SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MC3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 11 ASP A 473
SER A 475
ARG A 477
GLY A 449
THR A 450
 None
None
None
MC3  A 603 (-2.7A)
None
 1.46A 1jr1A-4c00A:
undetectable		 1jr1A-4c00A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 11 ASP A 473
SER A 475
ARG A 477
GLY A 502
THR A 450
 None
None
None
MC3  A 603 ( 3.2A)
None
 1.46A 1jr1A-4c00A:
undetectable		 1jr1A-4c00A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		3 / 3 THR A 536
GLU A 524
ASP A 528
 MC3  A 603 (-3.2A)
None
None
 0.54A 1nt2A-4c00A:
undetectable		 1nt2A-4c00A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		5 / 12 LEU A 499
LEU A 451
ALA A 470
ILE A 484
ILE A 529
 None
MC3  A 603 ( 3.5A)
None
None
None
 1.14A 1tw4A-4c00A:
2.1		 1tw4A-4c00A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		4 / 4 VAL A 103
ARG A 187
ILE A 193
THR A 108
 MC3  A 265 (-4.1A)
None
MC3  A 270 (-4.0A)
None
 1.25A 3cl9A-2b6oA:
undetectable		 3cl9A-2b6oA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 12 ASN A 184
ALA A  19
ALA A  99
VAL A 103
THR A  54
 None
None
MC3  A 270 ( 3.7A)
MC3  A 265 (-4.1A)
None
 1.16A 3czhB-2b6oA:
undetectable		 3czhB-2b6oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		4 / 6 VAL A  90
LEU A  28
ALA A 186
LEU A  94
 MC3  A 266 (-4.8A)
None
None
MC3  A 266 (-4.6A)
 0.88A 3kk6B-2b6oA:
undetectable		 3kk6B-2b6oA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 5 SER A 522
THR A 536
GLU A 524
ASP A 528
 MC3  A 603 (-2.6A)
MC3  A 603 (-3.2A)
None
None
 1.09A 3tm4A-4c00A:
undetectable		 3tm4A-4c00A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA
(Escherichia
coli) 		4 / 5 SER A 522
THR A 536
GLU A 524
ASP A 528
 MC3  A 603 (-2.6A)
MC3  A 603 (-3.2A)
None
None
 1.06A 3tm4B-4c00A:
undetectable		 3tm4B-4c00A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 12 VAL A  90
GLN A  93
LEU A  52
ALA A 186
ASN A 184
 MC3  A 266 (-4.8A)
None
None
None
None
 1.14A 4qckA-2b6oA:
undetectable		 4qckA-2b6oA:
19.28