SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ME8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 225
GLY A 227
GLY A 484
ASP A 486
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 0.80A 1ffyA-3kflA:
21.6		 1ffyA-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 228
GLY A 227
GLY A 484
ASP A 486
HIS A 513
 POP  A 802 ( 3.8A)
ME8  A 801 (-3.4A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 1.05A 1ffyA-3kflA:
21.6		 1ffyA-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  20
GLY A 261
ASP A 263
HIS A 290
PHE A 292
 ME8  A 801 (-3.6A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
ME8  A 801 (-4.9A)
 0.61A 1ffyA-6ax8A:
23.3		 1ffyA-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  18
GLY A  20
GLY A 261
ASP A 263
HIS A 290
 ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
 0.55A 1ffyA-6ax8A:
23.3		 1ffyA-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  21
GLY A  20
GLY A 261
ASP A 263
HIS A 290
 ME8  A 801 (-4.3A)
ME8  A 801 (-3.6A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
 1.28A 1ffyA-6ax8A:
23.3		 1ffyA-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		7 / 11 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
ILE A 487
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.6A)
 0.66A 1pg2A-3kflA:
35.5		 1pg2A-3kflA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		9 / 11 ALA A   9
HIS A  18
GLY A  20
HIS A  21
GLU A  24
GLY A 261
ASP A 263
ILE A 264
HIS A 290
 ME8  A 801 ( 3.8A)
ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
ME8  A 801 (-3.6A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.1A)
ME8  A 801 (-4.7A)
 0.44A 1pg2A-6ax8A:
39.3		 1pg2A-6ax8A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		6 / 11 GLY A  20
HIS A  18
GLY A 261
ASP A 263
ILE A 264
HIS A 290
 ME8  A 801 (-3.6A)
ME8  A 801 (-3.8A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.1A)
ME8  A 801 (-4.7A)
 1.14A 1pg2A-6ax8A:
39.3		 1pg2A-6ax8A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		6 / 12 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 0.83A 1qu2A-3kflA:
21.7		 1qu2A-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 228
GLY A 227
GLY A 484
ASP A 486
HIS A 513
 POP  A 802 ( 3.8A)
ME8  A 801 (-3.4A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 1.05A 1qu2A-3kflA:
21.7		 1qu2A-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  20
HIS A  18
GLY A 261
ASP A 263
HIS A 290
PHE A 292
 ME8  A 801 (-3.6A)
ME8  A 801 (-3.8A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
ME8  A 801 (-4.9A)
 1.09A 1qu2A-6ax8A:
23.3		 1qu2A-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  20
HIS A  21
GLY A 261
ASP A 263
HIS A 290
PHE A 292
 ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
ME8  A 801 (-4.9A)
 0.54A 1qu2A-6ax8A:
23.3		 1qu2A-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		6 / 12 HIS A  18
GLY A  20
HIS A  21
GLY A 261
ASP A 263
HIS A 290
 ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
 0.52A 1qu2A-6ax8A:
23.3		 1qu2A-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 225
GLY A 227
HIS A 228
ASP A 486
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 1.04A 1qu3A-3kflA:
16.0		 1qu3A-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  20
HIS A  18
ASP A 263
HIS A 290
PHE A 292
 ME8  A 801 (-3.6A)
ME8  A 801 (-3.8A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
ME8  A 801 (-4.9A)
 1.32A 1qu3A-6ax8A:
27.5		 1qu3A-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  20
HIS A  21
ASP A 263
HIS A 290
PHE A 292
 ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
ME8  A 801 (-4.9A)
 0.64A 1qu3A-6ax8A:
27.5		 1qu3A-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  18
GLY A  20
HIS A  21
ASP A 263
HIS A 290
 ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.7A)
 0.62A 1qu3A-6ax8A:
27.5		 1qu3A-6ax8A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		4 / 7 HIS A 470
TYR A 451
ASN A 449
LEU A 309
 None
None
ME8  A 801 (-4.6A)
None
 1.13A 1qzrA-3kflA:
undetectable		 1qzrA-3kflA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		4 / 6 MET A 407
LEU A 327
GLU A  24
MET A 259
 None
None
ME8  A 801 (-3.6A)
None
 1.02A 2kuhA-6ax8A:
undetectable		 2kuhA-6ax8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 TYR A 218
HIS A 491
ILE A 487
VAL A 483
MET A 295
 ME8  A 801 (-4.7A)
ME8  A 801 (-4.6A)
ME8  A 801 (-4.0A)
None
None
 1.00A 2qeoA-3kflA:
undetectable		 2qeoA-3kflA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		4 / 7 THR A 215
PRO A 216
PHE A 288
THR A 255
 None
ME8  A 801 (-4.4A)
None
None
 0.98A 2vl2B-3kflA:
3.4		 2vl2B-3kflA:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		7 / 11 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
ILE A 487
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.6A)
 0.52A 2x1lA-3kflA:
45.3		 2x1lA-3kflA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		10 / 11 ALA A   9
ALA A  11
HIS A  18
GLY A  20
HIS A  21
GLU A  24
GLY A 261
