SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MCF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		9 / 12 HIS A  42
HIS A  44
ASP A  46
PHE A  88
HIS A 225
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.5A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.58A 1a4lA-3ewdA:
42.2		 1a4lA-3ewdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A 225
ASP A  46
HIS A  42
GLU A 274
ASP A 197
 ZN  A 371 ( 3.4A)
MCF  A 372 (-3.5A)
ZN  A 371 (-3.3A)
None
None
 1.33A 1a4lA-3ewdA:
42.2		 1a4lA-3ewdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		8 / 12 HIS A  44
ASP A  46
PHE A  88
HIS A 225
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.5A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.56A 1a4lB-3ewdA:
42.3		 1a4lB-3ewdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 5 HIS A  42
LEU A  85
SER A 129
GLY A 200
 ZN  A 371 (-3.3A)
MCF  A 372 (-4.7A)
MCF  A 372 ( 4.6A)
MCF  A 372 (-3.4A)
 0.57A 1a4lB-3ewdA:
42.3		 1a4lB-3ewdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		9 / 12 HIS A  42
HIS A  44
ASP A  46
PHE A  88
HIS A 225
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.5A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.51A 1a4lC-3ewdA:
42.3		 1a4lC-3ewdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A 225
ASP A  46
HIS A  42
GLU A 274
ASP A 197
 ZN  A 371 ( 3.4A)
MCF  A 372 (-3.5A)
ZN  A 371 (-3.3A)
None
None
 1.29A 1a4lC-3ewdA:
42.3		 1a4lC-3ewdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		8 / 12 HIS A  44
ASP A  46
PHE A  88
GLY A 199
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.5A)
MCF  A 372 ( 3.9A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.79A 1a4lD-3ewdA:
42.4		 1a4lD-3ewdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		9 / 12 HIS A  44
ASP A  46
PHE A  88
GLY A 200
HIS A 225
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.5A)
MCF  A 372 (-3.4A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.57A 1a4lD-3ewdA:
42.4		 1a4lD-3ewdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 8 ASP A 309
HIS A  42
ILE A 170
HIS A 225
 MCF  A 372 ( 2.4A)
ZN  A 371 (-3.3A)
None
ZN  A 371 ( 3.4A)
 1.01A 1ei6D-3ewdA:
undetectable		 1ei6D-3ewdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 11 GLU A 274
HIS A 225
GLY A 251
HIS A  44
PRO A 311
 None
ZN  A 371 ( 3.4A)
None
MCF  A 372 ( 3.3A)
None
 1.47A 1mjqA-3ewdA:
undetectable
1mjqB-3ewdA:
undetectable		 1mjqA-3ewdA:
14.40
1mjqB-3ewdA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  42
HIS A 225
GLY A 199
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
ZN  A 371 ( 3.4A)
MCF  A 372 ( 3.9A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.23A 1t69A-3ewdA:
undetectable		 1t69A-3ewdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 LEU A 283
HIS A  42
HIS A  44
GLY A 199
PHE A 314
 None
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
MCF  A 372 ( 3.9A)
None
 1.21A 1zz1B-3ewdA:
undetectable
1zz1C-3ewdA:
undetectable		 1zz1B-3ewdA:
22.25
1zz1C-3ewdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 6 LEU A 283
HIS A  42
HIS A  44
HIS A 225
 None
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
ZN  A 371 ( 3.4A)
 0.92A 2ow9A-3ewdA:
undetectable		 2ow9A-3ewdA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  42
GLY A 199
GLU A 228
SER A 279
ASP A 309
 ZN  A 371 (-3.3A)
MCF  A 372 ( 3.9A)
MCF  A 372 (-2.8A)
MCF  A 372 ( 4.7A)
MCF  A 372 ( 2.4A)
 1.29A 2pgfA-3ewdA:
62.6		 2pgfA-3ewdA:
97.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		8 / 12 HIS A  44
ASP A  46
GLY A 199
GLU A 228
HIS A 252
SER A 279
ASP A 309
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 ( 3.9A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 4.7A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.87A 2pgfA-3ewdA:
62.6		 2pgfA-3ewdA:
97.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		11 / 12 HIS A  44
ASP A  46
PHE A  88
ILE A 170
GLY A 200
HIS A 225
GLU A 228
