SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MLG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 6 VAL A  93
SER A 209
LEU A 176
ILE A 207
LEU A  97
 None
None
None
None
MLG  A 709 ( 4.9A)
 1.45A 3kk6A-1o5wA:
undetectable		 3kk6A-1o5wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 6 VAL A  93
SER A 209
LEU A 176
ILE A 207
LEU A  97
 None
None
None
None
MLG  A 709 ( 4.9A)
 1.31A 3kk6B-1o5wA:
undetectable		 3kk6B-1o5wA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 8 TYR A  69
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 652 (-4.3A)
MLG  A 709 (-3.8A)
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.74A 3po7A-1o5wA:
61.3		 3po7A-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PO7_B_ZONB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		6 / 9 TYR A  69
ILE A 207
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 652 (-4.3A)
None
MLG  A 709 (-3.8A)
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.66A 3po7B-1o5wA:
61.6		 3po7B-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		7 / 12 PRO A 113
TRP A 128
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.76A 4a79A-1o5wA:
60.8		 4a79A-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		7 / 12 PRO A 113
TRP A 128
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.78A 4a79B-1o5wA:
61.0		 4a79B-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		6 / 11 TYR A  69
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 FAD  A 652 (-4.3A)
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.66A 4a7aA-1o5wA:
60.9		 4a7aA-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		7 / 12 PRO A 113
LEU A 176
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.84A 4a7aB-1o5wA:
61.2		 4a7aB-1o5wA:
70.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 6 TYR A 124
PRO A 114
PHE A 208
PHE A 108
 None
None
MLG  A 709 (-4.0A)
None
 1.30A 4kf9A-1o5wA:
0.0		 4kf9A-1o5wA:
20.11