SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MGD'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AEG_A_4APA296_1 (CYTOCHROME C PEROXIDASE)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	4 / 8	GLY A 248 THR A 424 GLY A 251 LEU A 434	MGD  A1003 (-3.8A) MGD  A1003 ( 4.9A) None None	0.81A	1aegA-5chcA: undetectable	1aegA-5chcA: 16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AJ6_A_NOVA1_1 (GYRASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 9	GLU A 116 ARG A 467 ILE A 443 PRO A 461 THR A 497	None MGD  A 811 ( 4.0A) MGD  A 811 (-3.9A) MGD  A 811 (-4.2A) None	1.38A	1aj6A-2jirA: undetectable	1aj6A-2jirA: 16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4F_D_ADND604_2 (S-ADENOSYLHOMOCYSTEI NE HYDROLASE)	1h0h	FORMATE DEHYDROGENASE SUBUNIT ALPHA FORMATE DEHYDROGENASE SUBUNIT BETA (Desulfovibrio gigas)	4 / 5	THR B  12 GLU A 197 HIS A 199 HIS A 218	SF4  B1011 (-4.3A) None MGD  A1002 ( 4.5A) None	1.37A	1d4fD-1h0hB: undetectable	1d4fD-1h0hB: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ESW_A_ACRA652_1 (AMYLOMALTASE)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	4 / 6	GLY A 248 ASP A 250 GLY A 201 SER A 430	MGD  A1003 (-3.8A) MGD  A1003 (-2.8A) MGD  A1003 (-3.4A) None	0.91A	1eswA-5chcA: undetectable	1eswA-5chcA: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_G_TRPG81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	4 / 7	HIS A 181 THR A 208 THR A 210 ILE A 172	MGD  A 812 ( 4.6A) MGD  A 812 ( 4.5A) None None	0.95A	1gtnF-2jirA: undetectable 1gtnG-2jirA: undetectable	1gtnF-2jirA: 7.68 1gtnG-2jirA: 7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_K_TRPK81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	4 / 7	HIS A 181 THR A 208 THR A 210 ILE A 172	MGD  A 812 ( 4.6A) MGD  A 812 ( 4.5A) None None	0.96A	1gtnJ-2jirA: undetectable 1gtnK-2jirA: undetectable	1gtnJ-2jirA: 7.68 1gtnK-2jirA: 7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_O_TRPO81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	5 / 10	GLY A  30 THR A 580 THR A  23 SER A 563 ALA A 173	F3S  A2005 (-4.1A) None None None MGD  A2001 ( 4.7A)	1.36A	1gtnO-5nqdA: undetectable 1gtnP-5nqdA: undetectable	1gtnO-5nqdA: undetectable 1gtnP-5nqdA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_Q_TRPQ81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	5 / 9	GLY A  30 THR A 580 THR A  23 SER A 563 ALA A 173	F3S  A2005 (-4.1A) None None None MGD  A2001 ( 4.7A)	1.36A	1gtnQ-5nqdA: undetectable 1gtnR-5nqdA: undetectable	1gtnQ-5nqdA: undetectable 1gtnR-5nqdA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K6C_B_MK1B902_1 (POL POLYPROTEIN)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 10	LEU A 224 ASP A 221 GLY A 722 GLY A 721 THR A 269	None MGD  A 802 (-2.7A) None None None	1.09A	1k6cA-2e7zA: undetectable	1k6cA-2e7zA: 9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KYV_A_RBFA501_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	6cza	- (-)	5 / 12	GLY A 348 SER A 344 ILE A 354 ILE A 271 LEU A 279	None None None MGD  A 902 ( 4.6A) None	1.02A	1kyvA-6czaA: undetectable 1kyvE-6czaA: undetectable	1kyvA-6czaA: undetectable 1kyvE-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KYV_C_RBFC503_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	6cza	- (-)	5 / 12	ILE A 271 LEU A 279 GLY A 348 SER A 344 ILE A 354	MGD  A 902 ( 4.6A) None None None None	1.01A	1kyvB-6czaA: undetectable 1kyvC-6czaA: undetectable	1kyvB-6czaA: undetectable 1kyvC-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KYV_D_RBFD504_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	6cza	- (-)	5 / 12	ILE A 271 LEU A 279 GLY A 348 SER A 344 ILE A 354	MGD  A 902 ( 4.6A) None None None None	1.02A	1kyvC-6czaA: undetectable 1kyvD-6czaA: undetectable	1kyvC-6czaA: undetectable 1kyvD-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KYV_E_RBFE505_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	6cza	- (-)	5 / 12	ILE A 271 LEU A 279 GLY A 348 SER A 344 ILE A 354	MGD  A 902 ( 4.6A) None None None None	1.03A	1kyvD-6czaA: undetectable 1kyvE-6czaA: undetectable	1kyvD-6czaA: undetectable 1kyvE-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXG_A_ACRA443_1 (ALPHA AMYLASE)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	4 / 8	SER A 307 THR A 309 ASN A 419 GLU A 809	MGD  A2002 ( 3.9A) None None None	1.19A	1mxgA-5nqdA: undetectable	1mxgA-5nqdA: 9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N3Z_A_ADNA126_1 (RIBONUCLEASE, SEMINAL)	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	5 / 9	ALA A 759 ASN A 737 GLN A 440 ALA A 641 VAL A 639	None MGD  A1001 (-3.0A) MGD  A1001 (-4.3A) MGD  A1001 (-3.6A) None	1.47A	1n3zA-1eu1A: 0.0	1n3zA-1eu1A: 8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P93_A_DEXA1999_1 (GLUCOCORTICOID RECEPTOR)	2iv2	FORMATE DEHYDROGENASE H (Escherichia coli)	5 / 12	GLY X 334 GLN X 335 GLN X 463 THR X  36 ILE X 161	MGD  X 802 ( 3.3A) 2MD  X 801 (-3.2A) None None None	1.34A	1p93A-2iv2X: undetectable	1p93A-2iv2X: 17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q8J_A_C2FA801_0 (5-METHYLTETRAHYDROFO LATE S-HOMOCYSTEINE METHYLTRANSFERASE)	6cza	- (-)	5 / 12	ASN A 827 ASP A 722 ASP A 754 GLY A 824 ARG A 125	MGD  A 903 (-2.2A) MGD  A 903 ( 2.1A) None None None	1.45A	1q8jA-6czaA: undetectable	1q8jA-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_1 (SUN PROTEIN)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	3 / 3	PRO A 303 ASP A 306 ASP A 277	None MGD  A5002 (-3.0A) MGD  A5002 (-2.8A)	0.73A	1sqfA-1g8kA: 2.2	1sqfA-1g8kA: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_1 (SUN PROTEIN)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	3 / 3	PRO A 222 ASP A 225 ASP A 204	MGD  A 812 (-4.5A) MGD  A 812 (-3.4A) MGD  A 812 (-2.7A)	0.43A	1sqfA-2jirA: 2.5	1sqfA-2jirA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_1 (SUN PROTEIN)	6cza	- (-)	3 / 3	PRO A 273 ASP A 276 ASP A 255	MGD  A 902 (-4.0A) MGD  A 902 (-1.9A) MGD  A 902 (-2.3A)	0.81A	1sqfA-6czaA: undetectable	1sqfA-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T9W_A_NFNA6002_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 7	MET A 474 GLN A 470 ALA A 703 ARG A  94	None MGD  A1765 (-3.8A) None None	1.24A	1t9wA-2vpwA: undetectable	1t9wA-2vpwA: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WSV_A_THHA3001_1 (AMINOMETHYLTRANSFERA SE)	6cza	- (-)	3 / 3	ASP A 561 GLU A 730 TYR A 809	MGD  A 903 (-3.0A) MGD  A 902 ( 4.1A) MGD  A 903 (-4.1A)	0.84A	1wsvA-6czaA: undetectable	1wsvA-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZLQ_A_ACTA1502_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	4 / 5	TRP A 801 GLY A 304 ASN A 391 GLY A 682	None MGD  A5002 (-3.6A) None None	1.11A	1zlqA-1g8kA: 0.0	1zlqA-1g8kA: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A1M_B_CAMB2422_0 (CYTOCHROME P450-CAM)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B (Methanothermobac ter sp. CaT2)	4 / 8	THR B  92 VAL B  99 GLY B 100 ILE B 417	MGD  B 503 ( 4.9A) None None None	0.79A	2a1mB-5t5iB: undetectable	2a1mB-5t5iB: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_A_RBFA300_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	5 / 11	GLY A 308 SER A 307 LEU A 715 ILE A 380 ALA A 312	MGD  A2002 (-3.5A) MGD  A2002 ( 3.9A) None None None	1.43A	2a58A-5nqdA: 2.4 2a58E-5nqdA: 2.4	2a58A-5nqdA: 18.75 2a58E-5nqdA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_D_RBFD303_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	5 / 11	ILE A 380 ALA A 312 GLY A 308 SER A 307 LEU A 715	None None MGD  A2002 (-3.5A) MGD  A2002 ( 3.9A) None	1.43A	2a58C-5nqdA: 2.5 2a58D-5nqdA: undetectable	2a58C-5nqdA: 18.75 2a58D-5nqdA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BPX_B_MK1B902_2 (HIV-1 PROTEASE)	2iv2	FORMATE DEHYDROGENASE H (Escherichia coli)	5 / 12	GLY X 296 ASP X 202 VAL X 200 ILE X 206 VAL X 170	MGD  X 802 (-3.1A) MGD  X 802 (-2.7A) None MGD  X 802 (-4.1A) None	0.85A	2bpxB-2iv2X: undetectable	2bpxB-2iv2X: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_D_MIXD3539_2 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	3 / 3	VAL A 350 VAL A 327 ASP A 236	None None MGD  A1766 (-2.6A)	0.73A	2fumD-2vpwA: undetectable	2fumD-2vpwA: 17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IEN_B_017B402_1 (PROTEASE)	1h0h	FORMATE DEHYDROGENASE SUBUNIT ALPHA (Desulfovibrio gigas)	5 / 12	LEU A 189 GLY A 192 VAL A 403 ILE A 242 ILE A 367	None MGD  A1002 (-3.7A) None None None	0.90A	2ienA-1h0hA: undetectable	2ienA-1h0hA: 7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9C_C_ACTC1120_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B (Methanothermobac ter sp. CaT2)	3 / 3	LYS B  41 TYR B 291 PRO B  10	MGD  B 503 ( 3.3A) None None	1.41A	2j9cC-5t5iB: undetectable	2j9cC-5t5iB: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2O4S_A_AB1A400_1 (PROTEASE)	2iv2	FORMATE DEHYDROGENASE H (Escherichia coli)	5 / 12	GLY X 296 ASP X 202 VAL X 200 ILE X 206 VAL X 170	MGD  X 802 (-3.1A) MGD  X 802 (-2.7A) None MGD  X 802 (-4.1A) None	0.85A	2o4sA-2iv2X: undetectable	2o4sA-2iv2X: 9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PYN_A_1UNA1001_3 (PROTEASE RETROPEPSIN)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	3 / 3	ASP A  13 THR A  40 PRO A  41	MGD  A 802 (-3.2A) MPD  A1004 (-3.4A) MPD  