SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MVL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 178
ASP A 199
GLU A 462
TRP A 200
 EDO  A1876 (-3.2A)
MVL  A1865 ( 2.9A)
MVL  A1865 ( 2.8A)
MVL  A1865 (-4.2A)
 1.20A 1mxgA-2vmfA:
7.7		 1mxgA-2vmfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  89
GLU A 585
HIS A 584
ASP A 642
ASP A 644
 None
MVL  A 801 (-4.0A)
None
None
CA  A 800 ( 2.8A)
 1.36A 2pgfA-2wzsA:
undetectable		 2pgfA-2wzsA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 11 ASN A 178
GLU A 179
TYR A 318
GLU A 389
TRP A 436
 MVL  A 501 (-2.9A)
MVL  A 501 (-2.6A)
MVL  A 501 (-3.8A)
MVL  A 501 (-2.8A)
MVL  A 501 (-3.7A)
 0.82A 2v3dB-4re2A:
3.8		 2v3dB-4re2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZS_A_GCSA1902_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 199
CYH A 424
GLU A 555
TRP A 645
TRP A 656
 MVL  A1865 ( 2.9A)
EDO  A1876 (-3.3A)
MVL  A1865 (-2.6A)
MVL  A1865 (-3.7A)
MVL  A1865 (-3.7A)
 1.18A 2vzsA-2vmfA:
30.3		 2vzsA-2vmfA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZS_B_GCSB1903_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 199
CYH A 424
GLU A 555
TRP A 645
TRP A 656
 MVL  A1865 ( 2.9A)
EDO  A1876 (-3.3A)
MVL  A1865 (-2.6A)
MVL  A1865 (-3.7A)
MVL  A1865 (-3.7A)
 1.18A 2vzsB-2vmfA:
30.2		 2vzsB-2vmfA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 TYR A 203
GLU A 151
ASN A  97
 MVL  A 400 (-3.8A)
MVL  A 400 (-2.6A)
BMA  A 401 (-3.2A)
 0.95A 2y7hC-4cd8A:
undetectable		 2y7hC-4cd8A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 ILE A 386
LEU A 275
GLU A 389
PRO A 180
ARG A  89
 None
None
MVL  A 501 (-2.8A)
None
None
 1.27A 3eigA-4re2A:
undetectable		 3eigA-4re2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 GLU A 389
TYR A 134
TYR A 318
TYR A 250
VAL A 248
 MVL  A 501 (-2.8A)
MVL  A 501 (-4.7A)
MVL  A 501 (-3.8A)
None
None
 1.43A 3rlbB-4re2A:
undetectable		 3rlbB-4re2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 GLU A 231
ARG A 104
GLU A 151
SER A 201
 MVL  A 400 (-2.8A)
MVL  A 400 (-2.9A)
MVL  A 400 (-2.6A)
MVL  A 400 ( 4.5A)
 1.18A 4kr3A-4cd8A:
undetectable		 4kr3A-4cd8A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ASP A 135
TRP A 436
SER A  91
 None
MVL  A 501 (-3.7A)
None
 0.96A 4lrhB-4re2A:
undetectable		 4lrhB-4re2A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 390
TRP A 385
SER A 379
 None
MVL  A 801 (-3.9A)
None
 1.13A 4lrhD-2wzsA:
undetectable		 4lrhD-2wzsA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ASP A 135
TRP A 436
SER A  91
 None
MVL  A 501 (-3.7A)
None
 1.05A 4lrhF-4re2A:
undetectable		 4lrhF-4re2A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 589
ASP A 199
GLN A 646
 None
MVL  A1865 ( 2.9A)
None
 0.88A 4oltA-2vmfA:
undetectable
4oltB-2vmfA:
undetectable		 4oltA-2vmfA:
14.69
4oltB-2vmfA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A 646
SER A 589
ASP A 199
 None
None
MVL  A1865 ( 2.9A)
 0.90A 4qwpA-2vmfA:
undetectable
4qwpB-2vmfA:
undetectable		 4qwpA-2vmfA:
14.57
4qwpB-2vmfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ASN A 178
PHE A 434
TYR A  88
 MVL  A 501 (-2.9A)
None
None
 0.67A 4u15A-4re2A:
undetectable		 4u15A-4re2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_A_GCSA602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 537
TRP A 656
TRP A 198
ASN A 461
GLU A 555
 MVL  A1865 (-4.7A)
MVL  A1865 (-3.7A)
MVL  A1865 (-4.3A)
MVL  A1865 (-2.9A)
MVL  A1865 (-2.6A)
 1.33A 5dgrA-2vmfA:
3.2		 5dgrA-2vmfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_B_GCSB602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 TYR A 537
TRP A 656
TRP A 198
ASN A 461
GLU A 555
 MVL  A1865 (-4.7A)
MVL  A1865 (-3.7A)
MVL  A1865 (-4.3A)
MVL  A1865 (-2.9A)
MVL  A1865 (-2.6A)
 1.33A 5dgrB-2vmfA:
0.9		 5dgrB-2vmfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 TYR A 134
TYR A  88
SER A 437
 MVL  A 501 (-4.7A)
None
None
 0.73A 5iktB-4re2A:
0.0		 5iktB-4re2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 ARG A 104
GLY A 149
GLU A 151
SER A 201
 MVL  A 400 (-2.9A)
None
MVL  A 400 (-2.6A)
MVL  A 400 ( 4.5A)
 1.00A 5ny7A-4cd8A:
4.0		 5ny7A-4cd8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 TYR A 318
ALA A 435
ALA A  27
LEU A 244
ILE A 243
 MVL  A 501 (-3.8A)
None
None
None
None
 1.17A 6aybA-4re2A:
undetectable		 6aybA-4re2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 ILE A 583
ASN A 601
CYH A 640
 None
MVL  A 801 ( 3.4A)
None
 0.82A 6bp4A-2wzsA:
undetectable		 6bp4A-2wzsA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 527
GLU A 533
GLU A 588
 None
MVL  A 801 (-3.0A)
None
 0.92A 6fhwA-2wzsA:
6.3		 6fhwA-2wzsA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 405
GLY A 665
TYR A 469
ASP A 348
THR A 349
 None
None
None
MVL  A 801 (-2.9A)
None
 1.47A 6mn1A-2wzsA:
0.0		 6mn1A-2wzsA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 405
GLY A 665
TYR A 469
ASP A 348
THR A 349
 None
None
None
MVL  A 801 (-2.9A)
None
 1.49A 6mn1B-2wzsA:
0.0		 6mn1B-2wzsA:
8.04