SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MGF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BLV_A_SAMA1281_1 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	4nv0	7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE (Drosophila melanogaster)	4 / 6	SER A 171 GLU A 103 ASP A 270 ASP A 57	MGF A 404 (-2.7A) MG7 A 403 (-2.8A) None MG7 A 403 (-3.9A)	1.08A	4blvA-4nv0A: 2.4	4blvA-4nv0A: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EOH_A_TEPA402_1 (PYRIDOXAL KINASE)	5mpm	SARCOPLASMIC/ENDOPLA SMIC RETICULUM CALCIUM ATPASE 2 (Sus scrofa)	4 / 5	SER A 350 GLY A 701 THR A 357 ASP A 706	None None None MGF A1001 ( 4.0A)	1.12A	4eohA-5mpmA: undetectable	4eohA-5mpmA: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LOG_A_LDPA1004_1 (PUTATIVE O-METHYLTRANSFERASE)	4bev	COPPER EFFLUX ATPASE (Legionella pneumophila)	4 / 6	ASP A 426 LYS A 605 ASP A 628 ASN A 627	MGF A 950 ( 2.0A) MGF A 950 (-3.5A) MGF A 950 ( 4.2A) MGF A 950 (-3.2A)	1.42A	5logA-4bevA: 2.9	5logA-4bevA: 16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W97_C_CHDC302_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	3jbz	SERINE/THREONINE-PRO TEIN KINASE MTOR (Homo sapiens)	4 / 7	LEU A2302 HIS A2340 ASP A2244 THR A2245	None MGF A2604 (-3.9A) None ADP A2601 (-4.1A)	1.21A	5w97C-3jbzA: 3.2 5w97a-3jbzA: undetectable 5w97c-3jbzA: 3.2	5w97C-3jbzA: 12.77 5w97a-3jbzA: 17.21 5w97c-3jbzA: 12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WAU_C_CHDC303_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	3jbz	SERINE/THREONINE-PRO TEIN KINASE MTOR (Homo sapiens)	4 / 7	LEU A2302 HIS A2340 ASP A2244 THR A2245	None MGF A2604 (-3.9A) None ADP A2601 (-4.1A)	1.21A	5wauC-3jbzA: 3.2 5waua-3jbzA: 2.3 5wauc-3jbzA: 3.2	5wauC-3jbzA: 12.77 5waua-3jbzA: 17.21 5wauc-3jbzA: 12.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4BLV_A_SAMA1281_1","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","4nv0","7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE","Drosophila melanogaster",4,"SER A 171;GLU A 103;ASP A 270;ASP A  57","MGF A 404 (-2.7A);MG7 A 403 (-2.8A);None;MG7 A 403 (-3.9A)","1.08A","4blvA-4nv0A:2.4",null],["4EOH_A_TEPA402_1","PYRIDOXAL KINASE","5mpm","SARCOPLASMIC\/ENDOPLASMIC RETICULUM CALCIUM ATPASE 2","Sus scrofa",4,"SER A 350;GLY A 701;THR A 357;ASP A 706","None;None;None;MGF A1001 ( 4.0A)","1.12A","4eohA-5mpmA:undetectable","4blvA-4nv0A:20.67"],["5LOG_A_LDPA1004_1","PUTATIVE O-METHYLTRANSFERASE","4bev","COPPER EFFLUX ATPASE","Legionella pneumophila",4,"ASP A 426;LYS A 605;ASP A 628;ASN A 627","MGF A 950 ( 2.0A);MGF A 950 (-3.5A);MGF A 950 ( 4.2A);MGF A 950 (-3.2A)","1.42A","5logA-4bevA:2.9","4eohA-5mpmA:16.79"],["5W97_C_CHDC302_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","3jbz","SERINE\/THREONINE-PROTEIN KINASE MTOR","Homo sapiens",4,"LEU A2302;HIS A2340;ASP A2244;THR A2245","None;MGF A2604 (-3.9A);None;ADP A2601 (-4.1A)","1.21A","5w97C-3jbzA:3.2;5w97a-3jbzA:undetectable;5w97c-3jbzA:3.2","5logA-4bevA:16.03"],["5WAU_C_CHDC303_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","3jbz","SERINE\/THREONINE-PROTEIN KINASE MTOR","Homo sapiens",4,"LEU A2302;HIS A2340;ASP A2244;THR A2245","None;MGF A2604 (-3.9A);None;ADP A2601 (-4.1A)","1.21A","5wauC-3jbzA:3.2;5waua-3jbzA:2.3;5wauc-3jbzA:3.2","5w97C-3jbzA:12.77;5w97a-3jbzA:17.21;5w97c-3jbzA:12.77"]]