ASP A 263
ILE A 264
HIS A 290
 ME8  A 801 ( 3.8A)
ME8  A 801 (-3.1A)
ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
ME8  A 801 (-3.6A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.1A)
ME8  A 801 (-4.7A)
 0.38A 2x1lA-6ax8A:
54.3		 2x1lA-6ax8A:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		6 / 11 GLY A  20
HIS A  18
GLY A 261
ASP A 263
ILE A 264
HIS A 290
 ME8  A 801 (-3.6A)
ME8  A 801 (-3.8A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.1A)
ME8  A 801 (-4.7A)
 1.09A 2x1lA-6ax8A:
54.3		 2x1lA-6ax8A:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		7 / 12 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
ILE A 487
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.6A)
 0.50A 2x1lB-3kflA:
43.3		 2x1lB-3kflA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		11 / 12 ALA A   9
ALA A  11
HIS A  18
GLY A  20
HIS A  21
GLU A  24
GLY A 261
ASP A 263
ILE A 264
HIS A 290
LEU A 293
 ME8  A 801 ( 3.8A)
ME8  A 801 (-3.1A)
ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
ME8  A 801 (-3.6A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.1A)
ME8  A 801 (-4.7A)
ME8  A 801 (-4.5A)
 0.30A 2x1lB-6ax8A:
52.2		 2x1lB-6ax8A:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  20
HIS A  18
GLY A 261
ASP A 263
ILE A 264
HIS A 290
 ME8  A 801 (-3.6A)
ME8  A 801 (-3.8A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.1A)
ME8  A 801 (-4.7A)
 1.08A 2x1lB-6ax8A:
52.2		 2x1lB-6ax8A:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		7 / 11 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
ILE A 487
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.6A)
 0.50A 2x1lC-3kflA:
43.0		 2x1lC-3kflA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		10 / 11 ALA A   9
ALA A  11
HIS A  18
GLY A  20
HIS A  21
GLU A  24
GLY A 261
ASP A 263
ILE A 264
HIS A 290
 ME8  A 801 ( 3.8A)
ME8  A 801 (-3.1A)
ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
ME8  A 801 (-3.6A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.1A)
ME8  A 801 (-4.7A)
 0.30A 2x1lC-6ax8A:
52.0		 2x1lC-6ax8A:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		6 / 11 GLY A  20
HIS A  18
GLY A 261
ASP A 263
ILE A 264
HIS A 290
 ME8  A 801 (-3.6A)
ME8  A 801 (-3.8A)
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
ME8  A 801 (-4.1A)
ME8  A 801 (-4.7A)
 1.09A 2x1lC-6ax8A:
52.0		 2x1lC-6ax8A:
51.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A  33
HIS A 290
ALA A  11
LEU A  84
GLN A  81
 None
ME8  A 801 (-4.7A)
ME8  A 801 (-3.1A)
None
None
 1.49A 3jwqA-6ax8A:
undetectable
3jwqD-6ax8A:
undetectable		 3jwqA-6ax8A:
12.38
3jwqD-6ax8A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		4 / 8 TYR A 450
HIS A 306
TRP A 495
LEU A 444
 ME8  A 801 (-4.7A)
None
None
None
 1.38A 3uzzB-3kflA:
undetectable		 3uzzB-3kflA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		4 / 6 HIS A  51
HIS A  99
ASP A 129
ASP A  49
 None
None
None
ME8  A 801 (-4.1A)
 1.31A 4blvA-6ax8A:
undetectable		 4blvA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		4 / 5 SER A 512
ARG A 401
LEU A 488
ASP A 486
 None
None
EDO  A 815 (-4.5A)
ME8  A 801 ( 2.6A)
 1.32A 4ig1A-3kflA:
undetectable		 4ig1A-3kflA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  18
GLY A  20
VAL A 227
GLY A 261
ASP A 263
 ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
None
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
 0.99A 5hg0A-6ax8A:
5.8		 5hg0A-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 225
GLY A 227
HIS A 228
VAL A 442
ASP A 486
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
None
ME8  A 801 ( 2.6A)
 0.96A 5hg0B-3kflA:
7.5		 5hg0B-3kflA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 225
GLY A 227
HIS A 228
VAL A 442
GLY A 484
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
None
ME8  A 801 (-3.2A)
 0.67A 5hg0B-3kflA:
7.5		 5hg0B-3kflA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		6 / 12 HIS A  18
GLY A  20
HIS A  21
VAL A 227
GLY A 261
ASP A 263
 ME8  A 801 (-3.8A)
ME8  A 801 (-3.6A)
ME8  A 801 (-4.3A)
None
ME8  A 801 (-2.9A)
ME8  A 801 (-3.1A)
 1.02A 5hg0B-6ax8A:
5.8		 5hg0B-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		4 / 7 THR A 301
ASP A 256
ASP A 445
GLY A 259
 None
ME8  A 801 (-3.7A)
None
None
 0.78A 5hwaA-3kflA:
undetectable		 5hwaA-3kflA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A  94
ASP A  49
ASP A 230
GLY A  52
 None
ME8  A 801 (-4.1A)
None
None
 0.95A 5hwaA-6ax8A:
undetectable		 5hwaA-6ax8A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6ax8 METHIONINE-TRNA
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 260
HIS A 268
PHE A 332
ALA A  27
PHE A 183
 None
ME8  A 801 (-4.6A)
None
None
None
 1.44A 5iwuA-6ax8A:
undetectable		 5iwuA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 ASN A 221
ILE A 487
TYR A 450
THR A 253
PHE A 284
 POP  A 802 (-3.3A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.7A)
None
None
 1.46A 6j20A-3kflA:
undetectable		 6j20A-3kflA:
20.58