SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MPG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 11 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.90A 1t3rB-5f15A:
undetectable		 1t3rB-5f15A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 246
GLY A 265
ALA A 325
ILE A 324
PRO A 317
 None
None
MPG  A 407 ( 3.9A)
None
None
 1.14A 1vq1A-4o6mA:
undetectable		 1vq1A-4o6mA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4ymk ACYL-COA DESATURASE
1
(Mus
musculus) 		4 / 5 TYR A 104
ARG A 249
MET A 105
THR A 106
 MPG  A 404 (-3.4A)
None
MPG  A 404 (-3.5A)
None
 1.42A 2eimJ-4ymkA:
undetectable		 2eimJ-4ymkA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4ymk ACYL-COA DESATURASE
1
(Mus
musculus) 		4 / 5 TYR A 104
ARG A 249
MET A 105
THR A 106
 MPG  A 404 (-3.4A)
None
MPG  A 404 (-3.5A)
None
 1.41A 2eimW-4ymkA:
undetectable		 2eimW-4ymkA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 11 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.89A 2fxeB-5f15A:
undetectable		 2fxeB-5f15A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.90A 2o4sB-5f15A:
undetectable		 2o4sB-5f15A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 8 PHE A 332
ILE A 346
GLY A 291
GLY A 292
 MPG  A 614 (-4.0A)
None
MPG  A 625 ( 3.7A)
MPG  A 603 ( 4.3A)
 0.85A 2qx4A-5f15A:
undetectable
2qx4B-5f15A:
undetectable		 2qx4A-5f15A:
17.19
2qx4B-5f15A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 6 PHE A 332
ILE A 346
GLY A 291
GLY A 292
 MPG  A 614 (-4.0A)
None
MPG  A 625 ( 3.7A)
MPG  A 603 ( 4.3A)
 0.83A 2qx6A-5f15A:
undetectable
2qx6B-5f15A:
undetectable		 2qx6A-5f15A:
17.19
2qx6B-5f15A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 LEU A 117
GLY A 163
PHE A  43
LEU A  46
VAL A 347
 MPG  A 611 (-4.3A)
None
MPG  A 610 (-4.3A)
None
None
 1.43A 2w8yA-5f15A:
undetectable		 2w8yA-5f15A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 10 TYR A 218
ILE A 326
PHE A 318
LEU A 169
LEU A 173
 None
MPG  A 612 ( 4.7A)
None
5TR  A 681 ( 4.3A)
None
 1.40A 2w98A-5f15A:
undetectable		 2w98A-5f15A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 8 TYR A 218
ALA A 328
ALA A 352
LEU A 173
 None
MPG  A 614 ( 3.9A)
None
None
 0.93A 2wx2B-5f15A:
undetectable		 2wx2B-5f15A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		6 / 12 GLY A  64
ALA A  65
ILE A  55
VAL A  52
ILE A  72
ILE A  60
 MPG  A 202 ( 3.2A)
None
None
None
None
None
 1.22A 3ekqA-5edlA:
undetectable		 3ekqA-5edlA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 9 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.90A 3ekvB-5f15A:
undetectable		 3ekvB-5f15A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 8 HIS A 454
ALA A 395
ILE A 398
ASN A 396
 CL  A 680 (-3.9A)
MPG  A 675 ( 4.0A)
None
None
 0.96A 3fxrA-5f15A:
undetectable		 3fxrA-5f15A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 10 SER A  53
VAL A 102
SER A 123
GLY A 120
GLY A 122
 None
None
None
None
MPG  A 203 ( 4.7A)
 1.50A 3ixlA-5edlA:
undetectable		 3ixlA-5edlA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 11 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 1.00A 3lzvB-5f15A:
undetectable		 3lzvB-5f15A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 9 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 1.00A 3ndwB-5f15A:
undetectable		 3ndwB-5f15A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.98A 3ndxA-5f15A:
undetectable		 3ndxA-5f15A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 10 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.99A 3nujA-5f15A:
undetectable		 3nujA-5f15A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4ymk ACYL-COA DESATURASE
1
(Mus
musculus) 		5 / 10 PHE A 319
VAL A 289
PHE A 315
PHE A 133
GLY A 110
 None
MPG  A 404 (-4.1A)
None
None
None
 1.27A 3t3rD-4ymkA:
undetectable		 3t3rD-4ymkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 6 ILE A 119
LEU A 142
MET A 159
THR A 160
 MPG  A 602 ( 4.5A)
None
None
None
 1.11A 3wg7A-5f15A:
5.4
3wg7J-5f15A:
undetectable		 3wg7A-5f15A:
23.90
3wg7J-5f15A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 10 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.88A 4dqcA-5f15A:
undetectable		 4dqcA-5f15A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 11 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.91A 4dqeA-5f15A:
undetectable		 4dqeA-5f15A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 11 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.94A 4dqhA-5f15A:
undetectable		 4dqhA-5f15A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		3 / 3 LYS A  62
PRO A  63
LYS A   3
 None
MPG  A 202 ( 4.3A)
None
 1.36A 4dr5L-5edlA:
undetectable		 4dr5L-5edlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		3 / 3 LYS A  62
PRO A  63