A1004 ( 4.9A)	0.61A	2pynB-2e7zA: undetectable	2pynB-2e7zA: 8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q64_B_1UNB1001_4 (PROTEASE RETROPEPSIN)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	3 / 3	ASP A  13 THR A  40 PRO A  41	MGD  A 802 (-3.2A) MPD  A1004 (-3.4A) MPD  A1004 ( 4.9A)	0.53A	2q64B-2e7zA: undetectable	2q64B-2e7zA: 10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QAK_A_1UNA1001_4 (PROTEASE RETROPEPSIN)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	3 / 3	ASP A  13 THR A  40 PRO A  41	MGD  A 802 (-3.2A) MPD  A1004 (-3.4A) MPD  A1004 ( 4.9A)	0.61A	2qakB-2e7zA: undetectable	2qakB-2e7zA: 10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD2_A_CHDA2_0 (FERROCHELATASE)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	4 / 8	MET A 189 LEU A 381 SER A 216 VAL A 212	None None MGD  A1804 (-2.3A) None	1.00A	2qd2A-1ogyA: 0.3	2qd2A-1ogyA: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD5_A_CHDA701_0 (FERROCHELATASE)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	4 / 8	MET A 189 LEU A 381 SER A 216 VAL A 212	None None MGD  A1804 (-2.3A) None	0.99A	2qd5A-1ogyA: 1.7	2qd5A-1ogyA: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD5_B_CHDB1103_0 (FERROCHELATASE)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	4 / 8	MET A 189 LEU A 381 SER A 216 VAL A 212	None None MGD  A1804 (-2.3A) None	0.97A	2qd5B-1ogyA: 1.8	2qd5B-1ogyA: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA509_0 (CHORISMATE SYNTHASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	3 / 3	ARG A  14 GLN A 346 PRO A 347	MGD  A 811 (-4.2A) CYN  A 813 (-4.0A) None	0.99A	2qhfA-2jirA: undetectable	2qhfA-2jirA: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QO6_A_CHDA130_0 (LIVER-BASIC FATTY ACID BINDING PROTEIN)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	5 / 12	ILE A 421 LEU A 420 ALA A 165 VAL A 153 HIS A 472	None None None None MGD  A1765 (-4.7A)	1.33A	2qo6A-2vpwA: undetectable	2qo6A-2vpwA: 9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QX6_A_ML1A233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 6	ILE A 301 PHE A 310 TRP A 229 GLY A 232 GLY A 386	None None None MGD  A5002 (-3.2A) MGD  A5002 (-3.1A)	1.25A	2qx6A-1g8kA: undetectable 2qx6B-1g8kA: 2.5	2qx6A-1g8kA: 14.95 2qx6B-1g8kA: 14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UVN_A_ECNA1409_1 (CYTOCHROME P450 130)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	5 / 12	ASP A 644 PRO A  80 THR A 214 GLY A 211 THR A 241	None None MGD  A1766 (-4.1A) None None	1.22A	2uvnA-2vpwA: undetectable	2uvnA-2vpwA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XF3_A_J01A600_1 (ORF12)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 11	THR A 259 ALA A 542 GLY A 541 SER A 254 ARG A1218	MGD  A1246 (-2.9A) MGD  A1246 (-3.2A) MGD  A1246 (-3.0A) MGD  A1246 (-4.3A) MGD  A1246 ( 2.7A)	1.30A	2xf3A-3egwA: undetectable	2xf3A-3egwA: 17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XF3_B_J01B600_1 (ORF12)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 11	THR A 259 ALA A 542 GLY A 541 SER A 254 ARG A1218	MGD  A1246 (-2.9A) MGD  A1246 (-3.2A) MGD  A1246 (-3.0A) MGD  A1246 (-4.3A) MGD  A1246 ( 2.7A)	1.30A	2xf3B-3egwA: undetectable	2xf3B-3egwA: 17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XFS_A_J01A600_1 (ORF12)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 10	THR A 259 ALA A 542 GLY A 541 SER A 254 ARG A1218	MGD  A1246 (-2.9A) MGD  A1246 (-3.2A) MGD  A1246 (-3.0A) MGD  A1246 (-4.3A) MGD  A1246 ( 2.7A)	1.35A	2xfsA-3egwA: 0.0	2xfsA-3egwA: 17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XFS_B_J01B600_1 (ORF12)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 11	THR A 259 ALA A 542 GLY A 541 SER A 254 ARG A1218	MGD  A1246 (-2.9A) MGD  A1246 (-3.2A) MGD  A1246 (-3.0A) MGD  A1246 (-4.3A) MGD  A1246 ( 2.7A)	1.31A	2xfsB-3egwA: undetectable	2xfsB-3egwA: 17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_E_ACHE1211_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	4 / 7	ILE A 250 SER A 255 TYR A 261 CYH A 441	None MGD  A1986 (-4.6A) None None	1.39A	2xz5D-2ivfA: undetectable 2xz5E-2ivfA: undetectable	2xz5D-2ivfA: 12.53 2xz5E-2ivfA: 12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_C_SAMC530_1 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	6cza	- (-)	3 / 3	TYR A 809 GLU A 513 ASN A 827	MGD  A 903 (-4.1A) None MGD  A 903 (-2.2A)	0.97A	2y7hC-6czaA: undetectable	2y7hC-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7W_C_SALC1300_1 (LYSR-TYPE REGULATORY PROTEIN)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	4 / 7	THR A 548 ILE A 550 GLY A 551 HIS A 482	MGD  A2001 (-4.5A) None None None	0.85A	2y7wC-5nqdA: undetectable	2y7wC-5nqdA: 15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z9W_A_PXLA1197_1 (ASPARTATE AMINOTRANSFERASE)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT FWDD (Methanothermobac ter sp. CaT2; Methanothermobac ter wolfeii)	5 / 11	PRO B 186 LEU B 201 ASP B 206 SER B 259 ASN D   6	MGD  B 504 (-4.4A) None MGD  B 504 (-2.9A) MGD  B 504 (-3.7A) MGD  B 504 (-3.3A)	1.23A	2z9wA-5t5iB: 2.8	2z9wA-5t5iB: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z9W_B_PXLB1197_1 (ASPARTATE AMINOTRANSFERASE)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT FWDD (Methanothermobac ter sp. CaT2; Methanothermobac ter wolfeii)	5 / 11	PRO B 186 LEU B 201 ASP B 206 SER B 259 ASN D   6	MGD  B 504 (-4.4A) None MGD  B 504 (-2.9A) MGD  B 504 (-3.7A) MGD  B 504 (-3.3A)	1.23A	2z9wB-5t5iB: undetectable	2z9wB-5t5iB: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZBU_D_ADND504_1 (UNCHARACTERIZED CONSERVED PROTEIN)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	3 / 3	PHE A 758 ASN A 766 PHE A 782	MGD  A3001 (-3.9A) MGD  A3001 (-2.8A) MGD  A3001 (-3.6A)	0.72A	2zbuD-2nyaA: 2.9	2zbuD-2nyaA: 16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZBU_D_ADND504_1 (UNCHARACTERIZED CONSERVED PROTEIN)	6cza	- (-)	3 / 3	PHE A 802 ASN A 827 PHE A 843	MGD  A 903 (-3.7A) MGD  A 903 (-2.2A) MGD  A 903 (-4.2A)	0.97A	2zbuD-6czaA: undetectable	2zbuD-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZUL_A_SAMA376_0 (PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE)	6cza	- (-)	5 / 12	GLY A 805 GLY A 823 LEU A 783 ASN A 826 PHE A 486	None None None MGD  A 903 ( 4.6A) None	1.11A	2zulA-6czaA: undetectable	2zulA-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A27_A_SAMA250_1 (UNCHARACTERIZED PROTEIN MJ1557)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	3 / 3	MET A 126 GLU A 494 ASN A 114	None None MGD  A 801 (-3.2A)	0.90A	3a27A-2e7zA: undetectable	3a27A-2e7zA: 16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_P_CHDP1525_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 7	HIS A 292 ASP A 257 THR A 258 HIS A 602	None MGD  A1766 (-2.8A) None None	1.31A	3abmN-2vpwA: undetectable 3abmP-2vpwA: undetectable	3abmN-2vpwA: 19.97 3abmP-2vpwA: 13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG4_A_CUA517_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	3 / 3	HIS A1098 HIS A1092 HIS A1163	MD1  A1245 ( 3.5A) MGD  A1246 ( 3.7A) MD1  A1245 (-3.4A)	0.74A	3ag4A-3egwA: undetectable	3ag4A-3egwA: 16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG4_N_CUN517_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	3 / 3	HIS A1098 HIS A1092 HIS A1163	MD1  A1245 ( 3.5A) MGD  A1246 ( 3.7A) MD1  A1245 (-3.4A)	0.75A	3ag4N-3egwA: undetectable	3ag4N-3egwA: 16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_A_PM6A302_1 (THIOPURINE S-METHYLTRANSFERASE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	4 / 6	HIS A 237 PHE A 241 LEU A 445 LEU A 407	MGD  A1019 ( 4.5A) None None None	0.79A	3bgdA-1kqfA: 2.7	3bgdA-1kqfA: 12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_B_PM6B302_1 (THIOPURINE S-METHYLTRANSFERASE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	4 / 7	HIS A 237 PHE A 241 LEU A 445 LEU A 407	MGD  A1019 ( 4.5A) None None None	0.79A	3bgdB-1kqfA: 2.6	3bgdB-1kqfA: 12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E23_A_SAMA221_1 (UNCHARACTERIZED PROTEIN RPA2492)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	3 / 3	TYR A 797 ASP A 441 HIS A 195	MGD  A5001 (-3.8A) None MGD  A5001 (-4.5A)	0.91A	3e23A-1g8kA: undetectable	3e23A-1g8kA: 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E23_A_SAMA221_1 (UNCHARACTERIZED PROTEIN RPA2492)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	3 / 3	TYR A 815 ASP A 471 HIS A 199	MGD  A2001 (-3.4A) None MGD  A2001 (-4.5A)	0.89A	3e23A-5nqdA: undetectable	3e23A-5nqdA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G89_A_SAMA303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	6 / 12	PHE A 119 ASP A 483 ALA A 484 ARG A  69 ALA A 500 GLU A 504	None MGD  A1803 (-2.9A) MGD  A1803 ( 4.2A) None None None	1.49A	3g89A-1ogyA: 3.2	3g89A-1ogyA: 16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H52_A_486A3_1 (GLUCOCORTICOID RECEPTOR)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	MET A 141 ASN A 311 GLY A 309 LEU A 305 ILE A 323	CYN  A 813 (-4.5A) None MGD  A 812 (-3.2A) None None	1.21A	3h52A-2jirA: undetectable	3h52A-2jirA: 17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HAV_C_SRYC403_1 (AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 12	ASN A 545 ASP A 