SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MJ8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN
(Geobacillus
sp.
Y4.1MC1) 		5 / 11 TYR A 607
VAL A 623
PRO A 624
ILE A 662
ILE A 657
 None
None
None
None
MJ8  A1601 (-4.7A)
 1.49A 3ganA-5u89A:
undetectable		 3ganA-5u89A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN
(Geobacillus
sp.
Y4.1MC1) 		4 / 6 GLY A 725
GLY A 724
ASN A 745
ILE A 657
 MJ8  A1601 (-3.7A)
MJ8  A1601 ( 4.5A)
MJ8  A1601 (-3.5A)
MJ8  A1601 (-4.7A)
 0.74A 4fglD-5u89A:
undetectable		 4fglD-5u89A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN
(Geobacillus
sp.
Y4.1MC1) 		5 / 7 ASP A 656
ILE A 657
GLY A 725
THR A 750
TRP A 755
 MJ8  A1601 (-2.7A)
MJ8  A1601 (-4.7A)
MJ8  A1601 (-3.7A)
MJ8  A1601 ( 4.6A)
None
 0.69A 4zxiA-5u89A:
41.6		 4zxiA-5u89A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN
(Geobacillus
sp.
Y4.1MC1) 		5 / 12 LEU A1000
GLY A 861
ASP A 925
PHE A 992
VAL A 980
 None
MJ8  A1601 ( 4.7A)
None
None
None
 1.42A 5d0yA-5u89A:
undetectable		 5d0yA-5u89A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN
(Geobacillus
sp.
Y4.1MC1) 		4 / 5 SER A 846
TYR A 747
SER A 730
ASP A 848
 None
MJ8  A1601 (-4.7A)
None
None
 1.40A 5fhrA-5u89A:
undetectable		 5fhrA-5u89A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN
(Geobacillus
sp.
Y4.1MC1) 		4 / 6 MET A 698
ASN A 745
VAL A 743
LEU A 719
 None
MJ8  A1601 (-3.5A)
None
None
 1.34A 5xdhA-5u89A:
undetectable
5xdhC-5u89A:
undetectable		 5xdhA-5u89A:
6.18
5xdhC-5u89A:
6.18