SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MEN'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OCU_A_TYLA3001_1 (LACTOTRANSFERRIN)	2bv8	C-PHYCOCYANIN BETA SUBUNIT (Gracilaria chilensis)	3 / 3	LEU B 113 TYR B 117 GLY B 121	CYC B1174 (-4.1A) None MEN B 72 ( 4.7A)	0.63A	2ocuA-2bv8B: undetectable	2ocuA-2bv8B: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OCU_A_TYLA3001_1 (LACTOTRANSFERRIN)	2vjh	PHYCOERYTHRIN BETA SUBUNIT (Gloeobacter violaceus)	3 / 3	LEU B 113 TYR B 117 GLY B 121	PEB B1082 (-4.5A) None MEN B 72 ( 4.5A)	0.60A	2ocuA-2vjhB: undetectable	2ocuA-2vjhB: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OCU_A_TYLA3001_1 (LACTOTRANSFERRIN)	2vjt	ALLOPHYCOCYANIN BETA SUBUNIT (Gloeobacter violaceus)	3 / 3	LEU B 112 TYR B 116 GLY B 120	None None MEN B 71 ( 4.2A)	0.63A	2ocuA-2vjtB: undetectable	2ocuA-2vjtB: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_ACTA402_0 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	3kvs	C-PHYCOCYANIN BETA CHAIN (Galdieria sulphuraria)	3 / 3	LYS B 73 TYR B 74 ARG B 78	MEN B 72 (-3.3A) None None	1.35A	4gc9A-3kvsB: undetectable	4gc9A-3kvsB: 19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_ACTA402_0 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	4f0t	C-PHYCOCYANIN BETA CHAIN (Synechocystis sp. PCC 6803)	3 / 3	LYS B 75 TYR B 76 ARG B 80	MEN B 72 (-3.4A) None MEN B 72 (-4.5A)	1.46A	4gc9A-4f0tB: undetectable	4gc9A-4f0tB: 17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_ACTA402_0 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	4f0u	ALLOPHYCOCYANIN, BETA SUBUNIT (Synechococcus elongatus)	3 / 3	LYS B 75 TYR B 76 ARG B 80	MEN B 72 (-3.2A) None None	1.34A	4gc9A-4f0uB: undetectable	4gc9A-4f0uB: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LSU_A_SAMA1304_0 (HISTONE-LYSINE N-METHYLTRANSFERASE NSD2)	1xg0	B-PHYCOERYTHRIN BETA CHAIN (Rhodomonas sp. CS24)	5 / 12	GLY C 121 ASN C 63 CYH C 73 CYH C 82 LEU C 66	MEN C 72 ( 4.5A) None PEB C 282 (-3.5A) PEB C 282 (-1.8A) PEB C 282 ( 4.8A)	1.36A	5lsuA-1xg0C: undetectable	5lsuA-1xg0C: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LSU_A_SAMA1304_0 (HISTONE-LYSINE N-METHYLTRANSFERASE NSD2)	2vjh	PHYCOERYTHRIN BETA SUBUNIT (Gloeobacter violaceus)	5 / 12	GLY B 121 ASN B 63 CYH B 73 CYH B 82 LEU B 66	MEN B 72 ( 4.5A) None PEB B1082 (-3.5A) PEB B1082 (-1.6A) PEB B1082 ( 4.7A)	1.36A	5lsuA-2vjhB: undetectable	5lsuA-2vjhB: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LSU_A_SAMA1304_0 (HISTONE-LYSINE N-METHYLTRANSFERASE NSD2)	3v57	PHYCOERYTHRIN BETA SUBUNIT (Porphyridium purpureum)	5 / 12	GLY B 121 ASN B 63 CYH B 73 CYH B 82 LEU B 66	MEN B 72 ( 4.5A) None PEB B 203 (-3.4A) PEB B 203 (-1.8A) PEB B 203 ( 4.6A)	1.41A	5lsuA-3v57B: undetectable	5lsuA-3v57B: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LSU_A_SAMA1304_0 (HISTONE-LYSINE N-METHYLTRANSFERASE NSD2)	4lms	CRYPTOPHYTE PHYCOCYANIN (BETA CHAIN) (Chroomonas sp.)	5 / 12	GLY B 121 ASN B 63 CYH B 73 CYH B 82 LEU B 66	MEN B 72 ( 4.6A) None CYC B 203 (-3.6A) CYC B 203 (-1.8A) CYC B 203 ( 4.8A)	1.34A	5lsuA-4lmsB: undetectable	5lsuA-4lmsB: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LSU_A_SAMA1304_0 (HISTONE-LYSINE N-METHYLTRANSFERASE NSD2)	5nb3	PHYCOERYTHRIN BETA SUBUNIT,PHYCOERYTHRI N BETA SUBUNIT (Phormidium rubidum)	5 / 12	GLY M 119 ASN M 61 CYH M 71 CYH M 80 LEU M 64	MEN M 70 ( 4.6A) None PEB M 186 (-3.5A) PEB M 186 (-2.0A) PEB M 186 ( 4.5A)	1.34A	5lsuA-5nb3M: undetectable	5lsuA-5nb3M: 18.