SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MOO'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans)
4 / 7 GLY A 164
PRO A 162
SER A 156
ALA A  48
None
MOO  A 500 (-3.3A)
None
MOO  A 500 (-3.2A)
0.97A 1gxsA-3k6xA:
undetectable
1gxsB-3k6xA:
undetectable
1gxsA-3k6xA:
22.07
1gxsB-3k6xA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri)
3 / 3 ALA A 121
VAL A 123
TRP A  62
SO4  A1403 (-3.9A)
MOO  A1300 (-4.8A)
None
0.91A 1jo4A-3gzgA:
undetectable
1jo4A-3gzgA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri)
3 / 3 ALA A 121
VAL A 123
TRP A  62
SO4  A1403 (-3.9A)
MOO  A1300 (-4.8A)
None
0.91A 1jo4B-3gzgA:
undetectable
1jo4B-3gzgA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans)
5 / 12 GLY A  77
ASP A 161
PRO A 162
ALA A 163
ALA A  75
MOO  A 500 (-3.7A)
MOO  A 500 (-2.7A)
MOO  A 500 (-3.3A)
MOO  A 500 (-3.3A)
SO4  A 504 (-3.5A)
0.86A 3jb1A-3k6xA:
undetectable
3jb1A-3k6xA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans)
5 / 12 GLY A  49
ASP A 161
SER A  81
ALA A  79
SER A 105
MOO  A 500 (-3.5A)
MOO  A 500 (-2.7A)
None
None
None
1.21A 3sueD-3k6xA:
undetectable
3sueD-3k6xA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans)
5 / 10 TYR A 165
LEU A 102
LEU A  51
ALA A  48
GLY A 295
None
None
None
MOO  A 500 (-3.2A)
None
1.25A 4rn6A-3k6xA:
undetectable
4rn6A-3k6xA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans)
5 / 12 LEU A 173
ALA A 174
TYR A 143
ALA A 163
TYR A 245
None
None
None
MOO  A 500 (-3.3A)
MOO  A 500 (-4.7A)
1.08A 5n5dB-3k6xA:
undetectable
5n5dB-3k6xA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)
6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1

(Arabidopsis
thaliana)
3 / 3 LYS A 294
SER A 328
SER A 400
None
MOO  A 507 (-2.7A)
MOO  A 507 (-2.6A)
0.49A 6gbfA-6gbcA:
53.4
6gbfA-6gbcA:
undetectable