SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MXA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
ARG A  70
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
None
 0.81A 1ao8A-1u71A:
19.1		 1ao8A-1u71A:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
MXA  A 187 (-4.3A)
 0.65A 1ao8A-1u71A:
19.1		 1ao8A-1u71A:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-4.4A)
None
None
MXA  A 187 (-4.3A)
 0.37A 1cd2A-1u71A:
25.4		 1cd2A-1u71A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.36A 1d1gA-1u71A:
16.5		 1d1gA-1u71A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.43A 1d1gB-1u71A:
16.7		 1d1gB-1u71A:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.60A 1ddrA-1u71A:
19.4		 1ddrA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.47A 1ddrB-1u71A:
19.8		 1ddrB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.50A 1ddsA-1u71A:
19.9		 1ddsA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.49A 1ddsB-1u71A:
20.2		 1ddsB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-4.4A)
None
None
None
 0.46A 1df7A-1u71A:
21.1		 1df7A-1u71A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
PRO A  61
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 (-4.4A)
None
 0.62A 1dg5A-1u71A:
21.1		 1dg5A-1u71A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		10 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
MXA  A 187 (-4.3A)
 0.39A 1dhfA-1u71A:
31.9		 1dhfA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		10 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
ASN A  64
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.5A)
None
None
None
MXA  A 187 (-4.3A)
 0.32A 1dhfB-1u71A:
32.2		 1dhfB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
PHE A  31
PHE A  34
THR A  56
ILE A  60
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-4.3A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
 1.23A 1dhfB-1u71A:
32.2		 1dhfB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.55A 1dhiA-1u71A:
19.8		 1dhiA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.79A 1dhiA-1u71A:
19.8		 1dhiA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 11 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.51A 1dhiB-1u71A:
20.3		 1dhiB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.58A 1dhjA-1u71A:
20.0		 1dhjA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
SER A  59
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
None
MXA  A 187 (-4.3A)
 0.77A 1dhjA-1u71A:
20.0		 1dhjA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.61A 1dhjB-1u71A:
20.3		 1dhjB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		10 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
ILE A  60
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
None
 0.33A 1dlsA-1u71A:
34.2		 1dlsA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
PHE A  31
SER A  59
ILE A  60
PRO A  61
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-4.3A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
 1.23A 1dlsA-1u71A:
34.2		 1dlsA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
None
 0.53A 1draA-1u71A:
20.0		 1draA-1u71A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.8A)
None
 0.76A 1draA-1u71A:
20.0		 1draA-1u71A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.49A 1draB-1u71A:
20.4		 1draB-1u71A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.59A 1drbA-1u71A:
19.9		 1drbA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.82A 1drbA-1u71A:
19.9		 1drbA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.54A 1drbB-1u71A:
20.3		 1drbB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
 0.66A 1dreA-1u71A:
20.4		 1dreA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ALA A   9
ARG A  32
PHE A  34
SER A  59
ILE A  60
PRO A  61
LEU A  67
TYR A 121
 MXA  A 187 (-3.6A)
None
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
 0.99A 1drfA-1u71A:
33.4		 1drfA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
PRO A  61
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
 0.31A 1drfA-1u71A:
33.4		 1drfA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
PHE A  31
PHE A  34
SER A  59
ILE A  60
PRO A  61
 MXA  A 187 (-4.5A)
MXA  A 187 (-4.3A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
 1.21A 1drfA-1u71A:
33.4		 1drfA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		4 / 4 GLU A  30
ASN A  64
ARG A  70
THR A 136
 MXA  A 187 (-2.9A)
MXA  A 187 (-4.5A)
None
MXA  A 187 (-4.3A)
 0.80A 1drfA-1u71A:
33.4		 1drfA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.46A 1dyiA-1u71A:
19.9		 1dyiA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.42A 1dyiB-1u71A:
20.1		 1dyiB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 11 ILE A   7
ALA A   9
GLU A  30
PHE A  34
ILE A  60
PRO A  61
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
MXA  A 187 (-4.3A)
 0.41A 1dyrA-1u71A:
25.1		 1dyrA-1u71A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.38A 1j3jA-1u71A:
23.0		 1j3jA-1u71A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 9 ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.35A 1j3jB-1u71A:
22.6		 1j3jB-1u71A:
25.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.55A 1jolA-1u71A:
20.0		 1jolA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.53A 1jolB-1u71A:
20.2		 1jolB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 11 ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.46A 1jomA-1u71A:
19.6		 1jomA-1u71A:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.61A 1qzfA-1u71A:
22.0		 1qzfA-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.62A 1qzfB-1u71A:
22.0		 1qzfB-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.62A 1qzfC-1u71A:
22.0		 1qzfC-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.62A 1qzfD-1u71A:
21.9		 1qzfD-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.63A 1qzfE-1u71A:
22.0		 1qzfE-1u71A:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.46A 1ra2A-1u71A:
19.9		 1ra2A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.53A 1ra3A-1u71A:
20.0		 1ra3A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.45A 1ra8A-1u71A:
19.8		 1ra8A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.48A 1rb2A-1u71A:
20.0		 1rb2A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
None
None
None
MXA  A 187 (-4.3A)
 0.34A 1rb2B-1u71A:
20.0		 1rb2B-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 10 ILE A   7
ALA A   9
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.50A 1rb3A-1u71A:
20.1		 1rb3A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.53A 1rb3B-1u71A:
20.2		 1rb3B-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.49A 1rd7A-1u71A:
19.4		 1rd7A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.56A 1rd7B-1u71A:
19.4		 1rd7B-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.46A 1re7A-1u71A:
19.6		 1re7A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.53A 1re7B-1u71A:
19.4		 1re7B-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.50A 1rg7A-1u71A:
18.4		 1rg7A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
THR A  56
SER A  59
ILE A  60
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
 0.78A 1rg7A-1u71A:
18.4		 1rg7A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
 0.64A 1rh3A-1u71A:
20.4		 1rh3A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.53A 1rx2A-1u71A:
20.9		 1rx2A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
 0.62A 1rx3A-1u71A:
20.8		 1rx3A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.53A 1rx7A-1u71A:
19.3		 1rx7A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.54A 1rx8A-1u71A:
20.6		 1rx8A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.60A 1tdrA-1u71A:
20.0		 1tdrA-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 10 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.59A 1tdrB-1u71A:
20.2		 1tdrB-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
ARG A  22
GLU A  30
PRO A  61
ASN A  64
LEU A  67
ARG A  70
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-4.5A)
MXA  A 187 (-2.9A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
 1.18A 1u70A-1u71A:
31.1		 1u70A-1u71A:
89.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
None
 0.51A 1u70A-1u71A:
31.1		 1u70A-1u71A:
89.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ALA A   9
GLU A  30
SER A  59
PRO A  61
ASN A  64
LEU A  67
ARG A  70
VAL A 115
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.8A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
MXA  A 187 (-4.3A)
None
 0.43A 1u72A-1u71A:
33.9		 1u72A-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 GLU A  30
PHE A  31
SER A  59
PRO A  61
VAL A 115
TYR A 121
 MXA  A 187 (-2.9A)
MXA  A 187 (-4.3A)
MXA  A 187 (-3.8A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.3A)
None
 1.42A 1u72A-1u71A:
33.9		 1u72A-1u71A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.47A 2bl9A-1u71A:
22.7		 2bl9A-1u71A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.65A 2blaA-1u71A:
22.3		 2blaA-1u71A:
28.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
THR A  56
PRO A  61
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 (-4.4A)
None
None
None
MXA  A 187 (-4.3A)
 0.36A 2cd2A-1u71A:
25.4		 2cd2A-1u71A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.42A 2d0kA-1u71A:
19.1		 2d0kA-1u71A:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.47A 2d0kB-1u71A:
19.3		 2d0kB-1u71A:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
 0.53A 2drcA-1u71A:
19.8		 2drcA-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.49A 2drcB-1u71A:
20.2		 2drcB-1u71A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.65A 2oipA-1u71A:
22.6		 2oipA-1u71A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
None
None
None
MXA  A 187 (-4.3A)
 0.55A 2oipB-1u71A:
21.1		 2oipB-1u71A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
None
None
None
MXA  A 187 (-4.3A)
 0.59A 2oipC-1u71A:
22.5		 2oipC-1u71A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.78A 2oipD-1u71A:
23.2		 2oipD-1u71A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.79A 2oipE-1u71A:
22.1		 2oipE-1u71A:
17.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
None
 0.69A 2qk8A-1u71A:
21.0		 2qk8A-1u71A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		11 / 11 ILE A   7
ALA A   9
GLU A  30
PHE A  31
PHE A  34
THR A  56
ILE A  60
PRO A  61
VAL A 115
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-4.3A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.3A)
None
MXA  A 187 (-4.3A)
 0.41A 2w3aA-1u71A:
32.2		 2w3aA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		10 / 10 ILE A   7
ALA A   9
GLU A  30
PHE A  31
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-4.3A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.53A 2w3aB-1u71A:
32.5		 2w3aB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		10 / 12 ILE A   7
ALA A   9
ARG A  32
PHE A  34
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
MXA  A 187 (-4.3A)
 0.74A 2w3bA-1u71A:
32.2		 2w3bA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		4 / 4 GLU A  30
GLN A  35
ASN A  64
ARG A  70
 MXA  A 187 (-2.9A)
None
MXA  A 187 (-4.5A)
None
 0.39A 2w3bA-1u71A:
32.2		 2w3bA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
MXA  A 187 (-4.3A)
 0.39A 2w3bB-1u71A:
32.3		 2w3bB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
MXA  A 187 (-4.3A)
 0.46A 2w3mA-1u71A:
31.9		 2w3mA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A   7
ALA A   9
GLU A  30
GLN A  35
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
None
MXA  A 187 (-4.3A)
 0.94A 2w3mB-1u71A:
32.4		 2w3mB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
ASN A  64
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.9A)
MXA  A 187 (-4.5A)
None
None
None
MXA  A 187 (-4.3A)
 0.47A 2w3mB-1u71A:
32.4		 2w3mB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.78A 2w9sA-1u71A:
20.7		 2w9sA-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.77A 2w9sB-1u71A:
20.7		 2w9sB-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 10 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.76A 2w9sC-1u71A:
20.7		 2w9sC-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.29A 2w9sD-1u71A:
20.5		 2w9sD-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		4 / 8 ILE A   7
ALA A   9
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-4.3A)
 0.29A 2w9sE-1u71A:
20.5		 2w9sE-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.29A 2w9sF-1u71A:
20.4		 2w9sF-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.61A 2zzaA-1u71A:
21.1		 2zzaA-1u71A:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 11 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.61A 2zzaB-1u71A:
21.1		 2zzaB-1u71A:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
GLU A  30
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-2.9A)
MXA  A 187 (-4.4A)
None
None
None
 0.35A 3cd2A-1u71A:
25.0		 3cd2A-1u71A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
THR A  56
SER A  59
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
MXA  A 187 (-4.4A)
None
None
None
 0.68A 3cl9A-1u71A:
21.6		 3cl9A-1u71A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
MXA  A 187 (-4.3A)
 0.68A 3clbA-1u71A:
21.8		 3clbA-1u71A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
ILE A  60
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
 0.36A 3clbB-1u71A:
20.8		 3clbB-1u71A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 THR A  56
SER A  59
ILE A  60
PRO A  61
TYR A 121
 SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
 0.76A 3clbB-1u71A:
20.8		 3clbB-1u71A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
MXA  A 187 (-4.3A)
 0.66A 3clbC-1u71A:
21.7		 3clbC-1u71A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
MXA  A 187 (-4.3A)
 0.70A 3clbD-1u71A:
21.7		 3clbD-1u71A:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
None
 0.78A 3datA-1u71A:
21.2		 3datA-1u71A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
 0.53A 3dauA-1u71A:
20.6		 3dauA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
SER A  59
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
None
MXA  A 187 (-4.3A)
 0.76A 3dfrA-1u71A:
21.0		 3dfrA-1u71A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
 0.51A 3drcA-1u71A:
19.9		 3drcA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.47A 3drcB-1u71A:
20.3		 3drcB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.8A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
None
 0.58A 3eigA-1u71A:
33.0		 3eigA-1u71A:
98.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
 1.10A 3fl9A-1u71A:
20.5		 3fl9A-1u71A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
GLU A  30
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.93A 3fl9B-1u71A:
20.2		 3fl9B-1u71A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 9 ALA A   9
GLU A  30
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
 0.99A 3fl9D-1u71A:
20.7		 3fl9D-1u71A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
