SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MLZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		8 / 12 HIS A  48
TYR A  50
LEU A 199
ASP A 228
HIS A 442
ASP A 443
ASP A 596
ARG A 600
 None
None
None
None
None
None
MLZ  A 513 ( 4.9A)
None
 0.77A 1dedA-1iv8A:
29.5		 1dedA-1iv8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		7 / 12 HIS A  48
TYR A  50
LEU A 199
GLU A 255
ASP A 443
ASP A 596
ARG A 600
 None
None
None
None
None
MLZ  A 513 ( 4.9A)
None
 1.03A 1dedA-1iv8A:
29.5		 1dedA-1iv8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		5 / 12 SER A 494
ASP A 483
ASN A 482
MET A 511
ILE A 507
 None
None
None
None
MLZ  A 508 ( 3.6A)
 1.26A 1lhuA-1iv8A:
0.0		 1lhuA-1iv8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		3 / 3 PHE A 552
TRP A 471
GLU A 470
 None
MLZ  A 467 ( 3.4A)
MLZ  A 467 ( 3.8A)
 1.10A 1mogA-1iv8A:
0.0		 1mogA-1iv8A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A  50
ILE A  51
VAL A  26
ALA A  25
PHE A 103
 None
MLZ  A 101 ( 4.2A)
None
None
MLZ  A 101 ( 2.9A)
 1.01A 1udtA-5jh8A:
undetectable		 1udtA-5jh8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 5 ALA A  98
TYR A  62
ILE A 106
ASP A 169
 None
MLZ  A 138 ( 4.1A)
None
MLZ  A 138 ( 2.7A)
 1.05A 1upfA-5jh8A:
undetectable		 1upfA-5jh8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 ALA A  50
ILE A  51
VAL A  26
ALA A  25
PHE A 103
 None
MLZ  A 101 ( 4.2A)
None
None
MLZ  A 101 ( 2.9A)
 1.03A 1xp0A-5jh8A:
undetectable		 1xp0A-5jh8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 8 LEU A 186
GLY A 183
LEU A 229
PRO A 240
 None
MLZ  A 181 ( 4.3A)
None
MLZ  A 239 ( 2.6A)
 0.95A 1ya4A-4d1eA:
undetectable		 1ya4A-4d1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 7 LEU A 186
GLY A 183
LEU A 229
PRO A 240
 None
MLZ  A 181 ( 4.3A)
None
MLZ  A 239 ( 2.6A)
 0.90A 1ya4B-4d1eA:
undetectable		 1ya4B-4d1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5fq2 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 4 LEU B 506
PRO B 478
ILE B 530
LEU B 517
 MLZ  B 505 ( 4.2A)
None
None
None
 1.12A 1ya4B-5fq2B:
undetectable		 1ya4B-5fq2B:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 11 PRO A 531
ILE A 486
HIS A 625
GLU A 496
ASN A 627
 None
None
MLZ  A 601 ( 4.1A)
MLZ  A 601 ( 4.4A)
MLZ  A 601 ( 4.0A)
 1.44A 2aqjA-4mboA:
undetectable		 2aqjA-4mboA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 4dws CHI2
(Yersinia
entomophaga) 		5 / 12 PRO A 351
GLY A 307
PHE A 314
ALA A 395
TYR A 369
 MLZ  A 405 ( 4.9A)
None
None
None
None
 1.46A 2axnA-4dwsA:
undetectable		 2axnA-4dwsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		6 / 12 LEU A 343
LEU A 380
ALA A 369
ILE A 366
ILE A 334
ALA A 329
 None
None
None
None
None
MLZ  A 326 ( 3.6A)
 1.14A 2bxcA-1iv8A:
0.0		 2bxcA-1iv8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 6 LEU A 565
ALA A 535
HIS A 558
ASP A 622
 MLZ  A 562 ( 4.2A)
None
MLZ  A 562 ( 4.1A)
MLZ  A 562 ( 3.8A)
 1.34A 2dpzA-4d1eA:
undetectable		 2dpzA-4d1eA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A  50
ILE A  51
VAL A  26
ALA A  25
PHE A 103
 None
MLZ  A 101 ( 4.2A)
None
None
MLZ  A 101 ( 2.9A)
 1.03A 2h42B-5jh8A:
undetectable		 2h42B-5jh8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 GLU X  52
LEU X 109
ASP X 106
VAL X 154
ALA X 156
 None
None
None
MLZ  X 155 ( 3.0A)
MLZ  X 155 ( 3.0A)
