SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MTN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3mpn TRANSPORTER
(Aquifex
aeolicus) 		5 / 12 LEU A 380
LEU A 183
ALA A 261
VAL A 180
MET A 360
 MTN  A 801 ( 4.9A)
None
None
None
None
 1.35A 1kt4A-3mpnA:
undetectable		 1kt4A-3mpnA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens) 		4 / 5 TYR N  34
SER N  32
THR A  95
ASN A  74
 None
None
MTN  N1111 ( 4.7A)
None
 1.40A 1yvpA-2verN:
undetectable		 1yvpA-2verN:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens) 		4 / 8 ASN N  97
ASN A  74
MET A  72
ILE A  96
 MTN  N1111 (-3.5A)
None
MTN  N1111 (-2.4A)
None
 1.35A 3kp6A-2verN:
undetectable
3kp6B-2verN:
undetectable		 3kp6A-2verN:
20.53
3kp6B-2verN:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens) 		5 / 12 THR A  95
GLY A   8
ALA N  55
GLY N  47
GLN N  53
 MTN  N1111 ( 4.7A)
None
None
None
None
 1.25A 3v3oA-2verA:
undetectable		 3v3oA-2verA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2ver AFIMBRIAL ADHESIN
AFA-III
(Escherichia
coli) 		4 / 7 GLY A  94
THR A  95
ILE A  96
THR A 134
 None
MTN  N1111 ( 4.7A)
None
None
 0.86A 4acaC-2verA:
undetectable		 4acaC-2verA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2k3m RV1761C
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  31
GLY A  32
LEU A  33
CYH A  48
 None
None
None
MTN  A 129 (-2.0A)
 0.84A 6nm4A-2k3mA:
undetectable		 6nm4A-2k3mA:
22.68