SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MHA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 HIS A  63
HIS A 188
HIS A 244
ASP A 322
 None
None
MHA  A 601 (-3.8A)
MHA  A 601 (-2.0A)
 0.68A 1e9yB-4gz7A:
21.1		 1e9yB-4gz7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 6 HIS A  63
HIS A  65
HIS A 188
HIS A 244
ASP A 322
 None
MHA  A 601 (-3.8A)
None
MHA  A 601 (-3.8A)
MHA  A 601 (-2.0A)
 0.67A 1fweC-4gz7A:
21.9		 1fweC-4gz7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 7 GLY A  84
SER A 349
SER A 347
ARG A  53
 MHA  A 403 (-3.2A)
MHA  A 403 ( 4.6A)
MHA  A 403 (-2.8A)
MHA  A 403 (-3.1A)
 1.09A 2c8aD-5hxzA:
undetectable		 2c8aD-5hxzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		4 / 8 HIS A 324
SER A 349
ARG A 220
ALA A 351
 None
MHA  A 403 ( 4.6A)
None
None
 1.28A 2rk8A-5hxzA:
undetectable		 2rk8A-5hxzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		3 / 3 LEU A 297
MET A 293
MET A 202
 None
MHA  A 601 (-4.3A)
None
 1.03A 2vavF-4gz7A:
undetectable		 2vavF-4gz7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 6 CYH A 324
THR A 325
ASN A 323
ASP A 322
 MHA  A 601 ( 4.1A)
None
None
MHA  A 601 (-2.0A)
 1.41A 3w9tB-4gz7A:
undetectable		 3w9tB-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 HIS A  63
HIS A 188
HIS A 244
ASP A 322
 None
None
MHA  A 601 (-3.8A)
MHA  A 601 (-2.0A)
 0.59A 4h9mA-4gz7A:
22.8		 4h9mA-4gz7A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		3 / 3 TYR A 160
HIS A 213
ARG A 217
 MHA  A 602 (-4.0A)
MHA  A 603 (-3.1A)
MHA  A 603 (-4.0A)
 0.98A 4htfA-4gz7A:
undetectable		 4htfA-4gz7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 6 HIS A  63
HIS A  65
HIS A 188
HIS A 244
ASP A 322
 None
MHA  A 601 (-3.8A)
None
MHA  A 601 (-3.8A)
MHA  A 601 (-2.0A)
 0.63A 4ubpC-4gz7A:
21.9		 4ubpC-4gz7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5hxz BARBITURASE
(Rhodococcus
erythropolis) 		6 / 12 ILE A 201
LEU A 123
LEU A 199
GLY A 195
ASN A 194
ILE A 134
 None
None
None
None
MHA  A 403 (-2.7A)
None
 1.42A 6qxsB-5hxzA:
undetectable		 6qxsB-5hxzA:
21.20