SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MDM'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V2X_A_SAMA400_0 (TRNA (GM18) METHYLTRANSFERASE)	5eyy	CENTROLOBIUM TOMENTOSUM LECTIN (Centrolobium tomentosum)	6 / 12	GLY A 106 GLY A 221 ILE A 89 LEU A 34 VAL A 48 ALA A 218	MDM A 304 (-3.4A) MDM A 304 (-3.2A) None None None None	1.48A	1v2xA-5eyyA: undetectable	1v2xA-5eyyA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_B_SAMB770_0 (23S RRNA METHYLTRANSFERASE)	5u38	LECTIN (Platypodium elegans)	6 / 12	LEU A 109 GLY A 106 GLY A 221 ILE A 89 LEU A 34 VAL A 48	None MDM A 304 ( 3.8A) MDM A 304 (-3.2A) None None None	1.44A	3nk7B-5u38A: undetectable	3nk7B-5u38A: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q5M_A_ROCA1101_3 (PROTEASE)	5eyy	CENTROLOBIUM TOMENTOSUM LECTIN (Centrolobium tomentosum)	3 / 3	ASP A 131 ASP A 142 ASN A 137	CA A 302 ( 2.1A) MN A 303 ( 2.7A) MDM A 304 (-2.9A)	0.83A	4q5mA-5eyyA: undetectable	4q5mA-5eyyA: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCI_A_ADNA2414_1 (RNA-DIRECTED RNA POLYMERASE L)	5eyy	CENTROLOBIUM TOMENTOSUM LECTIN (Centrolobium tomentosum)	4 / 6	GLU A 129 PHE A 133 TYR A 134 HIS A 147	MN A 303 (-2.6A) MDM A 304 ( 3.5A) None MN A 303 (-3.3A)	1.29A	4uciA-5eyyA: undetectable	4uciA-5eyyA: 18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCI_B_ADNB2415_1 (RNA-DIRECTED RNA POLYMERASE L)	5eyy	CENTROLOBIUM TOMENTOSUM LECTIN (Centrolobium tomentosum)	4 / 7	GLU A 129 PHE A 133 TYR A 134 HIS A 147	MN A 303 (-2.6A) MDM A 304 ( 3.5A) None MN A 303 (-3.3A)	1.28A	4uciB-5eyyA: undetectable	4uciB-5eyyA: 18.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1V2X_A_SAMA400_0","TRNA (GM18) METHYLTRANSFERASE","5eyy","CENTROLOBIUM TOMENTOSUM LECTIN","Centrolobium tomentosum",6,"GLY A 106;GLY A 221;ILE A  89;LEU A  34;VAL A  48;ALA A 218","MDM A 304 (-3.4A);MDM A 304 (-3.2A);None;None;None;None","1.48A","1v2xA-5eyyA:undetectable",null],["3NK7_B_SAMB770_0","23S RRNA METHYLTRANSFERASE","5u38","LECTIN","Platypodium elegans",6,"LEU A 109;GLY A 106;GLY A 221;ILE A  89;LEU A  34;VAL A  48","None;MDM A 304 ( 3.8A);MDM A 304 (-3.2A);None;None;None","1.44A","3nk7B-5u38A:undetectable","1v2xA-5eyyA:21.05"],["4Q5M_A_ROCA1101_3","PROTEASE","5eyy","CENTROLOBIUM TOMENTOSUM LECTIN","Centrolobium tomentosum",3,"ASP A 131;ASP A 142;ASN A 137"," CA A 302 ( 2.1A); MN A 303 ( 2.7A);MDM A 304 (-2.9A)","0.83A","4q5mA-5eyyA:undetectable","3nk7B-5u38A:20.14"],["4UCI_A_ADNA2414_1","RNA-DIRECTED RNA POLYMERASE L","5eyy","CENTROLOBIUM TOMENTOSUM LECTIN","Centrolobium tomentosum",4,"GLU A 129;PHE A 133;TYR A 134;HIS A 147"," MN A 303 (-2.6A);MDM A 304 ( 3.5A);None; MN A 303 (-3.3A)","1.29A","4uciA-5eyyA:undetectable","4q5mA-5eyyA:18.87"],["4UCI_B_ADNB2415_1","RNA-DIRECTED RNA POLYMERASE L","5eyy","CENTROLOBIUM TOMENTOSUM LECTIN","Centrolobium tomentosum",4,"GLU A 129;PHE A 133;TYR A 134;HIS A 147"," MN A 303 (-2.6A);MDM A 304 ( 3.5A);None; MN A 303 (-3.3A)","1.28A","4uciB-5eyyA:undetectable","4uciA-5eyyA:18.05"]]