SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MRC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  67
GLY A  66
GLY A 555
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.13A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  67
SER A 565
GLY A 555
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.25A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  67
SER A 566
GLY A 555
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.27A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		12 / 12 PRO A  56
HIS A  64
GLY A  66
ASN A  70
SER A 531
GLY A 555
ASP A 557
GLN A 558
HIS A 585
PHE A 587
VAL A 588
MET A 596
 MRC  A1993 (-3.4A)
MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 ( 4.2A)
MRC  A1993 ( 4.0A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.5A)
MRC  A1993 (-3.9A)
None
 0.07A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 PRO A  57
GLY A 555
ASP A 557
GLN A 558
HIS A 585
PHE A 587
 MRC  A1993 ( 4.7A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.5A)
 1.29A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FFY_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 6 PRO A  57
HIS A  67
TRP A 528
GLU A 554
TRP A 562
LYS A 598
 MRC  A1993 ( 4.7A)
MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.2A)
MRC  A1993 (-4.8A)
None
 0.05A 1ffyA-1qu2A:
62.3		 1ffyA-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		9 / 11 GLY A  55
PRO A  56
HIS A  64
HIS A  67
SER A 531
GLU A 554
GLY A 555
ASP A 557
GLN A 558
 MRC  A1993 ( 4.1A)
MRC  A1993 (-3.4A)
MRC  A1993 (-4.1A)
MRC  A1993 (-4.1A)
MRC  A1993 ( 4.0A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
 0.60A 1jzsA-1qu2A:
32.5		 1jzsA-1qu2A:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 SER A 565
GLU A 554
GLY A 555
ASP A 557
GLN A 558
 None
MRC  A1993 (-3.2A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
 1.14A 1jzsA-1qu2A:
32.5		 1jzsA-1qu2A:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 SER A 566
GLU A 554
GLY A 555
ASP A 557
GLN A 558
 None
MRC  A1993 (-3.2A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
 1.21A 1jzsA-1qu2A:
32.5		 1jzsA-1qu2A:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 GLY A  66
HIS A  64
GLY A 555
ASP A 557
HIS A 585
VAL A 588
 MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.9A)
 1.33A 1pg2A-1qu2A:
22.5		 1pg2A-1qu2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 GLY A  66
HIS A  67
GLY A 555
ASP A 557
HIS A 585
VAL A 588
 MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.9A)
 0.72A 1pg2A-1qu2A:
22.5		 1pg2A-1qu2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 HIS A  64
GLY A  66
HIS A  67
ASP A 557
HIS A 585
VAL A 588
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.9A)
 0.90A 1pg2A-1qu2A:
22.5		 1pg2A-1qu2A:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLY A  66
HIS A  64
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.37A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		11 / 12 HIS A  64
GLY A  66
HIS A  67
ASN A  70
SER A 531
GLU A 554
ASP A 557
GLN A 558
HIS A 585
PHE A 587
VAL A 588
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 ( 4.2A)
MRC  A1993 ( 4.0A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
MRC  A1993 (-3.5A)
MRC  A1993 (-3.9A)
 0.37A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  67
SER A 565
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.43A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  67
SER A 566
ASP A 557
GLN A 558
HIS A 585
 MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.2A)
MRC  A1993 (-3.5A)
MRC  A1993 (-4.5A)
 1.45A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QU3_A_MRCA993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 4 TRP A 562
SER A 597
LYS A 598
VAL A 603
 MRC  A1993 (-4.8A)
MRC  A1993 (-4.5A)
None
None
 0.67A 1qu3A-1qu2A:
45.8		 1qu3A-1qu2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 GLY A  66
HIS A  67
GLY A 555
ASP A 557
HIS A 585
 MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
 0.44A 2x1lA-1qu2A:
22.7		 2x1lA-1qu2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 HIS A  64
GLY A  66
HIS A  67
ASP A 557
HIS A 585
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
 0.69A 2x1lA-1qu2A:
22.7		 2x1lA-1qu2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  64
GLY A  66
HIS A  67
GLY A 555
ASP A 557
HIS A 585
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
 0.69A 2x1lB-1qu2A:
24.2		 2x1lB-1qu2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 HIS A  64
GLY A  66
HIS A  67
GLY A 555
ASP A 557
HIS A 585
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
MRC  A1993 (-4.5A)
 0.65A 2x1lC-1qu2A:
24.0		 2x1lC-1qu2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 GLN A 558
HIS A  67
HIS A  64
ASP A 557
 MRC  A1993 (-3.5A)
MRC  A1993 (-4.1A)
MRC  A1993 (-4.1A)
MRC  A1993 (-3.2A)
 1.13A 3nvcA-1qu2A:
undetectable		 3nvcA-1qu2A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ASP A  95
ARG A 455
THR A 154
 MRC  A1993 ( 4.7A)
None
None
 0.85A 4i13A-1qu2A:
undetectable		 4i13A-1qu2A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ASP A  95
ARG A 455
THR A 154
 MRC  A1993 ( 4.7A)
None
None
 0.84A 4p3rA-1qu2A:
undetectable		 4p3rA-1qu2A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 THR A 641
HIS A  67
LEU A 142
 None
MRC  A1993 (-4.1A)
None
 0.85A 5axdC-1qu2A:
undetectable		 5axdC-1qu2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 PHE A 148
HIS A  67
LEU A 142
PRO A  92
 None
MRC  A1993 (-4.1A)
None
None
 1.49A 5csyB-1qu2A:
undetectable		 5csyB-1qu2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 HIS A  64
GLY A  66
VAL A 527
GLY A 555
ASP A 557
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
None
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
 1.17A 5hg0A-1qu2A:
4.3		 5hg0A-1qu2A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 HIS A  64
GLY A  66
HIS A  67
VAL A 527
GLY A 555
ASP A 557
 MRC  A1993 (-4.1A)
MRC  A1993 ( 3.7A)
MRC  A1993 (-4.1A)
None
MRC  A1993 (-3.8A)
MRC  A1993 (-3.2A)
 1.30A 5hg0B-1qu2A:
4.4		 5hg0B-1qu2A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1qu2 ISOLEUCYL-TRNA
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 THR A 154
ASP A  95
ASP A 530
GLY A  98
 None
MRC  A1993 ( 4.7A)
None
None
 1.08A 5hwaA-1qu2A:
undetectable		 5hwaA-1qu2A:
12.58