222 ASN A  52 SER A 719 ASN A1217	None 6MO  A1247 (-2.1A) MGD  A1246 ( 3.6A) MD1  A1245 (-3.0A) MD1  A1245 (-3.0A)	1.27A	3havC-3egwA: 1.2	3havC-3egwA: 12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HBB_C_TMQC613_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	3o5a	DIHEME CYTOCHROME C NAPB PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	6 / 11	VAL A 481 ILE B  12 MET A 458 LEU A 442 ILE A 479 THR A 487	None None None None None MGD  A1803 (-4.0A)	1.40A	3hbbC-3o5aA: undetectable	3hbbC-3o5aA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCN_B_CHDB1_0 (FERROCHELATASE, MITOCHONDRIAL)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 9	ARG A 260 PRO A 224 SER A 227 VAL A 578 GLY A 541	MGD  A1246 ( 3.7A) None None MGD  A1246 (-3.9A) MGD  A1246 (-3.0A)	1.49A	3hcnB-3egwA: 1.9	3hcnB-3egwA: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCO_A_CHDA4_0 (FERROCHELATASE, MITOCHONDRIAL)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 9	ARG A 260 PRO A 224 SER A 227 VAL A 578 GLY A 541	MGD  A1246 ( 3.7A) None None MGD  A1246 (-3.9A) MGD  A1246 (-3.0A)	1.43A	3hcoA-3egwA: 0.0	3hcoA-3egwA: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCO_B_CHDB924_0 (FERROCHELATASE, MITOCHONDRIAL)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 10	ARG A 260 PRO A 224 SER A 227 VAL A 578 GLY A 541	MGD  A1246 ( 3.7A) None None MGD  A1246 (-3.9A) MGD  A1246 (-3.0A)	1.45A	3hcoB-3egwA: 1.7	3hcoB-3egwA: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_D_MTXD164_2 (DIHYDROFOLATE REDUCTASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	3 / 3	ARG A 314 ILE A 197 THR A 204	None None MGD  A 802 (-4.2A)	0.72A	3ia4D-2e7zA: 1.1	3ia4D-2e7zA: 13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IB1_A_IMNA701_1 (LACTOTRANSFERRIN)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	4 / 4	PRO A 419 THR A 422 GLY A 345 THR A 344	None MGD  A 811 (-2.5A) MGD  A 812 (-3.1A) None	0.80A	3ib1A-2jirA: undetectable	3ib1A-2jirA: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JVY_B_017B401_2 (GAG-POL POLYPROTEIN)	2iv2	FORMATE DEHYDROGENASE H (Escherichia coli)	5 / 12	GLY X 296 ASP X 202 VAL X 200 ILE X 206 VAL X 170	MGD  X 802 (-3.1A) MGD  X 802 (-2.7A) None MGD  X 802 (-4.1A) None	0.89A	3jvyB-2iv2X: undetectable	3jvyB-2iv2X: 9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JWQ_B_VIAB901_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	5 / 11	ASN A 358 LEU A 381 ALA A 179 LEU A 329 THR A 345	None None None None MGD  A1804 (-3.7A)	1.46A	3jwqB-3o5aA: undetectable 3jwqC-3o5aA: undetectable	3jwqB-3o5aA: 17.08 3jwqC-3o5aA: 17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP2_A_PNNA5001_0 (TRANSCRIPTIONAL REGULATOR TCAR)	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	4 / 8	THR A 225 GLN A 712 SER A 642 ASN A 192	MGD  A1002 ( 4.6A) None MGD  A1002 (-4.2A) None	1.12A	3kp2A-1eu1A: 0.0 3kp2B-1eu1A: 0.0	3kp2A-1eu1A: 13.81 3kp2B-1eu1A: 13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LS4_H_TCIH220_1 (HEAVY CHAIN OF ANTIBODY FAB FRAGMENT)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	5 / 10	VAL A 233 VAL A 235 LEU A 415 GLY A 410 VAL A 445	None MGD  A2002 ( 4.8A) None None None	1.26A	3ls4H-5nqdA: undetectable	3ls4H-5nqdA: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LTW_A_HLZA302_1 (ARYLAMINE N-ACETYLTRANSFERASE NAT)	6cza	- (-)	4 / 6	LEU A 719 PRO A 256 ARG A 709 HIS A 846	None MGD  A 902 (-4.5A) None None	1.49A	3ltwA-6czaA: undetectable	3ltwA-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M6V_A_SAMA465_0 (RRNA METHYLASE)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	6 / 12	GLY A 541 GLY A 543 ASP A 263 ARG A 260 PRO A 257 LEU A 290	MGD  A1246 (-3.0A) MGD  A1246 (-3.5A) None MGD  A1246 ( 3.7A) None None	1.41A	3m6vA-3egwA: 2.9	3m6vA-3egwA: 17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M6V_B_SAMB465_0 (RRNA METHYLASE)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	6 / 12	GLY A 541 GLY A 543 ASP A 263 ARG A 260 PRO A 257 LEU A 290	MGD  A1246 (-3.0A) MGD  A1246 (-3.5A) None MGD  A1246 ( 3.7A) None None	1.43A	3m6vB-3egwA: undetectable	3m6vB-3egwA: 17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MEK_A_SAMA510_0 (SET AND MYND DOMAIN-CONTAINING PROTEIN 3)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	GLY A 980 ASN A 106 GLU A 979 ASN A 558 HIS A 975	None None None None MGD  A1019 (-4.8A)	1.49A	3mekA-1kqfA: undetectable	3mekA-1kqfA: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MIH_A_CUA358_0 (PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE)	6cza	- (-)	3 / 3	HIS A 526 HIS A 527 MET A 528	MGD  A 903 ( 4.0A) MGD  A 903 ( 3.8A) None	1.00A	3mihA-6czaA: undetectable	3mihA-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N3I_A_ROCA201_2 (PROTEASE)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B (Methanothermobac ter sp. CaT2)	4 / 6	PRO B 345 ASP B 414 ILE B 365 VAL B 101	None MGD  B 503 (-3.0A) MGD  B 503 (-4.9A) None	0.88A	3n3iA-5t5iB: undetectable	3n3iA-5t5iB: 17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDU_D_ROCD100_3 (PROTEASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	3 / 3	ARG A 617 VAL A 183 THR A  18	MGD  A 811 (-3.2A) SF4  A 800 (-4.2A) SF4  A 800 ( 3.8A)	0.81A	3nduD-2jirA: 2.4	3nduD-2jirA: 10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NJZ_A_SALA370_1 (GENTISATE 1,2-DIOXYGENASE)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	5 / 12	HIS A 194 HIS A 855 HIS A 849 ASP A 223 ILE A 217	MD1  A1987 (-3.9A) MGD  A1986 ( 3.6A) MGD  A1986 (-3.6A) MO  A1985 ( 2.5A) None	1.31A	3njzA-2ivfA: 0.0	3njzA-2ivfA: 16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NJZ_A_SALA370_1 (GENTISATE 1,2-DIOXYGENASE)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 12	HIS A1163 HIS A1098 HIS A1092 HIS A 546 ILE A 191	MD1  A1245 (-3.4A) MD1  A1245 ( 3.5A) MGD  A1246 ( 3.7A) MD1  A1245 (-4.0A) None	1.30A	3njzA-3egwA: undetectable	3njzA-3egwA: 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NY4_A_SMXA310_1 (BETA-LACTAMASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	4 / 8	LEU A 423 ALA A 449 THR A 451 GLY A 135	None MGD  A 811 ( 3.8A) None None	0.87A	3ny4A-2jirA: undetectable	3ny4A-2jirA: 20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OWX_A_XRAA233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	5 / 9	GLY A 716 GLY A 717 TYR A 733 VAL A 773 GLU A 715	None None None None MGD  A1001 (-3.9A)	1.17A	3owxA-1eu1A: 2.4	3owxA-1eu1A: 16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_D_SAMD6735_0 (16S RRNA METHYLASE)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 12	GLY A 172 GLY A 426 ALA A 169 LEU A 538 SER A 619	None None MGD  A5001 ( 4.6A) None None	1.06A	3p2kD-1g8kA: 2.3	3p2kD-1g8kA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PRS_A_RITA1001_1 (ENDOTHIAPEPSIN)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B (Methanothermobac ter sp. CaT2)	5 / 10	ILE B 341 ASP B 414 ALA B 342 THR B 257 ILE B  37	None MGD  B 503 (-3.0A) MGD  B 503 (-3.4A) None SF4  B 501 (-4.5A)	1.16A	3prsA-5t5iB: undetectable	3prsA-5t5iB: 20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QOW_A_SAMA417_1 (HISTONE-LYSINE N-METHYLTRANSFERASE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	3 / 3	THR A 893 ASP A 259 GLU A 235	MGD  A1019 (-3.6A) MGD  A1019 (-3.0A) None	0.76A	3qowA-1kqfA: undetectable	3qowA-1kqfA: 16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QWP_A_SAMA510_0 (SET AND MYND DOMAIN-CONTAINING PROTEIN 3)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	GLY A 980 ASN A 106 GLU A 979 ASN A 558 HIS A 975	None None None None MGD  A1019 (-4.8A)	1.47A	3qwpA-1kqfA: undetectable	3qwpA-1kqfA: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXY_B_SAMB6735_0 (N-LYSINE METHYLTRANSFERASE SETD6 TRANSCRIPTION FACTOR P65)	2iv2	FORMATE DEHYDROGENASE H (Escherichia coli)	5 / 11	VAL X 576 ALA X 649 GLY X 648 ALA X 217 ASN X 220	None None None None MGD  X 802 ( 4.8A)	1.49A	3qxyB-2iv2X: undetectable 3qxyQ-2iv2X: undetectable	3qxyB-2iv2X: 20.87 3qxyQ-2iv2X: 3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SGL_A_SAMA692_0 (TRNA 5-METHYLAMINOMETHYL- 2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 12	GLY A 390 GLY A 304 THR A 305 LEU A 309 GLY A 386	MGD  A5002 ( 4.9A) MGD  A5002 (-3.6A) None None MGD  A5002 (-3.1A)	1.03A	3sglA-1g8kA: 2.2	3sglA-1g8kA: 22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SPK_B_TPVB100_2 (HIV-1 PROTEASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 12	ASP A 699 VAL A 702 ILE A 674 ILE A 600 THR A 653	MGD  A 801 (-3.0A) None None None None	0.85A	3spkB-2e7zA: undetectable	3spkB-2e7zA: 8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_B_9PLB1_1 (CYTOCHROME P450 2A13)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT FWDD (Methanothermobac ter sp. CaT2; Methanothermobac ter wolfeii)	4 / 6	PHE D 100 ASN D  85 PHE B 349 THR B 372	MGD  B 503 (-3.7A) MGD  B 503 (-3.2A) None None	1.07A	3t3sB-5t5iD: undetectable	3t3sB-5t5iD: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_E_9PLE1_1 (CYTOCHROME P450 2A13)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT FWDD (Methanothermobac ter sp. CaT2; Methanothermobac ter wolfeii)	4 / 8	PHE D 100 ASN D  85 PHE B 349 THR B 372	MGD  B 503 (-3.7A) MGD  B 503 (-3.2A) None