SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MFK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZP4_C_C2FC997_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 10 ASP A 271
GLN A 242
SER A 251
TYR A 246
LEU A 295
 None
None
MFK  A 401 (-2.6A)
None
MFK  A 401 (-3.8A)
 1.40A 1zp4C-4mfzA:
0.0		 1zp4C-4mfzA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.84A 3ln1A-4mfzA:
undetectable		 3ln1A-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.84A 3ln1B-4mfzA:
undetectable		 3ln1B-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.83A 3ln1C-4mfzA:
undetectable		 3ln1C-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.84A 3ln1D-4mfzA:
0.9		 3ln1D-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 ALA A 232
ARG A 215
ILE A 197
PRO A 198
LEU A 204
 None
None
MFK  A 401 (-4.0A)
None
MFK  A 401 (-4.6A)
 0.89A 4m6kA-4mfzA:
undetectable		 4m6kA-4mfzA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q36_A_GCSA404_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 5 MET A 161
TRP A 163
TRP A 164
PHE A 277
 None
None
None
MFK  A 401 (-4.5A)
 1.12A 4q36A-4mfzA:
43.5		 4q36A-4mfzA:
71.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
SER A 236
GLY A 234
LEU A 239
ILE A 205
 None
MFK  A 401 (-3.4A)
MFK  A 401 ( 3.9A)
MFK  A 401 ( 4.9A)
None
 1.44A 5fepA-4mfzA:
undetectable		 5fepA-4mfzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
SER A 236
GLY A 234
LEU A 239
ILE A 205
 None
MFK  A 401 (-3.4A)
MFK  A 401 ( 3.9A)
MFK  A 401 ( 4.9A)
None
 1.44A 5fesA-4mfzA:
undetectable		 5fesA-4mfzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.80A 5jw1A-4mfzA:
undetectable		 5jw1A-4mfzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.86A 5jw1B-4mfzA:
undetectable		 5jw1B-4mfzA:
21.67