:
15.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
LEU X  28
VAL X  31
ILE X  50
LEU X  54
ARG X  57
PHE X  92
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 ( 3.7A)
None
 0.66A 3datA-3i8aX:
25.5		 3datA-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
 0.65A 3dauA-3i8aX:
26.2		 3dauA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
 0.63A 3dauA-3i8aX:
26.2		 3dauA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 LEU X   5
ALA X   7
LEU X  20
ASP X  27
LEU X  28
LEU X  54
ARG X  57
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
None
N22  X 219 (-4.4A)
 0.56A 3dfrA-3i8aX:
23.9		 3dfrA-3i8aX:
35.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 LEU X   5
ALA X   7
LEU X  20
ASP X  27
SER X  49
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.4A)
 0.68A 3dfrA-3i8aX:
23.9		 3dfrA-3i8aX:
35.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
 0.63A 3drcA-3i8aX:
24.3		 3drcA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.91A 3drcA-3i8aX:
24.3		 3drcA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.58A 3drcB-3i8aX:
24.8		 3drcB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 3drcB-3i8aX:
24.8		 3drcB-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  20
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
None
 0.79A 3eigA-3i8aX:
19.9		 3eigA-3i8aX:
29.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 10 ALA X   7
LEU X  20
VAL X  31
ILE X  50
LEU X  54
PHE X  92
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
None
 0.76A 3fl9A-3i8aX:
25.0		 3fl9A-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
VAL X  31
ILE X  50
LEU X  54
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.76A 3fl9B-3i8aX:
24.6		 3fl9B-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 LEU X  20
LEU X  28
VAL X  31
ILE X  50
LEU X  54
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 4.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.72A 3fl9B-3i8aX:
24.6		 3fl9B-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 ALA X   7
VAL X  31
ILE X  50
LEU X  54
PHE X  92
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.81A 3fl9C-3i8aX:
24.9		 3fl9C-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 LEU X  28
VAL X  31
ILE X  50
LEU X  54
PHE X  92
THR X 111
 N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.71A 3fl9C-3i8aX:
24.9		 3fl9C-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 9 ALA X   7
LEU X  20
VAL X  31
ILE X  50
LEU X  54
PHE X  92
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
None
 0.68A 3fl9D-3i8aX:
25.5		 3fl9D-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 10 ALA X   7
LEU X  20
VAL X  31
ILE X  50
LEU X  54
PHE X  92
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.68A 3fl9E-3i8aX:
24.7		 3fl9E-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 10 LEU X  20
LEU X  28
VAL X  31
ILE X  50
LEU X  54
PHE X  92
THR X 111
 N22  X 219 ( 4.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.75A 3fl9E-3i8aX:
24.7		 3fl9E-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ALA X   7
LEU X  20
VAL X  31
ILE X  50
LEU X  54
PHE X  92
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
 0.67A 3fl9F-3i8aX:
25.0		 3fl9F-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
VAL X  31
ILE X  50
LEU X  54
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.77A 3fl9G-3i8aX:
24.6		 3fl9G-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 LEU X  20
LEU X  28
VAL X  31
ILE X  50
LEU X  54
PHE X  92
TYR X  98
THR X 111
 N22  X 219 ( 4.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.76A 3fl9G-3i8aX:
24.6		 3fl9G-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 9 ALA X   7
VAL X  31
ILE X  50
LEU X  54
PHE X  92
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.77A 3fl9H-3i8aX:
25.0		 3fl9H-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 9 LEU X  28
VAL X  31
ILE X  50
LEU X  54
PHE X  92
THR X 111
 N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.75A 3fl9H-3i8aX:
25.0		 3fl9H-3i8aX:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		10 / 11 LEU X   5
ALA X   7
LEU X  20
ASP X  27
LEU X  28
VAL X  31
ILE X  50
PHE X  92
TYR X  98
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.45A 3frbX-3i8aX:
31.0		 3frbX-3i8aX:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		10 / 11 LEU X   5
ALA X   7
LEU X  20
ASP X  27
VAL X  31
SER X  49
ILE X  50
PHE X  92
TYR X  98
THR X 111
 N22  X 219 (-4.0A)
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
None
N22  X 219 (-4.4A)
 0.55A 3frbX-3i8aX:
31.0		 3frbX-3i8aX:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 9 ALA X   7
LEU X  20
ASP X  27
LEU X  28
VAL X  31
ILE X  50
PHE X  92
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.54A 3freX-3i8aX:
30.9		 3freX-3i8aX:
98.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 9 ALA X   7
LEU X  20
ASP X  27
VAL X  31
SER X  49
ILE X  50
PHE X  92
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.58A 3freX-3i8aX:
30.9		 3freX-3i8aX:
98.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
 0.69A 3hbbA-3i8aX:
