SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MT2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AX7_A_SALA1336_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	3c8f	PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME (Escherichia coli)	4 / 8	GLU A 79 ARG A 166 VAL A 126 LEU A 103	None MT2 A 501 (-3.1A) None None	0.71A	3ax7A-3c8fA: undetectable	3ax7A-3c8fA: 10.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3CB8_A_SAMA501_0 (PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME)	3c8f	PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME (Escherichia coli)	5 / 12	TYR A 35 HIS A 37 LYS A 131 VAL A 168 TYR A 201	None MT2 A 501 (-4.2A) SF4 A 500 (-3.7A) None None	0.74A	3cb8A-3c8fA: 38.0	3cb8A-3c8fA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3CB8_A_SAMA501_0 (PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME)	3c8f	PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME (Escherichia coli)	7 / 12	TYR A 35 SER A 76 ASP A 104 LYS A 131 ARG A 166 VAL A 168 TYR A 201	None MT2 A 501 ( 4.0A) MT2 A 501 (-4.2A) SF4 A 500 (-3.7A) MT2 A 501 (-3.1A) None None	1.00A	3cb8A-3c8fA: 38.0	3cb8A-3c8fA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3CB8_A_SAMA501_0 (PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME)	3c8f	PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME (Escherichia coli)	7 / 12	TYR A 35 SER A 76 GLU A 79 ASP A 104 LYS A 131 VAL A 168 TYR A 201	None MT2 A 501 ( 4.0A) None MT2 A 501 (-4.2A) SF4 A 500 (-3.7A) None None	0.58A	3cb8A-3c8fA: 38.0	3cb8A-3c8fA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3CB8_A_SAMA501_0 (PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME)	3c8f	PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME (Escherichia coli)	6 / 12	TYR A 35 SER A 76 GLU A 79 LYS A 131 VAL A 168 LEU A 199	None MT2 A 501 ( 4.0A) None SF4 A 500 (-3.7A) None None	0.94A	3cb8A-3c8fA: 38.0	3cb8A-3c8fA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNI_A_SALA1344_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	3c8f	PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME (Escherichia coli)	4 / 7	GLU A 79 ARG A 166 VAL A 126 LEU A 103	None MT2 A 501 (-3.1A) None None	0.71A	3uniA-3c8fA: undetectable	3uniA-3c8fA: 10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNI_B_SALB1345_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	3c8f	PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME (Escherichia coli)	4 / 8	GLU A 79 ARG A 166 VAL A 126 LEU A 103	None MT2 A 501 (-3.1A) None None	0.69A	3uniB-3c8fA: undetectable	3uniB-3c8fA: 10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BXL_A_SAMA401_0 (2-(3-AMINO-3-CARBOXY PROPYL)HISTIDINE SYNTHASE)	3c8f	PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME (Escherichia coli)	5 / 12	LEU A 204 GLY A 205 HIS A 207 SER A 76 ASP A 40	None None None MT2 A 501 ( 4.0A) None	1.21A	6bxlA-3c8fA: undetectable	6bxlA-3c8fA: 20.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3AX7_A_SALA1336_1","XANTHINE DEHYDROGENASE\/OXIDASE","3c8f","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","Escherichia coli",4,"GLU A  79;ARG A 166;VAL A 126;LEU A 103","None;MT2 A 501 (-3.1A);None;None","0.71A","3ax7A-3c8fA:undetectable",null],["3CB8_A_SAMA501_0","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","3c8f","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","Escherichia coli",5,"TYR A  35;HIS A  37;LYS A 131;VAL A 168;TYR A 201","None;MT2 A 501 (-4.2A);SF4 A 500 (-3.7A);None;None","0.74A","3cb8A-3c8fA:38.0","3ax7A-3c8fA:10.53"],["3CB8_A_SAMA501_0","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","3c8f","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","Escherichia coli",7,"TYR A  35;SER A  76;ASP A 104;LYS A 131;ARG A 166;VAL A 168;TYR A 201","None;MT2 A 501 ( 4.0A);MT2 A 501 (-4.2A);SF4 A 500 (-3.7A);MT2 A 501 (-3.1A);None;None","1.00A","3cb8A-3c8fA:38.0","3cb8A-3c8fA:100.00"],["3CB8_A_SAMA501_0","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","3c8f","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","Escherichia coli",7,"TYR A  35;SER A  76;GLU A  79;ASP A 104;LYS A 131;VAL A 168;TYR A 201","None;MT2 A 501 ( 4.0A);None;MT2 A 501 (-4.2A);SF4 A 500 (-3.7A);None;None","0.58A","3cb8A-3c8fA:38.0","3cb8A-3c8fA:100.00"],["3CB8_A_SAMA501_0","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","3c8f","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","Escherichia coli",6,"TYR A  35;SER A  76;GLU A  79;LYS A 131;VAL A 168;LEU A 199","None;MT2 A 501 ( 4.0A);None;SF4 A 500 (-3.7A);None;None","0.94A","3cb8A-3c8fA:38.0","3cb8A-3c8fA:100.00"],["3UNI_A_SALA1344_1","XANTHINE DEHYDROGENASE\/OXIDASE","3c8f","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","Escherichia coli",4,"GLU A  79;ARG A 166;VAL A 126;LEU A 103","None;MT2 A 501 (-3.1A);None;None","0.71A","3uniA-3c8fA:undetectable","3cb8A-3c8fA:100.00"],["3UNI_B_SALB1345_1","XANTHINE DEHYDROGENASE\/OXIDASE","3c8f","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","Escherichia coli",4,"GLU A  79;ARG A 166;VAL A 126;LEU A 103","None;MT2 A 501 (-3.1A);None;None","0.69A","3uniB-3c8fA:undetectable","3uniA-3c8fA:10.53"],["6BXL_A_SAMA401_0","2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE","3c8f","PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME","Escherichia coli",5,"LEU A 204;GLY A 205;HIS A 207;SER A  76;ASP A  40","None;None;None;MT2 A 501 ( 4.0A);None","1.21A","6bxlA-3c8fA:undetectable","3uniB-3c8fA:10.53"]]