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OCU_A_TYLA3001_1","LACTOTRANSFERRIN","2bv8","C-PHYCOCYANIN BETA SUBUNIT","Gracilaria chilensis",3,"LEU B 113;TYR B 117;GLY B 121","CYC B1174 (-4.1A);None;MEN B  72 ( 4.7A)","0.63A","2ocuA-2bv8B:undetectable",null],["2OCU_A_TYLA3001_1","LACTOTRANSFERRIN","2vjh","PHYCOERYTHRIN BETA SUBUNIT","Gloeobacter violaceus",3,"LEU B 113;TYR B 117;GLY B 121","PEB B1082 (-4.5A);None;MEN B  72 ( 4.5A)","0.60A","2ocuA-2vjhB:undetectable","2ocuA-2bv8B:21.05"],["2OCU_A_TYLA3001_1","LACTOTRANSFERRIN","2vjt","ALLOPHYCOCYANIN BETA SUBUNIT","Gloeobacter violaceus",3,"LEU B 112;TYR B 116;GLY B 120","None;None;MEN B  71 ( 4.2A)","0.63A","2ocuA-2vjtB:undetectable","2ocuA-2vjhB:21.47"],["4GC9_A_ACTA402_0","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","3kvs","C-PHYCOCYANIN BETA CHAIN","Galdieria sulphuraria",3,"LYS B  73;TYR B  74;ARG B  78","MEN B  72 (-3.3A);None;None","1.35A","4gc9A-3kvsB:undetectable","2ocuA-2vjtB:18.77"],["4GC9_A_ACTA402_0","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","4f0t","C-PHYCOCYANIN BETA CHAIN","Synechocystis sp. PCC 6803",3,"LYS B  75;TYR B  76;ARG B  80","MEN B  72 (-3.4A);None;MEN B  72 (-4.5A)","1.46A","4gc9A-4f0tB:undetectable","4gc9A-3kvsB:19.94"],["4GC9_A_ACTA402_0","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","4f0u","ALLOPHYCOCYANIN, BETA SUBUNIT","Synechococcus elongatus",3,"LYS B  75;TYR B  76;ARG B  80","MEN B  72 (-3.2A);None;None","1.34A","4gc9A-4f0uB:undetectable","4gc9A-4f0tB:17.39"],["5LSU_A_SAMA1304_0","HISTONE-LYSINE N-METHYLTRANSFERASE NSD2","1xg0","B-PHYCOERYTHRIN BETA CHAIN","Rhodomonas sp. CS24",5,"GLY C 121;ASN C  63;CYH C  73;CYH C  82;LEU C  66","MEN C  72 ( 4.5A);None;PEB C 282 (-3.5A);PEB C 282 (-1.8A);PEB C 282 ( 4.8A)","1.36A","5lsuA-1xg0C:undetectable","4gc9A-4f0uB:16.94"],["5LSU_A_SAMA1304_0","HISTONE-LYSINE N-METHYLTRANSFERASE NSD2","2vjh","PHYCOERYTHRIN BETA SUBUNIT","Gloeobacter violaceus",5,"GLY B 121;ASN B  63;CYH B  73;CYH B  82;LEU B  66","MEN B  72 ( 4.5A);None;PEB B1082 (-3.5A);PEB B1082 (-1.6A);PEB B1082 ( 4.7A)","1.36A","5lsuA-2vjhB:undetectable","5lsuA-1xg0C:20.38"],["5LSU_A_SAMA1304_0","HISTONE-LYSINE N-METHYLTRANSFERASE NSD2","3v57","PHYCOERYTHRIN BETA SUBUNIT","Porphyridium purpureum",5,"GLY B 121;ASN B  63;CYH B  73;CYH B  82;LEU B  66","MEN B  72 ( 4.5A);None;PEB B 203 (-3.4A);PEB B 203 (-1.8A);PEB B 203 ( 4.6A)","1.41A","5lsuA-3v57B:undetectable","5lsuA-2vjhB:20.62"],["5LSU_A_SAMA1304_0","HISTONE-LYSINE N-METHYLTRANSFERASE NSD2","4lms","CRYPTOPHYTE PHYCOCYANIN (BETA CHAIN)","Chroomonas sp.",5,"GLY B 121;ASN B  63;CYH B  73;CYH B  82;LEU B  66","MEN B  72 ( 4.6A);None;CYC B 203 (-3.6A);CYC B 203 (-1.8A);CYC B 203 ( 4.8A)","1.34A","5lsuA-4lmsB:undetectable","5lsuA-3v57B:20.87"],["5LSU_A_SAMA1304_0","HISTONE-LYSINE N-METHYLTRANSFERASE NSD2","5nb3","PHYCOERYTHRIN BETA SUBUNIT,PHYCOERYTHRIN BETA SUBUNIT","Phormidium rubidum",5,"GLY M 119;ASN M  61;CYH M  71;CYH M  80;LEU M  64","MEN M  70 ( 4.6A);None;PEB M 186 (-3.5A);PEB M 186 (-2.0A);PEB M 186 ( 4.5A)","1.34A","5lsuA-5nb3M:undetectable","5lsuA-4lmsB:20.45"]]