SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MP5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVM_B_PFLB510_1 (PROTON-GATED ION CHANNEL)	1rtw	TRANSCRIPTIONAL ACTIVATOR, PUTATIVE (Pyrococcus furiosus)	4 / 6	ALA A 50 LEU A 51 ILE A 73 TYR A 164	MP5 A1213 (-3.6A) None None None	0.86A	5mvmB-1rtwA: 4.0 5mvmC-1rtwA: 4.0	5mvmB-1rtwA: 17.54 5mvmC-1rtwA: 17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TIX_B_OQRB302_0 (SULFOTRANSFERASE)	1rtw	TRANSCRIPTIONAL ACTIVATOR, PUTATIVE (Pyrococcus furiosus)	5 / 10	ILE A 204 VAL A 106 LEU A 109 PHE A 201 GLU A 128	None None None MP5 A1213 (-3.3A) MP5 A1213 (-3.8A)	1.46A	5tixB-1rtwA: undetectable	5tixB-1rtwA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AG0_C_ACRC608_1 (ALPHA-AMYLASE)	1rtw	TRANSCRIPTIONAL ACTIVATOR, PUTATIVE (Pyrococcus furiosus)	3 / 3	TYR A 44 ALA A 50 LEU A 51	None MP5 A1213 (-3.6A) None	0.67A	6ag0C-1rtwA: undetectable	6ag0C-1rtwA: 14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AN0_A_HISA520_0 (HISTIDINOL DEHYDROGENASE)	1rtw	TRANSCRIPTIONAL ACTIVATOR, PUTATIVE (Pyrococcus furiosus)	4 / 6	GLU A 198 LYS A 130 GLU A 134 ALA A 135	MP5 A1213 (-2.6A) None None None	1.24A	6an0A-1rtwA: 0.5	6an0A-1rtwA: 19.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5MVM_B_PFLB510_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","1rtw","TRANSCRIPTIONAL ACTIVATOR, PUTATIVE","Pyrococcus furiosus",4,"ALA A  50;LEU A  51;ILE A  73;TYR A 164","MP5 A1213 (-3.6A);None;None;None","0.86A","5mvmB-1rtwA:4.0;5mvmC-1rtwA:4.0",null],["5TIX_B_OQRB302_0","SULFOTRANSFERASE","1rtw","TRANSCRIPTIONAL ACTIVATOR, PUTATIVE","Pyrococcus furiosus",5,"ILE A 204;VAL A 106;LEU A 109;PHE A 201;GLU A 128","None;None;None;MP5 A1213 (-3.3A);MP5 A1213 (-3.8A)","1.46A","5tixB-1rtwA:undetectable","5mvmB-1rtwA:17.54;5mvmC-1rtwA:17.54"],["6AG0_C_ACRC608_1","ALPHA-AMYLASE","1rtw","TRANSCRIPTIONAL ACTIVATOR, PUTATIVE","Pyrococcus furiosus",3,"TYR A  44;ALA A  50;LEU A  51","None;MP5 A1213 (-3.6A);None","0.67A","6ag0C-1rtwA:undetectable","5tixB-1rtwA:21.84"],["6AN0_A_HISA520_0","HISTIDINOL DEHYDROGENASE","1rtw","TRANSCRIPTIONAL ACTIVATOR, PUTATIVE","Pyrococcus furiosus",4,"GLU A 198;LYS A 130;GLU A 134;ALA A 135","MP5 A1213 (-2.6A);None;None;None","1.24A","6an0A-1rtwA:0.5","6ag0C-1rtwA:14.08"]]