 1.28A 2kceA-5liyX:
undetectable		 2kceA-5liyX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 5 LEU A 339
ARG A 340
ALA A 329
ILE A 317
 None
None
MLZ  A 326 ( 3.6A)
None
 0.96A 2qhfA-1iv8A:
0.0		 2qhfA-1iv8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 10 GLU A 241
PHE A  42
VAL A 302
ALA A 105
LEU A 316
 None
MLZ  A  45 ( 4.4A)
None
None
None
 1.32A 3a3yA-3e3xA:
undetectable		 3a3yA-3e3xA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.92A 3abkA-1iv8A:
0.0
3abkJ-1iv8A:
0.0		 3abkA-1iv8A:
20.68
3abkJ-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.92A 3ag3A-1iv8A:
0.0
3ag3J-1iv8A:
0.0		 3ag3A-1iv8A:
20.68
3ag3J-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.90A 3asoN-1iv8A:
0.0
3asoW-1iv8A:
0.0		 3asoN-1iv8A:
20.68
3asoW-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Conexibacter
woesei) 		4 / 6 ASP A  66
LEU A  60
ASP A  92
HIS A 116
 None
None
MLZ  A  35 ( 3.8A)
BR  A 411 (-4.3A)
 1.15A 3bj8C-4p98A:
undetectable
3bj8D-4p98A:
undetectable		 3bj8C-4p98A:
19.63
3bj8D-4p98A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4dws CHI2
(Yersinia
entomophaga) 		5 / 12 ILE A 238
LEU A 372
ILE A 346
PRO A 351
ILE A 203
 None
None
None
MLZ  A 405 ( 4.9A)
None
 1.16A 3cd2A-4dwsA:
undetectable		 3cd2A-4dwsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 11 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
None
MLZ  A 601 ( 3.7A)
None
None
 1.00A 3clbA-4mboA:
undetectable		 3clbA-4mboA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 12 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
None
MLZ  A 601 ( 3.7A)
None
None
 1.00A 3clbC-4mboA:
undetectable		 3clbC-4mboA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 10 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
None
MLZ  A 601 ( 3.7A)
None
None
 1.02A 3hbbA-4mboA:
undetectable		 3hbbA-4mboA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 11 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
None
MLZ  A 601 ( 3.7A)
None
None
 1.03A 3hbbC-4mboA:
undetectable		 3hbbC-4mboA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		5 / 9 PHE A 667
LEU A 713
ILE A 575
ARG A 643
TYR A 634
 None
None
None
None
MLZ  A 638 ( 3.6A)
 1.44A 3m7rA-1iv8A:
0.0		 3m7rA-1iv8A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 572
LEU A 601
CYH A 554
ILE A 568
PHE A 570
 None
None
MLZ  A  20 ( 4.1A)
None
MLZ  A  20 (-4.0A)
 1.35A 3mnoA-3f70A:
undetectable		 3mnoA-3f70A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 572
LEU A 601
CYH A 554
ILE A 568
PHE A 570
 None
None
MLZ  A  20 ( 4.1A)
None
MLZ  A  20 (-4.0A)
 1.33A 3mnpA-3f70A:
undetectable		 3mnpA-3f70A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4p3z COPN
(Chlamydia
pneumoniae) 		3 / 3 VAL A 284
VAL A 329
SER A 310
 None
None
MLZ  A 313 ( 3.2A)
 0.66A 3n8xB-4p3zA:
1.4		 3n8xB-4p3zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 5oy9 GLYCOPROTEIN G
(Indiana
vesiculovirus) 		4 / 6 GLU A 327
PRO A 262
ARG A 329
GLY A 313
 None
None
MLZ  A  50 ( 4.0A)
None
 1.29A 3oxvA-5oy9A:
undetectable		 3oxvA-5oy9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.14A 3qxyA-2g46A:
6.7		 3qxyA-2g46A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.16A 3rc0B-2g46A:
6.7		 3rc0B-2g46A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		3 / 3 LYS A 205
LYS A 182