None	1.08A	3t3sE-5t5iD: undetectable	3t3sE-5t5iD: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKG_C_ROCC901_3 (PROTEASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	3 / 3	ASP A  13 THR A  40 PRO A  41	MGD  A 802 (-3.2A) MPD  A1004 (-3.4A) MPD  A1004 ( 4.9A)	0.51A	3tkgD-2e7zA: undetectable	3tkgD-2e7zA: 11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TL9_A_ROCA401_3 (PROTEASE)	1h0h	FORMATE DEHYDROGENASE SUBUNIT ALPHA (Desulfovibrio gigas)	5 / 12	LEU A 189 GLY A 192 VAL A 403 ILE A 242 ILE A 367	None MGD  A1002 (-3.7A) None None None	0.80A	3tl9B-1h0hA: undetectable	3tl9B-1h0hA: 7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_B_CLMB221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	5 / 12	THR A 489 SER A 472 LEU A 485 VAL A  90 PHE A  88	MGD  A3001 (-3.6A) None None None None	1.33A	3u9fB-2nyaA: undetectable 3u9fC-2nyaA: undetectable	3u9fB-2nyaA: 13.29 3u9fC-2nyaA: 13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_L_CLML221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	5 / 12	PHE A  88 THR A 489 SER A 472 LEU A 485 VAL A  90	None MGD  A3001 (-3.6A) None None None	1.35A	3u9fJ-2nyaA: 0.0 3u9fL-2nyaA: 0.0	3u9fJ-2nyaA: 13.29 3u9fL-2nyaA: 13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_N_CLMN221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	5 / 11	THR A 489 SER A 472 LEU A 485 VAL A  90 PHE A  88	MGD  A3001 (-3.6A) None None None None	1.39A	3u9fN-2nyaA: undetectable 3u9fO-2nyaA: undetectable	3u9fN-2nyaA: 13.29 3u9fO-2nyaA: 13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UM5_A_CP6A609_1 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 10	VAL A 206 SER A 290 ILE A 291 ILE A 197 THR A 204	None None None None MGD  A 802 (-4.2A)	1.29A	3um5A-2e7zA: undetectable	3um5A-2e7zA: 22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_A_ACTA502_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B (Methanothermobac ter sp. CaT2)	4 / 5	TYR B  87 VAL B 340 SER B 343 GLY B 346	None None MGD  B 503 (-2.7A) None	1.45A	3v4tA-5t5iB: undetectable 3v4tD-5t5iB: undetectable	3v4tA-5t5iB: 24.20 3v4tD-5t5iB: 24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_B_SAMB401_0 (MNMC2)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	6 / 12	HIS A 151 GLY A 120 ASN A 457 ALA A 132 PHE A 397 LEU A 145	MGD  A1803 ( 4.8A) None None None None None	0.81A	3vywB-1ogyA: undetectable	3vywB-1ogyA: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_B_SAMB401_0 (MNMC2)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	5 / 12	HIS A 142 GLY A 111 ASN A 447 ALA A 123 PHE A 387	MGD  A3001 ( 4.9A) None None None None	0.81A	3vywB-2nyaA: 2.2	3vywB-2nyaA: 16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_B_SAMB401_0 (MNMC2)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	5 / 12	HIS A 151 GLY A 120 ASN A 457 ALA A 132 PHE A 397	MGD  A1803 ( 4.6A) None None None FMT  A 803 (-3.6A)	0.72A	3vywB-3o5aA: 2.9	3vywB-3o5aA: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_C_SAMC401_0 (MNMC2)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	6 / 12	HIS A 151 GLY A 120 ASN A 457 ALA A 132 PHE A 397 LEU A 145	MGD  A1803 ( 4.8A) None None None None None	0.83A	3vywC-1ogyA: 2.3	3vywC-1ogyA: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_C_SAMC401_0 (MNMC2)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	5 / 12	HIS A 142 GLY A 111 ASN A 447 ALA A 123 PHE A 387	MGD  A3001 ( 4.9A) None None None None	0.79A	3vywC-2nyaA: 2.3	3vywC-2nyaA: 16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_C_SAMC401_0 (MNMC2)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	5 / 12	HIS A 151 GLY A 120 ASN A 457 ALA A 132 PHE A 397	MGD  A1803 ( 4.6A) None None None FMT  A 803 (-3.6A)	0.71A	3vywC-3o5aA: 2.7	3vywC-3o5aA: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_D_SAMD401_0 (MNMC2)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	6 / 12	HIS A 151 GLY A 120 ASN A 457 ALA A 132 PHE A 397 LEU A 145	MGD  A1803 ( 4.8A) None None None None None	0.80A	3vywD-1ogyA: 1.5	3vywD-1ogyA: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_D_SAMD401_0 (MNMC2)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	5 / 12	HIS A 142 GLY A 111 ASN A 447 ALA A 123 PHE A 387	MGD  A3001 ( 4.9A) None None None None	0.79A	3vywD-2nyaA: 2.2	3vywD-2nyaA: 16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_D_SAMD401_0 (MNMC2)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	5 / 12	HIS A 151 GLY A 120 ASN A 457 ALA A 132 PHE A 397	MGD  A1803 ( 4.6A) None None None FMT  A 803 (-3.6A)	0.70A	3vywD-3o5aA: undetectable	3vywD-3o5aA: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_F_W9TF512_1 (HEMOLYTIC LECTIN CEL-III)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	4 / 6	THR A 269 GLY A 219 ASP A 221 ILE A 170	None MGD  A 802 (-3.5A) MGD  A 802 (-2.7A) MGD  A 802 (-4.7A)	0.86A	3w9tF-2e7zA: undetectable	3w9tF-2e7zA: 18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZOD_A_HQEA1173_1 (FMN-BINDING PROTEIN)	1h0h	FORMATE DEHYDROGENASE SUBUNIT ALPHA FORMATE DEHYDROGENASE SUBUNIT BETA (Desulfovibrio gigas)	4 / 7	TYR A 938 HIS B  38 ARG A 222 HIS A 937	None None MGD  A1002 (-4.0A) MGD  A1002 (-4.5A)	1.31A	3zodA-1h0hA: 0.0	3zodA-1h0hA: 10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZQT_A_30ZA1920_1 (ANDROGEN RECEPTOR)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	4 / 6	PRO A 303 GLY A 304 ASN A 391 LEU A 683	None MGD  A5002 (-3.6A) None None	0.87A	3zqtA-1g8kA: 0.0	3zqtA-1g8kA: 14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6N_A_T1CA392_1 (TETX2 PROTEIN)	1h0h	FORMATE DEHYDROGENASE SUBUNIT ALPHA (Desulfovibrio gigas)	5 / 11	ASN A 198 GLY A 408 GLY A 864 GLU A 548 ASN A 518	MGD  A1002 (-3.4A) MGD  A1002 (-3.2A) None None None	1.27A	4a6nA-1h0hA: undetectable	4a6nA-1h0hA: 17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACA_C_DXCC1478_0 (TRANSLATION ELONGATION FACTOR SELB)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	4 / 7	GLY A 847 THR A 846 ILE A 917 THR A 288	None MGD  A1986 ( 4.1A) None None	0.91A	4acaC-2ivfA: undetectable	4acaC-2ivfA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AWU_A_4CHA502_0 (OXIDOREDUCTASE, FMN-BINDING)	1h0h	FORMATE DEHYDROGENASE SUBUNIT ALPHA FORMATE DEHYDROGENASE SUBUNIT BETA (Desulfovibrio gigas; Desulfovibrio gigas)	4 / 7	THR A 228 HIS A 218 ASN A 194 PHE B  67	None None MGD  A1002 (-4.3A) None	1.39A	4awuA-1h0hA: undetectable	4awuA-1h0hA: 16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BLV_A_SAMA1281_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 12	LEU A 199 GLY A 219 GLY A 722 LEU A 224 GLY A 270	MGD  A 802 (-4.6A) MGD  A 802 (-3.5A) None None None	1.17A	4blvA-2e7zA: undetectable	4blvA-2e7zA: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_A_C2FA300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	ASN A 638 PHE A 642 ASN A 209 ARG A 206 ILE A 619	None None None MGD  A 812 (-3.9A) None	1.39A	4djfA-2jirA: undetectable	4djfA-2jirA: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_A_C2FA300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	3o5a	PERIPLASMIC NITRATE REDUCTASE DIHEME CYTOCHROME C NAPB (Cupriavidus necator; Cupriavidus necator)	5 / 12	ASN A 455 ILE B  12 GLY A 468 ASN A 439 GLN A 438	MGD  A1803 (-4.9A) None None None None	1.48A	4djfA-3o5aA: undetectable	4djfA-3o5aA: 15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_B_C2FB300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 12	ASN A 750 LEU A 698 GLY A 782 SER A 463 ARG A 193	None None MGD  A5001 ( 4.4A) None None	1.35A	4djfB-1g8kA: undetectable	4djfB-1g8kA: 14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F93_B_SANB3004_1 (U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	4 / 8	ASN A 348 GLN A 111 GLY A 110 SER A 109	None MGD  A 811 (-2.8A) None None	0.92A	4f93B-2jirA: undetectable	4f93B-2jirA: 16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGJ_A_1PQA303_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 9	TRP A 229 GLY A 232 GLY A 386 ILE A 301 PHE A 310	None MGD  A5002 (-3.2A) MGD  A5002 (-3.1A) None None	1.38A	4fgjA-1g8kA: 1.0 4fgjB-1g8kA: 2.0	4fgjA-1g8kA: 15.34 4fgjB-1g8kA: 15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGK_A_0TXA302_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	4 / 7	GLY A 716 GLY A 717 TYR A 733 GLU A 715	None None None MGD  A1001 (-3.9A)	1.05A	4fgkB-1eu1A: undetectable	4fgkB-1eu1A: 16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_A_SAMA401_0 (METHYLTRANSFERASE NSUN4)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	GLY A 146 GLY A 147 GLY A 135 PRO A 711 LEU A 139	None None None None MGD  A 811 ( 4.4A)	1.03A	4fp9A-2jirA: undetectable	4fp9A-2jirA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_A_SAMA401_1 (METHYLTRANSFERASE NSUN4)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	3 / 3	ASP A 204 ARG A 206 ASP A 225	MGD  A 812 (-2.7A) MGD  A 812 (-3.9A) MGD  A 812 (-3.4A)	0.56A	4fp9A-2jirA: undetectable	4fp9A-2jirA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_C_SAMC401_0 (METHYLTRANSFERASE NSUN4)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	GLY A 146 GLY A 147 GLY A 135 PRO A 711 LEU A 139	None None None None MGD  A 811 ( 4.4A)	1.03A	4fp9C-2jirA: undetectable	4fp9C-2jirA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_C_SAMC401_1 (METHYLTRANSFERASE NSUN4)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	3 / 3	ASP A 204 ARG A 206 ASP A 225	MGD  A 812 (-2.7A) MGD  A 812 (-3.9A) MGD  A 812 (-3.4A)	0.64A	4fp9C-2jirA: undetectable	4fp9C-2jirA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_D_SAMD401_0 (METHYLTRANSFERASE NSUN4)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	GLY A 146 GLY A 147 GLY A 135 PRO A 711 LEU A 139	None None None None MGD  A 811 ( 4.4A)	1.04A	4fp9D-2jirA: undetectable	4fp9D-2jirA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_F_SAMF401_0 (METHYLTRANSFERASE NSUN4)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	GLY A 146 GLY A 147 GLY A 135 PRO A 711 LEU A 139	None None None None MGD  A 811 ( 4.4A)	1.04A	4fp9F-2jirA: undetectable	4fp9F-2jirA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_F_SAMF401_1 (METHYLTRANSFERASE NSUN4)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	3 / 3	ASP A 204 ARG A 206 ASP A 225	MGD  A 812 (-2.7A) MGD  A 812 (-3.9A) MGD  A 812 (-3.4A)	0.67A	4fp9F-2jirA: undetectable	4fp9F-2jirA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FUB_A_ACTA311_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	3 / 3	TYR A1005 ARG A 896 HIS A 902	MGD  A1018 (-3.3A) MGD  A1018 ( 3.3A) MGD  A1018 ( 3.7A)	1.05A	4fubA-1kqfA: 0.0	4fubA-1kqfA: 13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FUB_A_ACTA311_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	3 / 3	TYR A 713 ARG A 617 HIS A 623	MGD  A 811 (-3.6A) MGD  A 811 (-3.2A) MGD  A 811 ( 3.6A)	1.14A	4fubA-2jirA: undetectable	4fubA-2jirA: 16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FZV_A_SAMA401_0 (PUTATIVE METHYLTRANSFERASE NSUN4)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	GLY A 146 GLY A 147 GLY A 135 PRO A 711 LEU A 139	None None None None MGD  A 811 ( 4.4A)	1.01A	4fzvA-2jirA: undetectable	4fzvA-2jirA: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G0U_B_ASWB1301_1 (DNA TOPOISOMERASE 2-BETA)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	4 / 7	ILE A 775 GLY A 702 ALA A 718 GLN A 123	None None None MGD  A1803 (-2.9A)	0.92A	4g0uB-3o5aA: 2.0	4g0uB-3o5aA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_SAMA401_0 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 12	GLY A 304 ILE A 352 LEU A 683 PRO A 684 VAL A 687	MGD  A5002 (-3.6A) None None None None	0.71A	4gc9A-1g8kA: 2.8	4gc9A-1g8kA: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GRQ_C_AVLC203_1 (MACROPHAGE MIGRATION INHIBITORY FACTOR)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	4 / 7	PHE A 792 PRO A 147 GLN A 789 PHE A 119	MGD  A1803 (-3.6A) None None None	1.43A	4grqA-3o5aA: undetectable 4grqC-3o5aA: undetectable	4grqA-3o5aA: 9.67 4grqC-3o5aA: 9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	5 / 12	HIS A 697 ILE A 417 ASP A 466 ALA A 632 GLY A 439	MGD  A1765 (-3.5A) None MGD  A1765 (-2.8A) MGD  A1765 (-2.9A) MGD  A1765 (-3.1A)	1.08A	4hfpD-2vpwA: undetectable	4hfpD-2vpwA: 15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HYT_A_OBNA1104_2 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B (Methanothermobac ter sp. CaT2)	4 / 5	PRO B 186 ASP B 185 ILE B 256 VAL B 147	MGD  B 504 (-4.4A) MGD  B 504 (-3.1A) None None	1.25A	4hytA-5t5iB: 3.2	4hytA-5t5iB: 17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	5 / 12	LEU A 232 ASP A 228 VAL A 351 ALA A 178 LEU A 776	None MGD  A4001 (-3.2A) None MGD  A4001 ( 4.4A) None	1.34A	4iaqA-2nyaA: undetectable	4iaqA-2nyaA: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JQ1_B_NPSB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 8	TYR A 202 ILE A 206 TRP A 264 LEU A 250	None MGD  A1766 (-4.6A) None None	0.94A	4jq1B-2vpwA: undetectable	4jq1B-2vpwA: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI507_0 (RNA POLYMERASE 3D-POL)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	3 / 3	LYS A 167 PRO A 168 SER A 169	None MGD  A1765 ( 4.5A) None	0.35A	4k50I-2vpwA: undetectable	4k50I-2vpwA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8W_G_MTXG301_1 (GAMMA-GLUTAMYL HYDROLASE)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	5 / 9	PHE A 631 GLY A 713 GLY A 698 GLU A 677 GLN A 720	MGD  A1766 ( 3.5A) None None None MGD  A1765 (-3.5A)	1.42A	4l8wG-2vpwA: undetectable	4l8wG-2vpwA: 16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MDB_A_RLTA401_1 (MARINER MOS1 TRANSPOSASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	4 / 6	ASN A 418 ALA A 419 TYR A 423 ASP A 699	MGD  A 801 (-4.9A) None None MGD  A 801 (-3.0A)	0.99A	4mdbA-2e7zA: undetectable	4mdbA-2e7zA: 15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N49_A_SAMA601_1 (CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-M ETHYLTRANSFERASE 1)	6cza	- (-)	4 / 4	ASN A 728 GLY A 803 ASP A 832 ASP A 722	MGD  A 902 (-4.8A) None None MGD  A 903 ( 2.1A)	1.36A	4n49A-6czaA: undetectable	4n49A-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJU_A_TPVA500_1 (PROTEASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 12	ASP A 699 VAL A 702 ILE A 674 ILE A 600 THR A 653	MGD  A 801 (-3.0A) None None None None	0.87A	4njuA-2e7zA: undetectable	4njuA-2e7zA: 8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJU_C_TPVC500_1 (PROTEASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 12	ASP A 699 VAL A 702 ILE A 674 ILE A 600 THR A 653	MGD  A 801 (-3.0A) None None None None	0.86A	4njuC-2e7zA: undetectable	4njuC-2e7zA: 8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_D_SAMD601_1 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	3 / 3	ASN A 446 ASP A 473 ASP A  59	MGD  A3001 (-4.5A) MGD  A3001 (-2.9A) None	0.82A	4obwD-2nyaA: 2.7	4obwD-2nyaA: 14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ODO_B_FK5B203_2 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD)	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	3 / 3	ALA A 448 GLN A 440 GLY A 754	None MGD  A1001 (-4.3A) MGD  A1001 (-3.6A)	0.64A	4odoC-1eu1A: 0.0	4odoC-1eu1A: 12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PBH_A_BEZA401_0 (TRAP DICARBOXYLATE TRANSPORTER, DCTP SUBUNIT, PUTATIVE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 12	THR A 204 ALA A 666 LEU A 605 ASP A 664 LEU A 631	MGD  A 802 (-4.2A) None MGD  A 802 (-4.4A) None None	1.33A	4pbhA-2e7zA: undetectable	4pbhA-2e7zA: 20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PCU_B_SAMB603_0 (CYSTATHIONINE BETA-SYNTHASE)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	5 / 9	ASP A 284 GLN A 915 VAL A 300 ILE A 281 ASP A 303	MGD  A1986 (-3.0A) None MGD  A1986 ( 4.0A) MGD  A1986 (-4.1A) MGD  A1986 (-2.9A)	1.00A	4pcuA-2ivfA: 0.0 4pcuB-2ivfA: 1.4	4pcuA-2ivfA: 19.32 4pcuB-2ivfA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PD4_C_AOQC4003_1 (CYTOCHROME B)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 12	GLY A 171 ILE A 170 PRO A 201 LEU A 216 TYR A 218	MGD  A 802 (-3.5A) MGD  A 802 (-4.7A) MGD  A 802 (-4.3A) MGD  A 802 (-4.8A) MGD  A 802 (-3.9A)	0.94A	4pd4C-2e7zA: undetectable	4pd4C-2e7zA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 10	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.41A	4qvmH-5nqdB: 0.0 4qvmI-5nqdB: 0.0	4qvmH-5nqdB: 16.59 4qvmI-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 10	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.41A	4qvmV-5nqdB: 0.0 4qvmW-5nqdB: 0.0	4qvmV-5nqdB: 16.59 4qvmW-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVN_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 11	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.43A	4qvnH-5nqdB: undetectable 4qvnI-5nqdB: undetectable	4qvnH-5nqdB: 16.59 4qvnI-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVQ_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 11	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.42A	4qvqH-5nqdB: undetectable 4qvqI-5nqdB: undetectable	4qvqH-5nqdB: 16.59 4qvqI-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVQ_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 11	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.42A	4qvqV-5nqdB: undetectable 4qvqW-5nqdB: undetectable	4qvqV-5nqdB: 16.59 4qvqW-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 11	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.41A	4qw3V-5nqdB: undetectable 4qw3W-5nqdB: undetectable	4qw3V-5nqdB: 16.59 4qw3W-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWU_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 11	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.42A	4qwuH-5nqdB: undetectable 4qwuI-5nqdB: undetectable	4qwuH-5nqdB: 16.59 4qwuI-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWU_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 11	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.42A	4qwuV-5nqdB: undetectable 4qwuW-5nqdB: undetectable	4qwuV-5nqdB: 16.59 4qwuW-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_C_SAMC301_0 (UNCHARACTERIZED PROTEIN)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 12	ARG A 429 ALA A 169 GLY A 171 PHE A 164 GLU A 425	None MGD  A5001 ( 4.6A) None None None	1.24A	4r29C-1g8kA: 0.0	4r29C-1g8kA: 13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U8V_B_MIYB1103_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	ASP A 215 ILE A 201 ALA A 203 PHE A 220 VAL A 218	None