SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MTM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.75A 1jdvA-1zosA:
22.1
1jdvD-1zosA:
22.1		 1jdvA-1zosA:
24.81
1jdvD-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 10 VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.58A 1jdvA-3eeiA:
23.5
1jdvD-3eeiA:
23.4		 1jdvA-3eeiA:
25.76
1jdvD-3eeiA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.74A 1jdvB-1zosA:
21.9
1jdvC-1zosA:
9.8		 1jdvB-1zosA:
24.81
1jdvC-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 10 VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.56A 1jdvB-3eeiA:
23.2
1jdvC-3eeiA:
22.7		 1jdvB-3eeiA:
25.76
1jdvC-3eeiA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.75A 1jdvA-1zosA:
22.1
1jdvD-1zosA:
22.1		 1jdvA-1zosA:
24.81
1jdvD-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 10 VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.56A 1jdvA-3eeiA:
23.5
1jdvD-3eeiA:
23.4		 1jdvA-3eeiA:
25.76
1jdvD-3eeiA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 12 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.72A 1jdvE-1zosA:
22.0
1jdvF-1zosA:
21.5		 1jdvE-1zosA:
24.81
1jdvF-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 12 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.59A 1jdvE-3eeiA:
23.3
1jdvF-3eeiA:
22.8		 1jdvE-3eeiA:
25.76
1jdvF-3eeiA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.48A 1odiA-1zosA:
23.4		 1odiA-1zosA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.52A 1odiA-3eeiA:
18.2		 1odiA-3eeiA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.59A 1odiB-1zosA:
23.7		 1odiB-1zosA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.59A 1odiB-3eeiA:
25.9		 1odiB-3eeiA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.57A 1odiC-1zosA:
23.4		 1odiC-1zosA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.52A 1odiC-3eeiA:
25.4		 1odiC-3eeiA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.58A 1odiD-1zosA:
23.7		 1odiD-1zosA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.58A 1odiD-3eeiA:
25.8		 1odiD-3eeiA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.60A 1odiE-1zosA:
23.6		 1odiE-1zosA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.59A 1odiE-3eeiA:
25.8		 1odiE-3eeiA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.58A 1odiF-1zosA:
23.4		 1odiF-1zosA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.58A 1odiF-3eeiA:
25.5		 1odiF-3eeiA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 9 SER A  76
GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.69A 1pk7A-1zosA:
22.7		 1pk7A-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 9 SER A  79
GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.63A 1pk7A-3eeiA:
23.7		 1pk7A-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 8 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.71A 1pk7B-1zosA:
22.7		 1pk7B-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 8 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.58A 1pk7B-3eeiA:
23.9		 1pk7B-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		8 / 10 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.56A 1pk7C-1zosA:
23.5		 1pk7C-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 10 GLY A  82
VAL A 175
GLU A 176
SER A 200
ASP A 201
 None
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 1.47A 1pk7C-3eeiA:
24.7		 1pk7C-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 10 MET A  12
GLY A  81
GLU A 176
SER A 200
ASP A 201
 MTM  A 234 ( 3.9A)
MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 1.36A 1pk7C-3eeiA:
24.7		 1pk7C-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		8 / 10 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.53A 1pk7C-3eeiA:
24.7		 1pk7C-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		8 / 10 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.55A 1pk9A-1zosA:
22.7		 1pk9A-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		8 / 10 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.48A 1pk9A-3eeiA:
23.7		 1pk9A-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 9 SER A  76
GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.56A 1pk9B-1zosA:
22.7		 1pk9B-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 9 SER A  79
GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.52A 1pk9B-3eeiA:
23.9		 1pk9B-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		8 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.45A 1pk9C-1zosA:
23.8		 1pk9C-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		8 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.41A 1pk9C-3eeiA:
24.8		 1pk9C-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 10 SER A  76
GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.64A 1pw7A-1zosA:
22.8		 1pw7A-1zosA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 10 SER A  79
GLY A  81
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.60A 1pw7A-3eeiA:
23.7		 1pw7A-3eeiA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 9 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.57A 1pw7B-1zosA:
23.0		 1pw7B-1zosA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 9 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.48A 1pw7B-3eeiA:
24.2		 1pw7B-3eeiA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 9 SER A  76
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.61A 1pw7C-1zosA:
23.4		 1pw7C-1zosA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 9 SER A  79
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.55A 1pw7C-3eeiA:
24.6		 1pw7C-3eeiA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 8 ALA A  56
ILE A 178
ILE A   6
GLY A  49
ILE A  50
 None
None
None
None
MTM  A 301 (-4.0A)
 1.20A 1sh9A-1zosA:
undetectable		 1sh9A-1zosA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		3 / 3 SER A  51
GLY A  52
ARG A 197
 None
None
MTM  A 234 (-3.6A)
 0.64A 1t9wA-3eeiA:
undetectable		 1t9wA-3eeiA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.56A 1vhwA-1zosA:
23.0
1vhwD-1zosA:
22.9		 1vhwA-1zosA:
24.81
1vhwD-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.44A 1vhwA-3eeiA:
24.4
1vhwD-3eeiA:
24.2		 1vhwA-3eeiA:
25.19
1vhwD-3eeiA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 9 SER A  76
GLY A  78
VAL A 171
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.44A 1vhwB-1zosA:
23.2
1vhwF-1zosA:
23.0		 1vhwB-1zosA:
24.81
1vhwF-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 9 SER A  79
GLY A  81
VAL A 175
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.38A 1vhwB-3eeiA:
24.5
1vhwF-3eeiA:
24.2		 1vhwB-3eeiA:
25.19
1vhwF-3eeiA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.56A 1vhwC-1zosA:
23.0
1vhwE-1zosA:
23.0		 1vhwC-1zosA:
24.81
1vhwE-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.44A 1vhwC-3eeiA:
24.4
1vhwE-3eeiA:
24.4		 1vhwC-3eeiA:
25.19
1vhwE-3eeiA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.56A 1vhwA-1zosA:
23.0
1vhwD-1zosA:
22.8		 1vhwA-1zosA:
24.81
1vhwD-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.44A 1vhwA-3eeiA:
24.4
1vhwD-3eeiA:
24.2		 1vhwA-3eeiA:
25.19
1vhwD-3eeiA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.56A 1vhwC-1zosA:
23.0
1vhwE-1zosA:
23.0		 1vhwC-1zosA:
24.81
1vhwE-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.44A 1vhwC-3eeiA:
24.4
1vhwE-3eeiA:
24.4		 1vhwC-3eeiA:
25.19
1vhwE-3eeiA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 10 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.56A 1vhwB-1zosA:
23.2
1vhwF-1zosA:
23.0		 1vhwB-1zosA:
24.81
1vhwF-1zosA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 10 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.44A 1vhwB-3eeiA:
24.5
1vhwF-3eeiA:
24.2		 1vhwB-3eeiA:
25.19
1vhwF-3eeiA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 10 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.72A 1z35A-1zosA:
22.3		 1z35A-1zosA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 10 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.60A 1z35A-3eeiA:
23.9		 1z35A-3eeiA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 9 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.66A 1z37A-1zosA:
22.3		 1z37A-1zosA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 9 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.51A 1z37A-3eeiA:
24.0		 1z37A-3eeiA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 11 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.60A 2ac7A-1zosA:
22.0
2ac7B-1zosA:
21.9		 2ac7A-1zosA:
26.72
2ac7B-1zosA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 11 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.55A 2ac7A-3eeiA:
23.7
2ac7B-3eeiA:
23.6		 2ac7A-3eeiA:
24.70
2ac7B-3eeiA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 11 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.61A 2ac7A-1zosA:
22.0
2ac7B-1zosA:
21.9		 2ac7A-1zosA:
26.72
2ac7B-1zosA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 11 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.55A 2ac7A-3eeiA:
23.7
2ac7B-3eeiA:
23.6		 2ac7A-3eeiA:
24.70
2ac7B-3eeiA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		4 / 8 MET A   9
ALA A   8
GLY A  49
ILE A  50
 MTM  A 301 ( 4.6A)
MTM  A 301 (-3.4A)
None
MTM  A 301 (-4.0A)
 0.91A 2zm9A-1zosA:
undetectable		 2zm9A-1zosA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		4 / 7 GLU A 178
ARG A 197
GLU A 176
SER A 151
 MTM  A 234 (-2.6A)
MTM  A 234 (-3.6A)
MTM  A 234 (-4.6A)
None
 1.14A 2zt7A-3eeiA:
3.1		 2zt7A-3eeiA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens) 		3 / 3 MET A 196
MET A 185
PHE A 177
 MTM  A 401 (-3.7A)
None
MTM  A 401 (-4.8A)
 1.18A 3gn8A-1k27A:
undetectable		 3gn8A-1k27A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 9 SER A  76
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.79A 3u40A-1zosA:
22.3
3u40F-1zosA:
21.8		 3u40A-1zosA:
27.41
3u40F-1zosA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 9 SER A  79
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.63A 3u40A-3eeiA:
24.0
3u40F-3eeiA:
23.6		 3u40A-3eeiA:
26.25
3u40F-3eeiA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 10 SER A  76
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.74A 3u40B-1zosA:
22.4
3u40C-1zosA:
22.3		 3u40B-1zosA:
27.41
3u40C-1zosA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 10 SER A  79
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.57A 3u40B-3eeiA:
23.9
3u40C-3eeiA:
24.0		 3u40B-3eeiA:
26.25
3u40C-3eeiA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 12 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.66A 3u40B-1zosA:
22.4
3u40C-1zosA:
22.3		 3u40B-1zosA:
27.41
3u40C-1zosA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 12 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.51A 3u40B-3eeiA:
23.9
3u40C-3eeiA:
24.0		 3u40B-3eeiA:
26.25
3u40C-3eeiA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.65A 3u40D-1zosA:
22.6
3u40E-1zosA:
22.2		 3u40D-1zosA:
27.41
3u40E-1zosA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.49A 3u40D-3eeiA:
24.2
3u40E-3eeiA:
23.8		 3u40D-3eeiA:
26.25
3u40E-3eeiA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 12 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.63A 3u40D-1zosA:
22.6
3u40E-1zosA:
22.2		 3u40D-1zosA:
27.41
3u40E-1zosA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 12 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.48A 3u40D-3eeiA:
24.2
3u40E-3eeiA:
23.8		 3u40D-3eeiA:
26.25
3u40E-3eeiA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 10 SER A  76
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 MTM  A 301 (-3.1A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-2.9A)
 0.94A 3u40A-1zosA:
22.3
3u40F-1zosA:
21.8		 3u40A-1zosA:
27.41
3u40F-1zosA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 10 SER A  79
VAL A 175
GLU A 176
MET A 177
GLU A 178
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.0A)
 0.83A 3u40A-3eeiA:
24.0
3u40F-3eeiA:
23.6		 3u40A-3eeiA:
26.25
3u40F-3eeiA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 11 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.56A 3uawA-1zosA:
22.8		 3uawA-1zosA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 11 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.51A 3uawA-3eeiA:
24.7		 3uawA-3eeiA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 10 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.61A 3uayA-1zosA:
22.6		 3uayA-1zosA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 10 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.55A 3uayA-3eeiA:
24.2		 3uayA-3eeiA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 10 GLY A  10
GLU A 178
GLY A  78
SER A  79
PHE A 211
 None
MTM  A 234 (-2.6A)
None
MTM  A 234 (-3.1A)
MTM  A 234 (-4.4A)
 0.86A 4bwlC-3eeiA:
undetectable		 4bwlC-3eeiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.68A 4d9hA-1zosA:
22.8		 4d9hA-1zosA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  76
GLY A  78
VAL A 171
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.83A 4d9hA-1zosA:
22.8		 4d9hA-1zosA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.55A 4d9hA-3eeiA:
24.2		 4d9hA-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 SER A  79
GLY A  81
VAL A 175
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.78A 4d9hA-3eeiA:
24.2		 4d9hA-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 9 SER A  76
GLY A  78
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.60A 4da6A-1zosA:
22.4		 4da6A-1zosA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 9 SER A  76
GLY A  78
VAL A 171
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.62A 4da6A-1zosA:
22.4		 4da6A-1zosA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 9 SER A  79
GLY A  81
VAL A 175
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.65A 4da6A-3eeiA:
23.8		 4da6A-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 9 SER A  79
