SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MBT'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PO7_A_ZONA601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	7 / 8	TYR A 60 LEU A 171 CYH A 172 GLN A 206 PHE A 343 TYR A 398 TYR A 435	FAD A 600 (-4.4A) MBT A 601 (-4.2A) None MBT A 601 (-3.4A) MBT A 601 (-4.7A) MBT A 601 ( 3.6A) MBT A 601 ( 4.6A)	0.19A	3po7A-3zyxA: 65.2	3po7A-3zyxA: 99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PO7_B_ZONB601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	8 / 9	TYR A 60 LEU A 171 CYH A 172 ILE A 198 GLN A 206 PHE A 343 TYR A 398 TYR A 435	FAD A 600 (-4.4A) MBT A 601 (-4.2A) None None MBT A 601 (-3.4A) MBT A 601 (-4.7A) MBT A 601 ( 3.6A) MBT A 601 ( 4.6A)	0.14A	3po7B-3zyxA: 64.8	3po7B-3zyxA: 99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A79_A_P1BA601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	10 / 12	PRO A 104 TRP A 119 LEU A 164 LEU A 171 CYH A 172 GLN A 206 ILE A 316 PHE A 343 TYR A 398 TYR A 435	None None None MBT A 601 (-4.2A) None MBT A 601 (-3.4A) MBT A 601 (-4.6A) MBT A 601 (-4.7A) MBT A 601 ( 3.6A) MBT A 601 ( 4.6A)	0.33A	4a79A-3zyxA: 65.3	4a79A-3zyxA: 99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A79_B_P1BB601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	10 / 12	PRO A 104 TRP A 119 LEU A 164 LEU A 171 CYH A 172 GLN A 206 ILE A 316 PHE A 343 TYR A 398 TYR A 435	None None None MBT A 601 (-4.2A) None MBT A 601 (-3.4A) MBT A 601 (-4.6A) MBT A 601 (-4.7A) MBT A 601 ( 3.6A) MBT A 601 ( 4.6A)	0.43A	4a79B-3zyxA: 64.7	4a79B-3zyxA: 99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A7A_A_RGZA601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	9 / 11	TYR A 60 LEU A 164 LEU A 171 CYH A 172 GLN A 206 ILE A 316 PHE A 343 TYR A 398 TYR A 435	FAD A 600 (-4.4A) None MBT A 601 (-4.2A) None MBT A 601 (-3.4A) MBT A 601 (-4.6A) MBT A 601 (-4.7A) MBT A 601 ( 3.6A) MBT A 601 ( 4.6A)	0.20A	4a7aA-3zyxA: 65.3	4a7aA-3zyxA: 99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A7A_B_RGZB601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	10 / 12	PRO A 104 LEU A 164 LEU A 167 LEU A 171 CYH A 172 GLN A 206 ILE A 316 PHE A 343 TYR A 398 TYR A 435	None None None MBT A 601 (-4.2A) None MBT A 601 (-3.4A) MBT A 601 (-4.6A) MBT A 601 (-4.7A) MBT A 601 ( 3.6A) MBT A 601 ( 4.6A)	0.42A	4a7aB-3zyxA: 64.9	4a7aB-3zyxA: 99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PEV_B_ADNB501_1 (MEMBRANE LIPOPROTEIN FAMILY PROTEIN)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	5 / 12	VAL A 294 GLY A 57 PHE A 343 GLY A 342 ASP A 330	None FAD A 600 ( 3.8A) MBT A 601 (-4.7A) None None	1.35A	4pevB-3zyxA: 2.5	4pevB-3zyxA: 21.