SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MED'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
 1.21A 1a4lA-1kq0A:
undetectable		 1a4lA-1kq0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
 1.21A 1a4lB-1kq0A:
undetectable		 1a4lB-1kq0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
 1.19A 1a4lC-1kq0A:
undetectable		 1a4lC-1kq0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
 1.28A 1a4lD-1kq0A:
undetectable		 1a4lD-1kq0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 TYR A 444
GLU A 364
HIS A 331
GLY A 330
 MED  A 601 ( 4.7A)
ZN  A 480 (-2.6A)
ZN  A 480 ( 3.4A)
None
 0.82A 2ha4A-1kq0A:
undetectable		 2ha4A-1kq0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 TYR A 444
GLU A 364
HIS A 331
GLY A 330
 MED  A 601 ( 4.7A)
ZN  A 480 (-2.6A)
ZN  A 480 ( 3.4A)
None
 0.80A 2ha4B-1kq0A:
undetectable		 2ha4B-1kq0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY
(Vibrio
cholerae) 		4 / 6 GLU A 128
TYR A 164
HIS A 115
VAL A 167
 ZN  A 202 ( 2.5A)
MED  A 201 ( 4.6A)
None
None
 1.13A 4a97E-1y9qA:
undetectable		 4a97E-1y9qA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 LEU A 447
PRO A 220
ASP A 262
ILE A 338
HIS A 331
 None
None
ZN  A 479 (-2.2A)
MED  A 601 ( 4.7A)
ZN  A 480 ( 3.4A)
 1.39A 5dv4A-1kq0A:
undetectable		 5dv4A-1kq0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 GLY A 330
HIS A 331
ASP A 262
HIS A 231
 None
ZN  A 480 ( 3.4A)
ZN  A 479 (-2.2A)
MED  A 601 (-4.2A)
 0.81A 5nnwD-1kq0A:
0.0		 5nnwD-1kq0A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 GLY A 330
HIS A 331
ASP A 262
HIS A 231
 None
ZN  A 480 ( 3.4A)
ZN  A 479 (-2.2A)
MED  A 601 (-4.2A)
 0.82A 5no9D-1kq0A:
0.0		 5no9D-1kq0A:
10.06