LYS A   3
 None
MPG  A 202 ( 4.3A)
None
 1.42A 4dr6L-5edlA:
undetectable		 4dr6L-5edlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.87A 4fp9A-5f15A:
undetectable		 4fp9A-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.87A 4fp9C-5f15A:
undetectable		 4fp9C-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.87A 4fp9D-5f15A:
undetectable		 4fp9D-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.87A 4fp9F-5f15A:
undetectable		 4fp9F-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.90A 4fzvA-5f15A:
undetectable		 4fzvA-5f15A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.97A 4hlaA-5f15A:
undetectable		 4hlaA-5f15A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 11 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.94A 4hlaB-5f15A:
undetectable		 4hlaB-5f15A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 10 ALA A 145
GLY A 291
ILE A 290
VAL A 349
ILE A 350
 None
MPG  A 625 ( 3.7A)
MPG  A 625 ( 4.6A)
None
None
 0.90A 4q1wB-5f15A:
undetectable		 4q1wB-5f15A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_1
(RETINOL-BINDING
PROTEIN 2)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		3 / 3 LYS A 302
TRP A 369
GLN A 372
 CL  A 679 (-2.8A)
None
MPG  A 605 (-3.9A)
 1.49A 4qzuC-5f15A:
0.0		 4qzuC-5f15A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 10 ALA A 101
VAL A 102
SER A 124
SER A 123
GLY A  98
 MPG  A 202 (-2.8A)
None
None
None
MPG  A 203 ( 4.1A)
 1.39A 4xp1A-5edlA:
1.0		 4xp1A-5edlA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLY A 298
PHE A 137
THR A 138
TYR A 439
VAL A 432
 MPG  A 605 (-3.9A)
None
None
None
None
 1.11A 5d0yA-5f15A:
2.8		 5d0yA-5f15A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 6 PHE A 171
SER A 122
ALA A 125
LEU A 169
 MPG  A 617 ( 4.5A)
None
None
5TR  A 681 ( 4.3A)
 1.19A 5dzkB-5f15A:
undetectable
5dzkP-5f15A:
undetectable		 5dzkB-5f15A:
16.67
5dzkP-5f15A:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 7 PHE A 171
SER A 122
ALA A 125
LEU A 169
 MPG  A 617 ( 4.5A)
None
None
5TR  A 681 ( 4.3A)
 1.15A 5dzkD-5f15A:
undetectable
5dzkR-5f15A:
undetectable		 5dzkD-5f15A:
16.67
5dzkR-5f15A:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 8 PHE A 171
SER A 122
ALA A 125
LEU A 169
 MPG  A 617 ( 4.5A)
None
None
5TR  A 681 ( 4.3A)
 1.06A 5dzkF-5f15A:
undetectable
5dzkT-5f15A:
undetectable		 5dzkF-5f15A:
16.67
5dzkT-5f15A:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 6 PHE A 171
SER A 122
ALA A 125
LEU A 169
 MPG  A 617 ( 4.5A)
None
None
5TR  A 681 ( 4.3A)
 1.06A 5dzkg-5f15A:
undetectable
5dzku-5f15A:
undetectable		 5dzkg-5f15A:
16.67
5dzku-5f15A:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 PHE A  34
LEU A 433
ALA A 437
PHE A 137
LEU A  39
 MPG  A 602 (-4.6A)
None
MPG  A 602 ( 3.7A)
None
None
 1.22A 5ljbA-5f15A:
undetectable		 5ljbA-5f15A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 PHE A  34
LEU A 433
ALA A 437
PHE A 137
LEU A  39
 MPG  A 602 (-4.6A)
None
MPG  A 602 ( 3.7A)
None
None
 1.20A 5ljcA-5f15A:
undetectable		 5ljcA-5f15A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ymk ACYL-COA DESATURASE
1
(Mus
musculus) 		4 / 5 TYR A 104
ARG A 249
MET A 105
THR A 106
 MPG  A 404 (-3.4A)
None
MPG  A 404 (-3.5A)
None
 1.33A 5w97J-4ymkA:
undetectable		 5w97J-4ymkA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 ALA A 145
PRO A 146
GLY A 291
GLY A 358
LEU A 361
 None
None
MPG  A 625 ( 3.7A)
None
None
 1.09A 5wwsA-5f15A:
undetectable		 5wwsA-5f15A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4ymk ACYL-COA DESATURASE
1
(Mus
musculus) 		5 / 9 ILE A 282
GLY A 290
PHE A 293
ASN A 314
ALA A 256
 None
MPG  A 404 ( 4.9A)
None
None
ST9  A 403 ( 4.1A)
 1.39A 5x66C-4ymkA:
undetectable		 5x66C-4ymkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 12 GLY A 120
GLY A  96
GLY A  98
VAL A 102
ILE A  91
 None
None
MPG  A 203 ( 4.1A)
None
VIB  A 201 ( 4.2A)
 0.95A 5x7fA-5edlA:
undetectable		 5x7fA-5edlA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 11 TYR A 130
VAL A  94
GLY A  98
ALA A 105
VAL A 125
 None
MPG  A 203 ( 4.8A)
MPG  A 203 ( 4.1A)
None
None
 1.20A 6hu9A-5edlA:
0.7
6hu9E-5edlA:
0.0
6hu9I-5edlA:
undetectable		 6hu9A-5edlA:
18.45
6hu9E-5edlA:
20.75
6hu9I-5edlA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 10 TYR A 130
VAL A  94
GLY A  98
ALA A 105
VAL A 125
 None
MPG  A 203 ( 4.8A)
MPG  A 203 ( 4.1A)
None
None
 1.17A 6hu9L-5edlA:
undetectable
6hu9P-5edlA:
undetectable
6hu9T-5edlA:
undetectable		 6hu9L-5edlA:
18.45
6hu9P-5edlA:
20.75
6hu9T-5edlA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 6 ILE A 119
LEU A 142
MET A 159
THR A 160
 MPG  A 602 ( 4.5A)
None
None
None
 1.00A 6nmfN-5f15A:
2.5
6nmfW-5f15A:
undetectable		 6nmfN-5f15A:
23.90
6nmfW-5f15A:
6.64