19.3		 3hbbA-3i8aX:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 ALA X   7
ASP X  27
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.64A 3hbbC-3i8aX:
19.1		 3hbbC-3i8aX:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.38A 3hbbD-3i8aX:
19.2		 3hbbD-3i8aX:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.77A 3hj3A-3i8aX:
22.2		 3hj3A-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.62A 3hj3A-3i8aX:
22.2		 3hj3A-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LYS X  29
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
 0.91A 3hj3B-3i8aX:
22.2		 3hj3B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.73A 3hj3B-3i8aX:
22.2		 3hj3B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
LYS X  29
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
None
None
 0.96A 3hj3B-3i8aX:
22.2		 3hj3B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.66A 3hj3B-3i8aX:
22.2		 3hj3B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
None
None
None
N22  X 219 (-4.4A)
 0.76A 3hj3C-3i8aX:
20.9		 3hj3C-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.84A 3hj3D-3i8aX:
11.8		 3hj3D-3i8aX:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
 0.62A 3ia4A-3i8aX:
25.6		 3ia4A-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.91A 3ia4A-3i8aX:
25.6		 3ia4A-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
 0.64A 3ia4B-3i8aX:
25.7		 3ia4B-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.80A 3ia4B-3i8aX:
25.7		 3ia4B-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
 0.59A 3ia4C-3i8aX:
25.6		 3ia4C-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
SER X  49
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
 1.01A 3ia4C-3i8aX:
25.6		 3ia4C-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.79A 3ia4C-3i8aX:
25.6		 3ia4C-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
 0.60A 3ia4D-3i8aX:
25.7		 3ia4D-3i8aX:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.82A 3ia4D-3i8aX:
25.7		 3ia4D-3i8aX:
40.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
LEU X  28
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.4A)
None
None
N22  X 219 (-4.4A)
 0.66A 3ix9A-3i8aX:
25.1		 3ix9A-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
LYS X  32
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.79A 3ix9A-3i8aX:
25.1		 3ix9A-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
LEU X  28
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.4A)
None
None
N22  X 219 (-4.4A)
 0.63A 3ix9B-3i8aX:
25.3		 3ix9B-3i8aX:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LYS X  32
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
None
None
None
N22  X 219 (-4.4A)
 0.66A 3ix9B-3i8aX:
25.3		 3ix9B-3i8aX:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ALA X   7
LEU X  28
VAL X  31
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.56A 3jw3A-3i8aX:
26.1		 3jw3A-3i8aX:
44.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 ALA X   7
LEU X  20
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.6A)
None
None
 0.59A 3jw3B-3i8aX:
26.2		 3jw3B-3i8aX:
44.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 ALA X   7
LEU X  20
VAL X  31
ILE X  50
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-4.6A)
None
 0.42A 3jw3B-3i8aX:
26.2		 3jw3B-3i8aX:
44.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 11 ALA X   7
LEU X  20
LEU X  28
VAL X  31
ILE X  50
PHE X  92
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.48A 3jw5A-3i8aX:
26.1		 3jw5A-3i8aX:
44.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 10 ALA X   7
LEU X  20
LEU X  28
VAL X  31
ILE X  50
LEU X  54
PHE X  92
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
N22  X 219 (-4.4A)
 0.59A 3jw5B-3i8aX:
26.1		 3jw5B-3i8aX:
44.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.82A 3k2hA-3i8aX:
21.5		 3k2hA-3i8aX:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
None
 0.86A 3k2hB-3i8aX:
20.6		 3k2hB-3i8aX:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 1.06A 3k2hB-3i8aX:
20.6		 3k2hB-3i8aX:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 ALA X   7
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.86A 3n0hA-3i8aX:
20.4		 3n0hA-3i8aX:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
N22  X 219 (-4.4A)
 0.34A 3nrrA-3i8aX:
20.6		 3nrrA-3i8aX:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
THR X  46
ILE X  50
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
N22  X 219 (-4.4A)
 0.36A 3nrrB-3i8aX:
21.5		 3nrrB-3i8aX:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
THR X  46
SER X  49
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
None
N22  X 219 (-4.4A)
 0.65A 3qfxA-3i8aX:
20.0		 3qfxA-3i8aX:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
THR X  46
SER X  49
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
None
N22  X 219 (-4.4A)
 0.64A 3qfxB-3i8aX:
20.0		 3qfxB-3i8aX:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ALA X   7
ASP X  27
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.75A 3qg2A-3i8aX:
20.3		 3qg2A-3i8aX:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 ALA X   7
ASP X  27
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.71A 3qg2B-3i8aX:
20.3		 3qg2B-3i8aX:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ALA X   7
ASP X  27
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.70A 3qgtA-3i8aX:
20.3		 3qgtA-3i8aX:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ALA X   7
ASP X  27
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.65A 3qgtB-3i8aX:
9.8		 3qgtB-3i8aX:
14.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.44A 3ql0A-3i8aX:
26.1		 3ql0A-3i8aX:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 3ql0A-3i8aX:
26.1		 3ql0A-3i8aX:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.46A 3ql3A-3i8aX:
26.0		 3ql3A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.95A 3ql3A-3i8aX:
26.0		 3ql3A-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.92A 3s3vA-3i8aX:
20.2		 3s3vA-3i8aX:
29.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 9 ALA X   7
LEU X  20
ASP X  27
SER X  49
ILE X  50
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
N22  X 219 (-4.4A)
 0.59A 3tq8A-3i8aX:
25.6		 3tq8A-3i8aX:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.84A 3tq9A-3i8aX:
25.3		 3tq9A-3i8aX:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.52A 3tq9A-3i8aX:
25.3		 3tq9A-3i8aX:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 3tq9A-3i8aX:
25.3		 3tq9A-3i8aX:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 11 ALA X   7
LEU X  20
ASP X  27
LEU X  28
THR X  46
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.54A 3tqbA-3i8aX:
24.6		 3tqbA-3i8aX:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 11 ALA X   7
LEU X  20
ASP X  27
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.61A 3tqbA-3i8aX:
24.6		 3tqbA-3i8aX:
41.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ASP X  27
THR X  46
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.69A 3um5A-3i8aX:
20.4		 3um5A-3i8aX:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 10 ASP X  27
THR X  46
SER X  49
ILE X  50
TYR X  98
THR X 111
 N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.69A 3um5B-3i8aX:
20.3		 3um5B-3i8aX:
14.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
None
None
None
N22  X 219 (-4.4A)
 0.88A 4cd2A-3i8aX:
18.4		 4cd2A-3i8aX:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
THR X  46
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
None
None
None
N22  X 219 (-4.4A)
 0.78A 4cd2A-3i8aX:
18.4		 4cd2A-3i8aX:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 0.68A 4dfrA-3i8aX:
24.3		 4dfrA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
THR X  46
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.88A 4dfrA-3i8aX:
24.3		 4dfrA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.58A 4dfrB-3i8aX:
24.7		 4dfrB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.71A 4dfrB-3i8aX:
24.7		 4dfrB-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  20
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
N22  X 219 (-4.4A)
 0.83A 4eckA-3i8aX:
19.4		 4eckA-3i8aX:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.85A 4eckB-3i8aX:
19.5		 4eckB-3i8aX:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.54A 4eilA-3i8aX:
20.8		 4eilA-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.71A 4eilB-3i8aX:
21.0		 4eilB-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.57A 4eilC-3i8aX:
20.8		 4eilC-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.57A 4eilE-3i8aX:
21.4		 4eilE-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 9 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.70A 4eilF-3i8aX:
20.2		 4eilF-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.57A 4eilG-3i8aX:
20.8		 4eilG-3i8aX:
15.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
 0.43A 4ej1A-3i8aX:
24.0		 4ej1A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.66A 4ej1A-3i8aX:
24.0		 4ej1A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.59A 4ej1B-3i8aX:
24.0		 4ej1B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.67A 4ej1B-3i8aX:
24.0		 4ej1B-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.67A 4fhbA-3i8aX:
24.8		 4fhbA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.63A 4fhbA-3i8aX:
24.8		 4fhbA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
LEU X  20
SER X  49
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-3.3A)
None
N22  X 219 (-4.4A)
 0.65A 4g8zX-3i8aX:
19.9		 4g8zX-3i8aX:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
SER X  49
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
 0.72A 4gh8A-3i8aX:
24.9		 4gh8A-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 0.87A 4gh8A-3i8aX:
24.9		 4gh8A-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
 0.46A 4gh8B-3i8aX:
24.7		 4gh8B-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
ARG X  57
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
 0.86A 4gh8B-3i8aX:
24.7		 4gh8B-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
 0.53A 4i13A-3i8aX:
23.9		 4i13A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.70A 4i13A-3i8aX:
23.9		 4i13A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 ASP X  27
ARG X  57
THR X 111
 N22  X 219 (-2.8A)
None
N22  X 219 (-4.4A)
 0.45A 4i13A-3i8aX:
23.9		 4i13A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 11 ALA X   7
ASP X  27
LEU X  28
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
None
None
N22  X 219 (-4.4A)
 0.74A 4i1nA-3i8aX:
23.9		 4i1nA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 11 ALA X   7
ASP X  27
LYS X  32
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
N22  X 219 (-4.4A)
 0.78A 4i1nA-3i8aX:
23.9		 4i1nA-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
THR X  46
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
NDP  X 207 (-3.2A)
None
None
N22  X 219 (-4.4A)
 0.77A 4kebB-3i8aX:
20.3		 4kebB-3i8aX:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.74A 4kebB-3i8aX:
20.3		 4kebB-3i8aX:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.88A 4kfjB-3i8aX:
20.4		 4kfjB-3i8aX:
29.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.56A 4kjjA-3i8aX:
25.0		 4kjjA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ASP X  27
LEU X  28
ARG X  57
THR X 111
 N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
 0.55A 4kjjA-3i8aX:
25.0		 4kjjA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.71A 4kjkA-3i8aX:
25.6		 4kjkA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ASP X  27
LEU X  28
ARG X  57
THR X 111
 N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
 0.53A 4kjkA-3i8aX:
25.6		 4kjkA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.53A 4kjlA-3i8aX:
25.3		 4kjlA-3i8aX:
37.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
THR X  46
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 0.60A 4km0A-3i8aX:
21.8		 4km0A-3i8aX:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
THR X  46
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 0.55A 4km0B-3i8aX:
22.1		 4km0B-3i8aX:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
THR X  46
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 0.53A 4km2A-3i8aX:
22.5		 4km2A-3i8aX:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
THR X  46
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
None
None
N22  X 219 (-4.4A)
 0.85A 4km2A-3i8aX:
22.5		 4km2A-3i8aX:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.80A 4km2B-3i8aX:
21.9		 4km2B-3i8aX:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.70A 4ky8A-3i8aX:
9.3		 4ky8A-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.72A 4ky8A-3i8aX:
9.3		 4ky8A-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
LYS X  29
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
 0.78A 4ky8A-3i8aX:
9.3		 4ky8A-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
SER X  49
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.85A 4ky8A-3i8aX:
9.3		 4ky8A-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
SER X  49
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.95A 4ky8A-3i8aX:
9.3		 4ky8A-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  29
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
None
N22  X 219 (-4.4A)
 0.93A 4ky8B-3i8aX:
15.7		 4ky8B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LYS X  29
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
N22  X 219 (-4.4A)
 0.99A 4ky8B-3i8aX:
15.7		 4ky8B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
SER X  49
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.93A 4ky8B-3i8aX:
15.7		 4ky8B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.66A 4ky8B-3i8aX:
15.7		 4ky8B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
SER X  49
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.82A 4ky8B-3i8aX:
15.7		 4ky8B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  20
LYS X  32
SER X  49
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.4A)
 1.06A 4ky8B-3i8aX:
15.7		 4ky8B-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
SER X  49
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.85A 4ky8C-3i8aX:
21.8		 4ky8C-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.74A 4ky8C-3i8aX:
21.8		 4ky8C-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
LYS X  29
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
 0.80A 4ky8C-3i8aX:
21.8		 4ky8C-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
SER X  49
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.72A 4ky8C-3i8aX:
21.8		 4ky8C-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
SER X  49
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.98A 4ky8D-3i8aX:
18.3		 4ky8D-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.78A 4ky8D-3i8aX:
18.3		 4ky8D-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
LYS X  29
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
 0.76A 4ky8D-3i8aX:
18.3		 4ky8D-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
SER X  49
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.88A 4ky8D-3i8aX:
18.3		 4ky8D-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
SER X  49
ILE X  50
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 1.00A 4ky8E-3i8aX:
21.8		 4ky8E-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.74A 4ky8E-3i8aX:
21.8		 4ky8E-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
LYS X  29
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