LEU A  67
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.89A 3fl9E-1u71A:
20.3		 3fl9E-1u71A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
GLU A  30
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
None
None
MXA  A 187 (-4.3A)
 0.67A 3fl9G-1u71A:
20.3		 3fl9G-1u71A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A  30
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.96A 3fl9G-1u71A:
20.3		 3fl9G-1u71A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 11 ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.84A 3frbX-1u71A:
20.6		 3frbX-1u71A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
 0.69A 3hbbA-1u71A:
21.9		 3hbbA-1u71A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
MXA  A 187 (-4.3A)
 0.69A 3hbbC-1u71A:
21.8		 3hbbC-1u71A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
MXA  A 187 (-4.3A)
 0.65A 3hbbD-1u71A:
21.9		 3hbbD-1u71A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.69A 3hj3A-1u71A:
23.3		 3hj3A-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.65A 3hj3B-1u71A:
23.4		 3hj3B-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
None
None
None
MXA  A 187 (-4.3A)
 0.70A 3hj3C-1u71A:
6.1		 3hj3C-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.82A 3hj3D-1u71A:
19.0		 3hj3D-1u71A:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
GLU A  30
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
 0.82A 3ia4A-1u71A:
20.9		 3ia4A-1u71A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
 0.79A 3ia4B-1u71A:
21.0		 3ia4B-1u71A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ALA A   9
GLU A  30
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
 0.75A 3ia4C-1u71A:
20.9		 3ia4C-1u71A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
 0.74A 3ia4D-1u71A:
20.9		 3ia4D-1u71A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
GLU A  30
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.33A 3ix9A-1u71A:
21.0		 3ix9A-1u71A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
GLU A  30
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
None
None
MXA  A 187 (-4.3A)
 0.57A 3ix9A-1u71A:
21.0		 3ix9A-1u71A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
GLU A  30
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.63A 3ix9B-1u71A:
20.7		 3ix9B-1u71A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
LEU A  67
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 1.01A 3jw3A-1u71A:
21.3		 3jw3A-1u71A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.53A 3jw3A-1u71A:
21.3		 3jw3A-1u71A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 9 ALA A   9
GLU A  30
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
None
 1.06A 3jw3B-1u71A:
21.5		 3jw3B-1u71A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
LEU A  67
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.67A 3jw5B-1u71A:
21.1		 3jw5B-1u71A:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.45A 3k2hA-1u71A:
24.3		 3k2hA-1u71A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
 0.52A 3k2hB-1u71A:
23.6		 3k2hB-1u71A:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		10 / 11 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
ILE A  60
LEU A  67
VAL A 115
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
None
MXA  A 187 (-4.3A)
 0.35A 3n0hA-1u71A:
33.9		 3n0hA-1u71A:
98.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
THR A  56
ILE A  60
PRO A  61
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.3A)
 0.31A 3nrrA-1u71A:
23.6		 3nrrA-1u71A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
THR A  56
ILE A  60
PRO A  61
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.3A)
 0.34A 3nrrB-1u71A:
24.4		 3nrrB-1u71A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.38A 3qfxA-1u71A:
22.0		 3qfxA-1u71A:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.37A 3qfxB-1u71A:
22.1		 3qfxB-1u71A:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.36A 3qg2A-1u71A:
23.1		 3qg2A-1u71A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.36A 3qg2B-1u71A:
22.8		 3qg2B-1u71A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.40A 3qgtA-1u71A:
22.9		 3qgtA-1u71A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
PHE A  34
SER A  59
ILE A  60
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.3A)
 1.08A 3qgtB-1u71A:
22.4		 3qgtB-1u71A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.35A 3qgtB-1u71A:
22.4		 3qgtB-1u71A:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.49A 3ql0A-1u71A:
21.4		 3ql0A-1u71A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.53A 3ql3A-1u71A:
20.9		 3ql3A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		10 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
ILE A  60
LEU A  67
VAL A 115
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
None
MXA  A 187 (-4.3A)
 0.39A 3s3vA-1u71A:
33.8		 3s3vA-1u71A:
98.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
GLU A  30
PHE A  31
THR A  56
VAL A 115