HIS A 252
SER A 279
ASP A 309
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.5A)
None
MCF  A 372 (-3.4A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 4.7A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.22A 2pgfA-3ewdA:
62.6		 2pgfA-3ewdA:
97.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 HIS A  44
ILE A 170
GLY A 200
HIS A 225
SER A 279
ASP A 310
 MCF  A 372 ( 3.3A)
None
MCF  A 372 (-3.4A)
ZN  A 371 ( 3.4A)
MCF  A 372 ( 4.7A)
MCF  A 372 (-2.9A)
 1.32A 2pgfA-3ewdA:
62.6		 2pgfA-3ewdA:
97.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		11 / 12 HIS A  42
HIS A  44
ASP A  46
PHE A  88
ILE A 170
GLY A 200
HIS A 225
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.5A)
None
MCF  A 372 (-3.4A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.21A 2pgrA-3ewdA:
62.5		 2pgrA-3ewdA:
97.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		7 / 12 HIS A  44
ASP A  46
GLY A 199
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 ( 3.9A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.85A 2pgrA-3ewdA:
62.5		 2pgrA-3ewdA:
97.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
ILE A 170
GLY A 200
HIS A 225
ASP A 310
 MCF  A 372 ( 3.3A)
None
MCF  A 372 (-3.4A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.9A)
 1.06A 2pgrA-3ewdA:
62.5		 2pgrA-3ewdA:
97.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A 225
ASP A  46
HIS A  42
GLU A 274
ASP A 197
 ZN  A 371 ( 3.4A)
MCF  A 372 (-3.5A)
ZN  A 371 (-3.3A)
None
None
 1.14A 2pgrA-3ewdA:
62.5		 2pgrA-3ewdA:
97.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 5 HIS A  42
HIS A 225
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
ZN  A 371 ( 3.4A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.18A 3c0zA-3ewdA:
undetectable		 3c0zA-3ewdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 ILE A 144
ILE A 105
VAL A 104
PHE A  49
LEU A  47
 None
None
None
None
MCF  A 372 (-4.3A)
 1.02A 3em0B-3ewdA:
undetectable		 3em0B-3ewdA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 5 LEU A 283
HIS A  42
HIS A  44
HIS A 225
 None
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
ZN  A 371 ( 3.4A)
 0.97A 3kecA-3ewdA:
undetectable		 3kecA-3ewdA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 6 HIS A 252
HIS A 225
HIS A  42
ASP A 310
 MCF  A 372 (-4.1A)
ZN  A 371 ( 3.4A)
ZN  A 371 (-3.3A)
MCF  A 372 (-2.9A)
 0.88A 3nvcA-3ewdA:
undetectable		 3nvcA-3ewdA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		3 / 3 HIS A 225
HIS A  42
HIS A  44
 ZN  A 371 ( 3.4A)
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
 0.58A 3qpkA-3ewdA:
undetectable		 3qpkA-3ewdA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		3 / 3 HIS A 225
HIS A  42
HIS A  44
 ZN  A 371 ( 3.4A)
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
 0.60A 3qpkB-3ewdA:
undetectable		 3qpkB-3ewdA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		3 / 4 SER A 182
GLY A 200
GLU A  90
 None
MCF  A 372 (-3.4A)
None
 0.58A 3raeA-3ewdA:
undetectable
3raeC-3ewdA:
undetectable		 3raeA-3ewdA:
22.92
3raeC-3ewdA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 6 LEU A 283
HIS A  42
HIS A  44
HIS A 225
 None
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
ZN  A 371 ( 3.4A)
 0.91A 4a7bA-3ewdA:
undetectable		 4a7bA-3ewdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		7 / 12 LEU A  85
HIS A 225
GLU A 228
GLU A 202
HIS A 252
SER A 279
ASP A 309
 MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
None
MCF  A 372 (-4.1A)
MCF  A 372 ( 4.7A)
MCF  A 372 ( 2.4A)
 0.70A 4aqlA-3ewdA:
19.4		 4aqlA-3ewdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 GLY A 200
ASP A 310
HIS A  44
ASP A 309
HIS A  42
 MCF  A 372 (-3.4A)
MCF  A 372 (-2.9A)
MCF  A 372 ( 3.3A)
MCF  A 372 ( 2.4A)
ZN  A 371 (-3.3A)
 0.90A 4bz6C-3ewdA:
undetectable		 4bz6C-3ewdA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  42
HIS A 225
GLY A 199
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