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3PO7_A_ZONA601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","3zyx","AMINE OXIDASE [FLAVIN-CONTAINING] B","Homo sapiens",7,"TYR A  60;LEU A 171;CYH A 172;GLN A 206;PHE A 343;TYR A 398;TYR A 435","FAD A 600 (-4.4A);MBT A 601 (-4.2A);None;MBT A 601 (-3.4A);MBT A 601 (-4.7A);MBT A 601 ( 3.6A);MBT A 601 ( 4.6A)","0.19A","3po7A-3zyxA:65.2",null],["3PO7_B_ZONB601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","3zyx","AMINE OXIDASE [FLAVIN-CONTAINING] B","Homo sapiens",8,"TYR A  60;LEU A 171;CYH A 172;ILE A 198;GLN A 206;PHE A 343;TYR A 398;TYR A 435","FAD A 600 (-4.4A);MBT A 601 (-4.2A);None;None;MBT A 601 (-3.4A);MBT A 601 (-4.7A);MBT A 601 ( 3.6A);MBT A 601 ( 4.6A)","0.14A","3po7B-3zyxA:64.8","3po7A-3zyxA:99.61"],["4A79_A_P1BA601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","3zyx","AMINE OXIDASE [FLAVIN-CONTAINING] B","Homo sapiens",10,"PRO A 104;TRP A 119;LEU A 164;LEU A 171;CYH A 172;GLN A 206;ILE A 316;PHE A 343;TYR A 398;TYR A 435","None;None;None;MBT A 601 (-4.2A);None;MBT A 601 (-3.4A);MBT A 601 (-4.6A);MBT A 601 (-4.7A);MBT A 601 ( 3.6A);MBT A 601 ( 4.6A)","0.33A","4a79A-3zyxA:65.3","3po7B-3zyxA:99.61"],["4A79_B_P1BB601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","3zyx","AMINE OXIDASE [FLAVIN-CONTAINING] B","Homo sapiens",10,"PRO A 104;TRP A 119;LEU A 164;LEU A 171;CYH A 172;GLN A 206;ILE A 316;PHE A 343;TYR A 398;TYR A 435","None;None;None;MBT A 601 (-4.2A);None;MBT A 601 (-3.4A);MBT A 601 (-4.6A);MBT A 601 (-4.7A);MBT A 601 ( 3.6A);MBT A 601 ( 4.6A)","0.43A","4a79B-3zyxA:64.7","4a79A-3zyxA:99.61"],["4A7A_A_RGZA601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","3zyx","AMINE OXIDASE [FLAVIN-CONTAINING] B","Homo sapiens",9,"TYR A  60;LEU A 164;LEU A 171;CYH A 172;GLN A 206;ILE A 316;PHE A 343;TYR A 398;TYR A 435","FAD A 600 (-4.4A);None;MBT A 601 (-4.2A);None;MBT A 601 (-3.4A);MBT A 601 (-4.6A);MBT A 601 (-4.7A);MBT A 601 ( 3.6A);MBT A 601 ( 4.6A)","0.20A","4a7aA-3zyxA:65.3","4a79B-3zyxA:99.61"],["4A7A_B_RGZB601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","3zyx","AMINE OXIDASE [FLAVIN-CONTAINING] B","Homo sapiens",10,"PRO A 104;LEU A 164;LEU A 167;LEU A 171;CYH A 172;GLN A 206;ILE A 316;PHE A 343;TYR A 398;TYR A 435","None;None;None;MBT A 601 (-4.2A);None;MBT A 601 (-3.4A);MBT A 601 (-4.6A);MBT A 601 (-4.7A);MBT A 601 ( 3.6A);MBT A 601 ( 4.6A)","0.42A","4a7aB-3zyxA:64.9","4a7aA-3zyxA:99.61"],["4PEV_B_ADNB501_1","MEMBRANE LIPOPROTEIN FAMILY PROTEIN","3zyx","AMINE OXIDASE [FLAVIN-CONTAINING] B","Homo sapiens",5,"VAL A 294;GLY A  57;PHE A 343;GLY A 342;ASP A 330","None;FAD A 600 ( 3.8A);MBT A 601 (-4.7A);None;None","1.35A","4pevB-3zyxA:2.5","4a7aB-3zyxA:99.61"]]