SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MVI'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PRS_A_RITA1001_2 (ENDOTHIAPEPSIN)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	5 / 12	ASP A 48 ASP A 191 GLY A 190 GLY A 247 ASP A 189	None MVI A 305 ( 2.7A) SAH A 301 ( 4.0A) None MG A 304 (-2.5A)	1.14A	3prsA-4x81A: undetectable	3prsA-4x81A: 20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEM_A_ACRA1001_1 (ALPHA-GLUCOSIDASE)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	5 / 12	ASP A 244 ASP A 191 ILE A 220 ASP A 216 ARG A 61	None MVI A 305 ( 2.7A) MVI A 305 ( 4.3A) MG A 304 ( 2.9A) MVI A 305 ( 4.3A)	1.47A	3wemA-4x81A: undetectable	3wemA-4x81A: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEN_A_ACRA1001_1 (ALPHA-GLUCOSIDASE)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	5 / 12	ASP A 244 ASP A 191 ILE A 220 ASP A 216 ARG A 61	None MVI A 305 ( 2.7A) MVI A 305 ( 4.3A) MG A 304 ( 2.9A) MVI A 305 ( 4.3A)	1.46A	3wenA-4x81A: undetectable	3wenA-4x81A: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEO_A_ACRA1001_1 (ALPHA-GLUCOSIDASE)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	5 / 12	ASP A 244 ASP A 191 ILE A 220 ASP A 216 ARG A 61	None MVI A 305 ( 2.7A) MVI A 305 ( 4.3A) MG A 304 ( 2.9A) MVI A 305 ( 4.3A)	1.47A	3weoA-4x81A: undetectable	3weoA-4x81A: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZV2_B_LEVB801_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	3 / 3	TYR A 49 LEU A 143 ASP A 113	MVI A 305 ( 4.3A) SAH A 301 (-4.4A) SAH A 301 (-2.7A)	0.88A	5zv2B-4x81A: undetectable	5zv2B-4x81A: 14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G31_A_ZOLA401_0 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	4 / 7	ASP A 216 ASP A 217 ARG A 187 GLN A 246	MG A 304 ( 2.9A) MG A 304 ( 2.6A) None MVI A 305 (-3.3A)	1.49A	6g31A-4x81A: undetectable	6g31A-4x81A: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G31_B_ZOLB401_0 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	4 / 6	ASP A 216 ASP A 217 ARG A 187 GLN A 246	MG A 304 ( 2.9A) MG A 304 ( 2.6A) None MVI A 305 (-3.3A)	1.46A	6g31B-4x81A: undetectable	6g31B-4x81A: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G31_C_ZOLC401_0 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	4 / 5	ASP A 216 ASP A 217 ARG A 187 GLN A 246	MG A 304 ( 2.9A) MG A 304 ( 2.6A) None MVI A 305 (-3.3A)	1.41A	6g31C-4x81A: undetectable	6g31C-4x81A: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G31_K_ZOLK401_0 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	4 / 4	ASP A 216 ASP A 217 ARG A 187 GLN A 246	MG A 304 ( 2.9A) MG A 304 ( 2.6A) None MVI A 305 (-3.3A)	1.34A	6g31K-4x81A: undetectable	6g31K-4x81A: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G31_L_ZOLL401_0 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE)	4x81	MYCINAMICIN III 3''-O-METHYLTRANSFER ASE (Micromonospora griseorubida)	4 / 6	ASP A 216 ASP A 217 ARG A 187 GLN A 246	MG A 304 ( 2.9A) MG A 304 ( 2.6A) None MVI A 305 (-3.3A)	1.38A	6g31L-4x81A: undetectable	6g31L-4x81A: 21.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3PRS_A_RITA1001_2","ENDOTHIAPEPSIN","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",5,"ASP A  48;ASP A 191;GLY A 190;GLY A 247;ASP A 189","None;MVI A 305 ( 2.7A);SAH A 301 ( 4.0A);None; MG A 304 (-2.5A)","1.14A","3prsA-4x81A:undetectable",null],["3WEM_A_ACRA1001_1","ALPHA-GLUCOSIDASE","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",5,"ASP A 244;ASP A 191;ILE A 220;ASP A 216;ARG A  61","None;MVI A 305 ( 2.7A);MVI A 305 ( 4.3A); MG A 304 ( 2.9A);MVI A 305 ( 4.3A)","1.47A","3wemA-4x81A:undetectable","3prsA-4x81A:20.23"],["3WEN_A_ACRA1001_1","ALPHA-GLUCOSIDASE","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",5,"ASP A 244;ASP A 191;ILE A 220;ASP A 216;ARG A  61","None;MVI A 305 ( 2.7A);MVI A 305 ( 4.3A); MG A 304 ( 2.9A);MVI A 305 ( 4.3A)","1.46A","3wenA-4x81A:undetectable","3wemA-4x81A:15.52"],["3WEO_A_ACRA1001_1","ALPHA-GLUCOSIDASE","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",5,"ASP A 244;ASP A 191;ILE A 220;ASP A 216;ARG A  61","None;MVI A 305 ( 2.7A);MVI A 305 ( 4.3A); MG A 304 ( 2.9A);MVI A 305 ( 4.3A)","1.47A","3weoA-4x81A:undetectable","3wenA-4x81A:15.52"],["5ZV2_B_LEVB801_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",3,"TYR A  49;LEU A 143;ASP A 113","MVI A 305 ( 4.3A);SAH A 301 (-4.4A);SAH A 301 (-2.7A)","0.88A","5zv2B-4x81A:undetectable","3weoA-4x81A:15.52"],["6G31_A_ZOLA401_0","GERANYLGERANYL PYROPHOSPHATE SYNTHASE","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",4,"ASP A 216;ASP A 217;ARG A 187;GLN A 246"," MG A 304 ( 2.9A); MG A 304 ( 2.6A);None;MVI A 305 (-3.3A)","1.49A","6g31A-4x81A:undetectable","5zv2B-4x81A:14.72"],["6G31_B_ZOLB401_0","GERANYLGERANYL PYROPHOSPHATE SYNTHASE","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",4,"ASP A 216;ASP A 217;ARG A 187;GLN A 246"," MG A 304 ( 2.9A); MG A 304 ( 2.6A);None;MVI A 305 (-3.3A)","1.46A","6g31B-4x81A:undetectable","6g31A-4x81A:21.36"],["6G31_C_ZOLC401_0","GERANYLGERANYL PYROPHOSPHATE SYNTHASE","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",4,"ASP A 216;ASP A 217;ARG A 187;GLN A 246"," MG A 304 ( 2.9A); MG A 304 ( 2.6A);None;MVI A 305 (-3.3A)","1.41A","6g31C-4x81A:undetectable","6g31B-4x81A:21.36"],["6G31_K_ZOLK401_0","GERANYLGERANYL PYROPHOSPHATE SYNTHASE","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",4,"ASP A 216;ASP A 217;ARG A 187;GLN A 246"," MG A 304 ( 2.9A); MG A 304 ( 2.6A);None;MVI A 305 (-3.3A)","1.34A","6g31K-4x81A:undetectable","6g31C-4x81A:21.36"],["6G31_L_ZOLL401_0","GERANYLGERANYL PYROPHOSPHATE SYNTHASE","4x81","MYCINAMICIN III 3''-O-METHYLTRANSFERASE","Micromonospora griseorubida",4,"ASP A 216;ASP A 217;ARG A 187;GLN A 246"," MG A 304 ( 2.9A); MG A 304 ( 2.6A);None;MVI A 305 (-3.3A)","1.38A","6g31L-4x81A:undetectable","6g31K-4x81A:21.36"]]