PRO A 208
 None
MLZ  A 181 ( 3.1A)
MLZ  A 181 ( 4.8A)
 1.26A 4dv1L-4d1eA:
undetectable		 4dv1L-4d1eA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4dws CHI2
(Yersinia
entomophaga) 		3 / 3 PHE A 427
ASP A 454
ARG A 494
 None
None
MLZ  A 625 ( 3.9A)
 0.88A 4eahF-4dwsA:
undetectable		 4eahF-4dwsA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4dws CHI2
(Yersinia
entomophaga) 		3 / 3 PHE A 427
ASP A 454
ARG A 494
 None
None
MLZ  A 625 ( 3.9A)
 0.87A 4eahG-4dwsA:
undetectable		 4eahG-4dwsA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4feuB-1iv8A:
undetectable		 4feuB-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.19A 4feuF-1iv8A:
undetectable		 4feuF-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.17A 4fevB-1iv8A:
0.0		 4fevB-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4fevD-1iv8A:
undetectable		 4fevD-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.16A 4fevF-1iv8A:
undetectable		 4fevF-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.16A 4fewB-1iv8A:
undetectable		 4fewB-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4fewD-1iv8A:
0.0		 4fewD-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.16A 4fewF-1iv8A:
undetectable		 4fewF-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4fexB-1iv8A:
undetectable		 4fexB-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4gkhB-1iv8A:
undetectable		 4gkhB-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.17A 4gkhD-1iv8A:
0.0		 4gkhD-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4gkhF-1iv8A:
0.0		 4gkhF-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4gkhG-1iv8A:
undetectable		 4gkhG-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 6 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.17A 4gkhJ-1iv8A:
0.0		 4gkhJ-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4gkhC-1iv8A:
undetectable
4gkhK-1iv8A:
0.0		 4gkhC-1iv8A:
16.69
4gkhK-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.15A 4gkiA-1iv8A:
undetectable		 4gkiA-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.16A 4gkiC-1iv8A:
undetectable		 4gkiC-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 4dws CHI2
(Yersinia
entomophaga) 		4 / 5 ILE A 419
ASN A 407
TYR A 369
ILE A 394
 None
MLZ  A 405 ( 4.7A)
None
None
 1.04A 4jtpA-4dwsA:
undetectable		 4jtpA-4dwsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 9 THR X   9
LEU X   7
ALA X 156
GLN X 184
THR X 206
 None
None
MLZ  X 155 ( 3.0A)
NAP  X 401 (-3.8A)
EDO  X 403 (-4.6A)
 1.27A 4ltwA-5liyX:
undetectable		 4ltwA-5liyX:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		3 / 3 LEU A 154
LEU A 100
ASN A 178
 None
None
MLZ  A 105 ( 4.3A)
 0.64A 4otwA-1iv8A:
undetectable		 4otwA-1iv8A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3oa6 MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens) 		3 / 3 VAL A  36
PHE A  56
ARG A  65
 None
MLZ  G  20 ( 3.8A)
None
 0.84A 4xr4B-3oa6A:
undetectable		 4xr4B-3oa6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		3 / 3 GLU A 103
LYS A  49
ASN A  38
 MLZ  A  45 ( 3.8A)
MLY  A  48 ( 3.3A)
None
 0.92A 4y1dA-3e3xA:
undetectable
4y1dD-3e3xA:
undetectable		 4y1dA-3e3xA:
20.67
4y1dD-3e3xA:
1.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 183
SER A 179
ALA A 188
ASN A 170
TYR A 200
 MLZ  A 181 ( 4.3A)
None
None
None
None
 1.22A 4ymgA-4d1eA:
