SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MGN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
(Methanothermobac
ter
marburgensis) 		4 / 5 HIS A 486
GLU A 489
ALA A 407
HIS A 397
 DYA  A 452 ( 3.9A)
None
None
MGN  A 402 ( 4.7A)
 1.42A 1errA-5a8rA:
undetectable
1errB-5a8rA:
undetectable		 1errA-5a8rA:
18.67
1errB-5a8rA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1mro METHYL-COENZYME M
REDUCTASE
(Methanothermobac
ter
marburgensis) 		4 / 8 SER C 159
PHE A 396
LEU A  64
LEU A  69
 None
MGN  A 400 (-4.2A)
None
None
 0.91A 2bfpC-1mroC:
undetectable		 2bfpC-1mroC:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 SER C 162
PHE A 398
LEU A  67
LEU A  72
 None
MGN  A 402 (-4.2A)
None
None
 0.92A 2bfpD-5a8rC:
undetectable		 2bfpD-5a8rC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1mro METHYL-COENZYME M
REDUCTASE
(Methanothermobac
ter
marburgensis) 		4 / 8 GLY A 483
THR A 335
ALA A 336
ALA A 337
 None
None
MGN  A 400 ( 3.6A)
None
 0.56A 2ej3A-1mroA:
undetectable		 2ej3A-1mroA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
(Methanothermobac
ter
marburgensis) 		4 / 8 GLY A 485
THR A 337
ALA A 338
ALA A 339
 None
None
MGN  A 402 ( 3.7A)
None
 0.58A 2ej3A-5a8rA:
undetectable		 2ej3A-5a8rA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1mro METHYL-COENZYME M
REDUCTASE
(Methanothermobac
ter
marburgensis) 		5 / 10 GLY A 483
GLU A 487
THR A 335
ALA A 336
ALA A 337
 None
None
None
MGN  A 400 ( 3.6A)
None
 1.03A 2ej3B-1mroA:
undetectable		 2ej3B-1mroA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
(Methanothermobac
ter
marburgensis) 		5 / 10 GLY A 485
GLU A 489
THR A 337
ALA A 338
ALA A 339
 None
None
None
MGN  A 402 ( 3.7A)
None
 1.03A 2ej3B-5a8rA:
undetectable		 2ej3B-5a8rA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1mro METHYL-COENZYME M
REDUCTASE
(Methanothermobac
ter
marburgensis) 		5 / 8 GLY A 483
GLU A 487
THR A 335
ALA A 336
ALA A 337
 None
None
None
MGN  A 400 ( 3.6A)
None
 1.03A 2ej3C-1mroA:
undetectable		 2ej3C-1mroA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
(Methanothermobac
ter
marburgensis) 		5 / 12 GLN A 433
PHE A 445
GLY A 400
ALA A 404
GLY A 485
 DYA  A 452 ( 3.9A)
GL3  A 447 (-3.9A)
MGN  A 402 ( 4.2A)
None
None
 1.17A 3tegA-5a8rA:
3.9		 3tegA-5a8rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		5 / 12 GLN A 433
PHE A 445
GLY A 400
ALA A 404
GLY A 485
 TRX  A 429 ( 4.3A)
GL3  A 447 (-4.1A)
MGN  A 402 ( 4.4A)
None
TRX  A 429 ( 4.5A)
 1.14A 3tegA-5n28A:
4.0		 3tegA-5n28A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
(Methanothermobac
ter
marburgensis) 		4 / 8 SER A 401
TYR A 477
ARG A 473
GLY A 455
 MGN  A 402 ( 4.4A)
None
None
SMC  A 454 ( 2.4A)
 1.06A 4fgzA-5a8rA:
undetectable
4fgzB-5a8rA:
undetectable		 4fgzA-5a8rA:
17.81
4fgzB-5a8rA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1mro METHYL-COENZYME M
REDUCTASE
METHYL-COENZYME M
REDUCTASE
(Methanothermobac
ter
marburgensis;
Methanothermobac
ter
marburgensis) 		5 / 12 GLN A 395
GLY A 397
PHE A 346
THR A 378
HIS C 158
 MGN  A 400 ( 4.8A)
MGN  A 400 (-3.6A)
None
None
None
 1.46A 5d0yA-1mroA:
1.4		 5d0yA-1mroA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
(Methanothermobac
ter
marburgensis) 		4 / 6 LEU A   8
PHE A   7
ASP A 343
HIS A 397
 None
None
None
MGN  A 402 ( 4.7A)
 1.02A 5om3A-5a8rA:
undetectable
5om3B-5a8rA:
undetectable		 5om3A-5a8rA:
10.26
5om3B-5a8rA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanotorris
formicicus) 		4 / 6 LEU A   9
PHE A   8
ASP A 343
HIS A 397
 None
None
None
MGN  A 402 ( 4.7A)
 1.08A 5om3A-5n28A:
undetectable
5om3B-5n28A:
undetectable		 5om3A-5n28A:
9.24
5om3B-5n28A:
5.12