SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MFU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4csd FUCOSE-BINDING
LECTIN PROTEIN
(Ralstonia
solanacearum) 		3 / 3 TRP A  74
ARG A 108
THR A  71
 None
MFU  A 301 (-3.8A)
None
 0.96A 1df7A-4csdA:
undetectable		 1df7A-4csdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4csd FUCOSE-BINDING
LECTIN PROTEIN
(Ralstonia
solanacearum) 		3 / 3 TRP A 165
ARG A 199
THR A 162
 None
MFU  A 303 (-3.8A)
None
 1.00A 1df7A-4csdA:
undetectable		 1df7A-4csdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4csd FUCOSE-BINDING
LECTIN PROTEIN
(Ralstonia
solanacearum) 		3 / 3 TRP A 256
ARG A  17
THR A 253
 None
MFU  A 305 (-3.8A)
None
 0.99A 1df7A-4csdA:
undetectable		 1df7A-4csdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 5 GLY A 104
SER A 215
THR A  90
PHE A 107
 MFU  A 501 (-3.5A)
None
None
None
 1.22A 1icuC-1jxnA:
0.0
1icuD-1jxnA:
0.0		 1icuC-1jxnA:
21.84
1icuD-1jxnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 5 GLY A 104
SER A 215
THR A  90
PHE A 107
 MFU  A 501 (-3.5A)
None
None
None
 1.34A 1icvA-1jxnA:
0.0
1icvB-1jxnA:
0.0		 1icvA-1jxnA:
21.84
1icvB-1jxnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 5 GLY A 104
SER A 215
THR A  90
PHE A 107
 MFU  A 501 (-3.5A)
None
None
None
 1.32A 1icvC-1jxnA:
undetectable
1icvD-1jxnA:
undetectable		 1icvC-1jxnA:
21.84
1icvD-1jxnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4csd FUCOSE-BINDING
LECTIN PROTEIN
(Ralstonia
solanacearum) 		4 / 6 TRP A  10
ARG A  17
GLY A  33
ASP A  32
 None
MFU  A 305 (-3.8A)
None
None
 1.41A 1kf6M-4csdA:
undetectable
1kf6N-4csdA:
undetectable		 1kf6M-4csdA:
18.92
1kf6N-4csdA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 9 ASP A  87
GLY A 221
ILE A 220
VAL A 133
ILE A 129
 MFU  A 501 (-3.1A)
None
None
None
None
 1.26A 3ekyB-1jxnA:
undetectable		 3ekyB-1jxnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		5 / 12 PHE A  92
ASP A  87
PHE A 110
ASP A 137
SER A 152
 None
MFU  A 501 (-3.1A)
None
MN  A 245 ( 2.7A)
MN  A 245 ( 4.3A)
 1.22A 3ko0K-1jxnA:
undetectable
3ko0L-1jxnA:
undetectable
3ko0S-1jxnA:
undetectable
3ko0T-1jxnA:
undetectable		 3ko0K-1jxnA:
21.25
3ko0L-1jxnA:
21.25
3ko0S-1jxnA:
21.25
3ko0T-1jxnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5mxf PHOTORHABDUS
ASYMBIOTICA LECTIN
PHL
(Photorhabdus
asymbiotica) 		5 / 12 ALA A 276
ILE A  32
LEU A 294
ARG A 288
GLY A 337
 None
None
None
None
MFU  A 401 (-3.2A)
 1.27A 4l9qA-5mxfA:
undetectable		 4l9qA-5mxfA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 6 ILE A 129
GLY A 105
VAL A 150
HIS A 142
 None
MFU  A 501 (-3.1A)
None
MN  A 245 (-3.8A)
 0.90A 4oltA-1jxnA:
0.0		 4oltA-1jxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 6 ILE A 129
GLY A 105
VAL A 150
HIS A 142
 None
MFU  A 501 (-3.1A)
None
MN  A 245 (-3.8A)
 0.92A 4oltB-1jxnA:
undetectable		 4oltB-1jxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1jxn ANTI-H(O) LECTIN I
(Ulex
europaeus) 		4 / 8 GLY A 130
SER A 152
ASN A 134
HIS A 142
 CA  A 246 ( 4.4A)
MN  A 245 ( 4.3A)
MFU  A 501 ( 3.0A)
MN  A 245 (-3.8A)
 1.04A 4wrzA-1jxnA:
undetectable		 4wrzA-1jxnA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4csd FUCOSE-BINDING
LECTIN PROTEIN
(Ralstonia
solanacearum) 		4 / 6 TRP A  36
ILE A  16
ILE A  26
VAL A  48
 MFU  A 304 (-3.9A)
None
None
None
 0.93A 4zj8A-4csdA:
undetectable		 4zj8A-4csdA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4csd FUCOSE-BINDING
LECTIN PROTEIN
(Ralstonia
solanacearum) 		4 / 6 TRP A 127
ILE A 107
ILE A 117
VAL A 139
 MFU  A 306 (-3.9A)
None
None
None
 0.91A 4zj8A-4csdA:
undetectable		 4zj8A-4csdA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4csd FUCOSE-BINDING
LECTIN PROTEIN
(Ralstonia
solanacearum) 		4 / 6 TRP A 218
ILE A 198
ILE A 208
VAL A 230
 MFU  A 302 (-4.0A)
None
None
None
 0.94A 4zj8A-4csdA:
undetectable		 4zj8A-4csdA:
17.43