GLY A  81
VAL A 175
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.94A 4da6A-3eeiA:
23.8		 4da6A-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 10 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.69A 4da7A-1zosA:
22.8		 4da7A-1zosA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 10 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.55A 4da7A-3eeiA:
24.1		 4da7A-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.66A 4danA-1zosA:
22.3		 4danA-1zosA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.90A 4danA-1zosA:
22.3		 4danA-1zosA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.55A 4danA-3eeiA:
23.8		 4danA-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 SER A  79
GLY A  81
VAL A 175
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.82A 4danA-3eeiA:
23.8		 4danA-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		8 / 12 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
MTM  A 301 (-2.9A)
 0.87A 4danA-1zosA:
22.3
4danB-1zosA:
22.6		 4danA-1zosA:
24.06
4danB-1zosA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 12 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.55A 4danA-3eeiA:
23.8
4danB-3eeiA:
23.9		 4danA-3eeiA:
24.62
4danB-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 12 SER A  79
GLY A  81
VAL A 175
MET A 177
GLU A 178
SER A 200
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
MTM  A 234 (-3.0A)
 0.80A 4danA-3eeiA:
23.8
4danB-3eeiA:
23.9		 4danA-3eeiA:
24.62
4danB-3eeiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A 193
GLU A 174
ASN A  73
 MTM  A 301 (-3.2A)
MTM  A 301 (-2.6A)
None
 0.78A 4imaD-1zosA:
undetectable		 4imaD-1zosA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A  91
ILE A 145
ALA A  77
VAL A 221
 None
None
MTM  A 301 (-4.9A)
None
 0.81A 4jltA-1zosA:
undetectable		 4jltA-1zosA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		4 / 6 GLU A 178
ARG A 197
GLU A 176
SER A 151
 MTM  A 234 (-2.6A)
MTM  A 234 (-3.6A)
MTM  A 234 (-4.6A)
None
 1.17A 4kr3A-3eeiA:
undetectable		 4kr3A-3eeiA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		4 / 5 ALA A 170
ARG A 193
HIS A  98
ALA A 146
 None
MTM  A 301 (-3.2A)
None
None
 1.13A 5a06C-1zosA:
2.6
5a06D-1zosA:
undetectable		 5a06C-1zosA:
22.94
5a06D-1zosA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 9 SER A  76
GLY A  78
VAL A 171
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.33A 5i3cA-1zosA:
22.9		 5i3cA-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 9 SER A  79
GLY A  81
VAL A 175
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.32A 5i3cA-3eeiA:
24.3		 5i3cA-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		6 / 10 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
 0.51A 5i3cB-1zosA:
23.4		 5i3cB-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		6 / 10 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
 0.43A 5i3cB-3eeiA:
24.8		 5i3cB-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  76
ALA A  92
VAL A  90
SER A 196
ILE A  84
 MTM  A 301 (-3.1A)
None
None
MTM  A 301 (-3.4A)
None
 1.24A 5i3cC-1zosA:
23.0		 5i3cC-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.54A 5i3cC-1zosA:
23.0		 5i3cC-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		7 / 11 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.47A 5i3cC-3eeiA:
24.3		 5i3cC-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		4 / 6 VAL A  59
LEU A 190
ARG A 193
ILE A  91
 None
None
MTM  A 301 (-3.2A)
None
 0.98A 5jw1A-1zosA:
undetectable		 5jw1A-1zosA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 9 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
 0.58A 5zncA-1zosA:
21.6		 5zncA-1zosA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE
(Streptococcus
pneumoniae) 		5 / 9 SER A  76
VAL A 171
GLU A 172
MET A 173
ASP A 197
 MTM  A 301 (-3.1A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.9A)
 1.07A 5zncA-1zosA:
21.6		 5zncA-1zosA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 9 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
 0.38A 5zncA-3eeiA:
23.5		 5zncA-3eeiA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 9 SER A  79
VAL A 175
GLU A 176
MET A 177
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-3.0A)
 1.03A 5zncA-3eeiA:
23.5		 5zncA-3eeiA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE
(Neisseria
meningitidis) 		5 / 11 ASP A 201
VAL A  93
GLY A  95
SER A 124
ALA A 123
 MTM  A 234 (-3.0A)
None
None
None
None
 1.28A 6hu9A-3eeiA:
undetectable
6hu9E-3eeiA:
undetectable
6hu9I-3eeiA:
undetectable		 6hu9A-3eeiA:
21.12
6hu9E-3eeiA:
22.31
6hu9I-3eeiA:
16.10