SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MOH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5ej0 ENVELOPE PROTEIN H3
(Vaccinia
virus) 		3 / 3 HIS A 144
ASP A 149
ASN A 197
 None
MOH  A 720 (-2.8A)
None
 0.64A 1wg8B-5ej0A:
undetectable		 1wg8B-5ej0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		4 / 4 GLY A  50
SER A  34
VAL A 228
LEU A 191
 None
None
None
MOH  A 412 ( 4.0A)
 1.26A 1yajB-3u0fA:
undetectable		 1yajB-3u0fA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		5 / 12 ILE A 168
PHE A 227
MET A 205
ALA A  36
LEU A 191
 None
None
None
MOH  A 412 ( 4.9A)
MOH  A 412 ( 4.0A)
 1.32A 2x2nD-3u0fA:
undetectable		 2x2nD-3u0fA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 5 GLN A 157
ILE A  68
LEU A 158
PHE A  37
 MOH  A   3 ( 2.6A)
None
None
EDO  A   4 (-4.0A)
 1.21A 3ls4L-3r5tA:
undetectable		 3ls4L-3r5tA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		5 / 12 SER A 196
HIS A 296
THR A 298
HIS A 333
LEU A 335
 MOH  A 412 ( 4.7A)
None
None
None
07L  A 411 (-3.4A)
 1.08A 4ls7A-3u0fA:
61.5
4ls7B-3u0fA:
61.1		 4ls7A-3u0fA:
40.82
4ls7B-3u0fA:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		4 / 6 TYR A 252
GLU A  20
THR A  23
LEU A 348
 MOH  A 413 ( 4.3A)
None
None
None
 1.37A 4qztA-3u0fA:
undetectable		 4qztA-3u0fA:
16.10