SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MDO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2qve TYROSINE AMINOMUTASE
(Streptomyces
globisporus) 		3 / 3 MET A 447
LEU A 150
SER A 149
 None
None
MDO  A 152 ( 4.0A)
 0.66A 1ee2A-2qveA:
undetectable		 1ee2A-2qveA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 6at7 PHENYLALANINE
AMMONIA-LYASE
(Sorghum
bicolor) 		5 / 12 ASP A 192
ILE A 392
PRO A 391
ILE A 361
ALA A 257
 MDO  A 190 ( 4.4A)
None
None
None
None
 1.14A 1kijB-6at7A:
undetectable		 1kijB-6at7A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 6at7 PHENYLALANINE
AMMONIA-LYASE
(Sorghum
bicolor) 		5 / 12 GLY A 393
THR A 188
ALA A 357
THR A 358
ALA A 485
 None
MDO  A 190 ( 4.4A)
None
None
None
 0.90A 2gluB-6at7A:
undetectable		 2gluB-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 7 SER A 172
LYS A 178
SER A 463
VAL A 173
 MDO  A 176 ( 3.7A)
MDO  A 176 ( 3.3A)
MDO  A 176 ( 4.8A)
MDO  A 176 ( 4.6A)
 1.23A 2j9cA-3nz4A:
undetectable
2j9cB-3nz4A:
undetectable
2j9cC-3nz4A:
undetectable		 2j9cA-3nz4A:
9.90
2j9cB-3nz4A:
9.90
2j9cC-3nz4A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 10 ASP A 205
ASN A 260
GLY A 398
PRO A 404
GLY A 494
 MDO  A 203 ( 4.3A)
DTT  A1717 (-2.8A)
None
None
None
 1.45A 2y6rA-1w27A:
undetectable		 2y6rA-1w27A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 8 THR A 501
LYS A 509
ASP A 205
GLU A 275
 None
None
MDO  A 203 ( 4.3A)
None
 0.98A 2zw9A-1w27A:
undetectable		 2zw9A-1w27A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6at7 PHENYLALANINE
AMMONIA-LYASE
(Sorghum
bicolor) 		4 / 5 LEU A 255
GLY A 252
THR A 188
ILE A 463
 None
None
MDO  A 190 ( 4.4A)
None
 0.91A 3wriB-6at7A:
undetectable		 3wriB-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 6at7 PHENYLALANINE
AMMONIA-LYASE
(Sorghum
bicolor) 		4 / 7 PHE A 102
ASN A 247
GLY A 242
LEU A 124
 None
MDO  A 190 ( 3.2A)
None
None
 0.81A 4ejjD-6at7A:
undetectable		 4ejjD-6at7A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 6at7 PHENYLALANINE
AMMONIA-LYASE
(Sorghum
bicolor) 		5 / 12 GLY A 481
GLY A 252
THR A 188
ASN A 478
SER A 484
 None
None
MDO  A 190 ( 4.4A)
None
None
 1.18A 4f84A-6at7A:
undetectable		 4f84A-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5ltm PHENYLALANINE
AMMONIA LYASE
(Anabaena) 		3 / 3 ASP B 120
ARG B 466
ASP B 170
 None
None
MDO  B 168 ( 4.3A)
 0.73A 4fp9C-5ltmB:
undetectable		 4fp9C-5ltmB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 8 ASP A 178
SER A 172
ALA A 465
SER A 463
 MDO  A 176 ( 4.3A)
MDO  A 176 ( 3.7A)
None
MDO  A 176 ( 4.8A)
 0.94A 4lv9A-3nz4A:
undetectable
4lv9B-3nz4A:
undetectable		 4lv9A-3nz4A:
21.39
4lv9B-3nz4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 7 ASP A 178
SER A 172
ALA A 465
SER A 463
 MDO  A 176 ( 4.3A)
MDO  A 176 ( 3.7A)
None
MDO  A 176 ( 4.8A)
 0.95A 4lv9A-3nz4A:
undetectable
4lv9B-3nz4A:
undetectable		 4lv9A-3nz4A:
21.39
4lv9B-3nz4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		4 / 6 GLN A 488
THR A 114
HIS A 396
ASN A 260
 MDO  A 203 ( 3.9A)
None
None
DTT  A1717 (-2.8A)
 1.26A 4pfjB-1w27A:
undetectable		 4pfjB-1w27A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 ASP A 205
ILE A 405
PRO A 404
ILE A 374
SER A 270
 MDO  A 203 ( 4.3A)
None
None
None
None
 1.11A 4uroA-1w27A:
undetectable		 4uroA-1w27A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1w27 PHENYLALANINE
AMMONIA-LYASE 1
(Petroselinum
crispum) 		5 / 12 ASP A 205
ILE A 405
PRO A 404
ILE A 374
SER A 270
 MDO  A 203 ( 4.3A)
None
None
None
None
 1.14A 4uroC-1w27A:
undetectable		 4uroC-1w27A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 6at7 PHENYLALANINE
AMMONIA-LYASE
(Sorghum
bicolor) 		5 / 11 ASN A 465
ILE A 463
THR A 188
GLY A 481
ASP A 397
 None
None
MDO  A 190 ( 4.4A)
None
None
 1.37A 4xt7A-6at7A:
undetectable		 4xt7A-6at7A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 6at7 PHENYLALANINE
AMMONIA-LYASE
(Sorghum
bicolor) 		5 / 11 THR A 390
SER A 479
GLY A 389
ASP A 192
THR A 186
 None
MDO  A 190 ( 4.8A)
MDO  A 190 ( 4.9A)
MDO  A 190 ( 4.4A)
MDO  A 190 ( 4.9A)
 1.33A 4xt7A-6at7A:
undetectable		 4xt7A-6at7A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 6at7 PHENYLALANINE
AMMONIA-LYASE
(Sorghum
bicolor) 		4 / 6 SER A 159
GLY A 248
ASN A 369
ILE A 245
 None
MDO  A 190 ( 4.0A)
None
None
 1.12A 5j4nA-6at7A:
undetectable		 5j4nA-6at7A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2qve TYROSINE AMINOMUTASE
(Streptomyces
globisporus) 		4 / 5 HIS A 357
ALA A 362
SER A 446
GLY A 151
 MDO  A 152 ( 4.1A)
None
MDO  A 152 ( 4.4A)
MDO  A 152 ( 2.4A)
 1.18A 5yodD-2qveA:
undetectable		 5yodD-2qveA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2qve TYROSINE AMINOMUTASE
(Streptomyces
globisporus) 		4 / 6 SER A 149
ALA A 430
ALA A 452
SER A 451
 MDO  A 152 ( 4.0A)
None
None
None
 0.88A 6bocA-2qveA:
undetectable
6bocB-2qveA:
undetectable
6bocC-2qveA:
undetectable
6bocD-2qveA:
undetectable		 6bocA-2qveA:
4.36
6bocB-2qveA:
4.36
6bocC-2qveA:
4.36
6bocD-2qveA:
4.36