SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MTL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 5 TYR A 135
PRO A 133
LEU A 123
ARG A  65
 MTL  A 501 (-4.5A)
None
None
MTL  A 501 (-3.1A)
 1.36A 1i2wA-4ryaA:
undetectable		 1i2wA-4ryaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 7 ASP A  34
GLU A  61
GLU A 247
GLU A 191
 None
MTL  A 501 (-2.8A)
None
None
 1.11A 1knyA-4ryaA:
undetectable
1knyB-4ryaA:
undetectable		 1knyA-4ryaA:
20.60
1knyB-4ryaA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2W_A_MTLA5600_0
(MANNITOL
DEHYDROGENASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		9 / 9 ASN A 191
ASP A 230
LYS A 295
LEU A 299
ASN A 300
HIS A 303
ARG A 373
VAL A 374
LYS A 381
 NAD  A5500 ( 3.1A)
MTL  A5600 (-3.6A)
MTL  A5600 (-2.8A)
MTL  A5600 ( 4.7A)
MTL  A5600 (-3.2A)
MTL  A5600 (-3.8A)
MTL  A5600 ( 3.1A)
MTL  A5600 (-3.6A)
MTL  A5600 (-2.9A)
 0.04A 1m2wA-1m2wA:
67.1		 1m2wA-1m2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2W_B_MTLB6600_0
(MANNITOL
DEHYDROGENASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		9 / 9 ASN A 191
ASP A 230
LYS A 295
LEU A 299
ASN A 300
HIS A 303
ARG A 373
VAL A 374
LYS A 381
 NAD  A5500 ( 3.1A)
MTL  A5600 (-3.6A)
MTL  A5600 (-2.8A)
MTL  A5600 ( 4.7A)
MTL  A5600 (-3.2A)
MTL  A5600 (-3.8A)
MTL  A5600 ( 3.1A)
MTL  A5600 (-3.6A)
MTL  A5600 (-2.9A)
 0.08A 1m2wB-1m2wA:
64.9		 1m2wB-1m2wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 11 VAL A 374
VAL A 318
ARG A 373
ILE A 232
ASP A 369
 MTL  A5600 (-3.6A)
None
MTL  A5600 ( 3.1A)
MTL  A5600 (-4.5A)
None
 1.16A 1t6zA-1m2wA:
1.5		 1t6zA-1m2wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 11 VAL A 374
VAL A 318
ARG A 373
ILE A 232
ASP A 369
 MTL  A5600 (-3.6A)
None
MTL  A5600 ( 3.1A)
MTL  A5600 (-4.5A)
None
 1.19A 1t6zB-1m2wA:
1.2		 1t6zB-1m2wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 VAL A 341
VAL A 332
TYR A 350
TYR A 355
TYR A 135
 None
None
None
None
MTL  A 501 (-4.5A)
 1.41A 1wopA-4ryaA:
0.0		 1wopA-4ryaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 GLY A  85
GLU A  88
ARG A  65
ALA A 391
GLU A 137
 None
None
MTL  A 501 (-3.1A)
None
MTL  A 501 (-3.0A)
 1.15A 3ckkA-4ryaA:
undetectable		 3ckkA-4ryaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 PRO A 225
SER A 188
GLY A 196
MET A 228
LYS A 295
 None
None
None
None
MTL  A5600 (-2.8A)
 1.44A 3lsfB-1m2wA:
0.0
3lsfE-1m2wA:
undetectable		 3lsfB-1m2wA:
18.79
3lsfE-1m2wA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 TYR A 354
MET A 294
ASN A 300
LEU A 299
 None
None
MTL  A5600 (-3.2A)
MTL  A5600 ( 4.7A)
 1.50A 3lslG-1m2wA:
undetectable		 3lslG-1m2wA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		12 / 12 ASN A  32
ARG A  65
ARG A 184
GLY A 190
ALA A 194
PHE A 245
ALA A 263
VAL A 265
TRP A 298
TRP A 300
TRP A 302
GLN A 388
 MTL  A 501 (-3.5A)
MTL  A 501 (-3.1A)
MTL  A 501 (-2.7A)
MTL  A 501 (-3.6A)
MTL  A 501 ( 3.7A)
MTL  A 501 ( 3.6A)
MTL  A 501 ( 3.8A)
None
MTL  A 501 ( 4.3A)
MTL  A 501 (-3.6A)
MTL  A 501 (-4.0A)
MTL  A 501 (-3.8A)
 0.03A 4ryaA-4ryaA:
74.9		 4ryaA-4ryaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		3 / 3 GLU A  61
TYR A 135
GLU A 137
 MTL  A 501 (-2.8A)
MTL  A 501 (-4.5A)
MTL  A 501 (-3.0A)
 0.02A 4ryaA-4ryaA:
74.9		 4ryaA-4ryaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 ILE A 369
ASP A 262
ALA A 198
VAL A 387
GLY A 190
 None
None
None
None
MTL  A 501 (-3.6A)
 1.20A 5igiA-4ryaA:
undetectable		 5igiA-4ryaA:
22.43