SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MYP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1m6d CATHEPSIN F
(Homo
sapiens) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 MYP  A1280 (-3.2A)
MYP  A1280 (-3.5A)
None
None
None
MYP  A1280 ( 4.5A)
MYP  A1280 (-3.1A)
 1.31A 1stfE-1m6dA:
32.5
1stfI-1m6dA:
undetectable		 1stfE-1m6dA:
42.04
1stfI-1m6dA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1m6d CATHEPSIN F
(Homo
sapiens) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 159
ALA A 160
 MYP  A1280 (-3.2A)
MYP  A1280 (-3.5A)
None
MYP  A1280 (-4.9A)
None
None
MYP  A1280 (-3.6A)
MYP  A1280 ( 4.5A)
 0.46A 1stfE-1m6dA:
32.5
1stfI-1m6dA:
undetectable		 1stfE-1m6dA:
42.04
1stfI-1m6dA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1m6d CATHEPSIN F
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS A 159
TRP A 177
 MYP  A1280 (-3.2A)
MYP  A1280 (-3.5A)
MYP  A1280 (-3.6A)
MYP  A1280 (-3.8A)
 0.47A 3ai8A-1m6dA:
27.8		 3ai8A-1m6dA:
28.30