SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MHO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 GLY B 346
GLY B 383
GLU B 214
ALA B 351
HIS B 380
 None
None
None
None
MHO  A 499 ( 4.6A)
 0.96A 2fk8A-3sqgB:
undetectable		 2fk8A-3sqgB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A  94
GLY A  99
ALA A 100
ASP A 101
ILE A  69
 None
None
None
MHO  A   1 ( 3.2A)
None
 0.84A 2hs2A-4xkyA:
undetectable		 2hs2A-4xkyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A  94
GLY A  99
ALA A 100
ASP A 101
ILE A  69
 None
None
None
MHO  A   1 ( 3.2A)
None
 0.87A 2ieoA-4xkyA:
undetectable		 2ieoA-4xkyA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A  94
GLY A  99
ALA A 100
ASP A 101
ILE A  69
 None
None
None
MHO  A   1 ( 3.2A)
None
 0.81A 2nnkA-4xkyA:
undetectable		 2nnkA-4xkyA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A  94
GLY A  99
ALA A 100
ASP A 101
ILE A  69
 None
None
None
MHO  A   1 ( 3.2A)
None
 0.77A 2pymA-4xkyA:
undetectable		 2pymA-4xkyA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 7 LEU A 174
VAL A 177
THR A 178
VAL A 479
 None
MHO  A 181 ( 4.5A)
None
None
 0.88A 2qblA-2iqfA:
undetectable		 2qblA-2iqfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		3 / 3 THR A 183
SER A 162
LYS A 123
 None
MHO  A 122 ( 3.5A)
MHO  A 122 ( 3.5A)
 0.83A 3aocC-1nlrA:
undetectable		 3aocC-1nlrA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A  94
GLY A  99
ALA A 100
ASP A 101
ILE A  69
 None
None
None
MHO  A   1 ( 3.2A)
None
 0.90A 3ektA-4xkyA:
undetectable		 3ektA-4xkyA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A  94
GLY A  99
ALA A 100
ASP A 101
ILE A  69
 None
None
None
MHO  A   1 ( 3.2A)
None
 0.88A 3gguB-4xkyA:
undetectable		 3gguB-4xkyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 7 VAL A  68
VAL A 294
LEU A 260
SER A 261
TRP A 124
 None
MHO  A 292 ( 4.5A)
None
MHO  A 292 ( 3.9A)
None
 1.18A 3hs6B-2iqfA:
undetectable		 3hs6B-2iqfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 7 TRP A 179
PRO A 132
LEU A 291
ILE A 283
 None
None
MHO  A 292 ( 4.1A)
None
 1.04A 3u5jA-2iqfA:
undetectable		 3u5jA-2iqfA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A  94
GLY A  99
ALA A 100
ASP A 101
ILE A  69
 None
None
None
MHO  A   1 ( 3.2A)
None
 0.98A 4dqbB-4xkyA:
undetectable		 4dqbB-4xkyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A  94
GLY A  99
ALA A 100
ASP A 101
ILE A  69
 None
None
None
MHO  A   1 ( 3.2A)
None
 0.94A 4dqcB-4xkyA:
undetectable		 4dqcB-4xkyA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1up2 CELA1 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 371
PHE A 366
ALA A 107
ALA A 122
 None
None
None
MHO  A 105 ( 3.6A)
 0.94A 4du2A-1up2A:
undetectable		 4du2A-1up2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 5 PRO A 110
ASP A 109
ILE A 146
VAL A 163
 None
None
None
MHO  A 162 ( 3.4A)
 1.45A 4hytA-2iqfA:
undetectable		 4hytA-2iqfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 SER A 102
ASN A 100
GLN A  30
ASN A  21
GLN A  20
 MHO  A 122 ( 4.1A)
MHO  A 122 ( 4.7A)
None
None
None
 1.31A 4kukA-1nlrA:
undetectable		 4kukA-1nlrA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LYS A   2
SER A 187
PHE A 134
ASP A 101
 MHO  A   1 ( 3.0A)
None
None
MHO  A   1 ( 3.2A)
 1.21A 4ndnA-4xkyA:
undetectable		 4ndnA-4xkyA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 12 ILE A  80
LEU A 126
SER A 261
ILE A 262
LEU A 203
 None
None
MHO  A 292 ( 3.9A)
MHO  A 292 ( 4.5A)
None
 1.08A 4qi9A-2iqfA:
undetectable		 4qi9A-2iqfA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 11 ILE A  80
LEU A 126
SER A 261
ILE A 262
LEU A 203
 None
None
MHO  A 292 ( 3.9A)
MHO  A 292 ( 4.5A)
None
 1.02A 4qleB-2iqfA:
undetectable		 4qleB-2iqfA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		6 / 12 ALA A 200
SER A 102
GLY A  92
PHE A  39
GLN A  30
PRO A  58
 None
MHO  A 122 ( 4.1A)
None
None
None
None
 1.38A 4uilH-1nlrA:
undetectable
4uilL-1nlrA:
undetectable		 4uilH-1nlrA:
23.37
4uilL-1nlrA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 6 GLU A  40
GLY A 167
ASP A 168
GLY A 114
 MHO  A  10 ( 4.7A)
None
None
FMN  A 201 (-3.6A)
 0.95A 5cdpA-5f12A:
undetectable
5cdpB-5f12A:
3.6		 5cdpA-5f12A:
16.15
5cdpB-5f12A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2iqf CATALASE
(Helicobacter
pylori) 		5 / 12 ILE A  80
LEU A 126
SER A 261
ILE A 262
LEU A 203
 None
None
MHO  A 292 ( 3.9A)
MHO  A 292 ( 4.5A)
None
 1.08A 5hi6A-2iqfA:
undetectable		 5hi6A-2iqfA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2iqf CATALASE
(Helicobacter
pylori) 		4 / 7 GLN A 263
VAL A 264
ILE A  72
THR A  76
 None
MHO  A 292 ( 4.8A)
None
None
 0.90A 6cduF-2iqfA:
undetectable
6cduG-2iqfA:
undetectable		 6cduF-2iqfA:
20.32
6cduG-2iqfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		3 / 3 LEU A 188
ASP A 104
ILE A 123
 None
MHO  A 122 ( 3.8A)
MHO  A 122 ( 4.0A)
 0.60A 6dh0B-1nlrA:
undetectable		 6dh0B-1nlrA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2iqf CATALASE
(Helicobacter
pylori) 		3 / 3 GLN A 353
TYR A 376
ASN A 374
 MHO  A 372 ( 4.7A)
None
None
 1.05A 6dwdC-2iqfA:
undetectable		 6dwdC-2iqfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4xky DIHYDRODIPICOLINATE
SYNTHASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LYS A   2
SER A 187
PHE A 134
ASP A 101
 MHO  A   1 ( 3.0A)
None
None
MHO  A   1 ( 3.2A)
 1.18A 6fbnB-4xkyA:
undetectable		 6fbnB-4xkyA:
23.17