undetectable		 4ymgA-4d1eA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 183
SER A 179
ALA A 188
ASN A 170
TYR A 200
 MLZ  A 181 ( 4.3A)
None
None
None
None
 1.23A 4ymgB-4d1eA:
undetectable		 4ymgB-4d1eA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.12A 4ypuA-2g46A:
7.3		 4ypuA-2g46A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 LYS A 614
TYR A 637
LEU A 608
PHE A 605
 None
MLZ  A 638 ( 4.0A)
None
None
 1.08A 4yv5A-1iv8A:
undetectable		 4yv5A-1iv8A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 LYS A 614
TYR A 637
LEU A 608
PHE A 605
 None
MLZ  A 638 ( 4.0A)
None
None
 1.11A 4yv5B-1iv8A:
0.0		 4yv5B-1iv8A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.92A 5b1aA-1iv8A:
0.0
5b1aJ-1iv8A:
0.0		 5b1aA-1iv8A:
20.68
5b1aJ-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.92A 5b3sA-1iv8A:
0.0
5b3sJ-1iv8A:
undetectable		 5b3sA-1iv8A:
20.68
5b3sJ-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 7 PRO A 240
ILE A 245
LEU A 186
MET A 216
 MLZ  A 239 ( 2.6A)
None
None
None
 1.05A 5fxtA-4d1eA:
undetectable		 5fxtA-4d1eA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 LEU A 639
PRO A 714
ILE A 716
LEU A 642
 MLZ  A 638 ( 4.2A)
None
None
MLZ  A 638 ( 4.6A)
 0.90A 5g48A-1iv8A:
undetectable		 5g48A-1iv8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 6 LEU A  74
CYH A  48
HIS A  51
LEU A  52
 MLZ  A  71 ( 4.2A)
None
None
None
 1.07A 5hpuC-4d1eA:
undetectable
5hpuD-4d1eA:
undetectable		 5hpuC-4d1eA:
2.83
5hpuD-4d1eA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.06A 5jhnA-2g46A:
8.6		 5jhnA-2g46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.06A 5jhnB-2g46A:
7.6		 5jhnB-2g46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.06A 5jiyA-2g46A:
7.4		 5jiyA-2g46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.06A 5jiyB-2g46A:
7.5		 5jiyB-2g46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4dws CHI2
(Yersinia
entomophaga) 		3 / 3 THR A 132
SER A 130
TYR A 113
 MLZ  A 518 ( 4.6A)
None
None
 0.83A 5jsdA-4dwsA:
undetectable		 5jsdA-4dwsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4dws CHI2
(Yersinia
entomophaga) 		3 / 3 THR A 132
SER A 130
TYR A 113
 MLZ  A 518 ( 4.6A)
None
None
 0.84A 5jsdB-4dwsA:
undetectable		 5jsdB-4dwsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4dws CHI2
(Yersinia
entomophaga) 		3 / 3 THR A 132
SER A 130
TYR A 113
 MLZ  A 518 ( 4.6A)
None
None
 0.84A 5jsdC-4dwsA:
undetectable		 5jsdC-4dwsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4dws CHI2
(Yersinia
entomophaga) 		3 / 3 THR A 132
SER A 130
TYR A 113
 MLZ  A 518 ( 4.6A)
None
None
 0.87A 5jseA-4dwsA:
undetectable		 5jseA-4dwsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4dws CHI2
(Yersinia
entomophaga) 		3 / 3 THR A 132
SER A 130
TYR A 113
 MLZ  A 518 ( 4.6A)
None
None
 0.85A 5jseB-4dwsA:
undetectable		 5jseB-4dwsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4dws CHI2
(Yersinia
entomophaga) 		3 / 3 THR A 132
SER A 130
TYR A 113
 MLZ  A 518 ( 4.6A)
None
None
 0.85A 5jseC-4dwsA:
undetectable		 5jseC-4dwsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.04A 5kklB-2g46A:
8.3		 5kklB-2g46A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2qnu UNCHARACTERIZED
PROTEIN PA0076
(Pseudomonas
aeruginosa) 		3 / 3 TYR A  86
SER A  79
TRP A  48
 None
MLZ  A   9 ( 2.6A)