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-2.9A)
MXA  A 187 (-4.3A)
SO4  A 188 (-3.5A)
MXA  A 187 (-4.3A)
None
 1.35A 3s3vA-1u71A:
33.8		 3s3vA-1u71A:
98.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 9 ILE A   7
ALA A   9
PHE A  34
ILE A  60
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.3A)
 0.36A 3tq8A-1u71A:
21.1		 3tq8A-1u71A:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 9 ILE A   7
ALA A   9
SER A  59
ILE A  60
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.3A)
 0.71A 3tq8A-1u71A:
21.1		 3tq8A-1u71A:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.67A 3tq9A-1u71A:
21.2		 3tq9A-1u71A:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.40A 3tqbA-1u71A:
21.1		 3tqbA-1u71A:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 10 ILE A   7
PHE A  34
THR A  56
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.44A 3um5A-1u71A:
22.7		 3um5A-1u71A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 10 ILE A   7
PHE A  34
THR A  56
SER A  59
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.49A 3um5B-1u71A:
22.5		 3um5B-1u71A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		4 / 4 LEU A 166
ILE A   7
TYR A 162
TYR A 177
 None
MXA  A 187 (-4.5A)
None
None
 1.36A 3vt7A-1u71A:
undetectable		 3vt7A-1u71A:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
None
None
None
MXA  A 187 (-4.3A)
 0.39A 4cd2A-1u71A:
23.9		 4cd2A-1u71A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
 0.54A 4dfrA-1u71A:
19.7		 4dfrA-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.46A 4dfrB-1u71A:
20.2		 4dfrB-1u71A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
PHE A  34
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
None
None
MXA  A 187 (-4.3A)
 0.53A 4eckA-1u71A:
21.8		 4eckA-1u71A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
PHE A  34
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.69A 4eckB-1u71A:
21.3		 4eckB-1u71A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 11 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.34A 4eilA-1u71A:
24.6		 4eilA-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.33A 4eilB-1u71A:
23.8		 4eilB-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 11 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.31A 4eilC-1u71A:
24.6		 4eilC-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 11 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.31A 4eilE-1u71A:
25.4		 4eilE-1u71A:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.44A 4ej1A-1u71A:
19.6		 4ej1A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.41A 4ej1B-1u71A:
19.5		 4ej1B-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.46A 4fhbA-1u71A:
20.1		 4fhbA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 10 ILE A   7
ALA A   9
GLU A  30
PHE A  34
PRO A  61
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.9A)
MXA  A 187 (-4.4A)
None
MXA  A 187 (-4.3A)
 0.56A 4g8zX-1u71A:
25.2		 4g8zX-1u71A:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 10 ILE A   7
ALA A   9
GLU A  30
SER A  59
PRO A  61
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-2.9A)
MXA  A 187 (-3.8A)
MXA  A 187 (-4.4A)
None
MXA  A 187 (-4.3A)
 0.76A 4g8zX-1u71A:
25.2		 4g8zX-1u71A:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
None
 0.39A 4gh8A-1u71A:
22.1		 4gh8A-1u71A:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
PRO A  61
ASN A  64
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.5A)
None
None
 0.60A 4gh8B-1u71A:
21.8		 4gh8B-1u71A:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
PRO A  61
ARG A  70
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
 0.32A 4gh8B-1u71A:
21.8		 4gh8B-1u71A:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.46A 4i13A-1u71A:
19.5		 4i13A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 11 ILE A   7
ALA A   9
PHE A  34
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
None
None
None
MXA  A 187 (-4.3A)
 0.39A 4i1nA-1u71A:
19.5		 4i1nA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
ASN A  64
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.5A)
None
None
MXA  A 187 (-4.3A)
 0.42A 4kebB-1u71A:
32.1		 4kebB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
PHE A  31
THR A  56
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-4.3A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 1.35A 4kebB-1u71A:
32.1		 4kebB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ARG A  32
PHE A  34
VAL A 115
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-3.9A)
MXA  A 187 (-4.3A)
None
MXA  A 187 (-4.3A)
 1.06A 4kfjB-1u71A:
32.3		 4kfjB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
PRO A  61
LEU A  67
VAL A 115
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
MXA  A 187 (-4.3A)
None
MXA  A 187 (-4.3A)
 0.29A 4kfjB-1u71A:
32.3		 4kfjB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
PHE A  31
ILE A  60
PRO A  61
VAL A 115
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-4.3A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