 0.74A 4ky8E-3i8aX:
21.8		 4ky8E-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
ASP X  27
SER X  49
ILE X  50
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.89A 4ky8E-3i8aX:
21.8		 4ky8E-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 ALA X   7
ASP X  27
THR X  46
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
None
N22  X 219 (-4.4A)
 0.65A 4kyaA-3i8aX:
20.8		 4kyaA-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.76A 4kyaB-3i8aX:
20.9		 4kyaB-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.64A 4kyaC-3i8aX:
15.0		 4kyaC-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.76A 4kyaD-3i8aX:
13.5		 4kyaD-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 ALA X   7
ASP X  27
THR X  46
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
None
N22  X 219 (-4.4A)
 0.64A 4kyaE-3i8aX:
20.7		 4kyaE-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.75A 4kyaF-3i8aX:
13.4		 4kyaF-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 11 ALA X   7
ASP X  27
THR X  46
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
None
N22  X 219 (-4.4A)
 0.67A 4kyaG-3i8aX:
20.7		 4kyaG-3i8aX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
LEU X  54
ARG X  57
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.79A 4kyaH-3i8aX:
20.1		 4kyaH-3i8aX:
15.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.47A 4m2xC-3i8aX:
8.2		 4m2xC-3i8aX:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  20
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.73A 4m6kA-3i8aX:
20.8		 4m6kA-3i8aX:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.65A 4nx6A-3i8aX:
26.1		 4nx6A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.83A 4nx6A-3i8aX:
26.1		 4nx6A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.67A 4nx7A-3i8aX:
26.2		 4nx7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.92A 4nx7A-3i8aX:
26.2		 4nx7A-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
PRO X  55
TYR X  98
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
 1.05A 4p3qA-3i8aX:
26.0		 4p3qA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		4 / 5 ASP X  27
LEU X  28
ARG X  57
THR X 111
 N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
 0.44A 4p3qA-3i8aX:
26.0		 4p3qA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.71A 4p3rA-3i8aX:
26.2		 4p3rA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.71A 4p3rA-3i8aX:
26.2		 4p3rA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 ASP X  27
ARG X  57
THR X 111
 N22  X 219 (-2.8A)
None
N22  X 219 (-4.4A)
 0.48A 4p3rA-3i8aX:
26.2		 4p3rA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 11 ALA X   7
ASP X  27
LEU X  28
LYS X  32
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
None
None
None
N22  X 219 (-4.4A)
 0.63A 4p66A-3i8aX:
26.1		 4p66A-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 11 ASP X  27
LYS X  32
SER X  49
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.63A 4p68A-3i8aX:
25.9		 4p68A-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
 0.70A 4pssA-3i8aX:
undetectable		 4pssA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		4 / 4 ASP X  27
LYS X  32
ARG X  57
THR X 111
 N22  X 219 (-2.8A)
None
None
N22  X 219 (-4.4A)
 0.68A 4pssA-3i8aX:
undetectable		 4pssA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.59A 4pstA-3i8aX:
undetectable		 4pstA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.62A 4pstA-3i8aX:
undetectable		 4pstA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.67A 4psyA-3i8aX:
26.2		 4psyA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.60A 4psyA-3i8aX:
26.2		 4psyA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.72A 4pthA-3i8aX:
26.0		 4pthA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.49A 4ptjA-3i8aX:
25.9		 4ptjA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 ASP X  27
LYS X  32
LEU X  54
 N22  X 219 (-2.8A)
None
None
 0.84A 4ptjA-3i8aX:
25.9		 4ptjA-3i8aX:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.67A 4q0dA-3i8aX:
22.0		 4q0dA-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  29
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
N22  X 219 (-4.4A)
 1.16A 4q0dA-3i8aX:
22.0		 4q0dA-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 4q0dA-3i8aX:
22.0		 4q0dA-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  20
LYS X  32
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
N22  X 219 (-4.4A)
 1.15A 4q0dA-3i8aX:
22.0		 4q0dA-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.68A 4q0dB-3i8aX:
22.0		 4q0dB-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  29
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
N22  X 219 (-4.4A)
 1.16A 4q0dB-3i8aX:
22.0		 4q0dB-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 4q0dB-3i8aX:
22.0		 4q0dB-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  20
LYS X  32
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
N22  X 219 (-4.4A)
 1.15A 4q0dB-3i8aX:
22.0		 4q0dB-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  29
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
N22  X 219 (-4.4A)
 1.16A 4q0dC-3i8aX:
21.9		 4q0dC-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
SER X  49
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
None
None
None
N22  X 219 (-4.4A)
 0.81A 4q0dC-3i8aX:
21.9		 4q0dC-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
SER X  49
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
None
None
N22  X 219 (-4.4A)
 0.72A 4q0dC-3i8aX:
21.9		 4q0dC-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
LYS X  32
SER X  49
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-3.3A)
None
N22  X 219 (-4.4A)
 1.15A 4q0dC-3i8aX:
21.9		 4q0dC-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  29
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
N22  X 219 (-4.4A)
 1.16A 4q0dD-3i8aX:
22.0		 4q0dD-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
SER X  49
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
None
None
None
N22  X 219 (-4.4A)
 0.82A 4q0dD-3i8aX:
22.0		 4q0dD-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
SER X  49
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
None
None
N22  X 219 (-4.4A)
 0.72A 4q0dD-3i8aX:
22.0		 4q0dD-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  20
LYS X  32
SER X  49
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-3.3A)
None
N22  X 219 (-4.4A)
 1.16A 4q0dD-3i8aX:
22.0		 4q0dD-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.68A 4q0dE-3i8aX:
22.0		 4q0dE-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LYS X  29
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
None
None
None
N22  X 219 (-4.4A)
 1.16A 4q0dE-3i8aX:
22.0		 4q0dE-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  20
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 4q0dE-3i8aX:
22.0		 4q0dE-3i8aX:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
LEU X  20
LYS X  32
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
None
N22  X 219 (-4.4A)
 1.15A 4q0dE-3i8aX:
22.0		 4q0dE-3i8aX:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
SER X  49
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.70A 4qi9A-3i8aX:
22.5		 4qi9A-3i8aX:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.73A 4qi9A-3i8aX:
22.5		 4qi9A-3i8aX:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
SER X  49
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.66A 4qi9B-3i8aX:
23.1		 4qi9B-3i8aX:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.79A 4qi9B-3i8aX:
23.1		 4qi9B-3i8aX:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 11 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.78A 4qi9C-3i8aX:
22.0		 4qi9C-3i8aX:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.63A 4qleA-3i8aX:
25.0		 4qleA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
ASP X  27
LEU X  28
THR X  46
LEU X  40
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 1.34A 4qleA-3i8aX:
25.0		 4qleA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.62A 4qleA-3i8aX:
25.0		 4qleA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 11 ALA X   7
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.51A 4qleB-3i8aX:
24.7		 4qleB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 11 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.68A 4qleB-3i8aX:
24.7		 4qleB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 11 ALA X   7
ASP X  27
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.79A 4qleB-3i8aX:
24.7		 4qleB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 11 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.62A 4qlfA-3i8aX:
21.7		 4qlfA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 11 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.87A 4qlfA-3i8aX:
21.7		 4qlfA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.53A 4qlgA-3i8aX:
24.6		 4qlgA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.73A 4qlgA-3i8aX:
24.6		 4qlgA-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 4qlgB-3i8aX:
24.4		 4qlgB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.69A 4qlgB-3i8aX:
24.4		 4qlgB-3i8aX:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.66A 4rgcA-3i8aX:
26.2		 4rgcA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.71A 4rgcA-3i8aX:
26.2		 4rgcA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  28
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.67A 4x5fA-3i8aX:
24.8		 4x5fA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  28
LYS X  32
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.83A 4x5fB-3i8aX:
24.9		 4x5fB-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.62A 4x5fB-3i8aX:
24.9		 4x5fB-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.69A 4x5gA-3i8aX:
24.9		 4x5gA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA X   7
ASP X  27
THR X  46
LEU X  40
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 1.07A 4x5gA-3i8aX:
24.9		 4x5gA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
LEU X  28
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.92A 4x5gB-3i8aX:
25.0		 4x5gB-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
LYS X  32
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.70A 4x5hA-3i8aX:
24.3		 4x5hA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.79A 4x5hA-3i8aX:
24.3		 4x5hA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
LYS X  32
THR X  46
ILE X  50
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
N22  X 219 (-4.4A)
 0.78A 4x5iA-3i8aX:
24.2		 4x5iA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.52A 4x5iA-3i8aX:
24.2		 4x5iA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.75A 4x5iA-3i8aX:
24.2		 4x5iA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.63A 4x5iA-3i8aX:
24.2		 4x5iA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
LYS X  32
THR X  46
ILE X  50
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
N22  X 219 (-4.4A)
 0.85A 4x5jA-3i8aX:
24.1		 4x5jA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.57A 4x5jA-3i8aX:
24.1		 4x5jA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.56A 5e8qA-3i8aX:
24.3		 5e8qA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.55A 5e8qA-3i8aX:
24.3		 5e8qA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 ASP X  27
LEU X  54
ARG X  57
 N22  X 219 (-2.8A)
None
None
 0.57A 5e8qA-3i8aX:
24.3		 5e8qA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.74A 5e8qB-3i8aX:
24.8		 5e8qB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.70A 5e8qB-3i8aX:
24.8		 5e8qB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.55A 5eajA-3i8aX:
24.2		 5eajA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.71A 5eajA-3i8aX:
24.2		 5eajA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
PRO X  55
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.75A 5eajB-3i8aX:
24.8		 5eajB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
PRO X  55
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.72A 5eajB-3i8aX:
24.8		 5eajB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LEU X  28
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.79A 5hi6A-3i8aX:
24.4		 5hi6A-3i8aX:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		9 / 12 ALA X   7
ASP X  27
LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.78A 5hi6A-3i8aX:
24.4		 5hi6A-3i8aX:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LEU X  28
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.65A 5hi6B-3i8aX:
24.5		 5hi6B-3i8aX:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
ASP X  27
LYS X  32
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
None
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.81A 5hi6B-3i8aX:
24.5		 5hi6B-3i8aX:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 LYS X  32
SER X  49
ILE X  50
LEU X  54
ARG X  57
TYR X  98
 None
N22  X 219 (-3.3A)
N22  X 219 (-4.6A)
None
None
None
 1.09A 5hi6B-3i8aX:
24.5		 5hi6B-3i8aX:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 8 ALA X   7
ASP X  27
LEU X  28
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
 0.42A 5uihA-3i8aX:
24.0		 5uihA-3i8aX:
29.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		6 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
N22  X 219 (-4.4A)
 0.56A 5ujxA-3i8aX:
24.3		 5ujxA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.73A 5ujxA-3i8aX:
24.3		 5ujxA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.70A 5ujxB-3i8aX:
24.8		 5ujxB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		8 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
None
N22  X 219 (-4.4A)
 0.68A 5ujxB-3i8aX:
24.8		 5ujxB-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.46A 5z6fA-3i8aX:
25.9		 5z6fA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
ARG X  57
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.53A 5z6fA-3i8aX:
25.9		 5z6fA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.69A 5z6jA-3i8aX:
26.1		 5z6jA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.60A 5z6jA-3i8aX:
26.1		 5z6jA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LEU X  28
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-4.4A)
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.74A 5z6kA-3i8aX:
26.1		 5z6kA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.64A 5z6kA-3i8aX:
26.1		 5z6kA-3i8aX:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 9 ALA X   7
ASP X  27
LEU X  28
LYS X  32
ILE X  50
PRO X  55
ARG X  57
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.6A)
None
None
 0.73A 5z6lA-3i8aX:
25.4		 5z6lA-3i8aX:
36.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
THR X  46
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 0.36A 6aogA-3i8aX:
20.6		 6aogA-3i8aX:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 ALA X   7
ASP X  27
THR X  46
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
NDP  X 207 (-3.2A)
None
N22  X 219 (-4.4A)
 0.39A 6aogB-3i8aX:
20.6		 6aogB-3i8aX:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		7 / 12 ALA X   7
LYS X  32
THR X  46
ILE X  50
LEU X  54
TYR X  98
THR X 111
 N22  X 219 ( 3.6A)
None
NDP  X 207 (-3.2A)
N22  X 219 (-4.6A)
None
None
N22  X 219 (-4.4A)
 0.64A 7dfrA-3i8aX:
25.8		 7dfrA-3i8aX:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i8a DIHYDROFOLATE
REDUCTASE
(Staphylococcus
aureus) 		3 / 3 ASP X  27
LEU X  28
ARG X  57
 N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
 0.51A 7dfrA-3i8aX:
25.8		 7dfrA-3i8aX:
37.50