ZN  A 371 ( 3.4A)
MCF  A 372 ( 3.9A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.20A 4bz6C-3ewdA:
undetectable		 4bz6C-3ewdA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 4 HIS A  42
HIS A  44
HIS A 252
HIS A 225
 ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
MCF  A 372 (-4.1A)
ZN  A 371 ( 3.4A)
 1.03A 4ef3A-3ewdA:
undetectable		 4ef3A-3ewdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  42
HIS A 225
GLY A 199
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
ZN  A 371 ( 3.4A)
MCF  A 372 ( 3.9A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.17A 4lxzA-3ewdA:
undetectable		 4lxzA-3ewdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  42
HIS A 225
GLY A 199
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
ZN  A 371 ( 3.4A)
MCF  A 372 ( 3.9A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.16A 4lxzC-3ewdA:
undetectable		 4lxzC-3ewdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 9 ILE A 170
GLY A 171
ILE A 179
ILE A  93
VAL A  89
 None
None
None
None
MCF  A 372 ( 3.7A)
 1.10A 4nptA-3ewdA:
undetectable		 4nptA-3ewdA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 6 ILE A 170
ASP A 197
GLY A 200
HIS A  42
 None
None
MCF  A 372 (-3.4A)
ZN  A 371 (-3.3A)
 0.93A 4oltA-3ewdA:
undetectable		 4oltA-3ewdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 6 ILE A 170
ASP A 197
GLY A 200
HIS A  42
 None
None
MCF  A 372 (-3.4A)
ZN  A 371 (-3.3A)
 0.90A 4oltB-3ewdA:
undetectable		 4oltB-3ewdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 HIS A  44
LEU A  85
HIS A 225
HIS A 252
LEU A 283
ASP A 309
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-4.1A)
None
MCF  A 372 ( 2.4A)
 0.46A 4r88A-3ewdA:
22.7		 4r88A-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A  85
HIS A 225
LEU A 283
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
None
MCF  A 372 (-2.9A)
 1.39A 4r88A-3ewdA:
22.7		 4r88A-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A 283
HIS A 225
HIS A 252
ASP A 309
 MCF  A 372 ( 3.3A)
None
ZN  A 371 ( 3.4A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
 1.35A 4r88A-3ewdA:
22.7		 4r88A-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 HIS A  44
LEU A  85
HIS A 225
GLU A 228
LEU A 283
ASP A 309
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
None
MCF  A 372 ( 2.4A)
 0.45A 4r88B-3ewdA:
22.8		 4r88B-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A  85
HIS A 225
LEU A 283
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
None
MCF  A 372 (-2.9A)
 1.41A 4r88B-3ewdA:
22.8		 4r88B-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 HIS A  44
LEU A  85
HIS A 225
GLU A 228
LEU A 283
ASP A 309
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
None
MCF  A 372 ( 2.4A)
 0.46A 4r88C-3ewdA:
15.3		 4r88C-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A  85
HIS A 225
LEU A 283
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
None
MCF  A 372 (-2.9A)
 1.42A 4r88C-3ewdA:
15.3		 4r88C-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 HIS A  44
LEU A  85
HIS A 225
GLU A 228
LEU A 283
ASP A 309
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
None
MCF  A 372 ( 2.4A)
 0.43A 4r88D-3ewdA:
20.2		 4r88D-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A  85
HIS A 225
LEU A 283
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
None
MCF  A 372 (-2.9A)
 1.39A 4r88D-3ewdA:
20.2		 4r88D-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 HIS A  44
LEU A  85
HIS A 225
GLU A 228
LEU A 283
ASP A 309
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
None
MCF  A 372 ( 2.4A)
 0.45A 4r88E-3ewdA:
22.8		 4r88E-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A  85
HIS A 225
LEU A 283
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
None
MCF  A 372 (-2.9A)
 1.41A 4r88E-3ewdA:
22.8		 4r88E-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 HIS A  44
LEU A  85
HIS A 225
GLU A 228
LEU A 283
ASP A 309