MXA  A 187 (-4.3A)
None
MXA  A 187 (-4.3A)
 1.39A 4kfjB-1u71A:
32.3		 4kfjB-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.50A 4kjjA-1u71A:
20.0		 4kjjA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.51A 4kjkA-1u71A:
20.7		 4kjkA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
ARG A  65
LEU A  67
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
None
None
MXA  A 187 (-4.3A)
 1.12A 4kjlA-1u71A:
20.9		 4kjlA-1u71A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.54A 4kjlA-1u71A:
20.9		 4kjlA-1u71A:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
THR A  56
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
None
MXA  A 187 (-4.3A)
 0.66A 4km0A-1u71A:
19.6		 4km0A-1u71A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
None
MXA  A 187 (-4.3A)
 0.62A 4km0B-1u71A:
19.9		 4km0B-1u71A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
None
None
MXA  A 187 (-4.3A)
 0.41A 4km2A-1u71A:
20.0		 4km2A-1u71A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A   7
PHE A  34
THR A  56
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
None
None
 0.57A 4km2A-1u71A:
20.0		 4km2A-1u71A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
None
None
MXA  A 187 (-4.3A)
 0.49A 4km2B-1u71A:
19.7		 4km2B-1u71A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.72A 4ky8A-1u71A:
16.0		 4ky8A-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.80A 4ky8B-1u71A:
17.1		 4ky8B-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.64A 4ky8C-1u71A:
23.5		 4ky8C-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.83A 4ky8D-1u71A:
19.8		 4ky8D-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.81A 4ky8E-1u71A:
23.5		 4ky8E-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.30A 4kyaA-1u71A:
24.7		 4kyaA-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.36A 4kyaB-1u71A:
23.5		 4kyaB-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 10 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.28A 4kyaC-1u71A:
18.3		 4kyaC-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.41A 4kyaD-1u71A:
15.7		 4kyaD-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.31A 4kyaE-1u71A:
24.7		 4kyaE-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.37A 4kyaF-1u71A:
15.7		 4kyaF-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.30A 4kyaG-1u71A:
24.7		 4kyaG-1u71A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MXA  A 187 (-3.6A)
None
None
MXA  A 187 (-4.3A)
MXA  A 187 (-4.3A)
 0.39A 4kyaH-1u71A:
22.7		 4kyaH-1u71A:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ASP A  21
PHE A  34
PRO A  61
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-3.9A)
MXA  A 187 (-4.4A)
None
None
 0.44A 4m2xA-1u71A:
20.8		 4m2xA-1u71A:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-4.4A)
None
None
MXA  A 187 (-4.3A)
 0.41A 4m2xC-1u71A:
21.0		 4m2xC-1u71A:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
ASP A  21
PRO A  61
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-4.4A)
None
None
 0.51A 4m2xE-1u71A:
21.0		 4m2xE-1u71A:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A   7
ALA A   9
PRO A  61
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-4.4A)
None
MXA  A 187 (-4.3A)
 0.38A 4m2xG-1u71A:
20.9		 4m2xG-1u71A:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
ARG A  32
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.60A 4m6kA-1u71A:
33.3		 4m6kA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
None
MXA  A 187 (-4.3A)
 0.26A 4m6kA-1u71A:
33.3		 4m6kA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
PHE A  31
THR A  56
ILE A  60
PRO A  61
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-4.3A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
MXA  A 187 (-4.4A)
None
MXA  A 187 (-4.3A)
 1.39A 4m6kA-1u71A:
33.3		 4m6kA-1u71A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.53A 4nx6A-1u71A:
20.9		 4nx6A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.56A 4nx7A-1u71A:
20.9		 4nx7A-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.46A 4p3qA-1u71A:
20.9		 4p3qA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.52A 4p3rA-1u71A:
20.9		 4p3rA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ILE A   7
ALA A   9
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
None
None
MXA  A 187 (-4.3A)
 0.33A 4p66A-1u71A:
20.8		 4p66A-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 11 ILE A   7
PHE A  34
SER A  59
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.9A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.56A 4p68A-1u71A:
20.6		 4p68A-1u71A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
 0.52A 4pssA-1u71A:
undetectable		 4pssA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.59A 4pstA-1u71A:
undetectable		 4pstA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.52A 4psyA-1u71A:
20.8		 4psyA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.51A 4pthA-1u71A:
20.7		 4pthA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.51A 4ptjA-1u71A:
20.8		 4ptjA-1u71A:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.63A 4q0dA-1u71A:
23.4		 4q0dA-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.64A 4q0dB-1u71A:
23.4		 4q0dB-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
None
None
None
MXA  A 187 (-4.3A)
 0.50A 4q0dC-1u71A:
23.3		 4q0dC-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
None
None
None
MXA  A 187 (-4.3A)
 0.50A 4q0dD-1u71A:
23.4		 4q0dD-1u71A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.63A 4q0dE-1u71A:
23.4		 4q0dE-1u71A:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.58A 4qi9A-1u71A:
18.2		 4qi9A-1u71A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.65A 4qi9A-1u71A:
18.2		 4qi9A-1u71A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.54A 4qi9B-1u71A:
18.9		 4qi9B-1u71A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.71A 4qi9B-1u71A:
18.9		 4qi9B-1u71A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 11 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.58A 4qi9C-1u71A:
18.0		 4qi9C-1u71A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		5 / 11 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
MXA  A 187 (-4.3A)
 0.72A 4qi9C-1u71A:
18.0		 4qi9C-1u71A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.50A 4qleA-1u71A:
20.1		 4qleA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 11 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.52A 4qleB-1u71A:
20.2		 4qleB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ILE A   7
ALA A   9
SER A  59
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
None
MXA  A 187 (-4.3A)
 0.66A 4qleB-1u71A:
20.2		 4qleB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 11 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.50A 4qlfA-1u71A:
17.2		 4qlfA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.49A 4qlgA-1u71A:
20.2		 4qlgA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.45A 4qlgB-1u71A:
19.9		 4qlgB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.51A 4rgcA-1u71A:
20.9		 4rgcA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.47A 4x5fA-1u71A:
19.7		 4x5fA-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.46A 4x5fB-1u71A:
20.1		 4x5fB-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.47A 4x5gA-1u71A:
19.7		 4x5gA-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.50A 4x5gB-1u71A:
20.2		 4x5gB-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.47A 4x5hA-1u71A:
19.7		 4x5hA-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.50A 4x5iA-1u71A:
19.5		 4x5iA-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.47A 4x5jA-1u71A:
19.6		 4x5jA-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
MXA  A 187 (-4.3A)
 0.47A 5e8qA-1u71A:
19.8		 5e8qA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.45A 5e8qB-1u71A:
20.0		 5e8qB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.49A 5eajA-1u71A:
19.9		 5eajA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.48A 5eajB-1u71A:
20.1		 5eajB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.53A 5hi6A-1u71A:
19.9		 5hi6A-1u71A:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 12 ILE A   7
ALA A   9
SER A  59
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
None
None
MXA  A 187 (-4.3A)
 0.67A 5hi6A-1u71A:
19.9		 5hi6A-1u71A:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.8A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.78A 5hi6B-1u71A:
20.0		 5hi6B-1u71A:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		4 / 8 ILE A   7
ALA A   9
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-4.3A)
 0.30A 5uihA-1u71A:
19.2		 5uihA-1u71A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.52A 5ujxA-1u71A:
19.8		 5ujxA-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
None
MXA  A 187 (-4.3A)
 0.51A 5ujxB-1u71A:
20.0		 5ujxB-1u71A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.54A 5z6fA-1u71A:
20.9		 5z6fA-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.51A 5z6jA-1u71A:
21.0		 5z6jA-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.54A 5z6kA-1u71A:
20.9		 5z6kA-1u71A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 11 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
None
None
MXA  A 187 (-4.3A)
 0.48A 5z6mA-1u71A:
20.2		 5z6mA-1u71A:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 10 ALA A   9
PHE A  34
THR A  56
VAL A 115
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-4.3A)
None
MXA  A 187 (-4.3A)
 0.32A 6aogA-1u71A:
24.6		 6aogA-1u71A:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		6 / 10 ALA A   9
PHE A  34
THR A  56
VAL A 115
TYR A 121
THR A 136
 MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 (-4.3A)
None
MXA  A 187 (-4.3A)
 0.35A 6aogB-1u71A:
24.6		 6aogB-1u71A:
29.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
MXA  A 187 (-3.9A)
SO4  A 188 (-3.5A)
MXA  A 187 ( 4.7A)
None
None
MXA  A 187 (-4.3A)
 0.58A 7dfrA-1u71A:
20.7		 7dfrA-1u71A:
32.45