SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MIS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 8 THR A 323
ASN A 264
ASP A 379
GLY A 266
 MIS  A 324 ( 3.9A)
MIS  A 324 ( 3.0A)
CA  A1001 (-3.5A)
None
 0.99A 1bu5B-2z2xA:
2.1		 1bu5B-2z2xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 11 PHE X 114
GLY X  36
THR X 260
ASP X 332
ILE X  39
 None
MIS  X  77 ( 3.4A)
None
None
None
 1.16A 1phgA-4pkaX:
undetectable		 1phgA-4pkaX:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 10 GLY X 261
ILE X  34
GLY X  38
ILE X  39
ALA X  45
 None
None
MIS  X  77 ( 3.4A)
None
None
 1.00A 1sh9B-4pkaX:
undetectable		 1sh9B-4pkaX:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 THR X 187
ILE X  73
ILE X 152
THR X 148
PHE X  70
 MIS  X  77 ( 3.0A)
None
None
None
None
 1.43A 1vq1A-4pkaX:
2.0		 1vq1A-4pkaX:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 7 ALA X 190
TYR X 193
TYR X 106
PHE X 114
 MIS  X  77 ( 3.5A)
MIS  X  77 ( 4.9A)
None
None
 0.98A 2ajvH-4pkaX:
undetectable
2ajvL-4pkaX:
undetectable		 2ajvH-4pkaX:
21.51
2ajvL-4pkaX:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 SER X 153
MET X 253
ILE X 245
PHE X 307
ASP X  35
 MIS  X  77 ( 4.7A)
None
None
None
None
 1.36A 3aocC-4pkaX:
undetectable		 3aocC-4pkaX:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 11 ASN X 338
GLY X  37
ILE X  43
THR X 328
LEU X 324
 None
MIS  X  77 ( 3.5A)
None
None
None
 1.29A 3bf1E-4pkaX:
undetectable
3bf1F-4pkaX:
undetectable		 3bf1E-4pkaX:
20.31
3bf1F-4pkaX:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 4 THR X 148
VAL X 231
GLY X  75
THR X  76
 None
None
None
MIS  X  77 ( 3.8A)
 1.08A 3cflA-4pkaX:
undetectable		 3cflA-4pkaX:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 6 ALA X  84
LEU X  81
THR X  83
VAL X 150
 None
MIS  X  77 ( 4.0A)
None
None
 1.06A 3d2tB-4pkaX:
undetectable		 3d2tB-4pkaX:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 7 ALA X  84
LEU X  81
THR X  83
VAL X 150
 None
MIS  X  77 ( 4.0A)
None
None
 1.00A 3ozkB-4pkaX:
undetectable		 3ozkB-4pkaX:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 12 THR A 327
GLY A 283
GLY A 322
GLU A 265
ALA A 275
 MIS  A 324 ( 4.5A)
None
MIS  A 324 ( 3.2A)
None
None
 1.07A 3t7vA-2z2xA:
2.3		 3t7vA-2z2xA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 LYS A 325
VAL A 157
HIS A 156
 MIS  A 324 ( 3.2A)
MIS  A 324 ( 4.5A)
None
 0.97A 3tj7A-2z2xA:
undetectable		 3tj7A-2z2xA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 GLY X  80
TYR X 185
ILE X  34
ILE X  73
SER X  33
 MIS  X  77 ( 3.2A)
None
None
None
None
 1.30A 4xudA-4pkaX:
undetectable		 4xudA-4pkaX:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 ALA X 222
GLY X  79
GLY X  36
GLY X 259
ALA X 188
 None
MIS  X  77 ( 4.1A)
MIS  X  77 ( 3.4A)
None
MIS  X  77 ( 3.4A)
 1.01A 5c0oE-4pkaX:
undetectable		 5c0oE-4pkaX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		3 / 3 THR X  76
THR X 187
PHE X 155
 MIS  X  77 ( 3.8A)
MIS  X  77 ( 3.0A)
None
 0.76A 5cxvA-4pkaX:
undetectable		 5cxvA-4pkaX:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 8 SER A 271
GLY A 283
ALA A 274
THR A 323
 None
None
None
MIS  A 324 ( 3.9A)
 0.98A 5ef3L-2z2xA:
undetectable
5ef3V-2z2xA:
undetectable		 5ef3L-2z2xA:
14.34
5ef3V-2z2xA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 ILE X 102
ALA X 189
ALA X 188
GLY X 127
TYR X 129
 None
None
MIS  X  77 ( 3.4A)
None
None
 0.83A 5igpA-4pkaX:
undetectable		 5igpA-4pkaX:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 ILE X 102
ALA X 189
ALA X 188
GLY X 127
TYR X 129
 None
None
MIS  X  77 ( 3.4A)
None
None
 0.85A 5igtA-4pkaX:
undetectable		 5igtA-4pkaX:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		6 / 12 GLY X  38
PHE X 194
VAL X 133
THR X  83
GLY X  80
GLY X  79
 MIS  X  77 ( 3.4A)
MIS  X  77 ( 4.6A)
None
None
MIS  X  77 ( 3.2A)
MIS  X  77 ( 4.1A)
 1.29A 5koxA-4pkaX:
undetectable		 5koxA-4pkaX:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 9 ILE A 248
LEU A 244
ILE A 200
ILE A 231
ALA A 261
 None
None
None
None
MIS  A 324 ( 3.7A)
 0.95A 5nunA-2z2xA:
undetectable		 5nunA-2z2xA:
13.89