SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MMA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		3 / 3 ASP A 431
ASP A 311
ASP A 385
 MMA  A 502 (-3.1A)
None
None
 0.69A 1eizA-4mq0A:
undetectable		 1eizA-4mq0A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		3 / 3 ASP A 431
ASP A 311
ASP A 385
 MMA  A 502 (-3.1A)
None
None
 0.68A 1ej0A-4mq0A:
undetectable		 1ej0A-4mq0A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN
(Vibrio
cholerae) 		5 / 11 LEU A 626
GLY A 632
GLY A 631
ILE A 616
LEU A 639
 None
MMA  A 801 (-3.3A)
MMA  A 801 ( 3.7A)
None
None
 1.19A 1p91A-4gx7A:
undetectable		 1p91A-4gx7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		6 / 12 GLY A 227
GLY A  98
ILE A 210
LEU A 156
VAL A 170
ALA A  95
 MMA  A 242 (-3.5A)
MMA  A 242 ( 3.1A)
None
None
None
None
 1.44A 1v2xA-2ow4A:
undetectable		 1v2xA-2ow4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		3 / 3 ASP A 431
ASP A 311
ASP A 385
 MMA  A 502 (-3.1A)
None
None
 0.72A 3douA-4mq0A:
undetectable		 3douA-4mq0A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		3 / 3 TYR A 283
ASP A 285
ASP A 166
 MMA  A 503 (-4.2A)
MMA  A 503 (-3.0A)
None
 0.77A 3ou7B-4mq0A:
undetectable		 3ou7B-4mq0A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 LEU A 232
GLY A 171
LEU A 230
GLY A 227
PRO A 222
 None
None
None
MMA  A 242 (-3.5A)
None
 1.16A 4blvA-2ow4A:
undetectable		 4blvA-2ow4A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		5 / 12 ASP A 355
ALA A 429
TYR A 432
GLY A 349
THR A 391
 None
None
MMA  A 502 (-3.8A)
None
None
 1.31A 4mm6A-4mq0A:
undetectable		 4mm6A-4mq0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		5 / 10 ASP A 355
ALA A 429
TYR A 432
GLY A 357
GLY A 349
 None
None
MMA  A 502 (-3.8A)
None
None
 1.32A 4mmdA-4mq0A:
undetectable		 4mmdA-4mq0A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		5 / 12 ASP A  17
SER A  40
GLY A  16
ASP A 140
GLY A  56
 None
None
MMA  A 501 (-3.3A)
MMA  A 501 (-2.6A)
None
 1.37A 4pevB-4mq0A:
undetectable		 4pevB-4mq0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		5 / 12 ASP A 285
VAL A 240
GLY A 164
ASP A 165
PHE A 238
 MMA  A 503 (-3.0A)
None
MMA  A 503 (-3.8A)
MMA  A 503 (-2.6A)
MMA  A 503 ( 4.4A)
 1.41A 4pevB-4mq0A:
undetectable		 4pevB-4mq0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		5 / 12 ASP A 311
SER A 334
GLY A 310
ASP A 434
GLY A 350
 None
None
MMA  A 502 (-3.5A)
MMA  A 502 (-2.6A)
None
 1.34A 4pevB-4mq0A:
undetectable		 4pevB-4mq0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		4 / 6 ASP A 431
ALA A 429
THR A 389
TYR A 432
 MMA  A 502 (-3.1A)
None
None
MMA  A 502 (-3.8A)
 1.47A 4w5tA-4mq0A:
undetectable		 4w5tA-4mq0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		3 / 3 TYR A 138
ARG A  60
LYS A  63
 MMA  A 501 (-4.8A)
None
None
 1.41A 4wq5B-4mq0A:
undetectable		 4wq5B-4mq0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		4 / 6 ASP A 431
ALA A 429
THR A 389
TYR A 432
 MMA  A 502 (-3.1A)
None
None
MMA  A 502 (-3.8A)
 1.48A 4z4cA-4mq0A:
undetectable		 4z4cA-4mq0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		4 / 5 ASP A 431
ALA A 429
THR A 389
TYR A 432
 MMA  A 502 (-3.1A)
None
None
MMA  A 502 (-3.8A)
 1.47A 4z4gA-4mq0A:
undetectable		 4z4gA-4mq0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		4 / 5 ASP A 431
ALA A 429
THR A 389
TYR A 432
 MMA  A 502 (-3.1A)
None
None
MMA  A 502 (-3.8A)
 1.46A 4z4hA-4mq0A:
undetectable		 4z4hA-4mq0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)
(Parkia
biglobosa) 		4 / 6 ASP A 431
ALA A 429
THR A 389
TYR A 432
 MMA  A 502 (-3.1A)
None
None
MMA  A 502 (-3.8A)
 1.45A 4z4iA-4mq0A:
undetectable		 4z4iA-4mq0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 0.96A 4zdyA-2ow4A:
undetectable		 4zdyA-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.02A 4ze2A-2ow4A:
undetectable		 4ze2A-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.05A 5eqbA-2ow4A:
undetectable		 5eqbA-2ow4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6flz -
(-) 		5 / 12 ASP A  39
ILE A  38
LEU A  91
GLU A 110
GLY A 108
 MMA  A 201 (-2.7A)
None
None
None
None
 1.31A 5k7uA-6flzA:
undetectable		 5k7uA-6flzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1uqx LECTIN
(Ralstonia
solanacearum) 		4 / 8 ASN A  24
ALA A  23
GLN A  26
SER A  43
 MMA  A1116 (-3.8A)
MMA  A1116 (-3.4A)
None
None
 0.89A 5km8A-1uqxA:
undetectable
5km8B-1uqxA:
undetectable		 5km8A-1uqxA:
24.52
5km8B-1uqxA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 1uqx LECTIN
(Ralstonia
solanacearum) 		5 / 12 ALA A  22
ASN A  69
GLY A  44
SER A  43
GLY A  42
 MMA  A1116 (-3.3A)
None
None
None
None
 1.14A 6c79A-1uqxA:
undetectable		 6c79A-1uqxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 0.99A 6e8qA-2ow4A:
undetectable		 6e8qA-2ow4A:
16.90