None None MGD  A 812 (-4.7A) None	1.14A	4u8vB-2jirA: undetectable	4u8vB-2jirA: 22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U8Y_B_MIYB1102_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	ASP A 215 ILE A 201 ALA A 203 PHE A 220 VAL A 218	None None None MGD  A 812 (-4.7A) None	1.13A	4u8yB-2jirA: undetectable	4u8yB-2jirA: 22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCK_A_SAMA2409_1 (RNA-DIRECTED RNA POLYMERASE L)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	3 / 3	SER A 105 ASP A 466 ASP A 477	None MGD  A1765 (-2.8A) None	0.76A	4uckA-2vpwA: undetectable	4uckA-2vpwA: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UUU_A_SAMA1546_0 (CYSTATHIONINE BETA-SYNTHASE)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	5 / 11	ASP A 284 GLN A 915 VAL A 300 ILE A 281 ASP A 303	MGD  A1986 (-3.0A) None MGD  A1986 ( 4.0A) MGD  A1986 (-4.1A) MGD  A1986 (-2.9A)	1.29A	4uuuA-2ivfA: undetectable 4uuuB-2ivfA: undetectable	4uuuA-2ivfA: 9.52 4uuuB-2ivfA: 9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UUU_B_SAMB1548_0 (CYSTATHIONINE BETA-SYNTHASE)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	5 / 11	ASP A 284 GLN A 915 VAL A 300 ILE A 281 ASP A 303	MGD  A1986 (-3.0A) None MGD  A1986 ( 4.0A) MGD  A1986 (-4.1A) MGD  A1986 (-2.9A)	1.28A	4uuuB-2ivfA: undetectable	4uuuB-2ivfA: 9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UUU_B_SAMB1548_0 (CYSTATHIONINE BETA-SYNTHASE)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	5 / 11	SER A 451 ASP A 284 GLN A 915 VAL A 300 ASP A 303	MGD  A1986 (-4.5A) MGD  A1986 (-3.0A) None MGD  A1986 ( 4.0A) MGD  A1986 (-2.9A)	1.25A	4uuuB-2ivfA: undetectable	4uuuB-2ivfA: 9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNV_D_QI9D602_0 (CYTOCHROME P450 2D6)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	4 / 7	PHE A 243 LEU A 244 THR A 281 PHE A 824	None None MGD  A5002 (-4.4A) None	0.87A	4wnvD-1g8kA: 0.3	4wnvD-1g8kA: 20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_D_29SD601_2 (ESTROGEN RECEPTOR)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	3 / 3	LEU A 299 ASP A 306 ILE A 273	None MGD  A5002 (-3.0A) None	0.61A	4xi3D-1g8kA: undetectable	4xi3D-1g8kA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XUM_A_IMNA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	5 / 12	ILE A 440 LEU A 456 LEU A 459 LEU A 435 TYR A 462	MGD  A1765 (-4.3A) None None None None	1.15A	4xumA-2vpwA: undetectable	4xumA-2vpwA: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YHA_A_MZMA303_1 (ALPHA-CARBONIC ANHYDRASE)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	5 / 12	VAL A 280 VAL A 235 LEU A 428 THR A 424 ALA A 427	MGD  A2002 (-4.6A) MGD  A2002 ( 4.8A) None None None	1.35A	4yhaA-5nqdA: undetectable	4yhaA-5nqdA: 17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZDZ_A_TPFA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 7	ILE A  53 GLY A  46 THR A 630 LEU A 640	None SF4  A1764 (-3.7A) MGD  A1766 (-4.0A) None	0.94A	4zdzA-2vpwA: undetectable	4zdzA-2vpwA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJL_A_ERYA1101_0 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	1h0h	FORMATE DEHYDROGENASE SUBUNIT ALPHA (Desulfovibrio gigas)	5 / 12	SER A 853 PHE A 836 LEU A 236 GLY A 192 MET A 191	MGD  A1002 ( 4.0A) None None MGD  A1002 (-3.7A) None	1.39A	4zjlA-1h0hA: 0.0	4zjlA-1h0hA: 22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZVM_A_DM2A303_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 12	TRP A 229 GLY A 232 GLY A 386 ILE A 301 PHE A 310	None MGD  A5002 (-3.2A) MGD  A5002 (-3.1A) None None	1.26A	4zvmA-1g8kA: undetectable 4zvmB-1g8kA: 2.4	4zvmA-1g8kA: 14.95 4zvmB-1g8kA: 14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AXA_A_ADNA502_2 (ADENOSYLHOMOCYSTEINA SE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	4 / 5	THR A 455 THR A1002 HIS A 415 LEU A 410	None None MGD  A1019 (-3.9A) MGD  A1019 ( 3.4A)	1.22A	5axaA-1kqfA: undetectable	5axaA-1kqfA: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AXA_C_ADNC502_2 (ADENOSYLHOMOCYSTEINA SE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	4 / 5	THR A 455 THR A1002 HIS A 415 LEU A 410	None None MGD  A1019 (-3.9A) MGD  A1019 ( 3.4A)	1.27A	5axaC-1kqfA: undetectable	5axaC-1kqfA: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BMV_C_VLBC507_1 (TUBULIN BETA CHAIN TUBULIN ALPHA-1B CHAIN)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 6	ASP A 673 TYR A 723 PRO A 447 LEU A 734	None None None MGD  A1765 (-4.9A)	1.37A	5bmvB-2vpwA: 2.9	5bmvB-2vpwA: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BW4_A_SAMA301_0 (16S RRNA (ADENINE(1408)-N(1)) -METHYLTRANSFERASE)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	5 / 12	GLY A 236 ASP A 281 PRO A 282 ARG A 283 LEU A 448	MGD  A2002 (-3.4A) MGD  A2002 (-2.9A) MGD  A2002 (-4.4A) MGD  A2002 (-3.8A) None	1.02A	5bw4A-5nqdA: undetectable	5bw4A-5nqdA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C0O_H_SAMH301_1 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE TRMI)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B (Methanothermobac ter sp. CaT2)	4 / 5	THR B  92 GLU B 366 HIS B 368 ASP B 414	MGD  B 503 ( 4.9A) MGD  B 503 (-2.9A) MGD  B 503 (-4.4A) MGD  B 503 (-3.0A)	1.27A	5c0oH-5t5iB: 2.1	5c0oH-5t5iB: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C8T_B_SAMB605_0 (GUANINE-N7 METHYLTRANSFERASE)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	5 / 11	GLY A 731 ALA A 416 TRP A 336 ASN A 334 VAL A 179	None None MGD  A1766 (-4.3A) None None	1.45A	5c8tB-2vpwA: 1.1	5c8tB-2vpwA: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CCL_A_SAMA504_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SMYD3)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	GLY A 980 ASN A 106 GLU A 979 ASN A 558 HIS A 975	None None None None MGD  A1019 (-4.8A)	1.48A	5cclA-1kqfA: undetectable	5cclA-1kqfA: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CZ7_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 11	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.39A	5cz7H-5nqdB: undetectable 5cz7I-5nqdB: undetectable	5cz7H-5nqdB: 16.59 5cz7I-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0X_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE ARSENITE OXIDASE SMALL SUBUNIT AIOB RIESKE [2FE-2S] CLUSTER (Rhizobium sp. NT-26)	5 / 12	GLN B 140 CYH A 291 THR A 242 ALA A 239 THR A 237	None None MGD  A2002 (-3.0A) None MGD  A2002 (-4.4A)	1.39A	5d0xH-5nqdB: undetectable 5d0xI-5nqdB: undetectable	5d0xH-5nqdB: 16.59 5d0xI-5nqdB: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DB5_A_CYSA503_0 (CYSTEINE DESULFURASE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	4 / 8	ALA A 419 HIS A 415 ASN A 421 THR A1002	None MGD  A1019 (-3.9A) None None	1.32A	5db5A-1kqfA: 2.1 5db5B-1kqfA: undetectable	5db5A-1kqfA: 17.42 5db5B-1kqfA: 17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DB5_A_CYSA503_0 (CYSTEINE DESULFURASE)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	4 / 8	HIS A 849 ARG A 613 ARG A 615 HIS A 192	MGD  A1986 (-3.6A) MD1  A1987 (-3.9A) MD1  A1987 (-3.1A) ACT  A1978 ( 3.9A)	1.15A	5db5A-2ivfA: undetectable 5db5B-2ivfA: undetectable	5db5A-2ivfA: 16.93 5db5B-2ivfA: 16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_P_BEZP801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	4 / 5	SER A 222 ALA A 190 HIS A 220 LEU A 184	None None MGD  A1804 (-4.4A) None	1.42A	5dzkb-1ogyA: undetectable 5dzkp-1ogyA: undetectable	5dzkb-1ogyA: 14.45 5dzkp-1ogyA: 2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_P_BEZP801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	4 / 5	SER A 222 HIS A 220 MET A 192 LEU A 184	None MGD  A1804 (-4.4A) MGD  A1804 (-3.7A) None	1.49A	5dzkb-1ogyA: undetectable 5dzkp-1ogyA: undetectable	5dzkb-1ogyA: 14.45 5dzkp-1ogyA: 2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_P_BEZP801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	4 / 5	SER A 213 ALA A 181 HIS A 211 LEU A 175	None None MGD  A4001 (-4.2A) None	1.41A	5dzkb-2nyaA: undetectable 5dzkp-2nyaA: undetectable	5dzkb-2nyaA: 14.95 5dzkp-2nyaA: 3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_Q_BEZQ801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	1ogy	PERIPLASMIC NITRATE REDUCTASE (Rhodobacter sphaeroides)	4 / 5	SER A 222 ALA A 190 HIS A 220 LEU A 184	None None MGD  A1804 (-4.4A) None	1.42A	5dzkc-1ogyA: undetectable 5dzkq-1ogyA: undetectable	5dzkc-1ogyA: 14.45 5dzkq-1ogyA: 2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_Q_BEZQ801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	4 / 5	SER A 213 ALA A 181 HIS A 211 LEU A 175	None None MGD  A4001 (-4.2A) None	1.40A	5dzkc-2nyaA: undetectable 5dzkq-2nyaA: undetectable	5dzkc-2nyaA: 14.95 5dzkq-2nyaA: 3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECM_A_LEUA602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	4 / 5	THR A 624 ALA A 625 THR A 626 HIS A 421	MGD  A 811 (-2.7A) None MGD  A 811 (-3.2A) None	1.40A	5ecmA-2jirA: undetectable	5ecmA-2jirA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEN_A_5OGA804_1 (HDAC6 PROTEIN)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 12	PRO A 190 SER A1099 HIS A1092 ASP A 222 GLY A 579	MD1  A1245 (-4.5A) MD1  A1245 (-2.7A) MGD  A1246 ( 3.7A) 6MO  A1247 (-2.1A) MGD  A1246 (-3.5A)	1.32A	5eenA-3egwA: 3.5	5eenA-3egwA: 15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESJ_A_TPFA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 8	ILE A  53 GLY A  46 THR A 630 LEU A 640	None SF4  A1764 (-3.7A) MGD  A1766 (-4.0A) None	0.88A	5esjA-2vpwA: undetectable	5esjA-2vpwA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FA8_A_SAMA301_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	3 / 3	THR A 893 ASP A 259 GLU A 235	MGD  A1019 (-3.6A) MGD  A1019 (-3.0A) None	0.77A	5fa8A-1kqfA: 2.4	5fa8A-1kqfA: 9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FHZ_D_READ602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	5 / 12	ILE A 465 GLY A 518 ARG A 488 TRP A 520 GLU A 118	MGD  A1765 (-4.8A) None MGD  A1765 (-2.9A) None None	1.34A	5fhzD-2vpwA: undetectable	5fhzD-2vpwA: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_F_SAMF301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	ALA A 620 PRO A 584 GLN A 192 GLY A 168 SER A 167	None MGD  A1018 (-4.1A) MGD  A1018 (-3.7A) MGD  A1018 ( 4.8A) None	1.31A	5hfjF-1kqfA: 2.5	5hfjF-1kqfA: 12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HQA_A_ACRA705_2 (ALPHA-GLUCOSIDASE)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT ETHYLBENZENE DEHYDROGENASE BETA-SUBUNIT (Aromatoleum aromaticum)	4 / 8	ASN A 256 PHE B 144 HIS A 868 THR A 846	MGD  A1986 (-4.1A) None None MGD  A1986 ( 4.1A)	1.37A	5hqaA-2ivfA: undetectable	5hqaA-2ivfA: 20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I8F_A_ML1A210_1 (PHENOLIC OXIDATIVE COUPLING PROTEIN)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	5 / 12	LEU A 186 GLN A 182 LEU A 168 GLY A 171 LYS A 172	None None None MGD  A 802 (-3.5A) None	1.17A	5i8fA-2e7zA: undetectable	5i8fA-2e7zA: 12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGY_A_ERYA403_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	2nya	PERIPLASMIC NITRATE REDUCTASE (Escherichia coli)	5 / 12	GLY A 177 HIS A 184 GLU A 503 ALA A 181 ILE A 331	MGD  A4001 (-3.6A) None None None None	1.20A	5igyA-2nyaA: undetectable	5igyA-2nyaA: 15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IY5_C_CHDC301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 7	HIS A 292 ASP A 257 THR A 258 HIS A 602	None MGD  A1766 (-2.8A) None None	1.33A	5iy5A-2vpwA: undetectable 5iy5C-2vpwA: undetectable	5iy5A-2vpwA: 19.97 5iy5C-2vpwA: 13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JLC_A_1YNA602_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	4 / 5	GLY A 114 THR A 113 GLY A 172 LEU A 515	None None None MGD  A5001 (-4.0A)	0.87A	5jlcA-1g8kA: 0.0	5jlcA-1g8kA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5K9D_A_CE9A402_0 (DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL)	6cza	- (-)	5 / 12	ALA A 505 HIS A 506 ALA A 479 PHE A 514 LEU A 498	None MGD  A 903 ( 4.4A) None None None	1.18A	5k9dA-6czaA: undetectable	5k9dA-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KBW_B_RBFB201_1 (RIBOFLAVIN TRANSPORTER RIBU)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	5 / 12	ASP A 170 GLY A 459 ALA A  39 VAL A 769 ASN A 591	MO  A1002 ( 2.6A) BSY  A1013 ( 3.0A) None MGD  A1003 ( 4.1A) None	1.19A	5kbwB-5chcA: undetectable	5kbwB-5chcA: 11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KGP_A_GCSA407_1 (PREDICTED ACETYLTRANSFERASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	4 / 8	TRP A  83 GLU A 490 PRO A 487 GLY A 459	None None None MGD  A 801 ( 3.9A)	0.99A	5kgpA-2e7zA: undetectable	5kgpA-2e7zA: 17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KGP_B_GCSB405_1 (PREDICTED ACETYLTRANSFERASE)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	4 / 8	TRP A  83 GLU A 490 PRO A 487 GLY A 459	None None None MGD  A 801 ( 3.9A)	1.00A	5kgpB-2e7zA: undetectable	5kgpB-2e7zA: 17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KKZ_O_ASCO1004_0 (CYTOCHROME B UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 7	HIS A 697 ILE A 695 VAL A 696 GLN A 635	MGD  A1765 (-3.5A) None None None	1.32A	5kkzM-2vpwA: undetectable 5kkzO-2vpwA: undetectable	5kkzM-2vpwA: 12.29 5kkzO-2vpwA: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_A_SAMA401_1 (PAVINE N-METHYLTRANSFERASE)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	4 / 5	PHE A 773 SER A 768 ASN A 565 ASP A 563	None MGD  A1003 (-4.6A) MD1  A1004 (-2.9A) None	1.37A	5kpcA-5chcA: undetectable	5kpcA-5chcA: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LBT_A_6T0A304_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	1g8k	ARSENITE OXIDASE (Alcaligenes faecalis)	5 / 10	TRP A 229 GLY A 232 GLY A 386 ILE A 301 PHE A 310	None MGD  A5002 (-3.2A) MGD  A5002 (-3.1A) None None	1.21A	5lbtA-1g8kA: undetectable 5lbtB-1g8kA: undetectable	5lbtA-1g8kA: 14.30 5lbtB-1g8kA: 14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_I_Z80I401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	4 / 9	PHE A 765 VAL A 740 ASN A 776 ILE A 775	None None MGD  A1803 (-2.9A) None	0.90A	5lg3I-3o5aA: undetectable	5lg3I-3o5aA: 15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M54_E_TA1E502_1 (TUBULIN BETA-2B CHAIN)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	5 / 12	VAL A 286 GLN A 726 ARG A 283 GLY A 719 LEU A 791	None MGD  A2002 ( 3.3A) MGD  A2002 (-3.8A) MGD  A2002 (-3.3A) None	1.22A	5m54E-5nqdA: undetectable	5m54E-5nqdA: 9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_B_MMSB514_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	4 / 8	SER A 104 ASN A 106 LEU A 585 SER A 590	None None MGD  A1018 (-4.0A) None	0.91A	5m8rB-1kqfA: 0.0	5m8rB-1kqfA: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_C_MMSC516_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	4 / 8	HIS A 151 ASN A 776 LEU A 464 GLY A 468	MGD  A1803 ( 4.6A) MGD  A1803 (-2.9A) None None	0.96A	5m8rC-3o5aA: undetectable	5m8rC-3o5aA: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_D_MMSD509_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	4 / 8	SER A 104 ASN A 106 LEU A 585 SER A 590	None None MGD  A1018 (-4.0A) None	0.93A	5m8rD-1kqfA: undetectable	5m8rD-1kqfA: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NY7_A_NCAA303_0 (AMIDASE)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	4 / 6	ARG A 208 GLY A  38 GLU A 595 SER A 594	MGD  A1003 ( 3.6A) SF4  A1001 ( 3.8A) None None	1.06A	5ny7A-5chcA: undetectable	5ny7A-5chcA: 15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZX_A_9F2A1102_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	4 / 8	PHE A 214 ARG A 208 THR A  37 GLY A  38	None MGD  A1003 ( 3.6A) MGD  A1003 ( 4.8A) SF4  A1001 ( 3.8A)	1.00A	5nzxA-5chcA: undetectable	5nzxA-5chcA: 18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYE_B_TA1B502_1 (TUBULIN BETA CHAIN)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	5 / 12	VAL A 435 ASP A 303 ALA A 464 SER A 468 GLY A 477	None MGD  A1986 (-2.9A) None None None	1.30A	5syeB-2ivfA: undetectable	5syeB-2ivfA: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYF_B_TA1B502_1 (TUBULIN BETA CHAIN)	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	5 / 12	ASP A 459 LEU A 657 ASP A  47 SER A 118 ARG A 658	MGD  A1001 (-3.0A) None None MGD  A1001 (-2.7A) None	1.30A	5syfB-1eu1A: 2.2	5syfB-1eu1A: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYJ_A_NIZA810_1 (CATALASE-PEROXIDASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	4 / 6	HIS A 623 LEU A 139 PRO A 137 SER A 109	MGD  A 811 ( 3.6A) MGD  A 811 ( 4.4A) CYN  A 813 ( 4.6A) None	1.46A	5syjA-2jirA: undetectable	5syjA-2jirA: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYJ_B_NIZB810_1 (CATALASE-PEROXIDASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	4 / 6	HIS A 623 LEU A 139 PRO A 137 SER A 109	MGD  A 811 ( 3.6A) MGD  A 811 ( 4.4A) CYN  A 813 ( 4.6A) None	1.46A	5syjB-2jirA: undetectable	5syjB-2jirA: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TT3_H_EZLH303_1 (ALPHA-CARBONIC ANHYDRASE)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	4 / 8	VAL A 280 LEU A 428 THR A 424 ALA A 427	MGD  A2002 (-4.6A) None None None	0.87A	5tt3H-5nqdA: undetectable	5tt3H-5nqdA: 17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V37_A_SAMA504_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SMYD3)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	GLY A 980 ASN A 106 GLU A 979 ASN A 558 HIS A 975	None None None None MGD  A1019 (-4.8A)	1.46A	5v37A-1kqfA: undetectable	5v37A-1kqfA: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V4V_B_NCAB402_0 (NADPH DEHYDROGENASE 3)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT FWDD (Methanothermobac ter sp. CaT2; Methanothermobac ter wolfeii)	4 / 8	THR B 114 PHE D 100 PRO D  98 TYR B  87	MGD  B 503 ( 3.9A) MGD  B 503 (-3.7A) None None	1.32A	5v4vB-5t5iB: undetectable	5v4vB-5t5iB: 23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOP_B_C2FB3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	ASN A 638 ASP A 620 ASN A 209 ARG A 206 ILE A 619	None None None MGD  A 812 (-3.9A) None	1.17A	5vopB-2jirA: undetectable	5vopB-2jirA: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUN_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	4 / 8	SER A 832 ARG A 830 GLN A 881 PHE A 760	MGD  A1003 ( 4.9A) MGD  A1003 (-3.1A) MD1  A1004 (-3.1A) None	1.35A	5vunB-5chcA: undetectable	