SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MTV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 5 HIS A 233
LEU A  74
LEU A 301
GLY A 162
 MTV  A1479 (-3.7A)
None
None
None
 1.14A 1a4lB-2bihA:
undetectable		 1a4lB-2bihA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 6 ASP A 271
ARG A  89
ILE A 245
TYR A 202
 MTV  A1479 ( 4.5A)
MTV  A1479 (-4.8A)
MTV  A1479 (-3.6A)
MTV  A1479 (-3.7A)
 1.22A 2yfbB-2bihA:
undetectable		 2yfbB-2bihA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 VAL A 239
VAL A 250
LEU A 256
VAL A 189
VAL A 176
 None
MTV  A1479 (-3.8A)
None
None
None
 1.24A 3czvA-2bihA:
undetectable
3czvB-2bihA:
undetectable		 3czvA-2bihA:
20.73
3czvB-2bihA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2bii NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 VAL A 239
VAL A 250
LEU A 256
VAL A 189
VAL A 176
 None
MTV  A1479 (-3.8A)
None
None
None
 1.24A 3czvA-2biiA:
undetectable
3czvB-2biiA:
undetectable		 3czvA-2biiA:
21.15
3czvB-2biiA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gB-2bihA:
undetectable		 3j6gB-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gD-2bihA:
undetectable		 3j6gD-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gF-2bihA:
undetectable		 3j6gF-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gH-2bihA:
undetectable		 3j6gH-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gJ-2bihA:
undetectable		 3j6gJ-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gL-2bihA:
undetectable		 3j6gL-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gN-2bihA:
undetectable		 3j6gN-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gP-2bihA:
undetectable		 3j6gP-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gR-2bihA:
undetectable		 3j6gR-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.18A 3j6pB-2bihA:
undetectable		 3j6pB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 HIS A 233
SER A  67
THR A 136
PRO A  69
LEU A  74
 MTV  A1479 (-3.7A)
None
None
None
None
 1.26A 3j6pB-2bihA:
undetectable		 3j6pB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 11 PHE A  87
TRP A 158
GLY A 247
TYR A 202
ILE A 241
 MTV  A1479 (-3.5A)
None
MTV  A1479 (-3.4A)
MTV  A1479 (-3.7A)
None
 1.39A 3owxA-2bihA:
undetectable
3owxB-2bihA:
undetectable		 3owxA-2bihA:
17.82
3owxB-2bihA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2bii NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		3 / 3 ASP A 271
ASN A 199
PHE A 156
 MTV  A1479 ( 4.9A)
None
None
 0.69A 5jglB-2biiA:
undetectable		 5jglB-2biiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 2bii NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 6 GLN A 224
PHE A  87
CYH A 385
PHE A  79
 None
MTV  A1479 (-3.5A)
None
None
 1.24A 5mwyA-2biiA:
undetectable		 5mwyA-2biiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.14A 5ogcB-2bihA:
undetectable		 5ogcB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 HIS A 233
SER A  67
THR A 136
PRO A  69
LEU A  74
 MTV  A1479 (-3.7A)
None
None
None
None
 1.15A 5ogcB-2bihA:
undetectable		 5ogcB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bii NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 HIS A 233
SER A  67
THR A 136
PRO A  69
LEU A  74
 MTV  A1479 (-3.9A)
GOL  A 703 (-3.1A)
None
GOL  A 703 (-3.9A)
None
 1.11A 5ogcB-2biiA:
undetectable		 5ogcB-2biiA:
23.20