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
None
MCF  A 372 ( 2.4A)
 0.45A 4r88F-3ewdA:
22.8		 4r88F-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A  85
HIS A 225
LEU A 283
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
ZN  A 371 ( 3.4A)
None
MCF  A 372 (-2.9A)
 1.41A 4r88F-3ewdA:
22.8		 4r88F-3ewdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQL_A_KANA203_1
(2''-AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 9 ASP A 310
ASP A 309
GLU A 274
ASP A 197
GLU A 202
 MCF  A 372 (-2.9A)
MCF  A 372 ( 2.4A)
None
None
None
 1.24A 4wqlA-3ewdA:
0.1		 4wqlA-3ewdA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 5 LEU A 283
GLU A  87
LEU A  47
HIS A 225
 None
None
MCF  A 372 (-4.3A)
ZN  A 371 ( 3.4A)
 1.33A 4xi3B-3ewdA:
undetectable		 4xi3B-3ewdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 8 ASP A 310
ASP A 309
GLU A 274
ASP A 197
 MCF  A 372 (-2.9A)
MCF  A 372 ( 2.4A)
None
None
 0.93A 5cfsA-3ewdA:
undetectable		 5cfsA-3ewdA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  42
HIS A 225
GLY A 199
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
ZN  A 371 ( 3.4A)
MCF  A 372 ( 3.9A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.24A 5eeiA-3ewdA:
undetectable		 5eeiA-3ewdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  42
HIS A 225
GLY A 199
ASP A 309
ASP A 310
 ZN  A 371 (-3.3A)
ZN  A 371 ( 3.4A)
MCF  A 372 ( 3.9A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.23A 5eeiB-3ewdA:
undetectable		 5eeiB-3ewdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		3 / 3 HIS A 225
HIS A  42
HIS A  44
 ZN  A 371 ( 3.4A)
ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
 0.52A 5migA-3ewdA:
undetectable		 5migA-3ewdA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		4 / 9 ASP A 310
VAL A 306
SER A 305
ASP A 321
 MCF  A 372 (-2.9A)
None
None
None
 0.95A 6c2mD-3ewdA:
undetectable		 6c2mD-3ewdA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		9 / 12 HIS A  44
ASP A  46
LEU A  85
ILE A 170
HIS A 225
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.7A)
None
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.35A 6n91A-3ewdA:
42.6		 6n91A-3ewdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
ASP A  46
LEU A 283
GLU A 228
HIS A 252
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
None
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
 1.08A 6n91A-3ewdA:
42.6		 6n91A-3ewdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A  85
ILE A 170
GLU A 228
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
None
MCF  A 372 (-2.8A)
MCF  A 372 (-2.9A)
 1.05A 6n91A-3ewdA:
42.6		 6n91A-3ewdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 ILE A 170
SER A 129
HIS A 225
HIS A 252
ASP A 309
ASP A 310
 None
MCF  A 372 ( 4.6A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.47A 6n91A-3ewdA:
42.6		 6n91A-3ewdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		9 / 12 HIS A  44
ASP A  46
LEU A  85
ILE A 170
HIS A 225
GLU A 228
HIS A 252
ASP A 309
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
MCF  A 372 (-4.7A)
None
ZN  A 371 ( 3.4A)
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 0.36A 6n91B-3ewdA:
42.4		 6n91B-3ewdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
ASP A  46
LEU A 283
GLU A 228
HIS A 252
 MCF  A 372 ( 3.3A)
MCF  A 372 (-3.5A)
None
MCF  A 372 (-2.8A)
MCF  A 372 (-4.1A)
 1.07A 6n91B-3ewdA:
42.4		 6n91B-3ewdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		5 / 12 HIS A  44
LEU A  85
ILE A 170
GLU A 228
ASP A 310
 MCF  A 372 ( 3.3A)
MCF  A 372 (-4.7A)
None
MCF  A 372 (-2.8A)
MCF  A 372 (-2.9A)
 1.05A 6n91B-3ewdA:
42.4		 6n91B-3ewdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3ewd ADENOSINE DEAMINASE
(Plasmodium
vivax) 		6 / 12 ILE A 170
SER A 129
HIS A 225
HIS A 252
ASP A 309
ASP A 310
 None
MCF  A 372 ( 4.6A)
ZN  A 371 ( 3.4A)
MCF  A 372 (-4.1A)
MCF  A 372 ( 2.4A)
MCF  A 372 (-2.9A)
 1.49A 6n91B-3ewdA:
42.4		 6n91B-3ewdA:
13.33