5vunB-5chcA: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WAU_A_CUA603_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	3 / 3	HIS A1098 HIS A1092 HIS A1163	MD1  A1245 ( 3.5A) MGD  A1246 ( 3.7A) MD1  A1245 (-3.4A)	0.74A	5waua-3egwA: undetectable	5waua-3egwA: 16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XXD_A_SAMA501_0 (SMYD3 METHYLTRANSFERASE)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	GLY A 980 ASN A 106 GLU A 979 ASN A 558 HIS A 975	None None None None MGD  A1019 (-4.8A)	1.48A	5xxdA-1kqfA: undetectable	5xxdA-1kqfA: 17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XXG_A_SAMA502_0 (SMYD3)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	GLY A 980 ASN A 106 GLU A 979 ASN A 558 HIS A 975	None None None None MGD  A1019 (-4.8A)	1.47A	5xxgA-1kqfA: undetectable	5xxgA-1kqfA: 17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XXJ_A_SAMA505_0 (SMYD3)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	GLY A 980 ASN A 106 GLU A 979 ASN A 558 HIS A 975	None None None None MGD  A1019 (-4.8A)	1.47A	5xxjA-1kqfA: undetectable	5xxjA-1kqfA: 17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_X_NIOX401_1 (CASEIN KINASE II SUBUNIT ALPHA')	6cza	- (-)	5 / 9	LEU A 222 VAL A 252 VAL A 254 LYS A 267 ILE A 349	None None MGD  A 902 (-4.5A) None None	1.19A	5yf9X-6czaA: undetectable	5yf9X-6czaA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YJO_A_SAMA505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SMYD3)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 12	GLY A 980 ASN A 106 GLU A 979 ASN A 558 HIS A 975	None None None None MGD  A1019 (-4.8A)	1.47A	5yjoA-1kqfA: undetectable	5yjoA-1kqfA: 17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z85_P_CHDP301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	4 / 7	LEU A 215 HIS A 764 ASP A 211 HIS A 426	None MGD  A1003 ( 3.5A) None MD1  A1004 (-4.4A)	1.24A	5z85C-5chcA: undetectable 5z85N-5chcA: undetectable 5z85P-5chcA: undetectable	5z85C-5chcA: 14.30 5z85N-5chcA: 19.08 5z85P-5chcA: 14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRF_D_EVPD101_1 ()	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	4 / 5	GLY A 219 ASP A 221 ARG A 720 GLN A 714	MGD  A 802 (-3.5A) MGD  A 802 (-2.7A) MGD  A 802 (-2.5A) None	1.31A	5zrfB-2e7zA: 2.2	5zrfB-2e7zA: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA609_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	3 / 3	HIS A 192 HIS A 855 ARG A 612	ACT  A1978 ( 3.9A) MGD  A1986 ( 3.6A) MD1  A1987 (-2.8A)	1.03A	6b58A-2ivfA: undetectable	6b58A-2ivfA: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPL_B_PA1B605_1 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	5nqd	ARSENITE OXIDASE LARGE SUBUNIT AIOA [3FE-4S] CLUSTER, MO-MOLYBDOPTERIN COFACTOR-BINDING ACTIVE SITE (Rhizobium sp. NT-26)	3 / 3	ARG A 447 ARG A 720 ARG A 201	O  A2003 ( 4.5A) MGD  A2001 ( 3.3A) None	1.07A	6bplA-5nqdA: undetectable 6bplB-5nqdA: undetectable	6bplA-5nqdA: 18.09 6bplB-5nqdA: 18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQG_A_ERMA1201_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 12	ASP A 263 SER A 240 VAL A 578 ALA A 575 ASN A 798	None None MGD  A1246 (-3.9A) None None	1.19A	6bqgA-3egwA: undetectable	6bqgA-3egwA: 6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBP_C_DAHC123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	1kqf	FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT (Escherichia coli)	5 / 10	PHE A 180 ASP A 649 GLY A 655 ILE A 656 ILE A 582	None MGD  A1018 (-2.9A) None None MGD  A1018 (-4.5A)	1.19A	6ebpC-1kqfA: undetectable	6ebpC-1kqfA: 5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EKU_A_ZMRA901_1 (SIALIDASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 12	ILE A 715 GLU A 712 ARG A 313 ARG A 221 TYR A 612	None None MGD  A 812 (-3.7A) None None	1.40A	6ekuA-2jirA: undetectable	6ekuA-2jirA: 22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_B_TA1B501_2 (TUBULIN BETA CHAIN)	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	4 / 5	LEU A 670 THR A 225 PRO A 240 ARG A 239	None MGD  A1002 ( 4.6A) MGD  A1002 (-4.0A) None	1.20A	6ew0B-1eu1A: 1.8	6ew0B-1eu1A: 7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_D_TA1D501_2 (TUBULIN BETA CHAIN)	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	4 / 5	LEU A 670 THR A 225 PRO A 240 ARG A 239	None MGD  A1002 ( 4.6A) MGD  A1002 (-4.0A) None	1.20A	6ew0D-1eu1A: 2.0	6ew0D-1eu1A: 7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_H_TA1H501_2 (TUBULIN BETA CHAIN)	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	4 / 5	LEU A 670 THR A 225 PRO A 240 ARG A 239	None MGD  A1002 ( 4.6A) MGD  A1002 (-4.0A) None	1.20A	6ew0H-1eu1A: 1.9	6ew0H-1eu1A: 7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_I_TA1I501_2 (TUBULIN BETA CHAIN)	1eu1	DIMETHYL SULFOXIDE REDUCTASE (Rhodobacter sphaeroides)	4 / 5	LEU A 670 THR A 225 PRO A 240 ARG A 239	None MGD  A1002 ( 4.6A) MGD  A1002 (-4.0A) None	1.20A	6ew0I-1eu1A: 1.8	6ew0I-1eu1A: 7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F6S_B_CXQB705_1 (ENVELOPE GLYCOPROTEIN,ENVELOP E GLYCOPROTEIN,GP1 ENVELOPE GLYCOPROTEIN)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 6	VAL A 235 LEU A 260 LEU A 261 MET A 319	MGD  A1766 (-4.5A) None None None	0.97A	6f6sA-2vpwA: undetectable 6f6sB-2vpwA: undetectable	6f6sA-2vpwA: 7.82 6f6sB-2vpwA: 7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA824_0 (GEPHYRIN)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 4	LEU A 622 ASP A 236 PRO A 237 ARG A 238	MGD  A1766 (-3.9A) MGD  A1766 (-2.6A) MGD  A1766 (-4.4A) MGD  A1766 (-3.5A)	1.15A	6fgdA-2vpwA: undetectable	6fgdA-2vpwA: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GBN_C_ADNC501_2 (-)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT FWDD (Methanothermobac ter sp. CaT2; Methanothermobac ter wolfeii)	4 / 5	THR B 372 THR B 114 HIS B 290 GLY D  81	None MGD  B 503 ( 3.9A) MGD  B 504 (-3.5A) None	1.09A	6gbnC-5t5iB: undetectable	6gbnC-5t5iB: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GIQ_A_CUA601_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	3 / 3	HIS A1098 HIS A1092 HIS A1163	MD1  A1245 ( 3.5A) MGD  A1246 ( 3.7A) MD1  A1245 (-3.4A)	0.62A	6giqa-3egwA: undetectable	6giqa-3egwA: 17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GIQ_A_CUA601_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	5chc	DMSO REDUCTASE FAMILY TYPE II ENZYME, MOLYBDOPTERIN SUBUNIT (Azospira oryzae)	3 / 3	HIS A 770 HIS A 764 HIS A 835	MD1  A1004 ( 3.5A) MGD  A1003 ( 3.5A) MD1  A1004 ( 4.4A)	0.77A	6giqa-5chcA: undetectable	6giqa-5chcA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNE_B_ACRB602_2 (-)	2iv2	FORMATE DEHYDROGENASE H (Escherichia coli)	4 / 8	VAL X 332 TYR X 175 HIS X 187 GLU X 163	None MGD  X 802 (-4.9A) None None	1.32A	6gneB-2iv2X: 2.2	6gneB-2iv2X: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNE_B_ACRB602_2 (-)	2ivf	ETHYLBENZENE DEHYDROGENASE ALPHA-SUBUNIT (Aromatoleum aromaticum)	4 / 8	VAL A 918 ASN A 256 TYR A 259 CYH A 254	None MGD  A1986 (-4.1A) None MGD  A1986 (-3.4A)	1.17A	6gneB-2ivfA: 2.3	6gneB-2ivfA: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNG_B_QPSB601_3 (-)	5t5i	TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE SUBUNIT B TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT C (Methanothermobac ter sp. CaT2; Methanothermobac ter wolfeii)	3 / 3	ASP B 185 ASP B 204 ASN C 160	MGD  B 504 (-3.1A) None None	0.64A	6gngB-5t5iB: undetectable	6gngB-5t5iB: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_A_CUA601_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	3 / 3	HIS A1098 HIS A1092 HIS A1163	MD1  A1245 ( 3.5A) MGD  A1246 ( 3.7A) MD1  A1245 (-3.4A)	0.74A	6hu9a-3egwA: undetectable	6hu9a-3egwA: 17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_N_PCFN606_0 (CYTOCHROME B)	3egw	RESPIRATORY NITRATE REDUCTASE 1 ALPHA CHAIN (Escherichia coli)	5 / 12	MET A 194 ALA A 193 THR A 587 VAL A 578 TYR A 220	None None None MGD  A1246 (-3.9A) MD1  A1245 (-3.5A)	1.43A	6hu9N-3egwA: undetectable	6hu9N-3egwA: 14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IEY_A_CLMA401_0 (ESTERASE)	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	5 / 11	HIS A 623 ALA A 180 LEU A 343 HIS A 181 GLY A  17	MGD  A 811 ( 3.6A) MGD  A 812 (-3.2A) None MGD  A 812 ( 4.6A) None	1.16A	6ieyA-2jirA: undetectable 6ieyB-2jirA: undetectable	6ieyA-2jirA: 17.17 6ieyB-2jirA: 17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IFT_A_SAMA301_1 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A)	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	4 / 5	GLN A 444 GLU A 464 ASP A 493 TYR A 442	MGD  A 801 (-3.5A) None None MGD  A 801 (-3.7A)	0.90A	6iftA-2e7zA: 0.0	6iftA-2e7zA: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_C_CHDC303_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 6	HIS A 292 ASP A 257 THR A 258 HIS A 602	None MGD  A1766 (-2.8A) None None	1.34A	6nmpA-2vpwA: undetectable 6nmpC-2vpwA: undetectable	6nmpA-2vpwA: 19.97 6nmpC-2vpwA: 13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_P_CHDP302_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	4 / 7	HIS A 292 ASP A 257 THR A 258 HIS A 602	None MGD  A1766 (-2.8A) None None	1.36A	6nmpN-2vpwA: undetectable 6nmpP-2vpwA: undetectable	6nmpN-2vpwA: 19.97 6nmpP-2vpwA: 13.66