SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MSP'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FFY_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	5 / 12	HIS A  21 GLY A  23 GLY A 257 ASP A 259 HIS A 286	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-2.9A) MSP  A 501 (-3.0A) MSP  A 501 (-4.4A)	0.79A	1ffyA-2ct8A: 25.0	1ffyA-2ct8A: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FFY_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	5 / 12	HIS A  24 GLY A  23 GLY A 257 ASP A 259 HIS A 286	MSP  A 501 (-4.2A) MSP  A 501 (-3.6A) MSP  A 501 (-2.9A) MSP  A 501 (-3.0A) MSP  A 501 (-4.4A)	1.19A	1ffyA-2ct8A: 25.0	1ffyA-2ct8A: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PG2_A_ADNA552_1 (METHIONYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	7 / 11	HIS A  21 GLY A  23 HIS A  24 GLY A 257 ASP A 259 ILE A 260 HIS A 286	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-4.2A) MSP  A 501 (-2.9A) MSP  A 501 (-3.0A) MSP  A 501 (-4.1A) MSP  A 501 (-4.4A)	0.55A	1pg2A-2ct8A: 40.6	1pg2A-2ct8A: 28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU2_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	6 / 12	HIS A  21 GLY A  23 HIS A  24 GLY A 257 ASP A 259 HIS A 286	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-4.2A) MSP  A 501 (-2.9A) MSP  A 501 (-3.0A) MSP  A 501 (-4.4A)	0.79A	1qu2A-2ct8A: 25.0	1qu2A-2ct8A: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU3_A_MRCA993_1 (ISOLEUCYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	5 / 12	HIS A  21 GLY A  23 HIS A  24 ASP A 259 HIS A 286	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-4.2A) MSP  A 501 (-3.0A) MSP  A 501 (-4.4A)	0.94A	1qu3A-2ct8A: 29.4	1qu3A-2ct8A: 22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_A_ADNA601_1 (METHIONYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	8 / 11	HIS A  21 GLY A  23 HIS A  24 GLY A 257 ASP A 259 ILE A 260 HIS A 286 TRP A 288	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-4.2A) MSP  A 501 (-2.9A) MSP  A 501 (-3.0A) MSP  A 501 (-4.1A) MSP  A 501 (-4.4A) MSP  A 501 (-3.5A)	0.48A	2x1lA-2ct8A: 44.1	2x1lA-2ct8A: 44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_B_ADNB601_1 (METHIONYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	8 / 12	HIS A  21 GLY A  23 HIS A  24 GLY A 257 ASP A 259 ILE A 260 HIS A 286 TRP A 288	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-4.2A) MSP  A 501 (-2.9A) MSP  A 501 (-3.0A) MSP  A 501 (-4.1A) MSP  A 501 (-4.4A) MSP  A 501 (-3.5A)	0.46A	2x1lB-2ct8A: 47.1	2x1lB-2ct8A: 44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	8 / 11	HIS A  21 GLY A  23 HIS A  24 GLY A 257 ASP A 259 ILE A 260 HIS A 286 TRP A 288	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-4.2A) MSP  A 501 (-2.9A) MSP  A 501 (-3.0A) MSP  A 501 (-4.1A) MSP  A 501 (-4.4A) MSP  A 501 (-3.5A)	0.46A	2x1lC-2ct8A: 46.8	2x1lC-2ct8A: 44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	5 / 11	HIS A  24 GLY A  23 GLY A 257 ASP A 259 HIS A 286	MSP  A 501 (-4.2A) MSP  A 501 (-3.6A) MSP  A 501 (-2.9A) MSP  A 501 (-3.0A) MSP  A 501 (-4.4A)	1.08A	2x1lC-2ct8A: 46.8	2x1lC-2ct8A: 44.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKT_B_017B200_2 (PROTEASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	5 / 9	ASP A  52 GLY A 216 PRO A  69 ALA A  62 ILE A  58	MSP  A 501 (-3.9A) None None None None	1.08A	3ektB-2ct8A: undetectable	3ektB-2ct8A: 13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DSG_A_0HKA1201_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYS IN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	3 / 3	ASN A 236 LEU A 272 PHE A 263	MSP  A 501 (-4.7A) None None	0.82A	5dsgA-2ct8A: undetectable	5dsgA-2ct8A: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_B_SAMB301_0 (PANTOTHENATE SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	5 / 12	HIS A  21 GLY A  23 HIS A  24 VAL A 229 ASP A 259	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-4.2A) None MSP  A 501 (-3.0A)	1.01A	5hg0B-2ct8A: 6.4	5hg0B-2ct8A: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_B_SAMB301_0 (PANTOTHENATE SYNTHETASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	5 / 12	HIS A  21 GLY A  23 HIS A  24 VAL A 229 GLY A 257	MSP  A 501 (-4.6A) MSP  A 501 (-3.6A) MSP  A 501 (-4.2A) None MSP  A 501 (-2.9A)	0.89A	5hg0B-2ct8A: 6.4	5hg0B-2ct8A: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWA_A_GCSA302_1 (CHITOSANASE)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	4 / 7	THR A  97 ASP A  52 ASP A 232 GLY A  55	None MSP  A 501 (-3.9A) None None	0.89A	5hwaA-2ct8A: undetectable	5hwaA-2ct8A: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MXB_A_ML1A222_1 (CLASS 10 PLANT PATHOGENESIS-RELATED PROTEIN)	2ct8	METHIONYL-TRNA SYNTHETASE (Aquifex aeolicus)	5 / 10	VAL A 283 THR A 265 LEU A 234 GLY A 257 ALA A 285	None None MSP  A 501 ( 4.6A) MSP  A 501 (-2.9A) None	0.96A	5mxbA-2ct8A: undetectable	5mxbA-2ct8A: 11.68