None
 1.07A 5n8jB-2qnuA:
undetectable		 5n8jB-2qnuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.11A 5t0kA-2g46A:
7.5		 5t0kA-2g46A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.07A 5t0mB-2g46A:
7.4		 5t0mB-2g46A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 10 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.08A 5tqrB-2g46A:
6.4		 5tqrB-2g46A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 10 TYR A  16
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 SAH  A 301 (-4.7A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 0.90A 5tqrB-2g46A:
6.4		 5tqrB-2g46A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.08A 5ttfA-2g46A:
7.8		 5ttfA-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.06A 5ttfB-2g46A:
7.5		 5ttfB-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.11A 5ttfD-2g46A:
8.8		 5ttfD-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.11A 5ttgA-2g46A:
8.6		 5ttgA-2g46A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.12A 5ttgB-2g46A:
8.5		 5ttgB-2g46A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.06A 5tuyA-2g46A:
7.4		 5tuyA-2g46A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.06A 5tuyB-2g46A:
8.8		 5tuyB-2g46A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.14A 5tuzB-2g46A:
8.5		 5tuzB-2g46A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.05A 5v9iA-2g46A:
7.5		 5v9iA-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.06A 5v9iB-2g46A:
7.5		 5v9iB-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.07A 5v9iC-2g46A:
7.7		 5v9iC-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.10A 5vscB-2g46A:
8.6		 5vscB-2g46A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.11A 5vsdB-2g46A:
8.6		 5vsdB-2g46A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.10A 5vseA-2g46A:
7.5		 5vseA-2g46A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.10A 5vseB-2g46A:
7.4		 5vseB-2g46A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
 1.11A 5vsfB-2g46A:
8.6		 5vsfB-2g46A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 5 LEU A  52
VAL A  78
GLU A  77
LEU A  74
 None
None
None
MLZ  A  71 ( 4.2A)
 0.98A 5xooB-4d1eA:
undetectable		 5xooB-4d1eA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.91A 5zcpA-1iv8A:
0.0
5zcpJ-1iv8A:
0.0		 5zcpA-1iv8A:
20.68
5zcpJ-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 7 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.92A 5zcqA-1iv8A:
0.0
5zcqJ-1iv8A:
undetectable		 5zcqA-1iv8A:
20.68
5zcqJ-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5fq2 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 LEU B 506
VAL B 480
LEU B 490
ILE B 491
 MLZ  B 505 ( 4.2A)
None
None
None
 0.84A 6cb4A-5fq2B:
undetectable		 6cb4A-5fq2B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 VAL A 614
LEU A 565
PHE A 561
GLY A 534
PHE A 528
 None
MLZ  A 562 ( 4.2A)
MLZ  A 562 ( 4.5A)
None
None
 1.12A 6drzA-4d1eA:
3.2		 6drzA-4d1eA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASP A 596
GLU A 517
ASP A 394
GLU A 393
 MLZ  A 513 ( 4.9A)
MLY  A 390 ( 3.7A)
MLY  A 390 ( 3.8A)
None
 1.17A 6mn4C-1iv8A:
undetectable		 6mn4C-1iv8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 365
ARG A 551
GLU A 549
CYH A 554
 None
None
MLZ  A  20 ( 4.2A)
MLZ  A  20 ( 4.1A)
 1.45A 6mn5D-3f70A:
undetectable		 6mn5D-3f70A:
13.12